Implementation of software applied to energy efficiency and labeling of buildings

Las fuentes de energía más utilizadas en el mundo provienen de recursos no renovables como el carbón, el gas y el petróleo. Además, la obtención de estos recursos y uso implican problemas medioambientales producidos por diversos contaminantes. Por otra parte, en términos de eficiencia energética, en ocasiones se produce un uso ineficiente de energía, ya sea por malos hábitos en el consumo o, por no disponer de los recursos necesarios para optimizar el mismo. Este trabajo utiliza la Norma IRAM 11900:2009 “Etiqueta de eficiencia energética de calefacción para edificios”, para el desarrollo de herramientas informáticas destinadas a analizar y simular modelos de estructuras edilicias con fines educativos y de divulgación en el cálculo de envolventes térmicas y su empleo en etiquetado.Energy sources most used in the world comes from nonrenewable resources such as coal, gas and oil. In addition, obtaining and using these resources involve environmental problems caused by various pollutants. In terms of energy efficiency, inefficient use of energy is due to bad habits in consumption or by not having the necessary resources to optimize their usage. This article uses the standard IRAM 11900:2009 "label energy efficiency of heating for buildings" for the development of tools to analyze and simulate models of building structures for education and outreach in the calculation of thermal envelopes and their labeling.Eje: Eficiencia energética edilicia (Comunicaciones).Facultad de Arquitectura y Urbanism

Implementation of software applied to energy efficiency and labeling of buildings

Las fuentes de energía más utilizadas en el mundo provienen de recursos no renovables como el carbón, el gas y el petróleo. Además, la obtención de estos recursos y uso implican problemas medioambientales producidos por diversos contaminantes. Por otra parte, en términos de eficiencia energética, en ocasiones se produce un uso ineficiente de energía, ya sea por malos hábitos en el consumo o, por no disponer de los recursos necesarios para optimizar el mismo. Este trabajo utiliza la Norma IRAM 11900:2009 “Etiqueta de eficiencia energética de calefacción para edificios”, para el desarrollo de herramientas informáticas destinadas a analizar y simular modelos de estructuras edilicias con fines educativos y de divulgación en el cálculo de envolventes térmicas y su empleo en etiquetado.Energy sources most used in the world comes from nonrenewable resources such as coal, gas and oil. In addition, obtaining and using these resources involve environmental problems caused by various pollutants. In terms of energy efficiency, inefficient use of energy is due to bad habits in consumption or by not having the necessary resources to optimize their usage. This article uses the standard IRAM 11900:2009 "label energy efficiency of heating for buildings" for the development of tools to analyze and simulate models of building structures for education and outreach in the calculation of thermal envelopes and their labeling.Eje: Eficiencia energética edilicia (Comunicaciones).Facultad de Arquitectura y Urbanism

Implementation of software applied to energy efficiency and labeling of buildings

Las fuentes de energía más utilizadas en el mundo provienen de recursos no renovables como el carbón, el gas y el petróleo. Además, la obtención de estos recursos y uso implican problemas medioambientales producidos por diversos contaminantes. Por otra parte, en términos de eficiencia energética, en ocasiones se produce un uso ineficiente de energía, ya sea por malos hábitos en el consumo o, por no disponer de los recursos necesarios para optimizar el mismo. Este trabajo utiliza la Norma IRAM 11900:2009 “Etiqueta de eficiencia energética de calefacción para edificios”, para el desarrollo de herramientas informáticas destinadas a analizar y simular modelos de estructuras edilicias con fines educativos y de divulgación en el cálculo de envolventes térmicas y su empleo en etiquetado.Energy sources most used in the world comes from nonrenewable resources such as coal, gas and oil. In addition, obtaining and using these resources involve environmental problems caused by various pollutants. In terms of energy efficiency, inefficient use of energy is due to bad habits in consumption or by not having the necessary resources to optimize their usage. This article uses the standard IRAM 11900:2009 "label energy efficiency of heating for buildings" for the development of tools to analyze and simulate models of building structures for education and outreach in the calculation of thermal envelopes and their labeling.Eje: Eficiencia energética edilicia (Comunicaciones).Facultad de Arquitectura y Urbanism

Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans : joint RENEB and EURADOS inter-laboratory comparisons

Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

: Repeat expansions in the C9orf72 gene are the most common genetic cause of (ALS) and frontotemporal dementia (FTD). Like other genetic forms of neurodegeneration, pinpointing the precise mechanism(s) by which this mutation leads to neuronal death remains elusive, and this lack of knowledge hampers the development of therapy for C9orf72-related disease. We used an agnostic approach based on genomic data (n = 41,273 ALS and healthy samples, and n = 1,516 C9orf72 carriers) to overcome these bottlenecks. Our drug-repurposing screen, based on gene- and expression-pattern matching and information about the genetic variants influencing onset age among C9orf72 carriers, identified acamprosate, a γ-aminobutyric acid analog, as a potentially repurposable treatment for patients carrying C9orf72 repeat expansions. We validated its neuroprotective effect in cell models and showed comparable efficacy to riluzole, the current standard of care. Our work highlights the potential value of genomics in repurposing drugs in situations where the underlying pathomechanisms are inherently complex. VIDEO ABSTRACT

Association of variants in the SPTLC1 gene with juvenile amyotrophic lateral sclerosis

Importance Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized by age of symptom onset less than 25 years and a variable presentation. Objective To identify the genetic variants associated with juvenile ALS. Design, Setting, and Participants In this multicenter family-based genetic study, trio whole-exome sequencing was performed to identify the disease-associated gene in a case series of unrelated patients diagnosed with juvenile ALS and severe growth retardation. The patients and their family members were enrolled at academic hospitals and a government research facility between March 1, 2016, and March 13, 2020, and were observed until October 1, 2020. Whole-exome sequencing was also performed in a series of patients with juvenile ALS. A total of 66 patients with juvenile ALS and 6258 adult patients with ALS participated in the study. Patients were selected for the study based on their diagnosis, and all eligible participants were enrolled in the study. None of the participants had a family history of neurological disorders, suggesting de novo variants as the underlying genetic mechanism. Main Outcomes and Measures De novo variants present only in the index case and not in unaffected family members. Results Trio whole-exome sequencing was performed in 3 patients diagnosed with juvenile ALS and their parents. An additional 63 patients with juvenile ALS and 6258 adult patients with ALS were subsequently screened for variants in the SPTLC1 gene. De novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient) were identified in 3 unrelated patients diagnosed with juvenile ALS and failure to thrive. A fourth variant (p.Leu39del) was identified in a patient with juvenile ALS where parental DNA was unavailable. Variants in this gene have been previously shown to be associated with autosomal-dominant hereditary sensory autonomic neuropathy, type 1A, by disrupting an essential enzyme complex in the sphingolipid synthesis pathway. Conclusions and Relevance These data broaden the phenotype associated with SPTLC1 and suggest that patients presenting with juvenile ALS should be screened for variants in this gene

The Use of Low-Profile Angular-Stability Plates in a “Nutcracker” Tarsal Navicular Fracture Combined with a Cuboid Fracture: ORIF Experience

Background: Clear recommendations about the optimal treatment of traumatic tarsal navicular fractures are still very debated in the literature, and this is due to several factors: navicular fractures are rare and often misdiagnosed injuries, they are frequently associated with other fractures or a dislocation of the midfoot, and the current knowledge is based on few papers mainly considering a limited number of cases and dealing with different therapeutic approaches. The treatment of navicular body fractures is controversial and burdened by a high incidence of complications; in particular, Sangeorzan type III comminuted fractures represent a real challenge for the orthopedic surgeon. An accurate preoperative planning, a scrupulous surgical technique aimed at restoring volume and bony anatomy, and the use of low-profile angular-stability plates can lead to optimal clinical and functional results, decreasing the chances of arthritic evolution of mid-foot joints

Conical coupling angular stable plate fixation: A retrospective study

Backgrounds. Conical coupling represents an alternative to screw coupling on angular stable plate fixation. Aims of the present study was to evaluate clinical effectiveness and ease of plate removal of conical coupling locking plates into different scenario regarding quality of bone, type of fracture and operative technique. Methods. From May 2013 to December 2017, 198 patients with 206 fractures underwent open reduction and internal fixation with conical locking plate. In most cases fixation involved wrist (38%) and clavicle (24%) fractures but a varied type of fractures and bone were included in the study. Results. Ten complications related to plate fixation were observed (5,1%). Two case of intra-articular positioning of screws of wrist plate. One case of loss of reduction and breakage of wrist plate due to an inappropriate proximal fracture fixation. Five cases of complications involved clavicle fixation: three cases of non-union, one case of peri-implant fracture, one screw loosening. One non-union of distal tibial fracture, one non-union in olecranon fracture were finally observed. Thirty-four patients that have symptoms that could be traceable to the implants in-situ underwent plate removal. No complications were observed during surgical plates removal. Conical coupling angular stability plate represents an actractive alternative to threaded angular stability plate. Bush titanium insert, eliminating the problems of cold welding and cross-threading, simplifies surgical screws and plate removal

A Mono-Instrumental Approach to High-Quality 3D, Reality-Based Semantic Models. Application on the Palladio Library

The paper presents a new workflow to build geo-3D models able to populate a wide information system organizing and managing Palladio’s works documentation. Main goal is to smooth the integration of data from different sources and promote a more profound understanding of Palladio’s works. Starting from an integrated survey approach (laser scanner and Multi-Image Spherical Photogrammetry), reality-based 3D models are robustly constructed and semantically segmented from point cloud features based on Palladio treatise architectural semantics. The 3D models outputs are exported into a 3D Geographic Information System (GIS) to facilitate the visualization of Palladio’s works with reference to topography. At the end, an evaluation mechanism is employed to control the quality of 3D models. The workflow could be easily generalized to other architects documentation systems both because Palladian case is a superset of most of other architect documentation dataset, allowing to focus and to solve all existing problems and because techniques and methods are general and appropriate for most part of historical architecture