Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Study of Vector Boson Scattering and Search for New Physics in Events with Two Same-Sign Leptons and Two Jets

A study of vector boson scattering in pp collisions at a center-of-mass energy of 8 TeV is presented. The data sample corresponds to an integrated luminosity of 19.4 fb(-1) collected with the CMS detector. Candidate events are selected with exactly two leptons of the same charge, two jets with large rapidity separation and high dijet mass, and moderate missing transverse energy. The signal region is expected to be dominated by electroweak same-sign W-boson pair production. The observation agrees with the standard model prediction. The observed significance is 2.0 standard deviations, where a significance of 3.1 standard deviations is expected based on the standard model. Cross section measurements for (WW +/-)-W-+/- and WZ processes in the fiducial region are reported. Bounds on the structure of quartic vector-boson interactions are given in the framework of dimension-eight effective field theory operators, as well as limits on the production of doubly charged Higgs bosons

Measurement of prompt J/ψ pair production in pp collisions at√s = 7 Tev

Abstract: Production of prompt J/ψ meson pairs in proton-proton collisions at (formula presented.) = 7 TeV is measured with the CMS experiment at the LHC in a data sample corresponding to an integrated luminosity of about 4.7 fb−1. The two J/ψ mesons are fully reconstructed via their decays into μ+μ− pairs. This observation provides for the first time access to the high-transverse-momentum region of J/ψ pair production where model predictions are not yet established. The total and differential cross sections are measured in a phase space defined by the individual J/ψ transverse momentum (pTJ/ψ) and rapidity (|yJ/ψ|): |yJ/ψ | 6.5 GeV/c; 1.2 4.5 GeV/c. The total cross section, assuming unpolarized prompt J/ψ pair production is 1.49 ± 0.07 (stat) ±0.13 (syst) nb. Different assumptions about the J/ψ polarization imply modifications to the cross section ranging from −31% to +27%

First proton-proton collisions at the LHC as observed with the ALICE detector: measurement of the charged-particle pseudorapidity density at root s=900 GeV

On 23rd November 2009, during the early commissioning of the CERN Large Hadron Collider (LHC), two counter-rotating proton bunches were circulated for the first time concurrently in the machine, at the LHC injection energy of 450 GeV per beam. Although the proton intensity was very low, with only one pilot bunch per beam, and no systematic attempt was made to optimize the collision optics, all LHC experiments reported a number of collision candidates. In the ALICE experiment, the collision region was centred very well in both the longitudinal and transverse directions and 284 events were recorded in coincidence with the two passing proton bunches. The events were immediately reconstructed and analyzed both online and offline. We have used these events to measure the pseudorapidity density of charged primary particles in the central region. In the range vertical bar eta vertical bar S collider. They also illustrate the excellent functioning and rapid progress of the LHC accelerator, and of both the hardware and software of the ALICE experiment, in this early start-up phase

Search for neutral MSSM Higgs bosons decaying to a pair of tau leptons in pp collisions

A search for neutral Higgs bosons in the minimal supersymmetric extension of the standard model (MSSM) decaying to tau-lepton pairs in pp collisions is performed, using events recorded by the CMS experiment at the LHC. The dataset corresponds to an integrated luminosity of 24.6 fb(-1), with 4.9 fb(-1) at 7TeV and 19.7 fb(-1) at 8TeV. To enhance the sensitivity to neutral MSSM Higgs bosons, the search includes the case where the Higgs boson is produced in association with a b-quark jet. No excess is observed in the tau-lepton-pair invariant mass spectrum. Exclusion limits are presented in the MSSM parameter space for different benchmark scenarios, m(h)(max), m(h)(mod+), m(h)(mod-), light-stop, light-stau, T-phobic, and low-m(H). Upper limits on the cross section times branching fraction for gluon fusion and b-quark associated Higgs boson production are also given

Production of charged pions, kaons and protons at large transverse momenta in pp and Pb–Pb collisions at sNN=2.76 TeV

AbstractTransverse momentum spectra of π±, K± and p(p¯) up to pT=20 GeV/c at mid-rapidity in pp, peripheral (60–80%) and central (0–5%) Pb–Pb collisions at sNN=2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pion ratios both show a distinct peak at pT≈3 GeV/c in central Pb–Pb collisions. Below the peak, pT<3 GeV/c, both ratios are in good agreement with hydrodynamical calculations, suggesting that the peak itself is dominantly the result of radial flow rather than anomalous hadronization processes. For pT>10 GeV/c particle ratios in pp and Pb–Pb collisions are in agreement and the nuclear modification factors for π±, K± and p(p¯) indicate that, within the systematic and statistical uncertainties, the suppression is the same. This suggests that the chemical composition of leading particles from jets in the medium is similar to that of vacuum jets

