Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations

Kisspeptin receptor (KISS1R) signaling is essential for the hallmark increase in pulsatile GnRH secretion characteristic of the onset of puberty in humans and experimental animals. Loss-of-function mutations in KISS1R are associated with idiopathic hypogonadotropic hypogonadism in humans. Also, mutations with confirmed association with idiopathic central precocious puberty were identified in kisspeptin and KISS1R. These observations underscore the role of KISS1R signaling for normal pubertal development. Moreover, investigation of the mechanisms underlying the gain-of-function mutation in KISS1R indicates that the duration of KISS1R signaling is critical for the role of this receptor in timing the onset of puberty in humans. These findings further endorse the need to uncover the mechanisms, as well as yet-unknown proteins, involved in each step of KISS1R signaling. This knowledge is expected to advance our understanding of normal and abnormal pubertal development, as well as to help uncover the role of KISS1R signaling in non-hypothalamic tissues such as the placenta. This chapter discusses recent advances in the investigation of KISS1R signaling and function, as well as potential pathophysiological implications of naturally occurring mutations in this receptor identified in humans with reproductive disorders

Environmental Archaeology: What is in a name?

This book aims to thoroughly discuss new directions of thinking in the arena of environmental archaeology and test them by presenting new practical applications. Recent theoretical and epistemological advancement in the field of archaeology calls for a re-definition of the subdiscipline of environmental archaeology and its position within the practise of archaeology. New technological and methodological discoveries in hard sciences and computer applications opened fresh ways for interdisciplinary collaborations thus introducing new branches and specialisations that need now to be accommodated and integrated within the previous status-quo. This edited volume will take the challenge and engage with contemporary international discussions about the role of the discipline within the general framework of archaeology. By drawing upon these debates, the contributors to this volume will rethink what environmental archaeology is and what kind of input the investigation of this kind of materiality has to the reconstruction of human history and sociality