Uniform topologies on types

We study the robustness of interim correlated rationalizability to perturbations of higher-order beliefs. We introduce a new metric topology on the universal type space, called uniform weak topology, under which two types are close if they have similar first-order beliefs, attach similar probabilities to other players having similar first-order beliefs, and so on, where the degree of similarity is uniform over the levels of the belief hierarchy. This topology generalizes the now classic notion of proximity to common knowledge based on common p-beliefs (Monderer and Samet 1989). We show that convergence in the uniform weak topology implies convergence in the uniform strategic topology (Dekel, Fudenberg, and Morris 2006). Moreover, when the limit is a finite type, uniform-weak convergence is also a necessary condition for convergence in the strategic topology. Finally, we show that the set of finite types is nowhere dense under the uniform strategic topology. Thus, our results shed light on the connection between similarity of beliefs and similarity of behaviors in games.Rationalizability, incomplete information, higher-order beliefs, strategic topology, electronic mail game

Uniform Topologies on Types

We study the robustness of interim correlated rationalizability to perturbations of higher-order beliefs. We introduce a new metric topology on the universal type space, called uniform weak topology, under which two types are close if they have similar first-order beliefs, attach similar probabilities to other players having similar first-order beliefs, and so on, where the degree of similarity is uniform over the levels of the belief hierarchy. This topology generalizes the now classic notion of proximity to common knowledge based on common p-beliefs (Monderer and Samet (1989)). We show that convergence in the uniform weak topology implies convergence in the uniform strategic topology (Dekel, Fudenberg, and Morris (2006)). Moreover, when the limit is a finite type, uniform-weak convergence is also a necessary condition for convergence in the strategic topology. Finally, we show that the set of finite types is nowhere dense under the uniform strategic topology. Thus, our results shed light on the connection between similarity of beliefs and similarity of behaviors in games.Rationalizability, Incomplete information, Higher-order beliefs, Strategic topology, Electronic mail game

Uniform topologies on types

10.3982/TE462Theoretical Economics53445-47

Insulin and diabetes control in Argentina

En la Argentina al igual que en todo el mundo hay una brecha importante entre los conocimientos científicos sobre la diabetes mellitus (DM) y su aplicación en la práctica clínica. El control inadecuado de la DM y los factores de riesgo cardiovascular asociados genera una elevada morbimortalidad y el consecuente aumento de su carga socioeconómica. El diagnóstico tardío, la “inercia prescriptiva”, especialmente de insulina, y la educación deficiente de integrantes del equipo de salud y personas con diabetes, son algunos de los factores responsables de dicha situación. La implementación de un programa de educación diabetológica que incluya la organización de gabinetes de insulinización, a nivel nacional, dirigido tanto a prestadores como a personas con DM y sus familiares, contribuiría a optimizar la prescripción oportuna de insulina y mejorar la calidad de vida de las personas con DM, a la vez que reduciría la carga socioeconómica de la enfermedad. Para optimizar los resultados de esta estrategia educativa, es necesaria la participación de todos los subsectores de la salud (público, de la seguridad social y privado), de los medios masivos de comunicación, de las escuelas de ciencias de la salud, y de la industria farmacéutica.As in the rest of the world, there is a significant gap between scientific knowledge regarding diabetes mellitus and the daily practice outcome, in Argentina. Inadequate diabetes control combined with associated cardiovascular risk factors are responsible for an elevated morbid-mortality incidence and the consequent raise in the socioeconomic burden. Some of the factors leading to this situation are the late diagnosis of the disease, the clinical “inertia” (reluctance to prescribe insulin) and the poor education given to the health care team as well as the persons with diabetes. The implementation of a national diabetologic education program targeting health care providers, the persons with diabetes and their families, could contribute to optimize the appropriate insulin prescription, and consequently improve their life quality, while reducing the disease socioeconomic burden. In order to optimize the education program’s strategy outcome, insulinization cabinets should be incorporated, the participation of all health systems (public health, social security and private health insurance companies), the media, health sciences, schools and the pharmaceutical industry are needed.Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico La Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Costa Gil, José E.. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Faingold, María C.. Unidad Asistencial Dr. César Milstein; ArgentinaFil: Litwak, León. Hospital Italiano de Buenos Aires; ArgentinaFil: Fuente, Graciela V.. Hospital Carlos Durand; Argentin

