Remaking Chineseness: The Transition Of Inner Asian Groups In The Central Plain During The Sixteen Kingdoms Period And Northern Dynasties

This dissertation aims to examine the institutional transitions of the Inner Asian groups in the Central Plain during the Sixteen Kingdoms period and Northern Dynasties. Starting with an examination on the origin and development of Sinicization theory in the West and China, the first major chapter of this dissertation argues the Sinicization theory evolves in the intellectual history of modern times. This chapter, in one hand, offers a different explanation on the origin of the Sinicization theory in both China and the West, and their relationships. In the other hand, it incorporates Sinicization theory into the construction of the historical narrative of Chinese Nationality, and argues the theorization of Sinicization attempted by several scholars in the second half of 20th Century. The second and third major chapters build two case studies regarding the transition of the central and local institutions of the Inner Asian polities in the Central Plain, which are the succession system and the local administrative system. In the first case study, through applying the crown prince system, the Inner Asian rulers reached the centralization of authority, which was different from and even more centralized than the Han tradition. In the second case study, the polities of the Sixteen Kingdoms Period and Northern Dynasties largely followed the Inner Asian political tradition and the Inner Asian groups also remained as units inside the polities. The two case studies show the transition of the institutions of the Inner Asian polity in the Central Plain. The transition is neither a one-way change from Inner Asian institutions to Han and Jin institutions nor a simple hybridity. For different institutions, here the succession system in the central government and the administrative system in the local level, the dynamics for the transition are also not the same. This dissertation approaches the Chinese history with articulating not only what these Inner Asian groups took from the Chinese tradition, but also what they contributed to the institutional changes in Chinese history, which reshapes our understanding of what we call “Chinese” institutions, in other words, Chineseness

Remaking Chineseness: The Transition Of Inner Asian Groups In The Central Plain During The Sixteen Kingdoms Period And Northern Dynasties

This dissertation aims to examine the institutional transitions of the Inner Asian groups in the Central Plain during the Sixteen Kingdoms period and Northern Dynasties. Starting with an examination on the origin and development of Sinicization theory in the West and China, the first major chapter of this dissertation argues the Sinicization theory evolves in the intellectual history of modern times. This chapter, in one hand, offers a different explanation on the origin of the Sinicization theory in both China and the West, and their relationships. In the other hand, it incorporates Sinicization theory into the construction of the historical narrative of Chinese Nationality, and argues the theorization of Sinicization attempted by several scholars in the second half of 20th Century. The second and third major chapters build two case studies regarding the transition of the central and local institutions of the Inner Asian polities in the Central Plain, which are the succession system and the local administrative system. In the first case study, through applying the crown prince system, the Inner Asian rulers reached the centralization of authority, which was different from and even more centralized than the Han tradition. In the second case study, the polities of the Sixteen Kingdoms Period and Northern Dynasties largely followed the Inner Asian political tradition and the Inner Asian groups also remained as units inside the polities. The two case studies show the transition of the institutions of the Inner Asian polity in the Central Plain. The transition is neither a one-way change from Inner Asian institutions to Han and Jin institutions nor a simple hybridity. For different institutions, here the succession system in the central government and the administrative system in the local level, the dynamics for the transition are also not the same. This dissertation approaches the Chinese history with articulating not only what these Inner Asian groups took from the Chinese tradition, but also what they contributed to the institutional changes in Chinese history, which reshapes our understanding of what we call “Chinese” institutions, in other words, Chineseness

Using encrypted genotypes and phenotypes for collaborative genomic analyses to maintain data confidentiality.

To adhere to and capitalize on the benefits of the FAIR (Findable, Accessible, Interoperable and Reusable) principles in agricultural genome-to-phenome studies, it is crucial to address privacy and intellectual property issues that prevent sharing and reuse of data in research and industry. Direct sharing of genotype and phenotype data is often prohibited due to intellectual property and privacy concerns. Thus there is a pressing need for encryption methods that obscure confidential aspects of the data, without affecting the outcomes of certain statistical analyses. A homomorphic encryption method for genotypes and phenotypes (HEGP) has been proposed for single-marker regression in genome-wide association studies using linear mixed models with Gaussian errors. This methodology permits frequentist likelihood-based parameter estimation and inference. In this paper, we extend HEGP to broader applications in genome-to-phenome analyses. We show that HEGP is suited to commonly used linear mixed models for genetic analyses of quantitative traits including GBLUP and RR-BLUP, as well as Bayesian variable selection methods (e.g., those in Bayesian Alphabet), for genetic parameter estimation, genomic prediction, and genome-wide association studies. By advancing the capabilities of HEGP, we offer researchers and industry professionals a secure and efficient approach for collaborative genomic analyses while preserving data confidentiality

