2,367,125 research outputs found

    Aerodynamic forces of fluttering cylindrical and/or planar structures

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    Complexity of the phenomena of panel flutter instability has resulted in the necessity of developing separate design criteria for a variety of flow conditions and panel configurations. Vehicle panel configurations with low aspect ratios are of interest in low supersonic flow, where boundary layer effects are important

    Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments

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    The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution. The close correlation between gene transcription and function, allow the inference of biological processes from the assessed transcriptome profile. Among the sophisticated analytical problems in microarray technology at the front and back ends respectively, are the selection of optimal DNA oligos and computational analysis of the genes expression. In this review paper, we analyse important methods in use today in customized oligos design. In the course of executing this, we discovered that the oligos designer algorithm hanged on gene PFA0135w of chromosome 1, while designing oligos for the gene sequences of Plasmodium falciparum. We do not know the reason for this yet, as the algorithm runs on other sequences like the yeast (Saccharomyces cervisiae) and Neurospora crassa. We conclude the paper highlighting the procedures encompassing the back end phase and discuss their application to the development of vaccines and drugs for malaria treatment. Note that, malaria is the cause of significant global morbidity and mortality with 300-500 million cases annually. Our aims are not ends, but a means to achieve the following: Iterate the need for experimental biologists to (i) know how to design their customized oligos and (ii) have some idea about gene expression analysis and the need for cooperation between experimental biologists and their counterpart, the computational biologists. These will help experimental biologists to coordinate very well the front and the back ends of the system biology analysis of the whole genome effectively

    Marshall Amateur Club experiment (MARCE)

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    The integration of the Get Away Special (GAS) payload for the space shuttle is discussed in terms of systems design. In addition to the primary power, control, and distribution networks to electrically integrate the spaceborne experiments, an instrument measuring system, a data system, and a radio frequency downlink system were designed. A brief review of these systems is given

    Bipolar spin filter in a quantum dot molecule

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    We show that the tunable hybridization between two lateral quantum dots connected to non-magnetic current leads in a `hanging-dot' configuration that can be used to implement a bipolar spin filter. The competition between Zeeman, exchange interaction, and interdot tunneling (molecular hybridization) yields a singlet-triplet transition of the double dot {\it ground state} that allows spin filtering in Coulomb blockade experiments. Its generic nature should make it broadly useful as a robust bidirectional spin polarizer.Comment: 5 pages, 3 figures (to appear in Appl. Phys. Lett.

    Amplifier for measuring low-level signals in the presence of high common mode voltage

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    A high common mode rejection differential amplifier wherein two serially arranged Darlington amplifier stages are employed and any common mode voltage is divided between them by a resistance network. The input to the first Darlington amplifier stage is coupled to a signal input resistor via an amplifier which isolates the input and presents a high impedance across this resistor. The output of the second Darlington stage is transposed in scale via an amplifier stage which has its input a biasing circuit which effects a finite biasing of the two Darlington amplifier stages

    Preliminary Test of ERTS-1 Imagery for Improving Definition of Natural Streamflow

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    Preliminary test of ERTS-1 imagery for improving definition of natural streamflow, using two basins in Chesapeake Bay are

    Channel-type shell construction for rocket engines and the like Patent

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    Channel-type shell construction for rocket engines and related configuration

    The linear boom actuator designed for the Galileo spacecraft

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    Because the linear boom actuator is to be used on a flight spacecraft, as opposed to a ground based application, there is a comprehensive set of requirements. First, of course, the actuator must be capable of positioning and holding the load. Initially the load as predicted to be 4448 N (1000 lb) but with subsequent spacecraft configuration changes the load has been greatly reduced to a constant tensile pull of 1477 N (332 lb) due to centrifugal force. Lesser compressive loads of 1317 N (296 centrifugal lb) may be experienced during launch and deployment. This actuator must have the maximum redundancy possible. Life requirements were defined by the 10.16 to 15.24 cm (4 to 6 in.) total liner travel expected during the five-year flight duration. Liner range required of the actuator was set at plus and minus 5.08 cm to accommodate configuration changes
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