New frontiers for Biosocial Birth Cohort Research: interdisciplinary approaches to exposure, harmonisation and collaboration

In this Open Letter we bring together researchers from the Biosocial Birth Cohort Research (BBCR) network to reflect on interdisciplinary research and methods within birth cohorts and to draw attention to social science approaches to this field, which we argue are underutilized. A more comprehensive and consistent integration of social science approaches would expand the scope and value of research with birth cohorts. We critically engage three specific areas of birth cohort research that provide significant opportunities for exchange across disciplines; how exposure is defined and measured in birth cohorts, the harmonisation of data within and between birth cohorts and the broader experience of interdisciplinary collaboration in birth cohorts and birth cohort research. By reflecting on these three areas, we highlight the need for more in-depth dialogue between life and social sciences in the design of birth cohorts, the measures that are used, and the research made possible. We argue that improving the methodological tools for measuring social and biological exposures, incorporating the complexity of participant experience, and ensuring that longitudinal studies are recognised by a wider range of disciplines are essential for collaborative biosocial research with the goal of mitigating health disparities in global and public health

Structure of bacteriophage SPP1 tail reveals trigger for DNA ejection

The majority of known bacteriophages have long noncontractile tails (Siphoviridae) that serve as a pipeline for genome delivery into the host cytoplasm. The tail extremity distal from the phage head is an adsorption device that recognises the bacterial receptor at the host cell surface. This interaction generates a signal transmitted to the head that leads to DNA release. We have determined structures of the bacteriophage SPP1 tail before and after DNA ejection. The results reveal extensive structural rearrangements in the internal wall of the tail tube. We propose that the adsorption device–receptor interaction triggers a conformational switch that is propagated as a domino-like cascade along the 1600 Å-long helical tail structure to reach the head-to-tail connector. This leads to opening of the connector culminating in DNA exit from the head into the host cell through the tail tube