Lasing Efficiency and Photochemical Stability of IR Laser

The lasing efficiencies and photochemical stabilities of laser dyes useful in the 710-1080-nm spectral region have been investigated using a Q-switched ruby laser pumping source. The measured bleaching rates P defined as the probability of irreversible decomposition of a dye molecule per absorbed photon, varied from <= 1 exp-5 to 3 exp-4 for the different dye-solvent combinations investigated. Broad-band lasing efficiencies (the ratios of dye laser output to ruby radiation input) ranged from 4 to 43 percent. Shifts of wavelength tuning range with variations in solvent, dye concentration, and dye laser cavity geometry are reported

Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD)

Objectives: The optimal method of identifying people with chronic obstructive pulmonary disease (COPD) from electronic primary care records is not known. We assessed the accuracy of different approaches using the Clinical Practice Research Datalink, a UK electronic health record database. Setting: 951 participants registered with a CPRD practice in the UK between 1 January 2004 and 31 December 2012. Individuals were selected for ≥1 of 8 algorithms to identify people with COPD. General practitioners were sent a brief questionnaire and additional evidence to support a COPD diagnosis was requested. All information received was reviewed independently by two respiratory physicians whose opinion was taken as the gold standard. Primary outcome measure: The primary measure of accuracy was the positive predictive value (PPV), the proportion of people identified by each algorithm for whom COPD was confirmed. Results: 951 questionnaires were sent and 738 (78%) returned. After quality control, 696 (73.2%) patients were included in the final analysis. All four algorithms including a specific COPD diagnostic code performed well. Using a diagnostic code alone, the PPV was 86.5% (77.5-92.3%) while requiring a diagnosis plus spirometry plus specific medication; the PPV was slightly higher at 89.4% (80.7-94.5%) but reduced case numbers by 10%. Algorithms without specific diagnostic codes had low PPVs (range 12.2-44.4%). Conclusions: Patients with COPD can be accurately identified from UK primary care records using specific diagnostic codes. Requiring spirometry or COPD medications only marginally improved accuracy. The high accuracy applies since the introduction of an incentivised disease register for COPD as part of Quality and Outcomes Framework in 2004

Structure of the low latitude boundary layer

Observations at high temporal resolution of the frontside magnetopause and plasma boundary layer, made with the LASL/MPE fast plasma analyzer onboard the ISEE 1 and 2 spacecraft, revealed a complex quasiperiodic structure of some of the observed boundary layers. A cool tailward streaming boundary layer plasma was seen intermittently, with intervening periods of hot tenuous plasma which has properties similar to the magnetospheric population. While individual encounters with the boundary layer plasma last only a few minutes, the total observation time may extend over one hour or more

Deflection of coronal rays by remote CMEs: shock wave or magnetic pressure?

We analyze five events of the interaction of coronal mass ejections (CMEs) with the remote coronal rays located up to 90^\circ away from the CME as observed by the SOHO/LASCO C2 coronagraph. Using sequences of SOHO/LASCO C2 images, we estimate the kink propagation in the coronal rays during their interaction with the corresponding CMEs ranging from 180 to 920 km/s within the interval of radial distances form 3 R. to 6 R. . We conclude that all studied events do not correspond to the expected pattern of shock wave propagation in the corona. Coronal ray deflection can be interpreted as the influence of the magnetic field of a moving flux rope related to a CME. The motion of a large-scale flux rope away from the Sun creates changes in the structure of surrounding field lines, which are similar to the kink propagation along coronal rays. The retardation of the potential should be taken into account since the flux rope moves at high speed comparable with the Alfven speed.Comment: Accepted for Publication in Solar Physic

In vitro volatile organic compound profiling using GCGC-TOFMS to differentiate bacteria associated with lung infections: A proof-of-concept study

© 2016 IOP Publishing Ltd. Chronic pulmonary infections are the principal cause of morbidity and mortality in individuals with cystic fibrosis (CF). Due to the polymicrobial nature of these infections, the identification of the particular bacterial species responsible is an essential step in diagnosis and treatment. Current diagnostic procedures are time-consuming, and can also be expensive, invasive and unpleasant in the absence of spontaneously expectorated sputum. The development of a rapid, non-invasive methodology capable of diagnosing and monitoring early bacterial infection is desired. Future visions of real-time, in situ diagnosis via exhaled breath testing rely on the differentiation of bacteria based on their volatile metabolites. The objective of this proof-of-concept study was to investigate whether a range of CF-associated bacterial species (i.e. Pseudomonas aeruginosa, Burkholderia cenocepacia, Haemophilus influenzae, Stenotrophomonas maltophilia, Streptococcus pneumoniae and Streptococcus milleri) could be differentiated based on their in vitro volatile metabolomic profiles. Headspace samples were collected using solid phase microextraction (SPME), analyzed using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCGC-TOFMS) and evaluated using principal component analysis (PCA) in order to assess the multivariate structure of the data. Although it was not possible to effectively differentiate all six bacteria using this method, the results revealed that the presence of a particular pattern of VOCs (rather than a single VOC biomarker) is necessary for bacterial species identification. The particular pattern of VOCs was found to be dependent upon the bacterial growth phase (e.g. logarithmic versus stationary) and sample storage conditions (e.g. short-term versus long-term storage at -18 °C). Future studies of CF-associated bacteria and exhaled breath condensate will benefit from the approaches presented in this study and further facilitate the production of diagnostic tools for the early detection of bacterial lung infections

