Muscle Research and Human Space Exploration: Current Progress and Future Challenges

Since the beginning of human space flight, there has been serious concern over the exposure of human crewmembers to the microgravity of space due to the systemic effects on terrestrially-evolved creatures that are adapted to Earth gravity. Humans in the microgravity environment of space, within our currently developed space vehicles, are exposed to various periods of skeletal muscle unloading (unweighting). Unloading of skeletal muscle both on Earth and during spaceflight results in remodeling of muscle (atrophic response) as an adaptation to the reduced loads placed upon it. As a result, there are decrements in skeletal muscle strength, fatigue resistance, motor performance, and connective tissue integrity. This normal adaptive response to the microgravity environment is for the most part of little consequence within the space vehicle per se but may become a liability resulting in an increased risk of crewmember physical failure during extravehicular activities or abrupt transitions to environments of increased gravity (such as return to Earth or landing on another planetary body)

Urine Monitoring System

The Urine Monitoring System (UMS) is a system designed to collect an individual crewmember's void, gently separate urine from air, accurately measure void volume, allow for void sample acquisition, and discharge remaining urine into the Waste Collector Subsystem (WCS) onboard the International Space Station. The Urine Monitoring System (UMS) is a successor design to the existing Space Shuttle system and will resolve anomalies such as: liquid carry-over, inaccurate void volume measurements, and cross contamination in void samples. The crew will perform an evaluation of airflow at the ISS UMS urinal hose interface, a calibration evaluation, and a full user interface evaluation. o The UMS can be used to facilitate non-invasive methods for monitoring crew health, evaluation of countermeasures, and implementation of a variety of biomedical research protocols on future exploration missions

Improved Devices for Collecting Sweat for Chemical Analysis

Improved devices have been proposed for collecting sweat for biochemical analysis - especially for determination of the concentration of Ca2+ ions in sweat as a measure of loss of Ca from bones. Unlike commercially available sweat-collection patches used previously in monitoring osteoporosis and in qualitative screening for some drugs, the proposed devices would not allow evaporation of the volatile chemical components (mostly water) of sweat. Moreover, the proposed devices would be designed to enable determination of the volumes of collected sweat. From these volumes and the quantities of Ca(2+) and/or other analytes as determined by other means summarized below, one could determine the concentrations of the analytes in sweat. A device according to the proposal would be flexible and would be worn like a commercial sweat-collection patch. It would be made of molded polydimethylsiloxane (silicone rubber) or other suitable material having properties that, for the purpose of analyzing sweat, are similar to those of glass. The die for molding the silicone rubber would be fabricated by a combination of lithography and electroplating. The die would reproducibly form, in the silicone rubber, a precisely defined number of capillary channels per unit area, each channel having a precisely defined volume. Optionally, electrodes for measuring the Ca(2+) content of the sweat could be incorporated into the device. The volume of sweat collected in the capillary channels of the device would be determined from (1) the amount of light or radio waves of a given wavelength absorbed by the device and (2) the known geometry of the array of capillary channels. Then, in one of two options, centrifugation would be performed to move the sweat from the capillary tubes to the region containing the electrodes, which would be used to measure the Ca(2+) content by a standard technique. In the other option, centrifugation would be performed to remove the sweat from the device to make the sweat available to other analytical instruments for measuring concentrations of substances other than Ca(2+)

Multi-Bunch Longitudinal Dynamics and Diagnostics via a Digital

A bunch-by-bunch longitudinal feedback system based on a programmable DSP architecture is used to study coupled-bunch motion and its sources. Experimental results are presented from PEP-II, DA NE, ALS and SPEAR to highlight the operational experience from 4 installations, plus show novel accelerator diagnostics possible with the digital processing system. Modal growth and damping rates are measured via short ( 20 ms) transient recordings for unstable and stable coupled-bunch modes. Data from steady-state measurements are used to identify unstable modes and noise-driven beam motion. Anovel impedance measurement technique is presented which reveals the longitudinal impedance as a function of frequency. This technique uses the measured synchronous phase and charge of every bucket to calculate the impedance seen by the beam at revolution harmonics

自尊心がネガティブフィードバック後の課題遂行意欲に及ぼす影響

課題評価についてネガティブなフィードバックを受けた後の影響を実験的に検討した。特に、個人要因として自尊心、状況要因として「課題成績を上げることができるかもしれない」という示唆を与える操作である移行可能性に着目した。分析の結果、高自尊心者では移行可能性の高い群で課題遂行意欲が高かった。一方で、低自尊心者は移行可能性の低い群で課題遂行意欲が高かった