Comparative Analysis of Salivary Glucose and Electrolytes in Diabetic Individuals with Periodontitis

Background : A high incidence of periodontal disease has been reported among diabetics, however the role of saliva in the occurrence of this oral disease in these patients is yet to be understood.Objective: To determine the effects of type-2 diabetes and periodontal disease on salivary flow rate and biochemical composition.Design: A prospective study involving 40 adult human subjects divided equally into four groups of diabetics with periodontitis (group 1), diabetics without periodontitis (group 2), non diabetics with periodontitis (group 3) and non diabetics without periodontitis (group 4).Methodology: Saliva samples were collected and analyzed for salivary glucose, total protein, calcium, sodium, potassium, chloride and bicarbonate. Salivary flow rates were also determined. Results: Salivary glucose and potassium levels were significantly higher (P = 0.002 and 0.04 respectively) in diabetic patients regardless of periodontal disease (mean = 100.7 ± 9.33 mg/dl; 111.5 ± 32.85 mg/dl and 23.79 ± 5.19 mg/dl; 22.9 ± 6.25 mg/dl respectively) compared with non diabetic participants (mean = 80.5 ± 30.85 mg/dl; 62.5 ± 31.89 mg/dl and 19.23 ± 5.04 mg/dl; 17.74 ± 4.68 mg/dl respectively). In contrast, there was no significant difference in saliva flow rates and levels of total protein, Na+, Ca++, Cl- and HCO3- between the groups.Conclusion: Salivary glucose and potassium levels were significantly higher among diabetics with or without periodontitis compared with non-diabetics with or without periodontitis. However, biochemical composition of saliva in diabetic individuals has probably little role in their susceptibility to periodontitis.Keywords: periodontitis, type 2 diabetes mellitus, salivary electrolytes, salivary glucos

Evaluation of Dimethylformamide (DMF) as an Organic Modifier in Hydrophobicity Index (Rm) Determination.

Purpose: Ideal behaviour of mixtures of organic modifier and water is reflected by a linear relationship between refractive index and fraction of organic modifier in the mixture. This study was carried out to investigate dimethylformamide (DMF) as an organic modifier in hydrophobicity index (Rm) determination. Method: We quantitatively evaluated the problem of partial miscibility of phases associated with the reversed phase thin layer chromatographic (RPTLC) system, using liquid paraffin as stationary phase and acetone/water mixtures as mobile phase. Ideality of behaviour of acetone /water mixtures was investigated by refractive index measurements. Rm values of compounds were determined using mixtures of acetone and water as mobile phase. Results: DMF/water mixture behaved ideally across the whole concentration range investigated (0-100%) while acetone/water mixture deviated from ideal behaviour when the concentration of acetone in the mixture was 80%. DMF also gave a better extrapolation of Rm value from linear regression of partition data than acetone for bezafibrate used as a test-drug molecule. Conclusion: DMF is a better organic modifier than acetone in this RPTLC system. These findings could be extended to drug-receptor and drug design studies. The use of dimethylformamide (DMF) in preference to acetone as organic modifier is proposed in this study. Keywords: Drug design, dimethylformamide, hydrophobicity index, organic modifiers Tropical Journal of Pharmaceutical Research 2002; 1(2): 83-9

Increase in Adiposity of Type 2 Diabetes Patients following Withdrawal from Therapeutic Exercise

In order to achieve optimum health status, Type 2 Diabetes (T2D) patients are usually encouraged to undergo regular and consistent therapeutic exercises. This study investigated whether the gains of exercises on adiposity variables of T2D patients are maintained within a few weeks of withdrawal from exercise and whether it was significantly related to the age of the patient and the duration of diagnosis of T2D. Forty-three T2D patients aged between 30 and 64 years were recruited for this study. They were placed on a combination of endurance and strengthening exercises for 12 weeks. The participants were thereafter observed for another 12 weeks without exercises. The adiposity variables measured in both phases of the study include: body mass index (BMI), waist circumference (WC), waist-hip-ratio (WHR) and percent-body-fat (PBF). Significant improvements (P less than 0.05) for all the variables were achieved after 12 weeks of therapeutic exercises. The variables, however, showed significant relapses (P less than 0.05) within six weeks of withdrawal of exercise and these were significantly related (P less than 0.05) to both the age of the patient and the duration of diagnosis. The endurance and strengthening exercises improved the adiposity variables of theT2D patients, but the gains began to decline within six weeks of withdrawal from the exercises. The increase in adiposity was more as the age and duration of diagnosis of the patients increased. KEY WORDS: weight maintenance, body composition, diabetes mellitu

