Individual Professional Practice in the Company

Import 26/06/2013Tato bakalářská práce se zabývá průběhem mé praxe ve firmě KVADOS. V první části je představena firma KVADOS a doplněk aplikace Microsoft Word, na jehož rozšíření jsem pracoval. Dále jsou uvedeny a popsány jednotlivé úkoly zadané během praxe a jejich řešení. V závěrečné části jsou shrnuty znalosti, které jsem při praxi uplatnil nebo naopak postrádal.This thesis deals with professional practise in the company KVADOS. First part is introducion of KVADOS company and Microsoft Word add-in myDOC which i was extending. In next chapter describes tasks and solutions which was student working on. Last chapter summarizes the knowledge that the student has applied during practise, and those who lacked.460 - Katedra informatikyvelmi dobř

A Price Analyses on the Imperfect Competitive Market

Nedokonale konkurenční trhy jsou důsledkem působení různých faktorů na trzích. Patří mezi ně zejména úspory z rozsahu, různá právní omezení, vysoké náklady vstupu, diferenciace produktu, územní rozptýlení a nedokonalá informovanost spotřebitelů o trhu. Hlavními druhy nedokonalých konkurentů jsou monopoly, oligopoly a monopolistická konkurence. Charakteristickou vlastností těchto nedokonalých konkurentů je jejich schopnost určovat cenu produktu. Jsou takzvanými price-makery. Nedokonalí konkurenti se setkávají s klesající poptávkovou křivkou, neboli je zde závislost ceny na objemu produkce. Této schopnosti využívají při maximalizaci zisku. Nejběžnější metodou maximalizace zisku u nedokonalého konkurenta je cenová diskriminace, díky níž je firma schopna rozčlenit své odběratele na několik skupin a pro každou skupinu určit jinou cenu stejného produktu. V praxi se setkáváme z převážné většiny pouze s nedokonalou konkurencí, vzhledem k již výše zmíněným faktorům. Dokonalá konkurence je tak spíše teoretickým stavem, kterému se v praxi nejvíce blíží obchodování na burzách.To sum up, Imperfect competitive markets are results of influence of various market factors. They consist of economies of scale, variety of legal restrictions, a high amount of production costs, a product differentiation, a territorial dispersion and an imperfect consumer awareness of the market. Firstly, the principal sorts of imperfect competitors are monopolies, oligopolies and monopolist competition. The ability to stipulate the price of a product is characteristic for these kinds of imperfect competitors. Thus they are called price-makers. These imperfect competitors deal with a diminishing demand curve, in other words there is a dependence of a price on the volume of production. Moreover, this ability is used to maximalize a profit. Referring to the imperfect competitor, the most common method of maximalizing the profit is price discrimination, therefore the company is able to divide its customers into several groups and stipulate a different price of a same product for each of them. Nevertheless, in practice due to above mentioned factors we run across the imperfect competition in most of the cases. In addiction, the imperfect competition might be considered as a theoretical state, which is very similar to share dealing in general.

Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms.

Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer

Caracterización de las propiedades fisicoquímicas y del mecanismo de interacción con membranas biológicas de surfactantes derivados de arginina

Se caracterizaron algunas propiedades fisicoquímicas de dos surfactantes derivados de arginina, Bz-Arg-NHC10 y Bz-Arg-NHC12, así como su interacción con membranas biológicas utilizando glóbulos rojos humanos (GRH) como sistema modelo. Dichos compuestos fueron capaces de reducir la tensión superficial del agua a un valor constante, y mostraron además concentraciones micelares críticas (CMC) definidas. La observación de agregados cilíndricos de Bz-Arg-NHCn a través de microscopía de fuerza atómica corroboró las predicciones basadas en los valores del parámetro de empaquetamiento. Los estudios de la actividad hemolítica evidenciaron que la solubilización de la membrana de GRH es inducida por los agregados de los surfactantes, ya que solo se observó lisis celular a concentraciones mayores que sus respectivas CMC. Los cambios morfológicos observados en los GRH expuestos a los surfactantes demostraron la existencia de dos fenómenos involucrados en el mecanismo hemolítico: la incorporación de monómeros de surfactante en la capa externa de la membrana de los GRH, que provoca su desestabilización con la consiguiente formación de equinocitos y liberación de microvesículas, y la extracción de los componentes de la membrana, resultante de colisiones con los agregados de los surfactantes, lo que provoca una disminución del área relativa de la capa externa y favorece la aparición de estomatocitos.Trabajo presentado por el Centro de Investigación de Proteínas Vegetales (CIProVe

Metabolic and physiological responses of shiraz and cabernet sauvignon (Vitis vinifera L.) to near optimal temperatures of 25 and 35 \ub0C

