Il Nuovo soggettario in Aleph 500

This document illustrates a project for the adaptation of the ALEPH 500 software to the characteristics of the subject indexing language of "Nuovo soggettario", in respect of the international formats Unimarc/Authorities and Unimarc/Bibliographic. The base unit of the indexing language of "Nuovo soggettario", structured according to the method of GRIS (Gruppo di ricerca sull'indicizzazione per soggetto, Research Group on Subject Indexing), is the indexing term, either representing a concept or referring to an individually-named entity, in the form of a noun or noun phrase. The indexing terms are not coincident to the elements of the traditional subject headings, the so-called "descrittori" in SBN (the Italian National library service)

Synthesis, structural studies and photochemistry of cobalt(III) complexes of anthracenylcyclam macrocycles

This work reports the syntheses, structures and some photochemistry in DMF of the cobalt complexes trans-[CoIII( 2)Cl2]Cl·0.5CH3OH and trans-[CoIII( 3)Cl2]Cl·4H2O, where 2 is 6-(anthracen-9-ylmethyl)-1,4,8,11-tetraazacyclotetradecane-5,7-dione and 3 is 6-(anthracen-9-ylmethyl)-1,4,8,11-tetraazacyclotetradecane. In the preparation of the macrocyclic ligand, 3, the formation of a polycyclic bis(aminal) intermediate and its subsequent acid hydrolysis to 3 is a cleaner route than the traditional procedure in which the analogous dioxocyclam 2 is reduced with borane reagents. The crystal structure of trans-[CoIII( 3)Cl2]Cl·4H2O shows that the macrocycle adopts the trans-III conformation, in which the anthracene moiety is extended away from the cobalt ion and the anthracene to Co separation is 7.22 . For the related complex trans-[CoIII( 2)Cl2]Cl·0.5CH3OH, however, the anthracene is bent over the highly conjugated tetracycle and significant interactions between the anthracene and the complex occur. A novel new complex, trans-[Co( 12)Cl2](where 12 is 5,7-hydroxy-6-oxo-1,4,8,11-tetraazacyclotetradecane-4,7-diene) which is a degradation product of the complex trans-[CoIII( 2)Cl2]Cl is also reported

Increase globe artichoke cropping sustainability using sub-surface drip-irrigation systems in a Mediterranean coastal area for reducing groundwater withdrawal

During the last decades in coastal areas of the Mediterranean basin, human growth posed severe stresses on freshwater resources due to increasing demand by agricultural, industrial and civil activities, in particular on groundwater. This in turn led to worsening of water quality, loss/reduction of wetlands, up to soil salinization and abandonment of agricultural areas. Within the EU LIFE REWAT project a number of demonstration measures will take place in the lower Cornia valley (Livorno, Italy), both structural (pilot) and non-structural (education, dissemination and capacity building), aiming at achieving sustainable and participated water management. In particular, the five demonstration actions are related to: (1) set up of a managed aquifer recharge facility, (2) restoration of a Cornia river reach, (3) water saving in the civil water supply sector, (4) water saving in agriculture, (5) reuse of treated wastewater for irrigation purposes. Thus, the REWAT project general objective is to develop a new model of governance for sustainable development of the lower Cornia valley based on the water asset at its core. As per water use in agriculture, the lower Cornia valley is well known for the horticultural production. In this regard, globe artichoke (Cynara cardunculus L. var. scolymus L. (Fiori)) crops, a perennial cool-season vegetable, cover a surface of about 600 ha. In order to increase stability and productivity of the crop, about 2000 – 4000 m3 ha-1 yr-1 of irrigation water is required. Recent studies demonstrated that yield of different crops increases using Sub-surface Drip-Irrigation (SDI) system under high frequency irrigation management enhancing water use efficiency. In the SDI systems, the irrigation water is delivered to the plant root zone, below the soil surface by buried plastic tubes containing embedded emitters located at regular spacing. Within the LIFE REWAT, the specific objectives of the pilot on irrigation efficiency is to (i) demonstrate the suitability of SDI for globe artichoke cultivation, reducing the water consumption, while maintaining (or even increasing) crop production and (ii) assess the crop water use efficiency respect to surface drip-irrigation. The field test is located in Venturina (Italy) and it covers a surface of 4 ha. The soil is characterized by sandy-loam texture, 1.72% of organic matter at 7.81 pH. Groundwater is the main source of supply for irrigation. By the chemical point of view, a monitoring campaign in spring 2016 showed a neutral pH of 7.2, electrical conductivity of 1363 μS/cm, 373 and 243 mg/l of total sulphate and carbonate, respectively, thus demonstrating the suitability of groundwater for SDI application. The SDI system was implemented at the beginning of September 2016. The sub-surface buried pipelines, were placed at 0.25 m depth, with emitters spaced 0.5 m. The distance between pipelines was 1.5 m, according to globe artichoke layout (1.5 m between rows, 1 m in-row spacing). Surface-buried tubes were placed in an area about 0.75 ha wide for the comparison with SDI. Artichoke var. Terom were transplanted after the SDI operation test. In the next 3 years, both crop productivity and water use will be assessed. Results will be presented and discussed with the whole farmer’s community. Acknowledgement This paper is presented within the framework of the project LIFE REWAT, which has received funding from the LIFE Programme of the European Union Grant Agreement LIFE14 ENV/IT/001290

