Giant negative magnetoresistance in semiconductors doped by multiply charged deep impurities

A giant negative magnetoresistance has been observed in bulk germanium doped with multiply charged deep impurities. Applying a magnetic field the resistance may decrease exponentially at any orientation of the field. A drop of the resistance as much as about 10000% has been measured at 6 T. The effect is attributed to the spin splitting of impurity ground state with a very large g-factor in the order of several tens depending on impurity.Comment: 4 pages, 4 figure

Tenfold Magnetoconductance in a Non-Magnetic Metal Film

We present magnetoconductance (MC) measurements of homogeneously disordered Be films whose zero field sheet conductance (G) is described by the Efros-Shklovskii hopping law $G(T)=(2e^2/h)\exp{-(T_o/T)^{1/2}}$. The low field MC of the films is negative with G decreasing 200% below 1 T. In contrast the MC above 1 T is strongly positive. At 8 T, G increases 1000% in perpendicular field and 500% in parallel field. In the simpler parallel case, we observe {\em field enhanced} variable range hopping characterized by an attenuation of $T_o$ via the Zeeman interaction.Comment: 9 pages including 5 figure

Magneto-Conductance Anisotropy and Interference Effects in Variable Range Hopping

We investigate the magneto-conductance (MC) anisotropy in the variable range hopping regime, caused by quantum interference effects in three dimensions. When no spin-orbit scattering is included, there is an increase in the localization length (as in two dimensions), producing a large positive MC. By contrast, with spin-orbit scattering present, there is no change in the localization length, and only a small increase in the overall tunneling amplitude. The numerical data for small magnetic fields $B$, and hopping lengths $t$, can be collapsed by using scaling variables $B_\perp t^{3/2}$, and $B_\parallel t$ in the perpendicular and parallel field orientations respectively. This is in agreement with the flux through a `cigar'--shaped region with a diffusive transverse dimension proportional to $\sqrt{t}$. If a single hop dominates the conductivity of the sample, this leads to a characteristic orientational `finger print' for the MC anisotropy. However, we estimate that many hops contribute to conductivity of typical samples, and thus averaging over critical hop orientations renders the bulk sample isotropic, as seen experimentally. Anisotropy appears for thin films, when the length of the hop is comparable to the thickness. The hops are then restricted to align with the sample plane, leading to different MC behaviors parallel and perpendicular to it, even after averaging over many hops. We predict the variations of such anisotropy with both the hop size and the magnetic field strength. An orientational bias produced by strong electric fields will also lead to MC anisotropy.Comment: 24 pages, RevTex, 9 postscript figures uuencoded Submitted to PR

Stroma-targeting strategies in pancreatic cancer: Past lessons, challenges and prospects

Pancreatic ductal adenocarcinoma (PDAC) is projected to emerge as the second leading cause of cancer-related death after 2030. Extreme treatment resistance is perhaps the most significant factor that underlies the poor prognosis of PDAC. To date, combination chemotherapy remains the mainstay of treatment for most PDAC patients. Compared to other cancer types, treatment response of PDAC tumors to similar chemotherapy regimens is clearly much lower and shorter-lived. Aside from typically harboring genetic alterations that to date remain un-druggable and are drivers of treatment resistance, PDAC tumors are uniquely characterized by a densely fibrotic stroma that has well-established roles in promoting cancer progression and treatment resistance. However, emerging evidence also suggests that indiscriminate targeting and near complete depletion of stroma may promote PDAC aggressiveness and lead to detrimental outcomes. These conflicting results undoubtedly warrant the need for a more in-depth understanding of the heterogeneity of tumor stroma in order to develop modulatory strategies in favor of tumor suppression. The advent of novel techniques including single cell RNA sequencing and multiplex immunohistochemistry have further illuminated the complex heterogeneity of tumor cells, stromal fibroblasts, and immune cells. This new knowledge is instrumental for development of more refined therapeutic strategies that can ultimately defeat this disease. Here, we provide a concise review on lessons learned from past stroma-targeting strategies, new challenges revealed from recent preclinical and clinical studies, as well as new prospects in the treatment of PDAC

