Chemotherapy-induced myocardial necrosis in a patient with chronic lymphocytic leukemia

AbstractCardiac toxicity following the administration of chemotherapeutic agents is well documented. Vinca alkaloids, as well as high-dose cyclophosphamide, have been associated with myocardial ischemia. The present report describes a case of acute myocardial infarction occurring in a patient with no antecedent cardiac history who received both vincristine and conventional chemotherapeutic doses of cyclophosphamide for the treatment of chronic lymphocytic leukemia. Physicians should possess a heightened awareness of this potentially serious complication

Improving human immunodeficiency virus testing rates with an electronic clinical reminder.

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Semi-empirical branching fractions of the 3s²3p²–3s3p³ <i>J</i> = 2 transition array in P II¹This article is part of a Special Issue on the 10th International Colloquium on Atomic Spectra and Oscillator Strengths for Astrophysical and Laboratory Plasmas.

A semi-empirical method is used to characterize the 3s23p2–3s3p3 J = 2 transition array in P II. In this method Slater, spin–orbit, and radial parameters are fitted to experimental energy levels to obtain a description of the array in terms of LS-coupling basis vectors. The intermediate coupling (IC) and configuration interaction (CI) amplitudes so obtained are then used to predict the branching fractions of transitions within the array. These two configurations are particularly interesting because the 3s23p2 has been shown to be virtually free of CI, but affected by IC, whereas the 3s3p3 is virtually free of IC, but affected by CI. </jats:p

Skin Microbiome Alterations in Skin Diseases

A common oversimplification of the skin microbiome is a binary classification of individual microbes as either “beneficial” or “harmful.” In reality, however, skin microbes are much more complex and can act as either beneficial or harmful in different scenarios (for example, in altered skin or in healthy skin). In other cases, the ecological dynamics of bacteria interacting in a system add complexities to their characteristics. However, increasing evidence has associated altered microbial communities—or “dysbiosis”–in the skin with unhealthy skin, especially atopic dermatitis, which is highly associated with higher populations of Staphylococcus aureus. Here, we review the existing body of evidence around disruptions in the skin microbiome and their associations with skin diseases