38 research outputs found
Photodynamic Therapy With Verteporfin for Choroidal Neovascularization in Patients with Angioid Streaks
Get PDF
Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers
No full textSubthreshold transpupillary thermotherapy of the retina and experimental choroidal neovascularization in a rat model
No full textControlling Vascular Endothelial Growth Factor: Therapies for Ocular Diseases Associated with Nevascularization
No full text
Intravitreal treatment in patients with exudative age-related macular degeneration and visual acuity ≤ 0.05
No full textCopy number variation in VEGF gene as a biomarker of susceptibility to age-related macular degeneration
No full textSuppression of laser-induced choroidal neovascularization by oral administration of SA3443 in mice
Get PDFAbstractThe effect of a synthetic cyclic disulfide compound, SA3443, on neovascularization was investigated. In vitro, enzyme-linked immunosorbent assay and RT-PCR demonstrated that SA3443 suppressed the expression of the hypoxia-induced vascular endothelial growth factor (VEGF) at both protein and mRNA levels in ARPE-19 cells. In vivo, the administration of SA3443 to mice with laser-induced choroidal neovascularization (CNV) suppressed the leakage from the lesions and reduced their size. Furthermore, the expression level of VEGF protein was significantly reduced by the administration of SA3443. Taken together, our results demonstrate that SA3443 suppresses VEGF production and reduces vascular leakage and the growth of mouse experimental CNV
