Effect of high frequency ultrasounds on lycopene and total phenolic concentration, antioxidant properties and α-glucosidase inhibitory activity of tomato juice

Tomato juice was subjected to high frequency ultrasounds(378 and 583 kHz)at increasing energy densities (up to 250 MJ/m3). Results relevant to the treatments at high frequency providing an energy density of 250 MJ/m3 were compared with those obtained at 24 kHz delivering the same energy density. Lycopene and total phenolic concentration, as well as the α-glucosidase inhibitory activityof tomato juice, were not affected by ultrasound regardless the frequency and energy density. However, the antioxidant properties were negatively affected by high frequency ultrasounds

JTM's Tumor immunology goes broad: announcing the Immunobiology and Immunotherapy section.

For the last four years the Journal of Translational Medicine (JTM) has hosted the Section of Tumor Immunology and Biological Cancer Therapy. Under the editorial leadership of Dr. Pedro Romero and with the direct support of the Society for Immunotherapy of Cancer (SITC), this section enriched the communication between basic immunological sciences and the clinical investigation arena in oncology. We are re-launching this Section of JTM, now entitled Immunobiology and Immunotherapy, succeeding Tumor Immunology and Biological Cancer Therapy. While aiming to build on the editorial success and focus of its predecessor, this novel Section will have a broader scope, hosting translational immunology topics pertaining to immunotherapy beyond oncology, including disciplines such as inflammation, autoimmunity, transplantation, metabolic disorders and others. As the vision of this re-launched Section of JTM broadens up to serve a communication need for translational immunologists involved with immunotherapy irrespectively of the therapeutic area, a novel and focused journal entitled Journal for Immunotherapy of Cancer (JITC) has just been initiated, sponsored by the SITC

Hierarchical progressive surveys. Multi-resolution HEALPix data structures for astronomical images, catalogues, and 3-dimensional data cubes

Scientific exploitation of the ever increasing volumes of astronomical data requires efficient and practical methods for data access, visualisation, and analysis. Hierarchical sky tessellation techniques enable a multi-resolution approach to organising data on angular scales from the full sky down to the individual image pixels. Aims. We aim to show that the Hierarchical progressive survey (HiPS) scheme for describing astronomical images, source catalogues, and three-dimensional data cubes is a practical solution to managing large volumes of heterogeneous data and that it enables a new level of scientific interoperability across large collections of data of these different data types. Methods. HiPS uses the HEALPix tessellation of the sphere to define a hierarchical tile and pixel structure to describe and organise astronomical data. HiPS is designed to conserve the scientific properties of the data alongside both visualisation considerations and emphasis on the ease of implementation. We describe the development of HiPS to manage a large number of diverse image surveys, as well as the extension of hierarchical image systems to cube and catalogue data. We demonstrate the interoperability of HiPS and Multi-Order Coverage (MOC) maps and highlight the HiPS mechanism to provide links to the original data. Results. Hierarchical progressive surveys have been generated by various data centres and groups for ~200 data collections including many wide area sky surveys, and archives of pointed observations. These can be accessed and visualised in Aladin, Aladin Lite, and other applications. HiPS provides a basis for further innovations in the use of hierarchical data structures to facilitate the description and statistical analysis of large astronomical data sets.Comment: 21 pages, 6 figures. Accepted for publication in Astronomy & Astrophysic

The Structure of a Low-Metallicity Giant Molecular Cloud Complex

To understand the impact of low metallicities on giant molecular cloud (GMC) structure, we compare far infrared dust emission, CO emission, and dynamics in the star-forming complex N83 in the Wing of the Small Magellanic Cloud. Dust emission (measured by Spitzer as part of the S3MC and SAGE-SMC surveys) probes the total gas column independent of molecular line emission and traces shielding from photodissociating radiation. We calibrate a method to estimate the dust column using only the high-resolution Spitzer data and verify that dust traces the ISM in the HI-dominated region around N83. This allows us to resolve the relative structures of H2, dust, and CO within a giant molecular cloud complex, one of the first times such a measurement has been made in a low-metallicity galaxy. Our results support the hypothesis that CO is photodissociated while H2 self-shields in the outer parts of low-metallicity GMCs, so that dust/self shielding is the primary factor determining the distribution of CO emission. Four pieces of evidence support this view. First, the CO-to-H2 conversion factor averaged over the whole cloud is very high 4-11 \times 10^21 cm^-2/(K km/s), or 20-55 times the Galactic value. Second, the CO-to-H2 conversion factor varies across the complex, with its lowest (most nearly Galactic) values near the CO peaks. Third, bright CO emission is largely confined to regions of relatively high line-of-sight extinction, A_V >~ 2 mag, in agreement with PDR models and Galactic observations. Fourth, a simple model in which CO emerges from a smaller sphere nested inside a larger cloud can roughly relate the H2 masses measured from CO kinematics and dust.Comment: 17 pages, 10 figures (including appendix), accepted for publication in the Astrophysical Journa

