Novel Reflectometry Method Based on Time Reversal for Cable Aging Characterization

International audienceThis paper investigates the effects of aging on electrical cable characteristics and proposes a new method for detecting and characterizing cable aging (i.e. homogeneous slow degradation) based on time reversal. In case of a global cable aging, the commonly used methods such as reflectometry provide non-relevant or inaccurate information. Through theoretical study and numerical simulations, the benefits of this new method called Time Reversal Reflectometry (TRR) are presented. TRR is experimentally shown to be successful for the detection and quantification of cable aging

Interannual variations of the terrestrial water storage in the Lower Ob' Basin from a multisatellite approach

International audienceTemporal variations of surface water volume over inundated areas of the Lower Ob' Basin in Siberia, one of the largest contributor of freshwater to the Arctic Ocean, are estimated using combined observations from a multisatellite inundation dataset and water levels over rivers and floodplains derived from the TOPEX/POSEIDON (T/P) radar altimetry. We computed time-series of monthly maps of surface water volume over the common period of available T/P and multisatellite data (1993–2004). The results exhibit interannual variabilities similar to precipitation estimates and river discharge observations. This study also presents monthly estimates of groundwater and permafrost mass anomalies during 2003–2004 based on a synergistic analysis of multisatellite observations and hydrological models. Water stored in the soil is isolated from the total water storage measured by GRACE when removing the contributions of both the surface reservoir, derived from satellite imagery and radar altimetry, and the snow estimated by inversion of GRACE measurements. The time variations of groundwater and permafrost are then obtained when removing the water content of the root zone reservoir simulated by hydrological models

Do personality traits affect productivity?:Evidence from the lab

While survey data supports a strong relationship between personality and labor market outcomes, the exact mechanisms behind this association remain unexplored. In this paper, we take advantage of a controlled laboratory set-up to explore whether this relationship operates through productivity. Using a real-e ort task, we analyse the impact of the Big Five personality traits on performance. We nd that more neurotic subjects perform worse, and that more conscientious individuals perform better. These ndings are in line with previous survey studies and suggest that at least part of the e ect of personality on labor market outcomes operates through individual productivity. In addition, we nd evidence that gender and university major a ect the impact of the Big Five personality traits on performance

Satellite-based estimates of groundwater storage variations in large drainage basins with extensive floodplains

International audienceThis study presents monthly estimates of groundwater anomalies in a large river basin dominated by extensive floodplains, the Negro River Basin, based on the synergistic analysis using multisatellite observations and hydrological models. For the period 2003-2004, changes in water stored in the aquifer is isolated from the total water storage measured by GRACE by removing contributions of both the surface reservoir, derived from satellite imagery and radar altimetry, and the root zone reservoir simulated by WGHM and LaD hydrological models. The groundwater anomalies show a realistic spatial pattern compared with the hydrogeological map of the basin, and similar temporal variations to local in situ groundwater observations and altimetry-derived level height measurements. Results highlight the potential of combining multiple satellite techniques with hydrological modeling to estimate the evolution of groundwater storage

Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment: Collaborative Cohort Study.

BACKGROUND: CD4 count at start of combination antiretroviral therapy (ART) is strongly associated with short-term survival, but its association with longer-term survival is less well characterized. METHODS: We estimated mortality rates (MRs) by time since start of ART (<0.5, 0.5-0.9, 1-2.9, 3-4.9, 5-9.9, and ≥10 years) among patients from 18 European and North American cohorts who started ART during 1996-2001. Piecewise exponential models stratified by cohort were used to estimate crude and adjusted (for sex, age, transmission risk, period of starting ART [1996-1997, 1998-1999, 2000-2001], and AIDS and human immunodeficiency virus type 1 RNA at baseline) mortality rate ratios (MRRs) by CD4 count at start of ART (0-49, 50-99, 100-199, 200-349, 350-499, ≥500 cells/µL) overall and separately according to time since start of ART. RESULTS: A total of 6344 of 37 496 patients died during 359 219 years of follow-up. The MR per 1000 person-years was 32.8 (95% confidence interval [CI], 30.2-35.5) during the first 6 months, declining to 16.0 (95% CI, 15.4-16.8) during 5-9.9 years and 14.2 (95% CI, 13.3-15.1) after 10 years' duration of ART. During the first year of ART, there was a strong inverse association of CD4 count at start of ART with mortality. This diminished over the next 4 years. The adjusted MRR per CD4 group was 0.97 (95% CI, .94-1.00; P = .054) and 1.02 (95% CI, .98-1.07; P = .32) among patients followed for 5-9.9 and ≥10 years, respectively. CONCLUSIONS: After surviving 5 years of ART, the mortality of patients who started ART with low baseline CD4 count converged with mortality of patients with intermediate and high baseline CD4 counts

