849 research outputs found
An iterative design method for Coalitional control networks with constraints on the shapley Value
9th World CongressThe International Federation of Automatic ControlCape Town, South Africa. August 24-29In this work, we introduce a new iterative design method for a coalitional control scheme for linear systems recently proposed. In this scheme, the links in the network infrastructure are enabled or disabled depending on their contribution to the overall system performance. As a consequence, the local controllers are divided dynamically into sets or coalitions that cooperate in order to attain their control tasks. The new design method allows the control system designer to include new constraints regarding the game theoretical tools of the control architecture, while optimizing the matrices that define the controller
An Application of Cooperative Game Theory to Distributed Control
18th World CongressThe International Federation of Automatic ControlMilano (Italy) August 28 - September 2, 2011In this paper we propose to study the underlying properties of a given distributed control scheme in which a set of agents switch between different communication strategies that define which network links are used in order to regulate to the origin a set of unconstrained linear systems. The problems of how to decide the time-varying communication strategy, share the benefits/costs and detect which are the most critical links in the network are solved using tools from game theory. The proposed scheme is demonstrated through a simulation example
Volume-preserving normal forms of Hopf-zero singularity
A practical method is described for computing the unique generator of the
algebra of first integrals associated with a large class of Hopf-zero
singularity. The set of all volume-preserving classical normal forms of this
singularity is introduced via a Lie algebra description. This is a maximal
vector space of classical normal forms with first integral; this is whence our
approach works. Systems with a non-zero condition on their quadratic parts are
considered. The algebra of all first integrals for any such system has a unique
(modulo scalar multiplication) generator. The infinite level volume-preserving
parametric normal forms of any non-degenerate perturbation within the Lie
algebra of any such system is computed, where it can have rich dynamics. The
associated unique generator of the algebra of first integrals are derived. The
symmetry group of the infinite level normal forms are also discussed. Some
necessary formulas are derived and applied to appropriately modified
R\"{o}ssler and generalized Kuramoto--Sivashinsky equations to demonstrate the
applicability of our theoretical results. An approach (introduced by Iooss and
Lombardi) is applied to find an optimal truncation for the first level normal
forms of these examples with exponentially small remainders. The numerically
suggested radius of convergence (for the first integral) associated with a
hypernormalization step is discussed for the truncated first level normal forms
of the examples. This is achieved by an efficient implementation of the results
using Maple
Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up †
Renal Adenomas: Pathological Differential Diagnosis with Malignant Tumors
The renal adenomas can be confused by imaging diagnosis with malignant renal tumors, but there
are also real biological dilemmas to determine their behavior.
The consensus decisions are the following. (1) The adenoma of clear cells is not accepted, instead
it is considered that all the clear-cell tumors are carcinomas, with greater or lesser aggressiveness. (2)
Among the papillary neoplasms the WHO 2004 renal cell tumors classification are considered as papillary
adenomas tumors with a maximum diameter of 5 mm and may represent a continuum biological process to
papillary renal cell carcinoma. The papillary adenomas associated with End-kidney and/or acquired cystic
disease may have a different pathogenesis. (3) To consider a tumor as an oncocytoma the size is not important,
only the cytological features, microscopic, ultrastructural, and immunohistochemically can help, but some
chromosomal observations introduce some questions about its relation with the chromophobe renal cell carcinoma.
(4) Finally, the metanephric adenoma, a tumor with some morphological similarity with the nephroblastoma must be
considered in the renal adenomas diagnosis
Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB
Acinetobacter baumannii is a significant human pathogen associated with hospital-acquired infections. While adhesion, an initial and important step in A. baumannii infection, is well characterized, the intracellular trafficking of this pathogen inside host cells remains poorly studied. Here, we demonstrate that transcription factor EB (TFEB) is activated after A. baumannii infection of human lung epithelial cells (A549). We also show that TFEB is required for the invasion and persistence inside A549 cells. Consequently, lysosomal biogenesis and autophagy activation were observed after TFEB activation which could increase the death of A549 cells. In addition, using the Caenorhabditis elegans infection model by A. baumannii, the TFEB orthologue HLH-30 was required for survival of the nematode to infection, although nuclear translocation of HLH-30 was not required. These results identify TFEB as a conserved key factor in the pathogenesis of A. baumannii.Consejería de Innovación, Ciencia y EmpresaInstituto de Salud Carlos IIIMinisterio de Economía, Industria y Competitividad. Subdirección General de Redes y Centros de Investigación CooperativaSpanish Ministry of Economy and Competitivenes
Axiomatizations of two types of Shapley values for games on union closed systems
A situation in which a finite set of players can obtain certain payoffs by cooperation can be described by a cooperative game with transferable utility, or simply a TU-game. A (single-valued) solution for TU-games assigns a payoff distribution to every TU-game. A well-known solution is the Shapley value. In the literature various models of games with restricted cooperation can be found. So, instead of allowing all subsets of the player set N to form, it is assumed that the set of feasible coalitions is a subset of the power set of N. In this paper, we consider such sets of feasible coalitions that are closed under union, i.e. for any two feasible coalitions also their union is feasible. We consider and axiomatize two solutions or rules for these games that generalize the Shapley value: one is obtained as the conjunctive permission value using a corresponding superior graph, the other is defined as the Shapley value of a modified game similar as the Myerson value for games with limited communication. © 2010 The Author(s)
Gleason Grade 4 Prostate Adenocarcinoma Patterns: An Inter-observer Agreement Study among Genitourinary Pathologists
Aims
To assess the interobserver reproducibility of individual Gleason grade 4 growth patterns.
Methods and results
Twenty-three genitourinary pathologists participated in the evaluation of 60 selected high-magnification photographs. The selection included 10 cases of Gleason grade 3, 40 of Gleason grade 4 (10 per growth pattern), and 10 of Gleason grade 5. Participants were asked to select a single predominant Gleason grade per case (3, 4, or 5), and to indicate the predominant Gleason grade 4 growth pattern, if present. ‘Consensus’ was defined as at least 80% agreement, and ‘favoured’ as 60–80% agreement. Consensus on Gleason grading was reached in 47 of 60 (78%) cases, 35 of which were assigned to grade 4. In the 13 non-consensus cases, ill-formed (6/13, 46%) and fused (7/13, 54%) patterns were involved in the disagreement. Among the 20 cases where at least one pathologist assigned the ill-formed growth pattern, none (0%, 0/20) reached consensus. Consensus for fused, cribriform and glomeruloid glands was reached in 2%, 23% and 38% of cases, respectively. In nine of 35 (26%) consensus Gleason grade 4 cases, participants disagreed on the growth pattern. Six of these were characterized by large epithelial proliferations with delicate intervening fibrovascular cores, which were alternatively given the designation fused or cribriform growth pattern (‘complex fused’).
Conclusions
Consensus on Gleason grade 4 growth pattern was predominantly reached on cribriform and glomeruloid patterns, but rarely on ill-formed and fused glands. The complex fused glands seem to constitute a borderline pattern of unknown prognostic significance on which a consensus could not be reached
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