Submillimeter to centimeter excess emission from the Magellanic Clouds. II. On the nature of the excess

Dust emission at submm to cm wavelengths is often simply the Rayleigh-Jeans tail of dust particles at thermal equilibrium and is used as a cold mass tracer in various environments including nearby galaxies. However, well-sampled spectral energy distributions of the nearby, star-forming Magellanic Clouds have a pronounced (sub-)millimeter excess (Israel et al., 2010). This study attempts to confirm the existence of such a millimeter excess above expected dust, free-free and synchrotron emission and to explore different possibilities for its origin. We model NIR to radio spectral energy distributions of the Magellanic Clouds with dust, free-free and synchrotron emission. A millimeter excess emission is confirmed above these components and its spectral shape and intensity are analysed in light of different scenarios: very cold dust, Cosmic Microwave Background (CMB) fluctuations, a change of the dust spectral index and spinning dust emission. We show that very cold dust or CMB fluctuations are very unlikely explanations for the observed excess in these two galaxies. The excess in the LMC can be satisfactorily explained either by a change of the spectral index due to intrinsic properties of amorphous grains, or by spinning dust emission. In the SMC however, due to the importance of the excess, the dust grain model including TLS/DCD effects cannot reproduce the observed emission in a simple way. A possible solution was achieved with spinning dust emission, but many assumptions on the physical state of the interstellar medium had to be made. Further studies, using higher resolution data from Planck and Herschel, are needed to probe the origin of this observed submm-cm excess more definitely. Our study shows that the different possible origins will be best distinguished where the excess is the highest, as is the case in the SMC.Comment: 7 pages, 6 figures; accepted in A&

Millimeter dust continuum emission unveiling the true mass of giant molecular clouds in the Small Magellanic Cloud

CO observations have been so far the best way to trace molecular gas in external galaxies, but at low metallicity the gas mass deduced could be largely underestimated. At present, the kinematic information of CO data cubes are used to estimate virial masses and trace the total mass of the molecular clouds. Millimeter dust emission can also be used as a dense gas tracer and could unveil H2 envelopes lacking CO. These different tracers must be compared in different environments. This study compares virial masses to masses deduced from millimeter emission, in two GMC samples: the local molecular clouds in our Galaxy and their equivalents in the Small Magellanic Cloud (SMC), one of the nearest low metallicity dwarf galaxy. In our Galaxy, mass estimates deduced from millimeter emission are consistent with masses deduced from gamma ray analysis and trace the total mass of the clouds. Virial masses are systematically larger (twice on average) than mass estimates from millimeter dust emission. This difference decreases toward high masses and has already been reported in previous studies. In the SMC however, molecular cloud masses deduced from SIMBA millimeter observations are systematically higher (twice on average for conservative values of the dust to gas ratio and dust emissivity) than the virial masses from SEST CO observations. The observed excess can not be accounted for by any plausible change of dust properties. Taking a general form for the virial theorem, we show that a magnetic field strength of ~15 micro Gauss in SMC clouds could provide additional support to the clouds and explain the difference observed. Masses of SMC molecular clouds have therefore been underestimated so far. Magnetic pressure may contribute significantly to their support.Comment: 10 pages, 2 figures, Astronomy & Astrophysics accepte

The dust properties and physical conditions of the interstellar medium in the LMC massive star forming complex N11

We combine Spitzer and Herschel data of the star-forming region N11 in the Large Magellanic Cloud to produce detailed maps of the dust properties in the complex and study their variations with the ISM conditions. We also compare APEX/LABOCA 870um observations with our model predictions in order to decompose the 870um emission into dust and non-dust (free-free emission and CO(3-2) line) contributions. We find that in N11, the 870um can be fully accounted for by these 3 components. The dust surface density map of N11 is combined with HI and CO observations to study local variations in the gas-to-dust mass ratios. Our analysis leads to values lower than those expected from the LMC low-metallicity as well as to a decrease of the gas-to-dust mass ratio with the dust surface density. We explore potential hypotheses that could explain the low observed gas-to-dust mass ratios (variations in the XCO factor, presence of CO-dark gas or of optically thick HI or variations in the dust abundance in the dense regions). We finally decompose the local SEDs using a Principal Component Analysis (i.e. with no a priori assumption on the dust composition in the complex). Our results lead to a promising decomposition of the local SEDs in various dust components (hot, warm, cold) coherent with that expected for the region. Further analysis on a larger sample of galaxies will follow in order to understand how unique this decomposition is or how it evolves from one environment to another.Comment: 24 pages, 16 figures, accepted for publication in MNRA