A review of the latest real‐world evidence studies in diabetic kidney disease: What have we learned about clinical practice and the clinical effectiveness of interventions?

Diabetic nephropathy, also known as diabetic kidney disease (DKD), remains a challenge in clinical practice as this is the major cause of kidney failure worldwide. Clinical trials do not answer all the questions raised in clinical practice and real-world evidence provides complementary insights from randomized controlled trials. Real-life longitudinal data highlight the need for improved screening and management of diabetic nephropathy in primary care. Adherence to the recommended guidelines for comprehensive care appears to be suboptimal in clinical practice in patients with DKD. Barriers to the initiation of sodium-glucose cotransporter-2 (SGLT2) inhibitors for patients with DKD persist in clinical practice, in particular for the elderly. Attainment of blood pressure targets often remains an issue. Initiation of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in routine clinical practice is associated with a reduced risk of albuminuria progression and a possible beneficial effect on kidney function. Real-world evidence confirms a beneficial effect of SGLT2 inhibitors on the decline of glomerular filtration, even in the absence of albuminuria, with a lower risk of acute kidney injury events compared to GLP-1RA use. In addition, SGLT2 inhibitors confer a lower risk of hyperkalaemia after initiation compared with dipeptidyl peptidase-4 inhibitors in patients with DKD. Data from a large population indicate that diuretic treatment increases the risk of a significant decline in glomerular filtration rate in the first few weeks of treatment after SGLT2 inhibitor initiation. The perspective for a global approach targeting multifaceted criteria for diabetic individuals with DKD is emerging based on real-world evidence but there is still a long way to go to achieve this goal

Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment:collaborative cohort study

Background. CD4 count at start of combination antiretroviral therapy (ART) is strongly associated with short-term survival, but its association with longer-term survival is less well characterised. Methods. We estimated mortality rates (MR) by time since start of ART (&lt;0.5, 0.5-0.9, 1-2.9, 3-3.9, 5-9.9 and ≥10 years) among patients from 18 European and North American cohorts who started ART during 1996-2001. Piecewise exponential models stratified by cohort were used to estimate crude and adjusted (for sex, age, transmission risk, period of starting ART [1996-7, 1998-9, 2000-1], AIDS and HIV-1 RNA at baseline) mortality rate ratios (MRR) by CD4 count at start of ART (0-49, 50-99, 100-199, 200-349, 350-499, ≥500 cells/μL) overall and separately according to time since start of ART. Results. 6,344 of 37,496 patients died during 359,219 years of follow up. The MR per 1000 person-years was 32.8 (95% CI 30.2-35.5) during the first 6 months, declining to 16.0 (15.4, 16.8) during 5-9.9 years and 14.2 (13.3-15.1) after 10 years duration of ART. During the first year of ART there was a strong inverse association of CD4 count at start of ART with mortality. This diminished over the next 4 years. The adjusted MRR per CD4 group were 0.97 (0.94-1.00), p=0.054 and 1.02 (0.98-1.07), p=0.32 among patients followed for 5-9.9 and &gt;10 years respectively. Conclusions. After surviving five years of ART, the mortality of patients who started ART with low baseline CD4 count converged with mortality of patients with intermediate and high baseline CD4 counts. </p

CENPHER five year report 2009-2014: From a research project to a research center

Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C-reactive protein, interleukin (IL)-6, IL-10 and tumor necrosis factor (TNF)-α and the risk of TC. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer-free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49-0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67-2.76, Ptrend = 0.37). Increasing levels of IL-10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13-2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80-3.98, Ptrend = 0.17). Leptin, CRP, IL-6 and TNF-α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL-10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight