MOSEM2 project: Integration of data acquisition, modelling, simulation and animation for learning electromagnetism and superconductivity

The MOSEM2 project, funded by European Commission, seeks to extend the minds-on experiments and materials from the twin project MOSEM by adding a set of computer aided activities covering a series of topics in Electromagnetism and Superconductivity. The new activities will integrate different ICT technologies: data logging, data video, modelling, simulation and animation. The MOSEM2 primarily targets physics teachers in upper secondary schools and trainee physics teachers. Teacher training departments at universities will implement the teacher seminars and new materials developed in the project. During theWS4 workshop held at MPTL 14 examples of teaching and learning activities from MOSEM2 were demonstrated

Transition governance for just, sustainable urban mobility: An experimental approach from Rotterdam, the Netherlands

Cities across the global are looking for structural systemic solutions to mobility related problems such as congestion, pollution, and lack of (public) space. Electrification seems to accelerate and address (local) environmental problems, but not necessarily contributes to just mobility by opening up public space, creating broader access to mobility and supporting health. In this paper we describe an experimental transition governance process in the city of Rotterdam, the Netherlands, in the context of the local climate agreement. It used transition governance to explore how the social, cultural, institutional and technological changes needed to achieve a just and sustainable mobility future could be accelerated. The politically supported but informal governance process mobilized public-private-civil networks of actors in the context of the local climate agreement to co-create a transition strategy based on zero-emissions, social and shared mobility in 2030, aiming for all vehicles left to be shared and free from tailpipe emissions. It accelerated a number of debates, actions and changes in the city and pushed local policies to further prioritize walking, cycling, sharing and public transport. Its ambitions have helped shape current formal urban spatial and mobility policies and institutional experimentation in the city, accelerated during the COVID pandemic

Entering, enduring and exiting: the durability of shared mobility arrangements and habits

Car sharing could support a transition away from private vehicle ownership and use. Attempts to understand participation in car sharing have primarily focused on minor and major disruptions which catalyse change in practices. This paper examines how processes of entering, continuing or exiting car sharing systems unfold in Norway, the Netherlands, Sweden and the UK. Car sharing is conceptualised as an arrangement of elements assembled, adjusted and supported by events, practices and habits. Drawing on biographically-oriented household interviews, we build on and extend existing understandings of change and stability in car sharing in four ways. First, by focusing on households rather than individual users, the paper complements recent attempts to understand the decoupling of family and private-car-based mobility. Second, under-examined processes of exiting, alongside entry and continuation are considered. Third, it highlights the importance of recognising more imperceptible, gradual and continuous changes which might not necessarily coincide with a disruptive event. Fourth, habits of shared car arrangements are demonstrated to be fragile and not as deeply ingrained as those associated with ownership. Existing household practices and habits thus raise further questions about the potential for shared mobility services to disrupt the primacy of the car

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

Background Improved markers of prognosis are needed to stratify patients with early-stage colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to develop a biomarker of patient outcome after primary colorectal cancer resection by directly analysing scanned conventional haematoxylin and eosin stained sections using deep learning. Methods More than 12 000 000 image tiles from patients with a distinctly good or poor disease outcome from four cohorts were used to train a total of ten convolutional neural networks, purpose-built for classifying supersized heterogeneous images. A prognostic biomarker integrating the ten networks was determined using patients with a non-distinct outcome. The marker was tested on 920 patients with slides prepared in the UK, and then independently validated according to a predefined protocol in 1122 patients treated with single-agent capecitabine using slides prepared in Norway. All cohorts included only patients with resectable tumours, and a formalin-fixed, paraffin-embedded tumour tissue block available for analysis. The primary outcome was cancer-specific survival. Findings 828 patients from four cohorts had a distinct outcome and were used as a training cohort to obtain clear ground truth. 1645 patients had a non-distinct outcome and were used for tuning. The biomarker provided a hazard ratio for poor versus good prognosis of 3·84 (95% CI 2·72–5·43; p<0·0001) in the primary analysis of the validation cohort, and 3·04 (2·07–4·47; p<0·0001) after adjusting for established prognostic markers significant in univariable analyses of the same cohort, which were pN stage, pT stage, lymphatic invasion, and venous vascular invasion. Interpretation A clinically useful prognostic marker was developed using deep learning allied to digital scanning of conventional haematoxylin and eosin stained tumour tissue sections. The assay has been extensively evaluated in large, independent patient populations, correlates with and outperforms established molecular and morphological prognostic markers, and gives consistent results across tumour and nodal stage. The biomarker stratified stage II and III patients into sufficiently distinct prognostic groups that potentially could be used to guide selection of adjuvant treatment by avoiding therapy in very low risk groups and identifying patients who would benefit from more intensive treatment regimes