Pharmacokinetics, thrombogenicity and safety of a double viral inactivated factor IX concentrate compared with a prothrombin complex concentrate

Therapeutic options for developing countries have to assure an optimum safety and efficacy and low-cost antihaemophilic concentrates. A single blind randomized crossover study was carried out in 12 previously treated HB patients, comparing the pharmacokinetics (PK), thrombogenicity (TG) and safety of two plasma-derived double-inactivated (solvent/detergent heating at 100?C, 30 min) factor IX (FIX) concentrates, UMAN COMPLEX DI (product A) [plasma-derived prothrombin concentrates (PCC)] and a high purity FIX concentrate AIMAFIX DI (product B, HPFIX). In a non-bleeding state, they received one single intravenous dose 50 IU FIX kg−1 of PCC or HPFIX, and after a wash-out period of 14 days, the other product. We evaluated acute tolerance and determined PK parameters based on FIX levels measured over a 50 h postinfusion period. We studied fibrinogen, platelets, antithrombin, F1 + 2, TAT, D-dimer, over a 360 min postinfusion period. Ten cases remained in on-demand treatment for 6 months, five with PCC and five with HPFIX. PK and anti-FIX inhibitors were repeated at 3 and 6 months. No inhibitors were detected. PK values (PCC vs. HPFIX): clearence (CL; mL h−1 kg−1) 5.2 ? 1.4 vs. 6.5 ? 1.4; the volume of distribution at steady state (mL kg−1) 154.9 ? 54.9 vs. 197.5 ? 72.5; mean residence time (h) 29.7 ? 8.1 vs. 30.7 ? 9.2; T1/2 (h) 22.3 ? 7 vs. 23.5 ? 12.3; incremental recovery (IR; U dL−1 U−1 kg−1) 0.96 ? 0.17 vs. 0.76 ? 0.13. HPFIX showed significant lower IR and higher CL. There were no differences in PK at 3 and 6 months. In TG, significant increments in TAT and F1 + 2 at 30 min and 6 h were found with PCC. Product B PK results agrees with reported results for other HPFIX preparations. Use of PCC product A has to consider its thrombogenic activity

Modeling macroalgal forest distribution at Mediterranean scale : present status, drivers of changes and insights for conservation and management

Macroalgal forests are one of the most productive and valuable marine ecosystems, but yet strongly exposed to fragmentation and loss. Detailed large-scale information on their distribution is largely lacking, hindering conservation initiatives. In this study, a systematic effort to combine spatial data on Cystoseira C. Agardh canopies (Fucales, Phaeophyta) was carried out to develop a Habitat Suitability Model (HSM) at Mediterranean scale, providing critical tools to improve site prioritization for their management, restoration and protection. A georeferenced database on the occurrence of 20 Cystoseira species was produced collecting all the available information from published and grey literature, web data portals and co-authors personal data. Data were associated to 55 predictor variable layers in the (ASCII) raster format and were used in order to develop the HSM by means of a Random Forest, a very effective Machine Learning technique. Knowledge about the distribution of Cystoseira canopies was available for about the 14% of the Mediterranean coastline. Absence data were available only for the 2% of the basin. Despite these gaps, our HSM showed high accuracy levels in reproducing Cystoseira distribution so that the first continuous maps of the habitat across the entire basin was produced. Misclassification errors mainly occurred in the eastern and southern part of the basin, where large gaps of knowledge emerged. The most relevant drivers were the geomorphological ones, followed by anthropogenic variables proxies of pollution and urbanization. Our model shows the importance of data sharing to combine a large number of spatial and environmental data, allowing to individuate areas with high probability of Cystoseira occurrence as suitable for its presence. This approach encourages the use of this modeling tool for the prediction of Cystoseira distribution and for supporting and planning conservation and management initiatives. The step forward is to refine the spatial information of presence-absence data about Cystoseira canopies and of environmental predictors in order to address species-specific assessments.peer-reviewe

An expanded cavity hexaamine cage for copper(II)

The crystal structure of the bicyclic hexaamine complex [Cu(fac-Me-5-tricosane-N-6)](ClO4)(2) center dot H2O (fac-Me-5-tricosane-N-6 = facial-1,5,9,13,20-pentamethyl-3,7,11,15,18,22-hexaazabicyclo[7.7.7] tricosane) at 100 K defines an apparently tetragonally compressed octahedral geometry, which is attributed to a combination of dynamic interconversion and static disorder between two tetragonally elongated structures sharing a common short axis. This structure is fluxional at 60 K and above as shown by EPR spectroscopy. Aqueous cyclic voltammetry reveals that a remarkably stable Cu-I form of the complex is stabilised by the encapsulating nature of the expanded cage ligand