A case of intermittent left bundle branch block

An 82-year-old woman with uncontrolled hypertension and occasional exertional dyspnea was found to be in intermittent left bundle branch block (LBBB). Her laboratory results, echocardiogram, and ischemic workup were unremarkable. This case highlights that intermittent LBBB is not always associated with coronary ischemia, vasospasm, blunt cardiac injury, drugs, and high catecholaminergic or inflammatory states

Supernova 2013fc in a circumnuclear ring of a luminous infrared galaxy: the big brother of SN 1998S

We present photometric and spectroscopic observations of SN 2013fc, a bright type II supernova (SN) in a circumnuclear star-forming ring in the luminous infrared galaxy ESO 154-G010, observed as part of the Public ESO Spectroscopic Survey of Transient Objects. SN 2013fc is both photometrically and spectroscopically similar to the well-studied type IIn SN 1998S and to the bright type II-L SN 1979C. It exhibits an initial linear decline, followed by a short plateau phase and a tail phase with a decline too fast for 56Co decay with full γ-ray trapping. Initially, the spectrum was blue and featureless. Later on, a strong broad (∼8000 km s−1) H α emission profile became prominent. We apply a starlight stellar population model fit to the SN location (observed when the SN had faded) to estimate a high extinction of AV = 2.9 ± 0.2 mag and an age of 10 +3 −2 10−2+3 Myr for the underlying cluster. We compare the SN to SNe 1998S and 1979C and discuss its possible progenitor star considering the similarities to these events. With a peak brightness of B = −20.46 ± 0.21 mag, SN 2013fc is 0.9 mag brighter than SN 1998S and of comparable brightness to SN 1979C. We suggest that SN 2013fc was consistent with a massive red supergiant (RSG) progenitor. Recent mass loss probably due to a strong RSG wind created the circumstellar matter illuminated through its interaction with the SN ejecta. We also observe a near-infrared excess, possibly due to newly condensed dust

Perceptions de la variabilité climati que et stratégies d’adaptation dans le système oasien de Gouré (Sud-est Niger)

Les savoirs liés au temps et à l’espace, et l’identification des stratégies paysannes pour affronter les problèmes climatiques sont indispensables pour toute compréhension des questions climatiques. Pour mieux apprécier les perceptions de la variabilité climatique et les stratégies d’adaptation utilisées, une enquête semi structuré qui a concerné 60 personnes repartie dans 4 villages du département de Gouré, situé dans l’Est du Niger est conduite selon une approche qualitative et quantitative. Les effets de la variabilité climatique ressentis par les agriculteurs sont l’aridité du climat, l’augmentation de la température et le caractère aléatoire des pluies. Les éleveurs la perçoivent de façon indirecte à travers la réduction du fourrage et de la disponibilité d’eau. Ces effets ont poussé ces populations à adopter des stratégies d’adaptation comme la recherche de nouvelles variétés à cycle court et supportant les poches de sécheresse, la pratique des techniques de fixation des dunes pour la restauration du couvert herbacé, l’utilisation de la fumure organique, la modification des dates de semis, le stockage de fourrage, le déstockage des animaux pendant la soudure, les prières collectives de demande de pluies. Elles sont toutefois insuffisantes du fait de la persistance des effets négatifs de la variabilité climatiques au Niger.Mots clés: Variabilité climatique, perception, stratégies d’adaptation, Gouré, NigerEnglish Title: Farmers perception and adaptation strategies to climate change in the oasis system of Goure (Southeast Niger)English AbstractKnowledge related to the perception of time and space, and identification of farmers’ strategies for dealing with climate change is a perequisite for a good understanding of climate issues. Farmers’ climate variability perceptions and adaptation strategies was studied using a survey conducted with sixty (60) farmers in the department of Gouré, located in eastern Niger. Results showed that farmers directly experience changes in  climate variability through temperature increase, frequent drought and erratic rainfall. By contrast, herders sense the effects of climate change indirectly through fodder reduction and scarce water availability. These effects have prompted farmers to adopt coping strategies such as the use of improved varieties, early and drought tolerant, sand dune stabilization and land reclamation, use of organic manure, changing of planting dates, storage of fodder, the destocking of animals during drought periods, collective prayers for rain. These strategies, however, appear to be insufficient for addressing the negative effects of climate change in this part of Niger.Keywords: climate variability, perception, strategies of adaptation, Goure, Nige