"Bilingual Expert" Can Find Translation Errors

Recent advances in statistical machine translation via the adoption of neural sequence-to-sequence models empower the end-to-end system to achieve state-of-the-art in many WMT benchmarks. The performance of such machine translation (MT) system is usually evaluated by automatic metric BLEU when the golden references are provided for validation. However, for model inference or production deployment, the golden references are prohibitively available or require expensive human annotation with bilingual expertise. In order to address the issue of quality evaluation (QE) without reference, we propose a general framework for automatic evaluation of translation output for most WMT quality evaluation tasks. We first build a conditional target language model with a novel bidirectional transformer, named neural bilingual expert model, which is pre-trained on large parallel corpora for feature extraction. For QE inference, the bilingual expert model can simultaneously produce the joint latent representation between the source and the translation, and real-valued measurements of possible erroneous tokens based on the prior knowledge learned from parallel data. Subsequently, the features will further be fed into a simple Bi-LSTM predictive model for quality evaluation. The experimental results show that our approach achieves the state-of-the-art performance in the quality estimation track of WMT 2017/2018.Comment: Accepted to AAAI 201

A Semipersistent Plant Virus Differentially Manipulates Feeding Behaviors of Different Sexes and Biotypes of Its Whitefly Vector.

It is known that plant viruses can change the performance of their vectors. However, there have been no reports on whether or how a semipersistent plant virus manipulates the feeding behaviors of its whitefly vectors. Cucurbit chlorotic yellows virus (CCYV) (genus Crinivirus, family Closteroviridae) is an emergent plant virus in many Asian countries and is transmitted specifically by B and Q biotypes of tobacco whitefly, Bemisia tabaci (Gennadius), in a semipersistent manner. In the present study, we used electrical penetration graph (EPG) technique to investigate the effect of CCYV on the feeding behaviors of B. tabaci. The results showed that CCYV altered feeding behaviors of both biotypes and sexes of B. tabaci with different degrees. CCYV had stronger effects on feeding behaviors of Q biotype than those of B biotype, by increasing duration of phloem salivation and sap ingestion, and could differentially manipulate feeding behaviors of males and females in both biotype whiteflies, with more phloem ingestion in Q biotype males and more non-phloem probing in B biotype males than their respective females. With regard to feeding behaviors related to virus transmission, these results indicated that, when carrying CCYV, B. tabaci Q biotype plays more roles than B biotype, and males make greater contribution than females

Resolving Fine-Scale Surface Features on Polar Sea Ice: A First Assessment of UAS Photogrammetry Without Ground Control

Mapping landfast sea ice at a fine spatial scale is not only meaningful for geophysical study, but is also of benefit for providing information about human activities upon it. The combination of unmanned aerial systems (UAS) with structure from motion (SfM) methods have already revolutionized the current close-range Earth observation paradigm. To test their feasibility in characterizing the properties and dynamics of fast ice, three flights were carried out in the 2016–2017 austral summer during the 33rd Chinese National Antarctic Expedition (CHINARE), focusing on the area of the Prydz Bay in East Antarctica. Three-dimensional models and orthomosaics from three sorties were constructed from a total of 205 photos using Agisoft PhotoScan software. Logistical challenges presented by the terrain precluded the deployment of a dedicated ground control network; however, it was still possible to indirectly assess the performance of the photogrammetric products through an analysis of the statistics of the matching network, bundle adjustment, and Monte-Carlo simulation. Our results show that the matching networks are quite strong, given a sufficient number of feature points (mostly > 20,000) or valid matches (mostly > 1000). The largest contribution to the total error using our direct georeferencing approach is attributed to inaccuracies in the onboard position and orientation system (POS) records, especially in the vehicle height and yaw angle. On one hand, the 3D precision map reveals that planimetric precision is usually about one-third of the vertical estimate (typically 20 cm in the network centre). On the other hand, shape-only errors account for less than 5% for the X and Y dimensions and 20% for the Z dimension. To further illustrate the UAS’s capability, six representative surface features are selected and interpreted by sea ice experts. Finally, we offer pragmatic suggestions and guidelines for planning future UAS-SfM surveys without the use of ground control. The work represents a pioneering attempt to comprehensively assess UAS-SfM survey capability in fast ice environments, and could serve as a reference for future improvements

Development Status and Trend of Livestock and Poultry Manure Composting Technology and Equipment

Technical process of livestock and poultry manure composting and various technical equipment for manure composting were briefly described．Development trend of livestock and poultry manure composting technology and equipment was analyzed．It was concluded that technical equipment of livestock and poultry manure composting was an effective way to solve problem of manure treatment in aquaculture．It could promote green development and ecological cycle and provide a reference for design，production and application of livestock and poultry manure composting technology and equipment

Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1α dependent pathway

<p>Abstract</p> <p>Background</p> <p>Hypoxia plays an important role in vascular remodeling and directly affects vascular smooth muscle cells (VSMC) functions. Macrophage migration inhibitory factor (MIF) is a well known proinflammatory factor, and recent evidence suggests an important role of MIF in the progression of atherosclerosis and restenosis. However, the potential link between hypoxia and MIF in VSMC has not been investigated. The current study was designed to test whether hypoxia could regulate MIF expression in human VSMC. The effect of modulating MIF expression on hypoxia-induced VSMC proliferation and migration was also investigated at the same time.</p> <p>Results</p> <p>Expression of MIF mRNA and protein was up-regulated as early as 2 hours in cultured human VSMCs after exposed to moderate hypoxia condition (3% O₂). The up-regulation of MIF expression appears to be dependent on hypoxia-inducible transcription factor-1α(HIF-1α) since knockdown of HIF-1α inhibits the hypoxia induction of MIF gene and protein expression. The hypoxia induced expression of MIF was attenuated by antioxidant treatment as well as by inhibition of extracellular signal-regulated kinase (ERK). Under moderate hypoxia conditions (3% O₂), both cell proliferation and cell migration were increased in VSMC cells. Blocking the MIF by specific small interference RNA to MIF (MIF-shRNA) resulted in the suppression of proliferation and migration of VSMCs.</p> <p>Conclusion</p> <p>Our results demonstrated that in VSMCs, hypoxia increased MIF gene expression and protein production. The hypoxia-induced HIF-1α activation, reactive oxygen species (ROS) generation and ERK activation might be involved in this response. Both MIF and HIF-1α mediated the hypoxia response of vascular smooth muscle cells, including cell migration and proliferation.</p

