Empirical Studies Applied to Software Process Models

Working Group Report: ICSE'99 Workshop on Empirical Studies of Software Development and Evolutio

The Planck Surveyor mission: astrophysical prospects

Although the Planck Surveyor mission is optimized to map the cosmic microwave background anisotropies, it will also provide extremely valuable information on astrophysical phenomena. We review our present understanding of Galactic and extragalactic foregrounds relevant to the mission and discuss on one side, Planck's impact on the study of their properties and, on the other side, to what extent foreground contamination may affect Planck's ability to accurately determine cosmological parameters. Planck's multifrequency surveys will be unique in their coverage of large areas of the sky (actually, of the full sky); this will extend by two or more orders of magnitude the flux density interval over which mm/sub-mm counts of extragalactic sources can be determined by instruments already available (like SCUBA) or planned for the next decade (like the LSA-MMA or the space mission FIRST), which go much deeper but over very limited areas. Planck will thus provide essential complementary information on the epoch-dependent luminosity functions. Bright radio sources will be studied over a poorly explored frequency range where spectral signatures, essential to understand the physical processes that are going on, show up. The Sunyaev-Zeldovich effect, with its extremely rich information content, will be observed in the direction of a large number of rich clusters of Galaxies. Thanks again to its all sky coverage, Planck will provide unique information on the structure and on the emission properties of the interstellar medium in the Galaxy. At the same time, the foregrounds are unlikely to substantially limit Planck's ability to measure the cosmological signals. Even measurements of polarization of the primordial Cosmic Microwave background fluctuations appear to be feasible.Comment: 20 pages, Latex (use aipproc2.sty, aipproc2.cls, epsfig.sty), 10 PostScript figures; invited review talk, Proc. of the Conference: "3 K Cosmology", Roma, Italy, 5-10 October 1998, AIP Conference Proc, in press Note: Figures 6 and 7 have been replaced by new and correct version

Chinese Voices of social care: report on the factors that contribute to levels of satisfaction with social care for physical disabilities amongst people from Chinese backgrounds in England

Report on the factors that contribute to the levels of satisfaction with social care for physical disabilities amongst people from Chinese backgrounds in England

Planck Observations of M33

We have performed a comprehensive investigation of the global integrated flux density of M33 from radio to ultraviolet wavelengths, finding that the data between $\sim$100 GHz and 3 THz are accurately described by a single modified blackbody curve with a dust temperature of $T_\mathrm{dust}$ = 21.67$\pm$0.30 K and an effective dust emissivity index of $\beta_\mathrm{eff}$ = 1.35$\pm$0.10, with no indication of an excess of emission at millimeter/sub-millimeter wavelengths. However, sub-dividing M33 into three radial annuli, we found that the global emission curve is highly degenerate with the constituent curves representing the sub-regions of M33. We also found gradients in $T_\mathrm{dust}$ and $\beta_\mathrm{eff}$ across the disk of M33, with both quantities decreasing with increasing radius. Comparing the M33 dust emissivity with that of other Local Group members, we find that M33 resembles the Magellanic Clouds rather than the larger galaxies, i.e., the Milky Way and M31. In the Local Group sample, we find a clear correlation between global dust emissivity and metallicity, with dust emissivity increasing with metallicity. A major aspect of this analysis is the investigation into the impact of fluctuations in the Cosmic Microwave Background (CMB) on the integrated flux density spectrum of M33. We found that failing to account for these CMB fluctuations would result in a significant over-estimate of $T_\mathrm{dust}$ by $\sim$5 K and an under-estimate of $\beta_\mathrm{eff}$ by $\sim$0.4.Comment: Accepted for publication in MNRA

4th international workshop on ontologies and conceptual modeling (Onto.Com)

The theme of the 4th International Workshop on Ontologies and Conceptual Modeling is foundational ontologies and their meta-ontological choices. Expert representatives of major foundational ontologies have been invited to discuss and compare their meta-ontological choices within the context of a common case study. The workshop is aimed at exploring the ways in which different meta-ontological choices impact conceptual modelling in information systems

Faint Radio Sources and Star Formation History

Faint extragalactic radio sources provide important information about the global history of star formation. Sensitive radio observations of the Hubble Deep Field and other fields have found that sub-mJy radio sources are predominantly associated with star formation activity rather than AGN. Radio observations of star forming galaxies have the advantage of being independent of extinction by dust. We use the FIR-radio correlation to compare the radio and FIR backgrounds, and make several conclusions about the star forming galaxies producing the FIR background. We then use the redshift distribution of faint radio sources to determine the evolution of the radio luminosity function, and thus estimate the star formation density as a function of redshift.Comment: 12 pages, 9 figures, latex using texas.sty, to appear in the CD-ROM Proceedings of the 19th Texas Symposium on Relativistic Astrophysics and Cosmology, held in Paris, France, Dec. 14-18, 1998. Eds.: J. Paul, T. Montmerle, and E. Aubourg (CEA Saclay). No changes to paper, just updated publication info in this commen

