Fuzzy Bayesian estimation and consequence modeling of the domino effects of methanol storage tanks

YesIn this study, a Fuzzy Bayesian network (FBN) approach was proposed to analyze the domino effects of pool fire in storage tanks. Failure probabilities were calculated using triangular fuzzy numbers, the combined Center of area (CoA)/Sum-Product method, and the BN approach. Consequence modeling, probit equations, and Leaky-Noisy OR (L-NOR) gates were used to analyze the domino effects, and modify conditional probability tables (CPTs). Methanol storage tanks were selected to confirm the practical feasibility of the suggested method. Then the domino probability using bow-tie analysis (BTA), and FBN in the first and second levels was compared, and the Ratio of Variation (RoV) was used for sensitivity analysis. The probability of the domino effect in the first and second levels (FBN) was 0.0071472631 and 0.0090630640, respectively. The results confirm that this method is a suitable tool for analyzing the domino effects and using FBN and L-NOR gate is a good way for assessing the reliability of tanks.National Petrochemical Company (NPC) of IranThe full-text of this article will be released for public view at the end of the publisher embargo on 29 Dec 2022

Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing

In congenital Chuvash polycythemia (CP), VHLR200W homozygosity leads to elevated hypoxia inducible factor (HIF) levels at normoxia. CP is often treated by phlebotomy resulting in iron deficiency, permitting us to examine the separate and synergistic effects of iron deficiency and HIF signaling on gene expression. We compared peripheral blood mononuclear cell gene expression profiles of eight VHLR200W homozygotes with 17 wildtype individuals with normal iron status and found 812 up-regulated and 2120 down-regulated genes at false discovery rate of 0.05. Among differential genes we identified three major gene regulation modules involving induction of innate immune responses, alteration of carbohydrate and lipid metabolism, and down-regulation of cell proliferation, stress-induced apoptosis and T-cell activation. These observations suggest molecular mechanisms for previous observations in CP of lower blood sugar without increased insulin and low oncogenic potential. Studies including 16 additional VHLR200W homozygotes with low ferritin indicated that iron deficiency enhanced the induction effect of VHLR200W for 50 genes including hemoglobin synthesis loci but suppressed the effect for 107 genes enriched for HIF-2 targets. This pattern is consistent with potentiation of HIF-1α protein stability by iron deficiency but a trend for down-regulation of HIF-2α translation by iron deficiency overriding an increase in HIF-2α protein stability. © 2013 Elsevier Inc