Comparison of broad range 16S rDNA PCR and conventional blood culture for diagnosis of sepsis in the newborn: a case control study

<p>Abstract</p> <p>Background</p> <p>Early onset bacterial sepsis is a feared complication of the newborn. A large proportion of infants admitted to the Neonatal Intensive Care Unit (NICU) for suspected sepsis receive treatment with potent systemic antibiotics while a diagnostic workup is in progress. The gold standard for detecting bacterial sepsis is blood culture. However, as pathogens in blood cultures are only detected in approximately 25% of patients, the sensitivity of blood culture is suspected to be low. Therefore, the diagnosis of sepsis is often based on the development of clinical signs, in combination with laboratory tests such as a rise in C – reactive protein (CRP). Molecular assays for the detection of bacterial DNA in the blood represent possible new diagnostic tools for early identification of a bacterial cause.</p> <p>Methods</p> <p>A broad range 16S rDNA polymerase chain reaction (PCR) without preincubation was compared to conventional diagnostic work up for clinical sepsis, including BACTEC blood culture, for early determination of bacterial sepsis in the newborn. In addition, the relationship between known risk factors, clinical signs, and laboratory parameters considered in clinical sepsis in the newborn were explored.</p> <p>Results</p> <p>Forty-eight infants with suspected sepsis were included in this study. Thirty-one patients were diagnosed with sepsis, only 6 of these had a positive blood culture. 16S rDNA PCR analysis of blinded blood samples from the 48 infants revealed 10 samples positive for the presence of bacterial DNA. PCR failed to be positive in 2 samples from blood culture positive infants, and was positive in 1 sample where a diagnosis of a non-septic condition was established. Compared to blood culture the diagnosis of bacterial proven sepsis by PCR revealed a 66.7% sensitivity, 87.5% specificity, 95.4% positive and 75% negative predictive value. PCR combined with blood culture revealed bacteria in 35.1% of the patients diagnosed with sepsis. Irritability and feeding difficulties were the clinical signs most often observed in sepsis. CRP increased in the presence of bacterial infection.</p> <p>Conclusion</p> <p>There is a need for PCR as a method to quickly point out the infants with sepsis. However, uncertainty about a bacterial cause of sepsis was not reduced by the PCR result, reflecting that methodological improvements are required in order for DNA detection to replace or supplement traditional blood culture in diagnosis of bacterial sepsis.</p

Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway

BACKGROUND: Acute viral bronchiolitis is one of the most common causes of hospitalisation during infancy in our region with respiratory syncytial virus (RSV) historically being the major causative agent. Many infants with early-life RSV bronchiolitis have sustained bronchial hyperreactivity for many years after hospitalisation and the reasons for this are probably multifactorial. The principal aim of the present study was to investigate if children hospitalised for any acute viral bronchiolitis during infancy in our region, and not only those due to RSV, had more episodes of subsequent wheezing up to age seven years and reduced lung function at that age compared to children not hospitalised for acute bronchiolitis during infancy. A secondary aim was to compare the hospitalised infants with proven RSV bronchiolitis (RS+) to the hospitalised infants with non-RSV bronchiolitis (RS-) according to the same endpoints. METHODS: 57 infants hospitalised at least once with acute viral bronchiolitis during two consecutive winter seasons in 1993–1994 were examined at age seven years. An age-matched control group of 64 children, who had not been hospitalised for acute viral bronchiolitis during infancy, were recruited from a local primary school. Epidemiological and clinical data were collected retrospectively from hospital discharge records and through structured clinical interviews and physical examinations at the follow-up visit. RESULTS: The children hospitalised for bronchiolitis during infancy had decreased lung function, more often wheezing episodes, current medication and follow-up for asthma at age seven years than did the age matched controls. They also had lower average birth weight and more often first order family members with asthma. We did not find significant differences between the RSV+ and RSV- groups. CONCLUSION: Children hospitalised for early-life bronchiolitis are susceptible to recurrent wheezing and reduced pulmonary function by seven years compared to age-matched children not hospitalised for early-life bronchiolitis. We propose that prolonged bronchial hyperreactivity could follow early-life RSV negative as well as RSV positive bronchiolitis