The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)

Objective Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. Methods The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995â2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. Results During 2005â2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time. Conclusions The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions

Identification techniques for highly boosted W bosons that decay into hadrons

In searches for new physics in the energy regime of the LHC, it is becoming increasingly important to distinguish single-jet objects that originate from the merging of the decay products of W bosons produced with high transverse momenta from jets initiated by single partons. Algorithms are defined to identify such W jets for different signals of interest, using techniques that are also applicable to other decays of bosons to hadrons that result in a single jet, such as those from highly boosted Z and Higgs bosons. The efficiency for tagging W jets is measured in data collected with the CMS detector at a center-of-mass energy of 8TeV, corresponding to an integrated luminosity of 19.7 fb(-1). The performance of W tagging in data is compared with predictions from several Monte Carlo simulators.Austrian Federal Ministry of Science, Research and EconomyAustrian Science FundBelgian Fonds de la Recherche ScientifiqueFonds voor Wetenschappelijk OnderzoekConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Bulgarian Ministry of Education and ScienceCERNChinese Academy of SciencesMinistry of Science and TechnologyNational Natural Science Foundation of ChinaColombian Funding Agency (COLCIENCIAS)Croatian Ministry of Science, Education and SportCroatian Science FoundationResearch Promotion Foundation, CyprusMinistry of Education and Research, Estonian Research CouncilEuropean Regional Development Fund, EstoniaAcademy of FinlandFinnish Ministry of Education and CultureHelsinki Institute of PhysicsInstitut National de Physique Nucleaire et de Physique des Particules / CNRSCommissariat a l&apos;Energie Atomique et auxEnergies Alternatives / CEA, FranceBundesministerium fur Bildung und Forschung, GermanyDeutsche Forschungsgemeinschaft, GermanyHelmholtz-Gemeinschaft Deutscher Forschungszentren, GermanyGeneral Secretariat for Research and Technology, GreeceNational Scientific Research FoundationNational Innovation Office, HungaryDepartment of Atomic EnergyDepartment of Science and Technology, IndiaInstitute for Studies in Theoretical Physics and Mathematics, IranScience Foundation, IrelandIstituto Nazionale di Fisica Nucleare, ItalyKorean Ministry of Education, Science and TechnologyWorld Class University program of NRF, Republic of KoreaLithuanian Academy of SciencesMinistry of EducationUniversity of Malaya (Malaysia)CINVESTAVCONACYTSEPUASLP-FAIMinistry of Business, Innovation and Employment, New ZealandPakistan Atomic Energy CommissionMinistry of Science and Higher EducationNational Science Centre, PolandFundacao para a Ciencia e a Tecnologia, PortugalJINR, DubnaMinistry of Education and Science of the Russian FederationFederal Agency of Atomic Energy of the Russian FederationRussian Academy of ScienceSRussian Foundation for Basic ResearchMinistry of Education, Science and Technological Development of SerbiaSecretaria de Estado de Investigacion, Desarrollo e Innovacion and Programa Consolider-IngenioETH BoardETH ZurichPSISNFUniZHCantonMinistry of Science and