Internal Migration. Challenges and Perspectives for the Research Infrastructure

Research on internal migration covers a wide range of issues with regard to the reasons, distance and direction of moves as well as the process of decision-making. Given the rich field of relevant research objectives and the substantial developments in migration theory it is apparent that the availability of a broad set of data including detailed information on various aspects of life is one of the key factors for ongoing progress in the analysis of internal migration development. Available official aggregated data are useful for descriptive structural analyses. But they are very limited in explaining causal relations. The same holds for cross-sectional data. Some of the described longitudinal data sets consist of retrospective collected event history data that are not suitable for collecting essential information about attitudes and psychological states of the respondents over time. Several prospective longitudinal survey data do not represent essential aspects of internal migration. Data should at least include information on the place of residence (on the smallest possible spatial level), typologies about the characteristics of the place of residence, change of residence, reasons of a move, intentions to move, the dwelling and the neighbourhood as well as on commuting.internal migration, regional migration, migration theory, official data, cross-sectional data, longitudinal data.

Novel strategies to improve co-fermentation of pentoses with D-glucose by recombinant yeast strains in lignocellulosic hydrolysates

Economically feasible production of second-generation biofuels requires efficient co-fermentation of pentose and hexose sugars in lignocellulosic hydrolysates under very harsh conditions. Baker’s yeast is an excellent, traditionally used ethanol producer but is naturally not able to utilize pentoses. This is due to the lack of pentose-specific transporter proteins and enzymatic reactions. Thus, natural yeast strains must be modified by genetic engineering. Although the construction of various recombinant yeast strains able to ferment pentose sugars has been described during the last two decades, their rates of pentose utilization is still significantly lower than D-glucose fermentation. Moreover, pentoses are only fermented after D-glucose is exhausted, resulting in an uneconomical increase in the fermentation time. In this addendum, we discuss novel approaches to improve utilization of pentoses by development of specific transporters and substrate channeling in enzyme cascades. Addendum to: T Subtil, E Boles. Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae. Biotechnol Biofuels 2012; 5: 14 PMID: 22424089 DOI: 10.1186/1754-6834-5-1

Microsatellites within the feline androgen receptor are suitable for X chromosome-linked clonality testing in archival material

Objectives A hallmark of neoplasms is their origin from a single cell; that is, clonality. Many techniques have been developed in human medicine to utilise this feature of tumours for diagnostic purposes. One approach is X chromosome-linked clonality testing using polymorphisms of genes encoded by genes on the X chromosome. The aim of this study was to determine if the feline androgen receptor gene was suitable for X chromosome-linked clonality testing. Methods The feline androgen receptor gene, was characterised and used to test clonality of feline lymphomas by PCR and polyacrylamide gel electrophoresis, using archival formalin-fixed, paraffin-embedded material. Results Clonality of the feline lymphomas under study was confirmed and the gene locus was shown to represent a suitable target in clonality testing. Conclusions and relevance Because there are some pitfalls using X chromosome- linked clonality testing, further studies are necessary to establish this technique in the cat

Comment: The Unjust Side of Civil Asset Forfeiture in Illinois: Innocent Victims and Corrupted Incentives

Under the broad scope of modern civil asset forfeiture, law enforcement agencies routinely deprive citizens of their property without ever formally charging them with a crime. This system diminishes the ideal values of American justice, yet the Supreme Court has long held that civil asset forfeiture is constitutional, leaving prospects of judicial reform unlikely. Therefore, it is crucial that individual states take action to protect their citizens by abolishing the use of civil asset forfeiture. In 2017, the Illinois General Assembly attempted to reform its civil asset forfeiture system, but upon close analysis and application of the statute, it is evident that many of the most troubling aspects of civil forfeiture remain intact