Characterization of Dicer-deficient murine embryonic stem cells

Dicer is an RNase III-family nuclease that initiates RNA interference (RNAi) and related phenomena by generation of the small RNAs that determine the specificity of these gene silencing pathways. We have previously shown that Dicer is essential for mammalian development, with Dicer-deficient mice dying at embryonic day 7.5 with a lack of detectable multipotent stem cells. To permit a more detailed investigation of the biological roles of Dicer, we have generated embryonic stem cell lines in which their single Dicer gene can be conditionally inactivated. As expected, Dicer loss compromises maturation of microRNAs and leads to a defect in gene silencing triggered by long dsRNAs. However, the absence of Dicer does not affect the ability of small interfering RNAs to repress gene expression. Of interest, Dicer loss does compromise the proliferation of ES cells, possibly rationalizing the phenotype previously observed in Dicer-null animals. Dicer loss also affects the abundance of transcripts from mammalian centromeres but does so without a pronounced affect on histone modification status at pericentric repeats or methylation of centromeric DNA. These studies provide a conditional model of RNAi deficiency in mammals that will permit the dissection of the biological roles of the RNAi machinery in cultured mammalian cells

Thermal detection of single e-h pairs in a biased silicon crystal detector

We demonstrate that individual electron-hole pairs are resolved in a 1 cm$^2$ by 4 mm thick silicon crystal (0.93 g) operated at $\sim$35 mK. One side of the detector is patterned with two quasiparticle-trap-assisted electro-thermal-feedback transition edge sensor (QET) arrays held near ground potential. The other side contains a bias grid with 20\% coverage. Bias potentials up to $\pm$ 160 V were used in the work reported here. A fiber optic provides 650~nm (1.9 eV) photons that each produce an electron-hole ($e^{-} h^{+}$) pair in the crystal near the grid. The energy of the drifting charges is measured with a phonon sensor noise $\sigma$ $\sim$0.09 $e^{-} h^{+}$ pair. The observed charge quantization is nearly identical for $h^+$'s or $e^-$'s transported across the crystal.Comment: 4 journal pages, 5 figure

Flow and critical velocity of an imbalanced Fermi gas through an optical potential

Optical lattices offer the possibility to investigate the superfluid properties of both Bose condensates and Fermionic superfluid gases. When a population imbalance is present in a Fermi mixture, this leads to frustration of the pairing, and the superfluid properties will be affected. In this contribution, the influence of imbalance on the flow of a Fermi superfluid through an optical lattice is investigated. The flow through the lattice is analysed by taking into account coupling between neighbouring layers of the optical lattice up to second order in the interlayer tunneling amplitude for single atoms. The critical velocity of flow through the lattice is shown to decrease monotonically to zero as the imbalance is increased to 100%. Closed-form analytical expressions are given for the tunneling contribution to the action and for the critical velocity as a function of the binding energy of pairs in the (quasi) two-dimensional Fermi superfluid and as a function of the imbalance.Comment: 8 pages, 1 figure, contribution for the QFS 2007 conferenc

The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice

Background The liver plays a major role in regulating metabolic homeostasis and is vital for nutrient metabolism. Identifying the genetic factors regulating these processes could lead to a greater understanding of how liver function responds to a high-fat diet and how that response may influence susceptibilities to obesity and metabolic syndrome. In this study we examine differences in hepatic gene expression between the LG/J and SM/J inbred mouse strains and how gene expression in these strains is affected by high-fat diet. LG/J and SM/J are known to differ in their responses to a high-fat diet for a variety of obesity- and diabetes-related traits, with the SM/J strain exhibiting a stronger phenotypic response to diet. Results Dietary intake had a significant effect on gene expression in both inbred lines. Genes up-regulated by a high-fat diet were involved in biological processes such as lipid and carbohydrate metabolism; protein and amino acid metabolic processes were down regulated on a high-fat diet. A total of 259 unique transcripts exhibited a significant diet-by-strain interaction. These genes tended to be associated with immune function. In addition, genes involved in biochemical processes related to non-alcoholic fatty liver disease (NAFLD) manifested different responses to diet between the two strains. For most of these genes, SM/J had a stronger response to the high-fat diet than LG/J. Conclusions These data show that dietary fat impacts gene expression levels in SM/J relative to LG/J, with SM/J exhibiting a stronger response. This supports previous data showing that SM/J has a stronger phenotypic response to high-fat diet. Based upon these findings, we suggest that SM/J and its cross with the LG/J strain provide a good model for examining non-alcoholic fatty liver disease and its role in metabolic syndrome