From Cold War to Microchips: Stepping From the Past into Our Future

Malcolm Steve Forbes Jr., editor-in-chief of FORBES Magazine, looks often to history to explain the present and to predict the future. In an address to the 21st annual Governor\u27s Economic Development Conference at the University of Maine last fall, Forbes identified two important trends, one grounded in the past (the Cold War), and one symbolic of the rapid change experienced at present (the microchip), in suggesting that the economic future for Maine and the nation is only limited by our willingness to give in to our fears about what that future holds. This article is an edited version of Forbes’ remarks to the Governor\u27s Conference

A Quantitative Model of Energy Release and Heating by Time-dependent, Localized Reconnection in a Flare with a Thermal Loop-top X-ray Source

We present a quantitative model of the magnetic energy stored and then released through magnetic reconnection for a flare on 26 Feb 2004. This flare, well observed by RHESSI and TRACE, shows evidence of non-thermal electrons only for a brief, early phase. Throughout the main period of energy release there is a super-hot (T>30 MK) plasma emitting thermal bremsstrahlung atop the flare loops. Our model describes the heating and compression of such a source by localized, transient magnetic reconnection. It is a three-dimensional generalization of the Petschek model whereby Alfven-speed retraction following reconnection drives supersonic inflows parallel to the field lines, which form shocks heating, compressing, and confining a loop-top plasma plug. The confining inflows provide longer life than a freely-expanding or conductively-cooling plasma of similar size and temperature. Superposition of successive transient episodes of localized reconnection across a current sheet produces an apparently persistent, localized source of high-temperature emission. The temperature of the source decreases smoothly on a time scale consistent with observations, far longer than the cooling time of a single plug. Built from a disordered collection of small plugs, the source need not have the coherent jet-like structure predicted by steady-state reconnection models. This new model predicts temperatures and emission measure consistent with the observations of 26 Feb 2004. Furthermore, the total energy released by the flare is found to be roughly consistent with that predicted by the model. Only a small fraction of the energy released appears in the super-hot source at any one time, but roughly a quarter of the flare energy is thermalized by the reconnection shocks over the course of the flare. All energy is presumed to ultimately appear in the lower-temperature T<20 MK, post-flare loops

From Cold War to Microchips: Stepping From the Past into Our Future

Malcolm Steve Forbes Jr., editor-in-chief of FORBES Magazine, looks often to history to explain the present and to predict the future. In an address to the 21st annual Governor\u27s Economic Development Conference at the University of Maine last fall, Forbes identified two important trends, one grounded in the past (the Cold War), and one symbolic of the rapid change experienced at present (the microchip), in suggesting that the economic future for Maine and the nation is only limited by our willingness to give in to our fears about what that future holds. This article is an edited version of Forbes’ remarks to the Governor\u27s Conference

Evaluating the effects of bilingual traffic signs on driver performance and safety

Variable Message Signs (VMS) can provide immediate and relevant information to road users and bilingual VMS can provide great flexibility in countries where a significant proportion of the population speak an alternative language to the majority. The study reported here evaluates the effect of various bilingual VMS configurations on driver behaviour and safety. The aim of the study was to determine whether or not the visual distraction associated with bilingual VMS signs of different configurations (length, complexity) impacted on driving performance. A driving simulator was used to allow full control over the scenarios, road environment and sign configuration and both longitudinal and lateral driver performance was assessed. Drivers were able to read one and two-line monolingual signs and two-line bilingual signs without disruption to their driving behaviour. However, drivers significantly reduced their speed in order to read four-line monolingual and four-line bilingual signs, accompanied by an increase in headway to the vehicle in front. This implies that drivers are possibly reading the irrelevant text on the bilingual sign and various methods for reducing this effect are discussed

Mr. Saxophonist, Ben Vereecken: Performer, Pedagogue, Composer

This document explores the life and work of Benjamin Vereecken, a noted saxophonist of the early twentieth century. Vereecken was among the most prominent artists of his time, and performed with the bands of Sousa, Clarke, and Pryor. Vereecken’s career is traced from its beginnings in his native Belgium, through his rise in the band world, to his eventual retirement in California. In addition to his performance reputation, Vereecken was also well known as pedagogue, composer, and arranger. His innovative method materials were in widespread use at a time when the popularity of the saxophone was exploding. His substantial catalogue of solo compositions represents a significant portion of the published repertory available to saxophonists of the 1920s. In addition to providing a narrative of Vereecken’s life, this document reviews and contextualizes his artistic and pedagogical output. Particular attention is given to the features of his career that offer broader insight into the musical climate of the early twentieth century. Vereecken’s story reveals details of the work conditions under which instrumentalists lived and provides a window into the rise saxophone as a concert instrument