Internal migration: challenges and perspectives for the research infrastructure

"Research on internal migration covers a wide range of issues with regard to the reasons, distance and direction of moves as well as the process of decision-making. Given the rich field of relevant research objectives and the substantial developments in migration theory it is apparent that the availability of a broad set of data including detailed information on various aspects of life is one of the key factors for ongoing progress in the analysis of internal migration development. Available official aggregated data are useful for descriptive structural analyses. But they are very limited in explaining causal relations. The same holds for cross-sectional data. Some of the described longitudinal data sets consist of retrospective collected event history data that are not suitable for collecting essential information about attitudes and psychological states of the respondents over time. Several prospective longitudinal survey data do not represent essential aspects of internal migration. Data should at least include information on the place of residence (on the smallest possible spatial level), typologies about the characteristics of the place of residence, change of residence, reasons of a move, intentions to move, the dwelling and the neighbourhood as well as on commuting." (author's abstract

ActivSense Sidestick: a Force Sensing and Force Feedback Joystick

As aircraft systems continue to become more integrated and fully electronic, hence fly-by-wire, the pilot is slowly losing the physical cues that were once relied upon for the safe operation of the aircraft. Many commercial airliners, such as Airbus, use passive sidesticks that integrate with the electronic flight controls system. These sidesticks move much like a gaming joystick which results in the pilot not having any “feel” for the aerodynamic forces present on the control surfaces. Without the force feedback of a mechanically linked control system the pilot could inadvertently stall the aircraft or place it into an unstable flight condition. To combat this, the active sidestick will include a servo mechanism to provide force feedback and use strain gauges to determine the force applied to the sidestick by the pilot. Multiple sources of data, such as the aircraft configuration and critical speeds can be used to produce a force gradient which resist a pilot’s inputs if they are exceeding the aircraft capabilities. The active sidestick will interface with PC based flight simulation to control an aircraft and receive flight characteristic data to properly adjust the forces present on the sidestick. Being solely based on force input for aircraft control, if there were to be an in-flight failure of the servos the pilot would still be able to control the aircraft by force alone. Such a sidestick could be used in any number of aviation applications; it would improve the safety of unmanned aircraft operations in which the pilot/operator receives no tactile feedback at the controls. It could also become physically small enough and cost effective to be outfitted in modern general aviation aircraft to prevent the all-too-common loss of control scenario upon landing or takeoff

Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis

Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated that low-molecular-weight HA (LMW HA) may show a certain proinflammatory activity. We thus aimed to characterize an LMW-sized HA molecule that combines strong anti-aging abilities with efficient skin penetration but lacks potential proinflammatory effects. Methods: Total RNA and total protein were isolated from reconstituted human epidermis following incubation with HAs of various molecular weights (20, 50, 130, 300, 800 and 1,500 kDa). Tumor necrosis factor-alpha expression was determined using quantitative PCR. Genonnic and proteomic expression of various junctional proteins was determined using Affymetrix and common Western blotting techniques. Results: LMW HA of approximately 50 kDa did not significantly alter tumor necrosis factor-alpha expression compared to 20-kDa HA, but revealed significantly higher skin penetration rates than larger sized HA associated with increased expression of genes and proteins known to be involved in tight junction formation and keratinocyte cohesion. Conclusion: LMW HA of approximately 50 kDa shows better penetration abilities than larger-sized HA. In addition, LMW HA influences the expression of various genes including those contributing to keratinocyte differentiation and formation of intercellular tight junction complexes without showing proinflammatory activity. These observations contribute to current knowledge on the effects of LMW HA on keratinocyte biology and cutaneous physiology. Copyright (C) 2011 S. Karger AG, Base

Urban Revitalization: A Case Study of One Catholic Elementary School’s Journey

This article offers background information on U.S. trends in Catholic school enrollment from 1965 through the present, and presents a case study of one school that is attempting to address issues of enrollment, identity, effectiveness, and the elusive but critical essence of making a difference in the lies of students. The importance of leadership, mission, and a sense of community are reconfirmed as essential elements to the future success of Catholic schools in the United States