Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.

Processing of Aβ-precursor protein (APP) plays an important role in Alzheimer's disease (AD) pathogenesis. The APP intracellular domain contains residues important in regulating APP function and processing, in particular the 682YENPTY687 motif. To dissect the functions of this sequence in vivo, we created an APP knock-in allele mutating Y682 to Gly (APP(YG/YG) mice). This mutation alters the processing of APP and TrkA signaling and leads to postnatal lethality and neuromuscular synapse defects when expressed on an APP-like protein 2 KO background. This evidence prompted us to characterize further the APP(YG/YG) mice. Here, we show that APP(YG/YG) mice develop aging-dependent decline in cognitive and neuromuscular functions, a progressive reduction in dendritic spines, cholinergic tone, and TrkA levels in brain regions governing cognitive and motor functions. These data are consistent with our previous findings linking NGF and APP signaling and suggest a causal relationship between altered synaptic connectivity, cholinergic tone depression and TrkA signaling deficit, and cognitive and neuromuscular decline in APP(YG/YG) mice. The profound deficits caused by the Y682 mutation underscore the biological importance of APP and indicate that APP(YG/YG) are a valuable mouse model to study APP functions in physiological and pathological processes

Ethical Issues in Rehabilitation Counselor Supervision and the New 2010 Code of Ethics

The 2010 revision of the Code of Professional Ethics for Rehabilitation Counselors addresses changes in ethical standards related to rehabilitation counselor supervision. In an effort to promote awareness of these changes, this article offers a brief overview of the revisions and implications for practice including the responsibility of supervisors to actively engage in and support professional development activities

Relationship between vocational rehabilitation client outcomes and rehabilitation counselor multicultural counseling competencies

Thesis (Ph. D.)--Michigan State University, Department of Counseling, Educational Psychology, and Special Education, 2003Includes bibliographical references (pages 108-117

FROM AN INTEGRATED SURVEY WITH MMS TO A SCAN-TO-BIM PROCESS FOR EDUCATIONAL PURPOSES

The mobile mapping systems (MMSs) are increasingly used in the Architecture, Engineering and Construction sector (AEC). Their involvement in the digital transition of our cities and built heritage could be a valuable solution in speeding up the scan-to-BIM processes. In this framework, the course “Knowledge of the built heritage in the era of climate change” of Politecnico di Torino offers an innovative approach for MSc degree students in Building Engineering. In fact, it deals with the whole workflow from the surveying activities (data acquisition and processing), to the BIM modelling up to the final digital twin integrated with e.g. sensors data and management information. This contribution describes the case studies of the multidisciplinary course as an application for this methodology, where not only terrestrial laser scanning or UAVs (Unmanned Aerial Vehicles) have been used, but also MMSs have been tested to understand if they could be a suitable option. This paper aims to show the course experience derived from the collaboration of the geomatics and drawing domains along with students’ results and feedback. Moreover, the research underlines the pros and cons of this procedure

The Development of a 2D/3D BIM-GIS Web Platform for Planned Maintenance of Built and Cultural Heritage: the Main10ance Project

The integration of Building Information Modeling (BIM), or Historic BIM (HBIM), and Geographic Information Systems (GIS) has assumed a crucial role not only in the management of smart cities or urban districts, as well as in the construction sector or infrastructures but also in the management, conservation and safeguarding of cultural heritage. This integration opens up new opportunities for decision-makers to assess the impact of interventions on heritage sites, evaluate preservation strategies, and facilitate informed decision-making processes. This contribution presents and describes the open-source web platform developed within the Interreg MAIN10ANCE project. The project aims to promote a common methodology for the cooperation and collaboration of the various stakeholders involved in the restoration, management and maintenance activities of built and cultural heritage sites. This objective has been pursued by creating a BIM-GIS database, focused on the definition of planned maintenance activities, whose data has been made available to professionals and management bodies by means of a shared web platform, usable directly in situ on a tablet or portable devices. The paper highlights the key components of the web platform, including the BIM, GIS, and artifact Viewers, the Planner, and the overall Dashboard. The platform's multiscale and multi-source approach makes it extensible to various cultural assets, whether environmental, architectural, or movable. By integrating historical and geometric information and planning maintenance activities, the web platform thus supports public administrations and professionals, amending existing state-of-the-art solutions

