Holistic Module Learning: An Experiment in Teaching Reform of Basic Education in China

In the context of China’s social transformation and educational reform, addressing the problems of fragmented and ineffective learning in traditional teaching modes and enhancing students’ academic levels and developing their comprehensive abilities through structured classroom learning have become critical issues in educational reform. The holistic module learning model emerges in this context as the times dictate. It promotes the development of a systematic and holistic view of knowledge for all subjects by teachers and students. Students use major concepts to connect disparate knowledge, skills, and methods in order to develop a persistent and transferable understanding of knowledge and cognitive and noncognitive abilities. The purpose of this paper is to conduct a conceptual analysis of holistic module learning and to discuss its characteristics. The implementation strategies for this model are discussed, as well as the model’s significance

Corpuscular Event-by-Event Simulation of Quantum Optics Experiments: Application to a Quantum-Controlled Delayed-Choice Experiment

A corpuscular simulation model of optical phenomena that does not require the knowledge of the solution of a wave equation of the whole system and reproduces the results of Maxwell's theory by generating detection events one-by-one is discussed. The event-based corpuscular model gives a unified description of multiple-beam fringes of a plane parallel plate and single-photon Mach-Zehnder interferometer, Wheeler's delayed choice, photon tunneling, quantum eraser, two-beam interference, Einstein-Podolsky-Rosen-Bohm and Hanbury Brown-Twiss experiments. The approach is illustrated by application to a recent proposal for a quantum-controlled delayed choice experiment, demonstrating that also this thought experiment can be understood in terms of particle processes only.Comment: Invited paper presented at FQMT11. Accepted for publication in Physica Scripta 27 June 201

The Development of Home-School Partnership Courses: A Practice Based on Xingzhi Tao’s Life Education Theory

Home-school partnership plays a critical role in student growth and the home-school partnership courses provide important paths to achieving ideal results of the partnership. Under the guidance of the three principles of “life is education”, “society is school” and “integrating teaching, learning and practice” in Xingzhi Tao’s life education theory, Shandong 271 Education Group developed the parent school course and the family civilization course, which turn out to be a systematic support for the home-school partnership program. This paper analyses the status quo of home-school cooperation in China and focuses elaborations on the components and practice of the two courses in Shandong 271 Education Group

A Value-Consistent Method for Downscaling SMAP Passive Soil Moisture With MODIS Products Using Self-Adaptive Window

Many remote sensing soil moisture (SM) products have been developed with global coverage. However, most of them are derived from passive microwave observations with very coarse resolution, greatly constraining the applications at regional scales. To increase the spatial resolution, a downscaling method is developed to downscale the 36-km Soil Moisture Active Passive L3 SM (SMAP SM) product to 1 km using the Moderate Resolution Imaging Spectroradiometer (MODIS) products (8-d land surface temperature, LST, and 16-d normalized difference vegetation index, NDVI). In this method, a linking model is first established between SM and LST and NDVI, and a self-adaptive window method is applied with the use of the geographically weighted regression (GWR) method to obtain an optimal local regression. Then, the uncertainty of the linking model, expressed as the regression residual, is redistributed to fine-resolution pixels to analyze the consistency before and after downscaling. The method was applied to the Iberian Peninsula to produce the 8-d downscaled SM product in 2016. The downscaled SM was validated with the in-situ SM network (REMEDHUS). A good agreement was found between the two data sets, with a correlation coefficient (R) of 0.87 and an unbiased root-mean-squared error (ubRMSE) of 0.043 m3/m3 at a network level. At station level, the R is larger than 0.6 for all the REMEDHUS stations, with an ubRMSE smaller than 0.06 m3/m3. The evaluation indicates the good potential of the proposed method in the SM downscaling, which achieves a robust consistency and provides rich spatial information while maintaining good accuracy.National Natural Science Foundation of China Strategic Program of the Institute of Mountain Hazards and Environment, Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association Spanish Ministry of Science, Innovation and Universities State Research Agency (AEI) European Regional Development Fund under ProjectThe authors would like to thank the National Aeronautics and Space Administration (NASA, https://www.nasa.gov) for the provision of SMAP soil moisture product and MODIS products

Enrichment of a microbial community performing anaerobic oxidation of methane in a continuous high-pressure bioreactor