The remnant of SN1987A revealed at (sub-)mm wavelengths

Context: Supernova 1987A (SN1987A) exploded in the Large Magellanic Cloud (LMC). Its proximity and rapid evolution makes it a unique case study of the early phases in the development of a supernova remnant. One particular aspect of interest is the possible formation of dust in SN1987A, as SNe could contribute significantly to the dust seen at high redshifts. Aims: We explore the properties of SN1987A and its circumburst medium as seen at mm and sub-mm wavelengths, bridging the gap between extant radio and infrared (IR) observations of respectively the synchrotron and dust emission. Methods: SN1987A was observed with the Australia Telescope Compact Array (ATCA) at 3.2 mm in July 2005, and with the Atacama Pathfinder EXperiment (APEX) at 0.87 mm in May 2007. We present the images and brightness measurements of SN1987A at these wavelengths for the first time. Results: SN1987A is detected as an unresolved point source of 11.2 +/- 2.0 mJy at 3.2 mm (5" beam) and 21 +/- 4 mJy at 0.87 mm (18" beam). These flux densities are in perfect agreement with extrapolations of the powerlaw radio spectrum and modified-blackbody dust emission, respectively. This places limits on the presence of free-free emission, which is similar to the expected free-free emission from the ionized ejecta from SN1987A. Adjacent, fainter emission is observed at 0.87 mm extending ~0.5' towards the south-west. This could be the impact of the supernova progenitor's wind when it was still a red supergiant upon a dense medium. Conclusions: We have established a continuous spectral energy distribution for the emission from SN1987A and its immediate surroundings, linking the IR and radio data. This places limits on the contribution from ionized plasma. Our sub-mm image reveals complexity in the distribution of cold dust surrounding SN1987A, but leaves room for freshly synthesized dust in the SN ejecta.Comment: Accepted for publication in Astronomy and Astrophysics Letters on 28 April 2011. A better quality figure 1 can be had from http://www.astro.keele.ac.uk/~jacco/research/SN1987A087mm.ep

Multi-wavelength analysis of the dust emission in the Small Magellanic Cloud

We present an analysis of dust grain emission in the diffuse interstellar medium of the Small Magellanic Cloud (SMC). This study is motivated by the availability of 170 microns ISOPHOT data covering a large part of the SMC, with a resolution enabling to disentangle the diffuse medium from the star forming regions. After data reduction and subtraction of Galactic foreground emission, we used the ISOPHOT data together with HiRes IRAS data and ATCA/Parkes combined HI column density maps to determine dust properties for the diffuse medium. We found a far infrared emissivity per hydrogen atom 30 times lower than the Solar Neighborhood value. The modeling of the spectral energy distribution of the dust, taking into account the enhanced interstellar radiation field, gives a similar conclusion for the smallest grains (PAHs and very small grains) emitting at shorter wavelength. Assuming Galactic dust composition in the SMC, this result implies a difference in the gas-to-dust ratio (GDR) 3 times larger than the difference in metallicity. This low depletion of heavy elements in dust could be specific of the diffuse ISM and not apply for the whole SMC dust if it results from efficient destruction of dust by supernovae explosions.Comment: 11 pages, 10 figures. Accepted for publication in Astronomy & Astrophysic

Annual variability in the seasonal cycles of chlorophyll, nutrients and zooplankton on the North-West European continental shelf

Seasonal cycles of salinity, nutrients, chlorophyll and zooplankton at 8 locations on the West-European shelf were analysed with respect to their timing and magnitude in the period 1980-1984. A late spring bloom with low chlorophyll values (2-4 mg.m-³) is observed in the Irish Sea, off the Scottish east coast and the Channel entrance. An early spring bloom and relatively high chlorophyll values (7-12 mg.m-³) are found in the southern Bight and the Skagerrak, whereas a late spring bloom with high chlorophyll concentrations (24 mg.m-³) is found along the Dutch and Belgian coast. In contrast to the other regions, the peak of the phytoplankton cycle in the German Bight (Helgoland) occurs in the summer period instead of the spring period. The peak in the yearly abundance of copepods shifts from May-June in the south to July-August in the north of the shelf. In the Irish Sea and the Channel entrance two seasonal copepods peaks are observed. The January nitrate values in Irish Sea, the southern Bight and the Skagerrak are about 20 % higher than those in the Atlantic input signal in the Channel entrance and east off Scotland. The January DIP values in these regions are comparable to those of the input signal, but the Irish Sea forms an exception here the level is increased by 10-20%. If compared with the Atlantic input signal the January values for nitrate and DIP at the Dutch and Belgium coast are about 10 and 4, and in the German Bight (Helgoland) 4 and 3 times higher, respectively. At most sites changes in the seasonal cycles of chorophyll coincide with changes in nutrient concentrations, wheras the maximum level of the seasonal signal is related to the nutrient levels