Technology, TaipeiThailand Center of Excellence in PhysicsInstitute for the Promotion of Teaching Science and Technology of ThailandSpecial Task Force for Activating ResearchNational Science and Technology Development Agency of ThailandScientific and Technical Research Council of TurkeyTurkish Atomic Energy AuthorityNational Academy of Sciences of UkraineState Fund for Fundamental Researches, UkraineScience and Technology Facilities Council, U.K.US Department of EnergyUS National Science FoundationMarie-Curie programmeEuropean Research CouncilEPLANET (European Union)Leventis FoundationA. P. Sloan FoundationAlexander von Humboldt FoundationBelgian Federal Science Policy OfficeFonds pour la Formation a la Recherche dans l&apos;Industrie et dans l&apos;Agriculture (FRIA-Belgium)Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium)Ministry of Education, Youth and Sports (MEYS) of the Czech RepublicCouncil of Science and Industrial Research, IndiaHOMING PLUS programme of Foundation for Polish ScienceEuropean UnionRegional Development FundCompagnia di San Paolo (Torino)Consorzio per la Fisica (Trieste)MIUR project (Italy)Thalis and Aristeia programmesEU-ESFNSRFNational Priorities Research Program by Qatar National Research FundYerevan Phys Inst, Yerevan 375036, ArmeniaAustrian Acad Sci, Inst Hochenergiephys, OeAW, A-1050 Vienna, AustriaNatl Ctr Particle &High Energy Phys, Minsk, ByelarusUniv Antwerp, B-2020 Antwerp, BelgiumVrije Univ Brussel, Brussels, BelgiumUniv Libre Bruxelles, Brussels, BelgiumUniv Ghent, B-9000 Ghent, BelgiumCatholic Univ Louvain, Louvain, BelgiumUniv Mons, B-7000 Mons, BelgiumCtr Brasileiro Pesquisas Fis, Rio De Janeiro, BrazilUniv Estado Rio de Janeiro, BR-20550011 Rio De Janeiro, BrazilUniv Estadual Paulista, Sao Paulo, BrazilUniv Fed ABC, Sao Paulo, BrazilBulgarian Acad Sci, Inst Nucl Res &Nucl Energy, Sofia, BulgariaUniv Sofia, BU-1126 Sofia, BulgariaInst High Energy Phys, Beijing 100039, Peoples R ChinaPeking Univ, State Key Lab Nucl Phys &Technol, Beijing 100871, Peoples R ChinaUniv Los Andes, Bogota, ColombiaUniv Split, Fac Elect Engn Mech Engn &Naval Architecture, Split, CroatiaUniv Split, Fac Sci, Split, CroatiaRudjer Boskovic Inst, Zagreb, CroatiaUniv Cyprus, CY-1678 Nicosia, CyprusCharles Univ Prague, Prague, Czech RepublicAcad Sci Res &Technol Arab Republ Egypt, Egyptian Network High Energy Phys, Cairo, EgyptNICPB, Tallinn, EstoniaUniv Helsinki, Dept Phys, Helsinki, FinlandHelsinki Inst Phys, Helsinki, FinlandLappeenranta Univ Technol, Lappeenranta, FinlandCEA Saclay, DSM IRFU, F-91191 Gif Sur Yvette, FranceEcole Polytech, CNRS, IN2P3, Lab Leprince Ringuet, F-91128 Palaiseau, FranceUniv Strasbourg, Univ Haute Alsace Mulhouse, CNRS IN2P3, Inst Pluridisciplinaire Hubert Curien, Strasbourg, FranceCNRS, IN2P3, Ctr Calcul, Villeurbanne, FranceUniv Lyon 1, CNRS, IN2P3, Inst Phys Nucl Lyon, F-69622 Villeurbanne, FranceTbilisi State Univ, Inst High Energy Phys &Informat, GE-380086 Tbilisi, Rep of GeorgiaRhein Westfal TH Aachen, Inst Phys 1, Aachen, GermanyRhein Westfal TH Aachen, Inst Phys A 3, Aachen, GermanyRhein Westfal TH Aachen, Phys Inst B 3, Aachen, GermanyDESY, Hamburg, GermanyUniv Hamburg, D-20146 Hamburg, GermanyUniv Karlsruhe, Inst Expt Kernphys, Karlsruhe, GermanyNCSR Demokritos, Inst Nucl &Particle Phys INPP, Aghia Paraskevi, GreeceUniv Athens, Athens, GreeceUniv Ioannina, GR-45110 Ioannina, GreeceWigner Res Ctr Phys, Budapest, HungaryInst Nucl Res, ATOMKI, H-4001 Debrecen, HungaryUniv