The Tell-Tale Hand: Gothic Narratives and the Brain

The opening story in Winesburg, Ohio (1919) by Sherwood Anderson is called simply “Hands.” It is about a teacher’s remarkable hands that sometimes seem to move independently of his will. This essay explores some of the relevant contexts and potential links, beginning with other representations of teachers’ hands, such as Caravaggio’s St. Matthew and the Angel, early efforts to establish a sign-language for the deaf, and including the Montessori method of teaching children to read and write by tracing the shape of letters with their hands on rough emery paper. The essay then explores filmic hands that betray or work independently of conscious intentions, from Dr Strangelove, Mad Love, to The Beast With Five Fingers. Discussion of the medical literature about the “double” of our hands in the brain, including “phantom hands,” leads on to a series of images that register Rodin’s lifelong fascination with sculpting separate hands

Paradise Lost and the origin of "evil”: Classical or Judeo-Christian?

Milton'sParadise Lost is an epic opem about the origin of evil, mixing classical and Christian forms and sources. This essay first explores whether "evil” is primarily a classical or Judeo-Christian concept, and shows that it is a product of the religious syncretism of the Hellenistic period. Yet among the poets, we meet this new sense of malignance chiefly in Virgil, especially in such a figure as Allecto. The essay then shows how Milton's language carefully discriminates among these origins, so that the imagery of Hell comes from Virgil, while the conception of evil remains principally Christian, both in the narrative and in philosophical reflection. But in the final section of the essay, we see that the being whose identity is the answer to the poem's initiating epic question (‘Who first seduc'd them to that foul revolt?'), and whose actions drive the poem into motion and inaugurate its story—Stan—, is, like his daughter Sin, a complex and seductive blend of both—and this helps to explain some of the tension we feel in his presence. He is a much more complex answer than those required by the initiating questions in Homer or Virgil, and indeed it takes the whole poem to understand that answe

The Presbyterian interpretation of Scottish history, 1800-1914

The nineteenth century saw the revival and widespread propagation in Scotland of a view of Scottish history that put Presbyterianism at the heart of the nation's identity, and told the story of Scotland's history largely in terms of the church's struggle for religious and constitutional liberty. Key to this development was the Anti-Burgher minister Thomas M'Crie, who, spurred by attacks on Presbyterianism found in eighteenth-century and contemporary historical literature, between the years 1811 and 1819 wrote biographies of John Knox and Andrew Melville and a vindication of the Covenanters. M'Crie generally followed the very hard line found in the Whig- Presbyterian polemical literature that emerged from the struggles of the sixteenth and seventeenth century; he was particularly emphatic in support of the independence of the church from the state within its own sphere. His defence of his subjects embodied a Scottish Whig interpretation of British history, in which British constitutional liberties were prefigured in Scotland and in a considerable part won for the British people by the struggles of Presbyterian Scots during the seventeenth century. M'Crie's work won a huge following among the Scottish reading public, and spawned a revival in Presbyterian historiography which lasted through the century. His influence was considerably enhanced through the affinity felt for his work by the Anti- Intrusionists in the Church of Scotland and their successors in the Free Church (1843- 1900), who were particularly attracted by his uncompromising defence of the spiritual independence of the church. The steady stream of historical works from Free Church ministers and laymen during the lifetime of the church corresponded with a very weak output of academic history, and in consequence the Free Church interpretation was probably the strongest single influence in forming the Scots' picture of their history in the late nineteenth century. Much of this interpretation, - particularly the belief in the particularly Presbyterian nature of the Scottish character and of the British constitution, was accepted by historians of the other main branches of the Presbyterian community, while the most determined opposition to the thesis was found in the work of historians of the Episcopal Church. Although the hold of the Presbyterian interpretation was weakened at the end of the century by factors including the merger of most of the Free Church in 1900 and the increasing appearance from 1900 of secular and sometimes anti-Presbyterian Scottish history, elements of it continued to influence the Scottish national self-image well into the twentieth century

Milton et la Tradition Classique

On a l’habitude d’inscrire Milton dans la tradition des grands écrivains littéraires de l’Antiquité. Et c’est lui, bien sûr, qui nous dirige vers Homère, Virgile, Ovide, auteurs de grandes épopées qu’il cite souvent, parfois de façon explicite, dans Le paradis perdu, ou encore vers Eschyle, Sophocle, et Euripide qui sont ses modèles pour Samson Agonistes. Mais il y a aussi une autre tradition classique qui est d’une importance capitale pour ce grand révolutionnaire : la littérature « républicaine », de Platon et Cicéron à Lucain, une tradition qui arrivait directement à Milton par ses études, mais qui passait aussi par des auteurs comme Machiavel, et qui faisait partie intégrale des discours de la révolution anglaise du XVIIe siècle. Il y a une tension évidente entre ces deux aspects de sa relation à l’Antiquité, surtout en ce qui concerne la représentation de Satan