Therapeutic effects and safety of resveratrol for lung cancer: an updated preclinical systematic review and meta-analysis

BackgroundLung cancer (LC) is the most common cause of cancer-related death worldwide, while there are limited treatment methods. Resveratrol (RESV), a natural food-derived compound, has attracted attention around the world for its anti-LC effects. However, little is known about the efficacy and safety of RESV for LC.PurposeThis study aimed to provide preclinical evidence for the efficacy and safety of RESV for LC, and to find the optimal dose and duration.MethodsIn vivo studies of RESV against LC, published before 24 July 2024, were retrieved from PubMed, Embase, Web of Science, and Cochrane Library. The CAMARADES checklist was used to assess study quality. Primary outcomes were tumor volume and tumor weight. Secondary outcomes included body weight, lung metastases number, and the apoptotic cell proportion. Statistical analysis was performed using RevMan 5.3 and Stata 16.0. Dose–duration–effect model was conducted to determine the optimal dose and duration, and the toxicology of RESV was predicted through the ProTox 3.0 platform.ResultsA total of 23 studies involving 425 animals were included. The methodological quality of included studies was medium-to-low. RESV significantly reduced tumor volume, tumor weight, and lung metastases number, and increased apoptotic cell proportion, while having no effect on body weight. High heterogeneity was observed, and subgroup analysis suggested that the heterogeneity was partly attributed to the dose of RESV. The optimal dose and duration of RESV were 30–100 mg/kg and 25–28 days, respectively. The median lethal dose of RESV was 1,560 mg/kg.ConclusionRESV demonstrated a significant inhibitory effect on LC in vivo. However, the lower research quality and high heterogeneity call for more high-quality preclinical studies to be conducted. Before achieving clinical translational research on RESV, the problem of low bioavailability of RESV needs to be solved

Tomato SlMKK2 and SlMKK4 contribute to disease resistance against Botrytis cinerea

BACKGROUND: Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules that mediate the transduction of extracellular stimuli via receptors/sensors into intracellular responses and play key roles in plant immunity against pathogen attack. However, the function of tomato MAPK kinases, SlMKKs, in resistance against Botrytis cinerea remains unclear yet. RESULTS: A total of five SlMKK genes with one new member, SlMKK5, were identified in tomato. qRT-PCR analyses revealed that expression of SlMKK2 and SlMKK4 was strongly induced by B. cinerea and by jasmonic acid and ethylene precursor 1-amino cyclopropane-1-carboxylic acid. Virus-induced gene silencing (VIGS)-based knockdown of individual SlMKKs and disease assays identified that SlMKK2 and SlMKK4 but not other three SlMKKs (SlMKK1, SlMKK3 and SlMKK5) are involved in resistance against B. cinerea. Silencing of SlMKK2 or SlMKK4 resulted in reduced resistance to B. cinerea, increased accumulation of reactive oxygen species and attenuated expression of defense genes after infection of B. cinerea in tomato plants. Furthermore, transient expression of constitutively active phosphomimicking forms SlMKK2(DD) and SlMKK4(DD) in leaves of Nicotiana benthamiana plants led to enhanced resistance to B. cinerea and elevated expression of defense genes. CONCLUSIONS: VIGS-based knockdown of SlMKK2 and SlMKK4 expression in tomato and gain-of-function transient expression of constitutively active phosphomimicking forms SlMKK2(DD) and SlMKK2(DD) in N. benthamiana demonstrate that both SlMKK2 and SlMKK4 function as positive regulators of defense response against B. cinerea

Exopolysaccharide-Derived Carbon Dots for Microbial Viability Assessment

Fluorescent dye staining combined with fluorescence microscopy or flow cytometry is becoming a routine way to monitor microorganism viability that is necessary for food safety, antibiotic development, and human health. However, the conventional live/dead assay dyes suffer from high cost, inconvenient staining steps, and high cytotoxicity, which is urgently needed to overcome. Herein, cheap carbon dots, CDs-EPS605, were reported to successfully assess microbial viability in a convenient way with neglectable cytotoxicity. The fluorescent N-doped CDs-EPS605 could be facilely prepared from bacterial amino exopolysaccharide (EPS) by one-step hydrothermal carbonization, which is cost-effective and sustainable. The negatively charged CDs-EPS605 consisted of C, H, O, N, P, and S, and featured various functional groups, including -COOH, -OH, -CONH-, and -NH2. CDs-EPS605 were observed to sensitively and selectively stain dead microorganisms instead of live ones to enable discrimination of live/dead microorganisms. The labeling method with CDs-EPS605 did not require protection from light, or washing, which is convenient. Additionally, CDs-EPS605 displayed better photostability and much less cytotoxicity compared to the commercial counterpart. Altogether, CDs-EPS605 represent a simple, yet powerful staining agent for microbial viability assessment, and at the same time enrich the current applications of microbial EPS