An FPGA-based Embedded System For Fingerprint Matching Using Phase Only Correlation Algorithm

none5There is an increasing interest in inexpensive and reliable personal identification in many emerging civilian, commercial and financial applications. Traditional systems such as passwords, PINs, Badges, Smart Cards and Tokens may either be stolen or easy to guess but also to forget, in same cases they may be lost by the user who carries them; all this can lead to identified. Fingerprint-based identification is one of the most used biometric techniques in automated systems for personal identification and it is becoming socially acceptable and cost-effective, since a fingerprint is univocally related to a particular individual. Typical fingerprint identification methods employ feature-based image matching, where minutiae points in the ridge lines (i.e., ridge endings and bifurcations) are identified. Unfortunately this approach is highly influenced by fingertip surface condition. Fingerprint recognition is a complex pattern recognition problem. The efforts to make automatic the matching process based on digital representation of fingerprints, led to the development of Automatic Fingerprint Identification Systems (AFIS). Typically, there are millions of fingerprint records in a database which needs to be entirely searched for a match, to establish the identity of the individual. In order to provide a reasonable response time for each query, it will be better to develop special hardware solutions to implement matching and/or classification algorithms in a really efficient way. In this work we realised a system able to outperform modern PCs in recognising and classifying fingerprints and based on FPGA technology.Il lavoro si è classificato al II posto nell'Altera Contest 2009 Innovate Italy, gara annuale indetta da Altera tra progetti di team di giovani studenti universitari su tutto il territorio nazionale.Giovanni Danese; Mauro Giachero; Francesco Leporati; Giulia Matrone; Nelson NazzicariDanese, Giovanni; Giachero, Mauro; Leporati, Francesco; Matrone, Giulia; Nelson, Nazzicar

A European Interoperable Database (EID) to increase resilience of Cultural Heritage

The set of laws, actions and organizations for Cultural Heritage (CH) protection is born in the different countries of the European Union from local cultural situations, so the ability to cope with the emergency is certainly different. In addition to the damages that can occur to cultural assets after a disaster, an inadequate emergency intervention can sometimes cause further losses to the CH. The effectiveness of response depends on the adequacy of advanced planning. Some countries have designed emergency plans but their databases (DBs) are fragmented, incomplete and not standardized. It is thus necessary to establish a DB for emergency assistance and maps of CH at risk to be compared with maps of natural hazards and risks, in order to take preventive and operational measures, as well as agree on a common terminology and international standards. The project aims to enhance the capability of Civil Protection to prevent disasters impacts on CH by implementing a European Interoperable Database (EID) as supporting decision tool to understand the risk of damage to cultural assets. The EID, starting from the international standards to represent the map objects (CityGML, INSPIRE), the classification of CH in Europe (UNESCO), in Italy (MiBACT), in Germany and in France and from risks and disasters analysis, will design, with its Conceptual Data Model, an extension of the INSPIRE UML model. This DB will also support 3D models to help finding and recognizing dispersed artworks and facilitate a post-emergency restoration, preserving thus a digital memory in case of destruction

hbim in a semantic 3d gis database

Abstract. This work describes the different attempts and the consequent results derived from the integration of an HBIM model into an already structured spatial database (DB) and its 3D visualisation in a GIS project.This study is connected to the European ResCult (Increasing Resilience of Cultural Heritage) project where a DB for multiscale analyses was defined. To test the methodology proposed, the case study of Santa Maria dei Miracoli church in Venice was chosen since it represents a complex architectural heritage piece in a risk zone, it has been subject to a vast restoration intervention in the recent past but a digital documentation and model concerning it was missing.The 3D model of the church was structured in Revit as a HBIM, with the association of different kind of information and data related to the architectural elements by means of 'shared parameters' and 'system families'. This procedure allows to reach an even higher Level of Detail (LOD4), but lead to some issues related to the semantic and software interoperability. To solve these problems the existing DB for the resilience of cultural heritage was extended adding a new entity representing the architectural elements designed in the BIM project.The aim of the test is to understand how the data and attributes inserted in the HBIM are converted and handled when dealing with a GIS DB, stepping from the IFC to the CityGML standard, through the FME software.</p

Initial Experiments on the Use of Radiance Fields for Underwater 3D Reconstruction

Underwater photogrammetry presents unique challenges, including light attenuation, refraction, and turbidity, that affect the accuracy and quality of 3D reconstructions. This study investigates the performance of novel neural rendering techniques, Neural Radiance Fields (NeRF), SeaThru-NeRF, and 3D Gaussian Splatting (3DGS), in comparison to conventional Structure-from-Motion (SfM) workflows. Using a dataset acquired during the SIFET benchmark campaign on a submerged Roman archaeological site, we processed image data via Nerfacto, SeaThru, and Jawset Postshot (3DGS) and compared outputs against a reference model produced in Agisoft Metashape. Evaluation criteria included processing time, geometric accuracy (via M3C2 analysis), point cloud density and roughness, and point cloud completeness. Results show that radiance fields-based methods significantly reduce processing time while providing competitive visual results. SeaThru-NeRF demonstrated the highest geometric accuracy, benefiting from underwater-specific corrections, while 3DGS offered photorealistic rendering. These findings highlight the potential of neural methods for underwater cultural heritage documentation, though further improvements are needed in data fidelity and robustness under challenging underwater conditions