An Investigation into the environmental impact of off-licensed premises on residential neighbourhoods

In recent times there has been a great deal of concern about levels of anti-social behaviour across the UK. Several reports have investigated the role of alcohol as a potentially important contributor to this problem. Most research has concentrated on public houses and nightclubs. This is in contrast to the view that the off-trade sector is indicated as the source of the current rise in alcohol consumption across the UK over the past 20 years. This research focusing on licensed convenience stores (grocers / newsagents) operating in residential areas and these often provide a broad range of services for the wider community, not just drinkers or the over-18s. The impact of such premises on residents is likely to be continuous and long-lasting, affecting the whole community

Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches

The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibrosis causing aberrant lung remodelling and organ dysfunction. Post-insult failure of regeneration leads to various incurable lung diseases including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis. Therefore, identification of true endogenous lung progenitors/stem cells, and their regenerative pathway are crucial for next-generation therapeutic development. Recent studies provide exciting and novel insights into postnatal lung development and post-injury lung regeneration by native lung progenitors. Furthermore, exogenous application of bone marrow stem cells, embryonic stem cells and inducible pluripotent stem cells (iPSC) show evidences of their regenerative capacity in the repair of injured and diseased lungs. With the advent of modern tissue engineering techniques, whole lung regeneration in the lab using de-cellularised tissue scaffold and stem cells is now becoming reality. In this review, we will highlight the advancement of our understanding in lung regeneration and development of stem cell mediated therapeutic strategies in combating incurable lung diseases

The efficacy of core stability assessment as a determiner of performance in dynamic balance and agility tests

Aim: The aim of this study was to investigate if tests used to assess core stability could be used to determine success in physiological tests applied to assess dynamic balance and agility for a young active population. Methods: Pearson's r correlation coefficient was used to assess the relationship between the core stability tests and the dynamic balance and agility tests. Evaluation of the tests was established using Cronbach's coefficient of variance as part of intra-rater reliability tests. An analysis of 18 active college aged students was conducted (males: n= 13, females: n= 5). The mean ± SD age for males was 19.2 years ± 3.22 years and for females was 19.4 years ± 1.14 years. Conclusion: The results indicate that there is no significant relationship between tests that assess core stability and tests conducted to assess dynamic balance in active young adults. With the exception of the abdominal flexion test, no significant relationship exists between the remaining core stability tests and agility T-Test. Core stability is not a determinant of balance and agility

Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study.

Background and purposeAlthough arteriopathies are the most common cause of childhood arterial ischemic stroke, and the strongest predictor of recurrent stroke, they are difficult to diagnose. We studied the role of clinical data and follow-up imaging in diagnosing cerebral and cervical arteriopathy in children with arterial ischemic stroke.MethodsVascular effects of infection in pediatric stroke, an international prospective study, enrolled 355 cases of arterial ischemic stroke (age, 29 days to 18 years) at 39 centers. A neuroradiologist and stroke neurologist independently reviewed vascular imaging of the brain (mandatory for inclusion) and neck to establish a diagnosis of arteriopathy (definite, possible, or absent) in 3 steps: (1) baseline imaging alone; (2) plus clinical data; (3) plus follow-up imaging. A 4-person committee, including a second neuroradiologist and stroke neurologist, adjudicated disagreements. Using the final diagnosis as the gold standard, we calculated the sensitivity and specificity of each step.ResultsCases were aged median 7.6 years (interquartile range, 2.8-14 years); 56% boys. The majority (52%) was previously healthy; 41% had follow-up vascular imaging. Only 56 (16%) required adjudication. The gold standard diagnosis was definite arteriopathy in 127 (36%), possible in 34 (9.6%), and absent in 194 (55%). Sensitivity was 79% at step 1, 90% at step 2, and 94% at step 3; specificity was high throughout (99%, 100%, and 100%), as was agreement between reviewers (κ=0.77, 0.81, and 0.78).ConclusionsClinical data and follow-up imaging help, yet uncertainty in the diagnosis of childhood arteriopathy remains. This presents a challenge to better understanding the mechanisms underlying these arteriopathies and designing strategies for prevention of childhood arterial ischemic stroke