Using encrypted genotypes and phenotypes for collaborative genomic analyses to maintain data confidentiality

To adhere to and capitalize on the benefits of the FAIR (findable, accessible, interoperable, and reusable) principles in agricultural genome- to-phenome studies, it is crucial to address privacy and intellectual property issues that prevent sharing and reuse of data in research and industry. Direct sharing of genotype and phenotype data is often prohibited due to intellectual property and privacy concerns. Thus, there is a pressing need for encryption methods that obscure confidential aspects of the data, without affecting the outcomes of certain statistical analyses. A homomorphic encryption method for genotypes and phenotypes (HEGP) has been proposed for single-marker regression in genome-wide association studies (GWAS) using linear mixed models with Gaussian errors. This methodology permits frequentist likelihood-based parameter estimation and inference. In this paper, we extend HEGP to broader applications in genome- to-phenome analyses. We show that HEGP is suited to commonly used linear mixed models for genetic analyses of quantitative traits including genomic best linear unbiased prediction (GBLUP) and ridge-regression best linear unbiased prediction (RR-BLUP), as well as Bayesian variable selection methods (e.g. those in Bayesian Alphabet), for genetic parameter estimation, genomic prediction, and GWAS. By advancing the capabilities of HEGP, we offer researchers and industry professionals a secure and efficient approach for collaborative genomic analyses while preserving data confidentiality

Dual active sites engineering of electrocatalysts for alkaline hydrogen evolution

Hydrogen evolution reaction (HER) in alkaline medium plays an important role in producing green hydrogen but suffers from sluggish reaction kinetics owing to additional water dissociation step. Extensive research interest has been placed on engineering dual active sites (i.e., water-dissociation sites and hydrogen-adsorption/recombination sites) within a catalyst to enhance the HER activity. This article reviews recent progress in developing alkaline HER catalysts with high-efficiency dual active sites via strategies of heterogeneous interfaces constructing and heteroatoms doping or alloying. The latest advances in the component design, synthetic strategy, catalytic performance, and mechanistic understanding are discussed with selective examples of the hybrid between metal/alloy or metal phosphide/nitride/sulfide and transition metal hydroxides, oxyhydroxide or bicarbonates. Furthermore, remaining challenges and perspectives in the field of dual-site engineering are highlighted for future development of better alkaline HER electrocatalysts

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968.Objective: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking.Data Sources: Primary data.Study Selection: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy.DataExtraction: Uniform statistical analysis scripts were runlocally. Starting with 94 050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD 16 years), and a logistic regression of heavy vs light smoking with ther s16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum.Data Synthesis: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR]=1.45; 95% CI, 1.36-1.55; n=13 843) than were carriers of the risk allele who were late-onset smokers (OR=1.27; 95% CI, 1.21-1.33, n=19 505) (P=.01).Conclusion: These results highlight an increased genetic vulnerability to smoking in early-onset smokers

An Assay for Systematically Quantifying the Vestibulo-Ocular Reflex to Assess Vestibular Function in Zebrafish Larvae

Zebrafish (Danio rerio) larvae are widely used to study otic functions because they possess all five typical vertebrate senses including hearing and balance. Powerful genetic tools and the transparent body of the embryo and larva also make zebrafish a unique vertebrate model to study otic development. Due to its small larval size and moisture requirement during experiments, accurately acquiring the vestibulo-ocular reflex (VOR) of zebrafish larva is challenging. In this report, a new VOR testing device has been developed for quantifying linear VOR (LVOR) in zebrafish larva, evoked by the head motion about the earth horizontal axis. The system has a newly designed larva-shaped chamber, by which live fish can be steadily held without anesthesia, and the system is more compact and easier to use than its predecessors. To demonstrate the efficacy of the system, the LVORs in wild-type (WT), dlx3b and dlx4b morphant zebrafish larvae were measured and the results showed that LVOR amplitudes were consistent with the morphological changes of otoliths induced by morpholino oligonucleotides (MO). Our study represents an important advance to obtain VOR and predict the vestibular conditions in zebrafish