Cigarette smoke pollution promotes oxidative stress imbalance and hormonal changes affecting pregnancy outcome in rats

Background: The deleterious effect of cigarette smoke on several health parameters due to pollution of air is of international concern. How these affect all living organisms and their wellbeing is a major research area. The development of oxidative stress, alteration in lipid peroxidation, thyroid and pregnancy hormone pattern was examined in pregnant rats exposed to cigarette smoke throughout the gestation period. Methods: Cigarette smoke exposed and control pregnant rats were sacrificed at gestational day 6, 12 and 20. Serum was collected for hormonal assay. Some vital organs were also dissected out, homogenized and used for oxidative stress and lipid peroxidation assay. Gestational weights, corporal luteum and implanted embryos were also recorded. Results: There was a significant increased loss of corpora lutea, embryonic implants and a disruption of the hormonal pattern of LH, progesterone and estradiol during pregnancy in cigarette smoke exposed rats. A significant increase in serum cortisol and brain tissue level of MDA, SOD and a significant decrease in GSH in cigarette smoke exposed rats was recorded. Conclusion: Exposing pregnant rats to cigarette smoke precipitated oxidative stress, early loss of corpora lutea, disruption in hormonal pattern and an increasing loss of embryonic implants.Keywords: Cigarette smoke, implantation, corpus luteum, pregnancy, female sex hormone, thyroid hormone, oxidative stres

The effect of health sector industrial actions on TB and TB/HIV case finding in Ogun State, Nigeria: Is Public-Private Mix a viable solution?

Background: Though industrial disputes are a global phenomenon, there is a rising concern of its frequent occurrence in Sub-Saharan Africa. Objective: To assess the effect of industrial actions embarked upon by the health workers during the year 2014 on Tuberculosis (TB) notification in Ogun State, Nigeria. Methods: A retrospective review of TB notification in 2013 and 2014 was conducted. Quarterly TB case notification, the proportions of Human Immunodeficiency Virus (HIV) test, Co-trimoxazole (CPT) uptake and Antiretroviral Therapy (ART) uptake in the years 2013 and 2014 were compared using the Epi-info software. Results: There was a decline in the proportion of TB cases reported by the public sector health services and an increase in the proportion of TB cases reported by the private health facilities during the period of industrial disputes in the public health sector (doctors and non-doctors) (p = 0.001). Compared to the year 2013, the proportion of presumptive TB cases tested for HIV declined significantly during the period of the strike actions by the non-doctors but not during the strike actions by doctors in 2014. There was no difference in the uptake of Co-trimoxazole (p = 0.456 and 0.511) and Anti-retroviral Therapy (p = 0.192 and 0.544) by TB/HIV co-infected patients during the strike actions by the doctors and the non-doctors respectively. Conclusion: This study demonstrated the importance of Public-Private–Mix for TB case finding efforts in the developing countries, where there are incessant strike actions by health workers in the public sector

Wastewater-based epidemiology in hazard forecasting and early-warning systems for global health risks

With the advent of the SARS-CoV-2 pandemic, Wastewater-Based Epidemiology (WBE) has been applied to track community infection in cities worldwide and has proven succesful as an early warning system for identification of hotspots and changingprevalence of infections (both symptomatic and asymptomatic) at a city or sub-city level. Wastewater is only one of environmental compartments that requires consideration. In this manuscript, we have critically evaluated the knowledge-base and preparedness for building early warning systems in a rapidly urbanising world, with particular attention to Africa, which experiences rapid population growth and urbanisation. We have proposed a Digital Urban Environment Fingerprinting Platform (DUEF) – a new approach in hazard forecasting and early-warning systems for global health risks and an extension to the existing concept of smart cities. The urban environment (especially wastewater) contains a complex mixture of substances including toxic chemicals, infectious biological agents and human excretion products. DUEF assumes that these specific endo- and exogenous residues, anonymously pooled by communities’ wastewater, are indicative of community-wide exposure and the resulting effects. DUEF postulates that the measurement of the substances continuously and anonymously pooled by the receiving environment (sewage, surface water, soils and air), can provide near real-time dynamic information about the quantity and type of physical, biological or chemical stressors to which the surveyed systems are exposed, and can create a risk profile on the potential effects of these exposures. Successful development and utilisation of a DUEF globally requires a tiered approach including: Stage I: network building, capacity building, stakeholder engagement as well as a conceptual model, followed by Stage II: DUEF development, Stage III: implementation, and Stage IV: management and utilization. We have identified four key pillars required for the establishment of a DUEF framework: (1) Environmental fingerprints, (2) Socioeconomic fingerprints, (3) Statistics and modelling and (4) Information systems. This manuscript critically evaluates the current knowledge base within each pillar and provides recommendations for further developments with an aim of laying grounds for successful development of global DUEF platforms

Efficacy of Quasi Agro Binding Fibre on the Hybrid Composite Used in Advance Application

The choice for natural fibre obtained from agricultural products is on the rise due to its solution to eco-friendly, environmental and improved mechanical properties concerns. Its abundant availability, low cost, emission reduction and adaptability to base material for composite make it a prime material for selection. This review explores diverse perspectives to the future trend of agro fibre in terms of the thermo-mechanical properties as it applies to advanced application in building structures. It is important to investigate the ecofriendliness of the products of composites from fibres in agricultural wastes so as to achieve a green and sustainable environment. This will come to fore by the combined efforts of both researchers and feedback from building stakeholders

A Spatial-Statistical Analysis of Urban Deprivation in Durban, South Africa

Urban sustainability problems are of global concern as developing countries’ population get more urbanised. Examining urban deprivation, 18 socio-demographic variables were used to identify deprivation dimensions with principal component analysis and general deprivation index. Seven deprivation types were mapped with Geographic Information System to determine the spatial distribution of deprivation by census sub-places for Durban, South Africa. Results showed that deprivation was neither clustered nor confined to the inner city areas as would normally be expected. Key determining factors were the proportion of Black Africans and informal settlements occurring in a sub-place.Keywords: Deprivation, Geographic Information System (GIS), General Deprivation Index, Principal component analysis, South Afric

Recent sediment accumulation rates in contrasting lakes in the Carpathians (Romania) : Impacts of shifts in socio-economic regime

Longer-term environmental studies are increasingly used to better understand contemporary ecosystems conditions and for forecasting their future trajectories. Here, we use radiometric measurements and the characterisation of sediment properties from six mountain and a lowland lake in Central Eastern Europe with the aim to assess temporal and spatial variability in sediment accumulation rates (SARs) in relation to three socio-economic regimes: traditional (1840–1948), socialist (1948–1989) and post-socialist (post-1990). We also set out to determine reference conditions for these lakes i.e. conditions before significant human impact. Our results show a trend of increasing SARs from basal sediments (pre 1840) towards the present at only two sites. This contrasts with findings from Western and Central European lakes where SARs have predominantly increased from 1850 towards the top of cores. We highlight the differential impacts of the traditional, socialist and post-socialist periods on the SARs at these lakes. Lowland and mid-elevations lakes (n = 2) were most markedly impacted by the socialist period of land use regime; lakes from the southern Carpathians (n = 2) were more impacted in the traditional period (transhumance pastoral activities), whereas those from the north (n = 3) in the socialist and post-socialist periods (summer pastoralism). Results from our study show a continuous anthropogenic impact during the entire period considered, even in remote mountain areas. This suggests that a temporal frame of 100–150 years is too short to meaningfully register the reference conditions of these lakes. Furthermore, a predominantly natural state may not have existed for centuries in this region