Psychosocial stress among patients with type 2 diabetes: habitual physical activity as a promising moderator

Psychosocial stress is a disabling condition and is common among people with diabetes mellitus in view of the complexity of the disorder. It is however not clear if the psychosocial stress has any link with habitual physical activity, which is an important component in the care of people with diabetes. This study was conducted to investigate the likely connection between habitual physical activity and psychosocial stress among people with type 2 diabetes. A total of 193 adults with type 2 diabetes took part in this study. Psychosocial stress was assessed using the Revised Questionnaire on Stress in patients with Diabetes (QSD-R) while physical activity was assessed using the Baecke Habitual Physical Activity Questionnaire. Data were analysed using descriptive and inferential statistics at p < .05. The mean age of the participants was 58.76 ± 14.27 years with mean duration of diagnosis being 6.41 ± 4. 51 years. With a mean score of 2.8, work activity was the main source of physical activity for the patients with the least activity index of 1.2 coming from sports participation. Hypoglycaemia and self-medication/diet were the most important sources of stress to the patients and the overall psychosocial stress was related to habitual physical activity (r = - .73, p = .002). Significantly, patients with higher physical activity index presented with lower psychosocial stress. Apart from the well-known improvement in glycaemic control, type 2 diabetes patients that participate more in physical activity may be able to reduce their psychosocial stress.Keywords: Type 2 diabetes, psychosocial stress, habitual physical activit

Neuromusculoskeletal disorders in patients with Type 2 diabetes mellitus: Outcome of a twelve-week Therapeutic exercise programme

Usual line of management of diabetes patients is drug and diet with theirphysical needs usually receiving minimal attention. Among the physical needs, requiring attention is their neuromusculoskeletal disorders. This study was designed to investigate the effect of a twelve-week therapeuticexercise on neuromusculoskeletal disorders ofType 2 Diabetes (T2D) patients. Forty-three participants from the Diabetes Specialty Clinic ofAminu KanoTeaching Hospital, Kano completed the study. Selected neuromusculoskeletal disorders including pain, dermatological foot grades,disorders of ranges of motion and strength of selected joints and muscles were assessed before and after a period of twelve weeks of therapeutic exercises. Participants were followed up for another twelve weekswithout therapeutic exercises. Baseline assessment revealed poor neuromusculoskeletal status. Significant improvements (P0.05). T2D patients presented with neuromusculoskeletal disorders at baseline. Therapeutic exercises however assisted in the improvement of these disorders but relapsed when exercises were suspended. Engagement in therapeutic exercises enhanced neuromusculoskeletal health, while withdrawal from the exercise contributed to a decline. T2D patients should be encouraged to participate in therapeutic exercises in order to promote their health and function

Habitual Physical Activity, Peripheral Neuropathy, Foot Deformities and Lower Limb Function: Characterizing Prevalence and Interlinks in Patients with Type 2 Diabetes Mellitus

Background: Patients with type 2 diabetes mellitus (T2DM) may have diverse foot problems, but how these problems are linked with physical activity is not clear. This study investigated the prevalence of foot problems among patients with T2DM and investigated how the problems were related to physical activity.Methods: Habitual physical activity, peripheral neuropathy, lower limb functions and foot deformities of 246 T2DM patients were respectively assessed with the Baecke Physical Activity Questionnaire, Michigan Neuropathy Screening Instrument, Lower Limb Function Scale, and a self-designed foot deformity audit form.Results: Habitual physical activity index (3.2 ± 0.83) was highest in work-related activities; 69 (26.1 %) patients presented with peripheral neuropathy and 52 (19. 7%) had the lowest limb function. Pes planus was the most prevalent foot deformity (20.1%). Significant differences existed in physical activity indices across deformity groups (p < 0.05) and total activity index was related to neuropathic and lower limb function scores (p < 0.05).Conclusion: A higher work-related but reduced participation in sports and leisure time physical activity among the patients was observed. Habitual physical activity was lowest in patients with a forefoot deformity, higher neuropathic scores and lesser lower limb function scores. Patients with T2DM in these categories may be a target for special physical activity intervention programmes.Keywords: Diabetes Mellitus, Foot Complications, Physical Activit

Stepping Up Physical Exercise Among Nigerian Patients With Type 2 Diabetes: The Impact Of A Domesticated Type 2 Diabetes-Oriented Exercise Education Curriculum