Shiraz and Cabernet Sauvignon (Cs) grapevines were grown at near optimal temperatures (25 or 35 \ub0C). Gas exchange, fluorescence, metabolic profiling and correlation based network analysis were used to characterize leaf physiology. When grown at 25 \ub0C, the growth rate and photosynthesis of both cultivars were similar. At 35 \ub0C Shiraz showed increased respiration, non-photochemical quenching and reductions of photosynthesis and growth. In contrast, Cs maintained relatively stable photosynthetic activity and growth regardless of the condition. In both cultivars, growth at 35 \ub0C resulted in accumulations of secondary sugars (raffinose, fucose and ribulose) and reduction of primary sugars concentration (glucose, fructose and sucrose), more noticeably in Shiraz than Cs. In spite of similar patterns of metabolic changes in response to growth at 35 \ub0C, significant differences in important leaf antioxidants and antioxidant precursors (DHA/ascorbate, quinates, cathechins) characterized the cultivar response. Correlation analysis reinforced Shiraz sensitivity to the 35 \ub0C, showing higher number of newly formed edges at 35 \ub0C and higher modularity in Shiraz as compared to Cs. The results suggest that the optimal growth temperatures of grapevines are cultivar dependent, and allow a first insight into the variability of the metabolic responses of grapevines under varied temperatures

Conserved changes in dynamics of metabolic processes during fruit development and ripening across species

Computational analyses of molecular phenotypes traditionally aim at identifying biochemical components that exhibit differential expression under various scenarios (e.g. environmental and internal perturbations) in a single species. High-throughput metabolomics technologies allow the quantification of (relative) metabolite levels across developmental stages in different tissues, organs, and species. Novel methods for analyzing the resulting multiple data tables could reveal preserved dynamics of metabolic processes across species. The problem we address in this study is 2-fold. (1) We derive a single data table, referred to as a compromise, which captures information common to the investigated set of multiple tables containing data on different fruit development and ripening stages in three climacteric (i.e. peach [Prunus persica] and two tomato [Solanum lycopersicum] cultivars, Ailsa Craig and M82) and two nonclimacteric (i.e. strawberry [Fragaria × ananassa] and pepper [Capsicum chilense]) fruits; in addition, we demonstrate the power of the method to discern similarities and differences between multiple tables by analyzing publicly available metabolomics data from three tomato ripening mutants together with two tomato cultivars. (2) We identify the conserved dynamics of metabolic processes, reflected in the data profiles of the corresponding metabolites that contribute most to the determined compromise. Our analysis is based on an extension to principal component analysis, called STATIS, in combination with pathway overenrichment analysis. Based on publicly available metabolic profiles for the investigated species, we demonstrate that STATIS can be used to identify the metabolic processes whose behavior is similarly affected during fruit development and ripening. These findings ultimately provide insights into the pathways that are essential during fruit development and ripening across species.Fil: Klie, Sebastian. Max Planck Institute of Molecular Plant Physiology; AlemaniaFil: Osorio, Sonia. Consejo Superior de Investigaciones Cientificas. Instituto de Hortofruticultura Subtropical y Mediterránea; EspañaFil: Tohge, Takayuki. Max Planck Institute of Molecular Plant Physiology; AlemaniaFil: Drincovich, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Centro de Estudios Fotosintéticos y Bioquímicos (i); ArgentinaFil: Fait, Aaron. Ben-Gurion University of the Negrev; IsraelFil: Giovannoni, Federico. Cornell University; Estados UnidosFil: Fernie, Alisdair R.. Max Planck Institute of Molecular Plant Physiology; AlemaniaFil: Nikoloski, Zoran. Max Planck Institute of Molecular Plant Physiology; Alemani

The Compatibility of Cryptocurrencies and Islamic Finance

In this article, I shall examine the compatibility of Bitcoin and other cryptocurrencies within the context of Islamic law. I shall begin by an introduction of Bitcoin and other cryptocurrencies. I will then discuss the history of money in Islamic history, with an emphasis on the importance ethical financial dealings. I will then argue that Bitcoin and other cryptocurrencies are highly compatible within Islamic finance, and in many cases, actually provide solutions to problems of government institution controlled currencies, arguing that Bitcoin and other cryptocurrencies better address several problems that early Islamic finance scholars were concerned with. Unlike traditional fiat, the supply of Bitcoin and many other digital currencies are fixed, thereby eliminating potential for gharar (deception), and also inflation. In addition, unlike fiat and precious metal coins, digital currencies cannot be altered, forged, or manipulated. Moreover, cryptocurrencies’ peer-to-peer transactions remove the need for any banking institution, thereby eliminating any risk with a third party controlling one’s money. I shall then conclude with a summary of the main points of the article, and examine future possibilities with regards to the role of digital and cryptocurrencies