High TSH and low T4 as prognostic markers in older patients

OBJECTIVE: To examine the association between thyroid profile and morbidity/mortality (MM) in hospitalized older patients. DESIGN: This is a retrospective study of patients over the age of 60yr admitted to the Dr. Cesar Milstein Hospital between 2009 and 2010 and who had thyroid function tests (TFT). The patients were grouped as per their thyroid tests and their clinical characteristics and MM was associated with their TFT. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75thpercentile), and mortality assessed during an 18-month follow-up period after their hospital discharge. RESULTS: Out of 2599 older patients admitted to our hospital, 7% had TFT performed for various reasons. The patients who had TFT were mostly women and presented in a more serious clinical condition compared to the rest of the patients. The patients were grouped as per their thyroid values as follows: 61% of them had a non-thyroidal illness, 25% were euthyroid, 7% had overt hyperthyroidism, 5% overt hypothyroidism and 1% had subclinical hyper- or hypothyroidism. The hypothyroid patients had a worse clinical outcome compared to the others. Patients with increased MM exhibited higher TSH and lower TT4 (p<0.005). Short-term MM (OR=2.0,95%CI=1.1-3.6, p<0.01) was associated with the decrease of TT4 adjusted by age, sex, T3 and TSH, while for long-term MM the increase in TSH (OR=1.6,95%CI 1.1-2.3, p<0.05) was also significant. CONCLUSION: Among hospitalized older patients who had TFT tests, low TT4 and high TSH were associated with a worse prognosis. We propose that TFT be used as an additional tool in assessing MM in elderly hospitalized patients.Fil: Mingote, Evelin. Hospital "Dr. César Milstein"; ArgentinaFil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rujelman, Rocío. Hospital "Dr. César Milstein"; ArgentinaFil: Marquez, Alejandra. Hospital "Dr. César Milstein"; ArgentinaFil: Fossati, Pia. Hospital "Dr. César Milstein"; ArgentinaFil: Gurfinkiel, Mirta. Hospital "Dr. César Milstein"; ArgentinaFil: Schnitman, Marta. Hospital "Dr. César Milstein"; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Faingold, Cristina. Hospital "Dr. César Milstein"; ArgentinaFil: Brenta, Gabriela. Hospital "Dr. César Milstein"; Argentin

Postictal serotonin levels are associated with peri-ictal apnea.

ObjectiveTo determine the relationship between serum serotonin (5-HT) levels, ictal central apnea (ICA), and postconvulsive central apnea (PCCA) in epileptic seizures.MethodsWe prospectively evaluated video EEG, plethysmography, capillary oxygen saturation (SpO2), and ECG for 49 patients (49 seizures) enrolled in a multicenter study of sudden unexpected death in epilepsy (SUDEP). Postictal and interictal venous blood samples were collected after a clinical seizure for measurement of serum 5-HT levels. Seizures were classified according to the International League Against Epilepsy 2017 seizure classification. We analyzed seizures with and without ICA (n = 49) and generalized convulsive seizures (GCS) with and without PCCA (n = 27).ResultsPostictal serum 5-HT levels were increased over interictal levels for seizures without ICA (p = 0.01), compared to seizures with ICA (p = 0.21). In patients with GCS without PCCA, serum 5-HT levels were increased postictally compared to interictal levels (p &lt; 0.001), but not in patients with seizures with PCCA (p = 0.22). Postictal minus interictal 5-HT levels also differed between the 2 groups with and without PCCA (p = 0.03). Increased heart rate was accompanied by increased serum 5-HT levels (postictal minus interictal) after seizures without PCCA (p = 0.03) compared to those with PCCA (p = 0.42).ConclusionsThe data suggest that significant seizure-related increases in serum 5-HT levels are associated with a lower incidence of seizure-related breathing dysfunction, and may reflect physiologic changes that confer a protective effect against deleterious phenomena leading to SUDEP. These results need to be confirmed with a larger sample size study

Recomendaciones para gestantes con diabetes pregestacional

Este articulo detalla las recomendaciones para gestantes con diabetes pregestacional. Las mismas se redactaron a partir de las conclusiones del Consenso reunido por convocatoria del Comité de Diabetes y Embarazo de la Sociedad Argentina de Diabetes en Octubre de 2009.Fil: Faingold, María Cristina. Unidad Asistencial Doctor César Milstein; ArgentinaFil: Lamelas, C..Fil: Gheggi, María Soledad.Fil: Lapertosa, Silvia.Fil: Di Marco, Ingrid.Fil: Basualdo, María Natalia.Fil: Rovira, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Glatstein, Liliana.Fil: Salzberg, Susana.Fil: López, C..Fil: Rodríguez, María Elena

WDR19 : An ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior‐Loken syndrome

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99013/1/cge12196.pd