Gastric cancer with radiographically occult metastatic disease: Biology, challenges, and diagnostic approaches

Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile. It remains the third leading cause of cancer deaths worldwide and was estimated to result in 782,000 deaths in 2018. Challenges exist in accurately assessing the disease burden, as available radiological staging often underestimates metastatic disease. This diagnostic handicap, along with the poor understanding of the heterogeneous biology of gastric cancer, has hindered the development of effective therapeutic solutions and thus halted improvement in patient outcomes over the last few decades. The management of occult peritoneal disease is complicated, as most patients are understaged by standard imaging studies and therefore thought to have local diseases. In this article, we systematically review recent literature on the limitations that are associated with standard radiographic staging, discuss recent molecular biology advances to better identify and diagnose occult peritoneal disease, and propose possible management strategies to approach this complicated clinical problem

Experimental Study on Friction Properties of Rubber Material: Influence of Surface Roughness on Sliding Friction

AbstractThis study investigated the influence of the surface roughness of rubber on sliding friction. The friction was measured by using textured specimens and plain (non-textured) specimens. Under a dry condition, the textured specimens, whose contact area was smaller than that of the plain ones, showed low coefficients of friction. Under a lubricated condition, the coefficients of friction of the textured specimens were higher in a low speed region, but those were lower in a higher speed region. Therefore, the lubrication conditions should be considered in the application of the texturing on rubber surface

Hoop structures for Missouri swine finishing facilities (1999)

Many Missouri pork producers are looking for lower-cost structures in which to raise pigs. The search for low-cost animal housing has created a great interest in so-called hoop structures, or hoop shelters, as facilities in which to grow pigs from about 60 pounds to market weight. Hoop structures can be used successfully in such grow-finish operations, but producers need to be aware of the advantages and disadvantages of this type of housing.New 3/99/5M

Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses

ACKNOWLEDGMENTS We thank Dennis Winge (University of Utah) and the members of the Khalimonchuk laboratory for critical comments. We also thank Christoph Schuller (University of Natural Resources, Austria) and Paul Herman (Ohio State University) for reagents. We acknowledge the expert technical assistance of Nataliya Zahayko. We also thank Donna MacCallum for help with the Candida virulence assays. This research was supported by grants from the NIH (P30GM103335 and 5R01GM108975 [O.K.], GM071775-06 and GM105781-01 [A.B.], DK079209 [J.L.]), the U.K. Biotechnology and Biological Research Council (BB/K017365/1 [A.J.P.B.]), the U.K. Medical Research Council (MR/ M026663/1 [A.J.P.B.]), and the European Research Council (C-2009- AdG-249793 [A.J.P.B.]). We declare that we have no competing financial interests. FUNDING INFORMATION This work, including the efforts of Alistair J. P. Brown, was funded by Biotechnology and Biological Research Counsil (BB/K017365/1). This work, including the efforts of Oleh Khalimonchuk, was funded by HHS | National Institutes of Health (NIH) (5R01GM108975). This work, including the efforts of Oleh Khalimonchuk, was funded by HHS | National Institutes of Health (NIH) (P30GM103335).This work, including the efforts of Antoni Barrientos, was funded by HHS | National Institutes of Health (NIH) (GM071775-06). This work, including the efforts of Antoni Barrientos, was funded by HHS | National Institutes of Health (NIH) (GM105781-01). This work, including the efforts of Jaekwon Lee, was funded by HHS | National Institutes of Health (NIH) (DK079209). This work, including the efforts of Alistair J. P. Brown, was funded by Medical Research Council (MRC) (MR/M026663/1). This work, including the efforts of Alistair J. P. Brown, was funded by EC | European Research Council (ERC) (C-2009-AdG-249793).Peer reviewedPublisher PD

Life, Life Support, and Death Principles, Guidelines, Policies and Procedures for Making Decisions That Respect Life

The following is the third edition of a booklet by the American Life League, Inc. The section on Ordinary/Extraordinary Means has been revised. The sections on Quality of Life, Pain, Paired Organ and Non-vital Organ and Tissue Transplant, and Determination of Death have been added. There are other changes throughout the booklet

The memoirs of Ivan Doig: Donning new roles and revising old myths

“If, somewhere beneath the blood, the past must beat in me to make a rhythm of survival for itself—to go on as this half-life which echoes as a second pulse inside the ticking moments of my existence—if this is what must be, why is the pattern of remembered instant so uneven, so gapped and rugged and plunging and soaring? I can only believe it is because memory takes its pattern from the earliest moments in the mind, from childhood. In childhood is a most queer flame-lit and shadow-chilled time” (Sky 10). In his memoirs, Heart Earth and This House of Sky: Landscapes of a Western Mind, Ivan Doig remembers with respect and fondness the lives of his mother, father, and Grandfather and the role in his coming of age. Doig’s recollections show that he owes his maturation—from a boy bent on dream to a man sure of reality, yet still fond of dreaming—to his mother, his grandmother, and his father. Maternal grace, or “heart,” is the foundation for Ivan\u27s sensibility of the values of pity and endurance—values associated with myth in western literature—and the paternal extension of these values, namely Charlie\u27s hard work and persistence, are the chief reasons why Ivan is able to cope with loss in a world rough to the touch of youth. With concern for how the past and its people shaped us in the present, Doig makes revelations about his family that are simultaneously revelations about himself. The beauty of these memoirs is that Doig can synthesize with retrospective maturity the events in words of his parents that impressed him most

A descriptive study of nonverbal communication between and within the professions of nursing and medicine

Due to the feminist movement, male-female communication has become a topic of increased interest, especially in the area of nonverbal communication. Julius Fast (1970) made 51 body language” a household phrase, for better or for worse. But the study of nonverbal behavior has.only recently become a serious subject of research. As Randall Harrison (l97l) put it, We have important problems to solve. In short, I see us on the threshold of an exciting era of research in nonverbal communication (p. 2).