Background: Most diabetes patients in Nigeria either do not exercise at all or do not exercise appropriately and this is thought to be due partly to an inadequate exercise education.Objectives: To investigate the impact of a type 2 diabetes-oriented exercise education curriculum (T2DEEC) on exercise performance and adiposity of type 2 diabetes patients.Materials and Methods: The patients (n=86) were randomized into either the T2DEEC or the control groups. The T2DEEC was administered to patients in the T2DEEC group while the controls were encouraged to exercise but did not go through the T2DEEC. The participants continued exercises at home for 12 weeks. Outcomes were amount of time and days spent on each of aerobic, resistance, joint mobilization and foot care exercises per week; waist circumference, body mass index, and percent body fat.Results: By the 12th week, the T2DEEC participants increased their exercise days from 1.2 to 3.8 days and increased aerobic, resistance, joint mobilization and foot care exercise times by 56.5, 42.3, 39.8 and 28.1 minutes respectively (p<0.05). The controls only increased their aerobic exercise time by 5.1 minutes (p=0.141) and maintained zero exercise times for resistance, joint mobilization and foot care exercises. Also the T2DEEC group but not the controls recorded significant improvements (p<0.05) in adiposity variables.Conclusions: The participants who were taught with the T2DEEC unlike those who received verbal encouragement to exercise improved their exercise performance and adiposity parameters significantly. The T2DEEC is recommended for exercise education of type 2 diabetes patients.Keywords: Type 2 diabetes, exercise education, joint mobilization, aerobic activities, curriculu

Mucosal Healing in Ulcerative Colitis: A Comprehensive Review

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by periods of remission and periods of relapse. Patients often present with symptoms such as rectal bleeding, diarrhea and weight loss, and may require hospitalization and even colectomy. Long-term complications of UC include decreased quality of life and productivity and an increased risk of colorectal cancer. Mucosal healing (MH) has gained progressive importance in the management of UC patients. In this article, we review the endoscopic findings that define both mucosal injury and MH, and the strengths and limitations of the scoring systems currently available in clinical practice. The basic mechanisms behind colonic injury and MH are covered, highlighting the pathways through which different drugs exert their effect towards reducing inflammation and promoting epithelial repair. A comprehensive review of the evidence for approved drugs for UC to achieve and maintain MH is provided, including a section on the pharmacokinetics of anti-tumor necrosis factor (TNF)-alpha drugs. Currently approved drugs with proven efficacy in achieving MH in UC include salicylates, corticosteroids (induction only), calcineurin inhibitors (induction only), thiopurines, vedolizumab and anti-TNF alpha drugs (infliximab, adalimumab, and golimumab). MH is of crucial relevance in the outcomes of UC, resulting in lower incidences of clinical relapse, the need for hospitalization and surgery, as well as reduced rates of dysplasia and colorectal cancer. Finally, we present recent evidence towards the need for a more strict definition of complete MH as the preferred endpoint for UC patients, using a combination of both endoscopic and histological findings.info:eu-repo/semantics/publishedVersio

Changes in mediators of inflammation and pro-thrombosis after 12 months of dietary modification in adults with metabolic syndrome.

Objective: This study evaluated the effects of a 12-month dietary modification on indices of inflammation and pro-thrombosis in adults with metabolic syndrome (MS). Materials and methods: This longitudinal study involved 252 adults with MS recruited from the Bodija market, Ibadan and its environs. Participants were placed on 20%, 30% and 50% calories obtained from protein, total fat and carbohydrate respectively and were followed up monthly for 12 months. Anthropometry and blood pressure were measured using standard methods. Fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), fibrinogen, plasminogen activator inhibitor-1 (PAI-1)], interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured using spectrophotometric methods and ELISA as appropriate. Data was analysed using ANCOVA, Student\u2019s t-test, Mann-Whitney U and Wilcoxon signed-rank tests. P-values less than 0.05 were considered significant. Results: After 6 months of dietary modification, there was a significant reduction in waist circumference (WC), while the levels of HDL-C, fibrinogen and PAI-1 were significantly increased when compared with the corresponding baseline values. However, WC and fibrinogen reduced significantly, while HDL-C and IL-10 significantly increased after 12 months of dietary modification as compared with the respective baseline values. Conclusion: Long-term regular dietary modification may be beneficial in ameliorating inflammation and pro-thrombosis in metabolic syndrome