Pattern recognition receptors in immune disorders affecting the skin.

Contains fulltext : 109004.pdf (publisher's version ) (Open Access)Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs

Influence on temperature profile in an oil film in thrust bearings using an embedded cooling circuitry beneath the pad surface: An experimental investigation

This paper describes the design and development of a test rig, for the experimental assessment of performance characteristics of thrust bearing used in hydro power plants. This test rig has features to study experimentally the conventional pad-based thrust bearing and the newly designed water cooling enabled pad. In this paper, a cooling circuit designated as Circuit-I has been installed and then testing is performed. The shaft speed and axial load has been set at 1400 r/min and 5.0 kN. The lubricating oil used SAE-30 and inlet temperature of oil was maintained at 40℃. The main focus of the present work is to compute the influence on the temperature distribution in the oil film on the top surface of the pad with the embodiment of cooling circuit arrangement. From the experimental results, the overall reduction in the oil film temperature or on the top surface of the pad has been found to be 14% when the conventional thrust bearing set up is replaced by water cooling enabled pad of this kind. </jats:p

Performance characteristics of journal bearings (porous type): A coupled solution using Hartmann number and roughness parameter

The influence of magnetic field and roughness factor on long journal (porous) bearing with heterogeneous slip/no-slip surface has been described in this paper. Assumptions of hydrodynamic lubrication theory and Navier slip relation were employed during the investigation, and the generalized Reynolds equation for the oil film pressure was obtained using appropriate boundary conditions and the expressions for pressure distribution and load-carrying capacity as a function of Hartmann number, permeability parameter, roughness parameter, and slip parameter were derived in integral forms. Integrals involved are evaluated by using Simpsons 1/3rd rule and Gauss quadrature 16-point formula in MATLAB code. Christensen stochastic process is adopted to study the roughness behavior. In the present analysis, it has been revealed that there is a noticeable escalation in the load-carrying capacity with the embodiment of magnetic field effect, which enables the journal (rotating part) to levitate inside the domain of bearing (stationary part) that indeed supports the lubricant performance. </jats:p

Skin manifestations as potential symptoms of diffuse vascular injury in critical COVID

As a respiratory viral infection caused by a novel coronavirus, COVID-19 became rapidly pandemic within a few months. Despite the wide range of manifestations and organ involvement in COVID-19 patients, the exact pathogenesis of severe and fatal types of COVID-19 and causes involved with the individual base of the disease is not yet understood. Several studies have reported clinical, laboratory, and histopathological data in favor of vascular injury in multiple organs of critically ill patients with COVID-19 as a result of hyperactive immune response, inflammation, and cytokine storm. Also, both clinical and histopathological evidence points to such vascular involvements in the skin. Given the ease of clinical examinations and skin biopsy and the lower risks of transmission of COVID-19 to healthcare workers, the present review article was conducted to investigate the vascular skin manifestations of COVID-19 patients clinically and/or histopathologically as helpful clues for better understanding the pathogenesis and predicting the prognosis of the disease, especially in severe cases

Insights from Characterizing Extinct Human Gut Microbiomes

In an effort to better understand the ancestral state of the human distal gut microbiome, we examine feces retrieved from archaeological contexts (coprolites). To accomplish this, we pyrosequenced the 16S rDNA V3 region from duplicate coprolite samples recovered from three archaeological sites, each representing a different depositional environment: Hinds Cave (~8000 years B.P.) in the southern United States, Caserones (1600 years B.P.) in northern Chile, and Rio Zape in northern Mexico (1400 years B.P.). Clustering algorithms grouped samples from the same site. Phyletic representation was more similar within sites than between them. A Bayesian approach to source-tracking was used to compare the coprolite data to published data from known sources that include, soil, compost, human gut from rural African children, human gut, oral and skin from US cosmopolitan adults and non-human primate gut. The data from the Hinds Cave samples largely represented unknown sources. The Caserones samples, retrieved directly from natural mummies, matched compost in high proportion. A substantial and robust proportion of Rio Zape data was predicted to match the gut microbiome found in traditional rural communities, with more minor matches to other sources. One of the Rio Zape samples had taxonomic representation consistent with a child. To provide an idealized scenario for sample preservation, we also applied source tracking to previously published data for Otzi the Iceman and a soldier frozen for 93 years on a glacier. Overall these studies reveal that human microbiome data has been preserved in some coprolites, and these preserved human microbiomes match more closely to those from the rural communities than to those from cosmopolitan communities. These results suggest that the modern cosmopolitan lifestyle resulted in a dramatic change to the human gut microbiome