<p>Abstract</p> <p>Background</p> <p>Anaerobic oxidation of methane coupled to sulphate reduction (SR-AOM) prevents more than 90% of the oceanic methane emission to the atmosphere. In a previous study, we demonstrated that the high methane pressure (1, 4.5, and 8 MPa) stimulated <it>in vitro </it>SR-AOM activity. However, the information on the effect of high-pressure on the microbial community structure and architecture was still lacking.</p> <p>Results</p> <p>In this study we analysed the long-term enrichment (286 days) of this microbial community, which was mediating SR-AOM in a continuous high-pressure bioreactor. 99.7% of the total biovolume represented cells in the form of small aggregates (diameter less then 15 μm). An increase of the total biovolume was observed (2.5 times). After 286 days, the ANME-2 (anaerobic methanotrophic archaea subgroup 2) and SRB (sulphate reducing bacteria) increased with a factor 12.5 and 8.4, respectively.</p> <p>Conclusion</p> <p>This paper reports a net biomass growth of communities involved in SR-AOM, incubated at high-pressure.</p

Trends in admission rates of primary angle closure diseases for the urban population in China, 2011–2021

BackgroundCataract surgery and laser peripheral iridotomy (LPI) are effective approaches for preventing primary angle closure diseases (PACDs), as well as acute primary angle closure (APAC). Due to the development of population screening and increases in cataract surgery rates, this study aimed to examine trends in the admission rates of PACD among the urban population in China.MethodsThis cross-sectional study examined patients who were admitted to a hospital for PACD, and who underwent cataract surgery or LPI operations. The data were obtained from the Yinzhou Regional Health Information Platform (YRHIP) from 2011 to 2021. The annual rates of PACD and APAC admissions, cataract surgery and LPI were analyzed, with the number of cases used as numerators and the annual resident population in Yinzhou district used as denominators.ResultsA total of 2,979 patients with PACD admissions, 1,023 patients with APAC admissions, 53,635 patients who underwent cataract surgery and 16,450 patients who underwent LPI were included. The number of annual admissions for PACD gradually increased from 22 cases (1.6/100000) in 2011 to 387 cases (30.8/100000) in 2016, after which it decreased to 232 cases (16.2/100000) in 2019 and then increased to 505 cases (30.6/100000) in 2021. The number of cataract surgeries gradually increased from 1728 (127.7/100000) in 2011 to 7002 (424.9/100000) in 2021. Similarly, the number of LPI gradually increased from 109 (8.0/100000) in 2011 to 3704 (224.8/100000) in 2021.ConclusionThe admission rates of PACD for the urban population in China have declined in recent years after a long increasing trend in the rates of cataract surgery and LPI. However, it increased rapidly during the COVID-19 epidemic. The national health database should be further utilized to investigate temporal trends in the prevalence of PACD

Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients

<p>Abstract</p> <p>Background</p> <p>Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance.</p> <p>Methods</p> <p>To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.</p> <p>Results</p> <p>We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global <it>p </it>= 0.0005.</p> <p>Conclusions</p> <p>Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.</p

Target of Rapamycin (TOR) Regulates the Expression of lncRNAs in Response to Abiotic Stresses in Cotton

TOR (Target of Rapamycin) kinase is an evolutionarily conserved protein kinase, which integrates stress-related cues with growth and metabolic outputs. Long non-coding RNAs (lncRNAs) play a vital role in the regulation of eukaryotic genes. However, little is known about TOR's function in regulating the expression of lncRNAs in plants. In this study, four putative homologous genes encoding the TOR protein were identified by utilizing the recently completed cotton genome. Pharmacological experiments with TOR inhibitor AZD8055 and on silencing GhTOR genes resulted in obvious cotton growth retardation, indicating the conserved role of TOR in plant growth. The expression pattern analyses in different tissues reveal that TOR may play a role in root development, and the transcript levels of TOR genes were changed under different stress conditions. Importantly, we found TOR may be a key player in regulating the expression of long non-coding RNAs (lncRNAs). A total of 10,315 lncRNAs were discovered in cotton seedlings, 90.7% of which were long intergenic ncRNAs. Moreover, we identified the differentially expressed lncRNAs, of which 296 were significantly upregulated and 105 were downregulated in TOR inactivated plants. GO and KEGG analyses of differentially expressed lncRNA neighboring genes reveal that these differentially expressed lncRNA-targeted genes are involved in many life processes, including stress response, glutathione, and ribosomes in cotton. A series of differentially expressed lncRNAs potentially involved in plant stress response was identified under TOR inhibition. Collectively, these results suggest that cotton TOR proteins may directly modulate the expression of putative stress-related lncRNAs and eventually play a potential role in the cotton stress response