2,367,125 research outputs found
Aerodynamic forces of fluttering cylindrical and/or planar structures
Complexity of the phenomena of panel flutter instability has resulted in the necessity of developing separate design criteria for a variety of flow conditions and panel configurations. Vehicle panel configurations with low aspect ratios are of interest in low supersonic flow, where boundary layer effects are important
Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments
The sequencing race has ended and the functional race has already begun. Microarray technology enables
simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’
transcriptome at an unprecedented resolution. The close correlation between gene transcription and
function, allow the inference of biological processes from the assessed transcriptome profile. Among the
sophisticated analytical problems in microarray technology at the front and back ends respectively, are the
selection of optimal DNA oligos and computational analysis of the genes expression. In this review paper,
we analyse important methods in use today in customized oligos design. In the course of executing this,
we discovered that the oligos designer algorithm hanged on gene PFA0135w of chromosome 1, while
designing oligos for the gene sequences of Plasmodium falciparum. We do not know the reason for this
yet, as the algorithm runs on other sequences like the yeast (Saccharomyces cervisiae) and Neurospora
crassa. We conclude the paper highlighting the procedures encompassing the back end phase and discuss
their application to the development of vaccines and drugs for malaria treatment. Note that, malaria is the
cause of significant global morbidity and mortality with 300-500 million cases annually. Our aims are not
ends, but a means to achieve the following: Iterate the need for experimental biologists to (i) know how to
design their customized oligos and (ii) have some idea about gene expression analysis and the need for
cooperation between experimental biologists and their counterpart, the computational biologists. These
will help experimental biologists to coordinate very well the front and the back ends of the system
biology analysis of the whole genome effectively
Marshall Amateur Club experiment (MARCE)
The integration of the Get Away Special (GAS) payload for the space shuttle is discussed in terms of systems design. In addition to the primary power, control, and distribution networks to electrically integrate the spaceborne experiments, an instrument measuring system, a data system, and a radio frequency downlink system were designed. A brief review of these systems is given
Bipolar spin filter in a quantum dot molecule
We show that the tunable hybridization between two lateral quantum dots
connected to non-magnetic current leads in a `hanging-dot' configuration that
can be used to implement a bipolar spin filter. The competition between Zeeman,
exchange interaction, and interdot tunneling (molecular hybridization) yields a
singlet-triplet transition of the double dot {\it ground state} that allows
spin filtering in Coulomb blockade experiments. Its generic nature should make
it broadly useful as a robust bidirectional spin polarizer.Comment: 5 pages, 3 figures (to appear in Appl. Phys. Lett.
Amplifier for measuring low-level signals in the presence of high common mode voltage
A high common mode rejection differential amplifier wherein two serially arranged Darlington amplifier stages are employed and any common mode voltage is divided between them by a resistance network. The input to the first Darlington amplifier stage is coupled to a signal input resistor via an amplifier which isolates the input and presents a high impedance across this resistor. The output of the second Darlington stage is transposed in scale via an amplifier stage which has its input a biasing circuit which effects a finite biasing of the two Darlington amplifier stages
Preliminary Test of ERTS-1 Imagery for Improving Definition of Natural Streamflow
Preliminary test of ERTS-1 imagery for improving definition of natural streamflow, using two basins in Chesapeake Bay are
Channel-type shell construction for rocket engines and the like Patent
Channel-type shell construction for rocket engines and related configuration
The linear boom actuator designed for the Galileo spacecraft
Because the linear boom actuator is to be used on a flight spacecraft, as opposed to a ground based application, there is a comprehensive set of requirements. First, of course, the actuator must be capable of positioning and holding the load. Initially the load as predicted to be 4448 N (1000 lb) but with subsequent spacecraft configuration changes the load has been greatly reduced to a constant tensile pull of 1477 N (332 lb) due to centrifugal force. Lesser compressive loads of 1317 N (296 centrifugal lb) may be experienced during launch and deployment. This actuator must have the maximum redundancy possible. Life requirements were defined by the 10.16 to 15.24 cm (4 to 6 in.) total liner travel expected during the five-year flight duration. Liner range required of the actuator was set at plus and minus 5.08 cm to accommodate configuration changes
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