Debrecen, Debrecen, HungaryNatl Inst Sci Educ &Res, Bhubaneswar, Orissa, IndiaPanjab Univ, Chandigarh 160014, IndiaUniv Delhi, Delhi 110007, IndiaSaha Inst Nucl Phys, Kolkata, IndiaBhabha Atom Res Ctr, Bombay 400085, Maharashtra, IndiaTata Inst Fundamental Res, Mumbai 400005, Maharashtra, IndiaInst Res Fundamental Sci IPM, Tehran, IranUniv Coll Dublin, Dublin 2, IrelandIst Nazl Fis Nucl, Sez Bari, I-70126 Bari, ItalyUniv Bari, Bari, ItalyPolitecn Bari, Bari, ItalyIst Nazl Fis Nucl, Sez Bologna, I-40126 Bologna, ItalyUniv Bologna, Bologna, ItalyIst Nazl Fis Nucl, Sez Catania, I-95129 Catania, ItalyUniv Catania, Catania, ItalyCSFNSM, Catania, ItalyIst Nazl Fis Nucl, Sez Firenze, I-50125 Florence, ItalyUniv Florence, Florence, ItalyIst Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, ItalyIst Nazl Fis Nucl, Sez Genova, I-16146 Genoa, ItalyUniv Genoa, Genoa, ItalyIst Nazl Fis Nucl, Sez Milano Bicocca, I-20133 Milan, ItalyUniv Milano Bicocca, Milan, ItalyIst Nazl Fis Nucl, Sez Napoli, I-80125 Naples, ItalyUniv Naples Federico II, Naples, ItalyUniv Basilicata, Naples, ItalyUniv G Marconi Roma, Naples, ItalyIst Nazl Fis Nucl, Sez Padova, Padua, ItalyUniv Padua, Padua, ItalyUniv Trent, Padua, ItalyIst Nazl Fis Nucl, Sez Pavia, I-27100 Pavia, ItalyUniv Pavia, I-27100 Pavia, ItalyIst Nazl Fis Nucl, Sez Perugia, I-06100 Perugia, ItalyUniv Perugia, I-06100 Perugia, ItalyIst Nazl Fis Nucl, Sez Pisa, Pisa, ItalyUniv Pisa, Pisa, ItalyScuola Normale Super Pisa, Pisa, ItalyIst Nazl Fis Nucl, Sez Roma, Rome, ItalyUniv Rome, Rome, ItalyIst Nazl Fis Nucl, Sez Torino, I-10125 Turin, ItalyUniv Turin, Turin, ItalyUniv Piemonte Orientale Novara, Turin, ItalyIst Nazl Fis Nucl, Sez Trieste, Trieste, ItalyUniv Trieste, Trieste, ItalyKangwon Natl Univ, Chunchon, South KoreaKyungpook Natl Univ, Taegu, South KoreaChonbuk Natl Univ, Jeonju 561756, South KoreaChonnam Natl Univ, Inst Universe &Elementary Particles, Kwangju, South KoreaKorea Univ, Seoul, South KoreaUniv Seoul, Seoul, South KoreaSungkyunkwan Univ, Suwon, South KoreaVilnius Univ, Vilnius, LithuaniaUniv Malaya, Natl Ctr Particle Phys, Kuala Lumpur, MalaysiaInst Politecn Nacl, Ctr Invest &Estudios Avanzados, Mexico City, DF, MexicoUniv Iberoamer, Mexico City, DF, MexicoBenemerita Univ Autonoma Puebla, Puebla, MexicoUniv Autonoma San Luis Potosi, San Luis Potosi, MexicoUniv Auckland, Auckland 1, New ZealandUniv Canterbury, Christchurch 1, New ZealandQuaid I Azam Univ, Natl Ctr Phys, Islamabad, PakistanNatl Ctr Nucl Res, Otwock, PolandUniv Warsaw, Fac Phys, Inst Expt Phys, Warsaw, PolandLab Instrumentacao &Fis Expt Particulas, Lisbon, PortugalJoint Nucl Res Inst, Dubna, RussiaPetersburg Nucl Phys Inst, Gatchina, St Petersburg, RussiaRussian Acad Sci, Inst Nucl Res, Moscow 117312, RussiaInst Theoret &Expt Phys, Moscow 117259, RussiaPN Lebedev Phys Inst, Moscow 117924, RussiaMoscow MV Lomonosov State Univ, Moscow, RussiaInst High Energy Phys, State Res Ctr Russian Federat, Protvino, RussiaUniv Belgrade, Fac Phys, YU-11001 Belgrade, SerbiaVinca Inst Nucl Sci, Belgrade, SerbiaCIEMAT, E-28040 Madrid, SpainUniv Autonoma Madrid, Madrid, SpainUniv Oviedo, Oviedo, SpainUniv Cantabria, CSIC, Inst Fis Cantabria IFCA, E-39005 Santander, SpainCERN, European Org Nucl Res, CH-1211 Geneva, SwitzerlandPaul Scherrer Inst, Villigen, SwitzerlandETH, Inst Particle Phys, Zurich, SwitzerlandUniv Zurich, Zurich, SwitzerlandNatl Cent Univ, Chungli 32054, TaiwanNatl Taiwan Univ, Taipei 10764, TaiwanChulalongkorn Univ, Fac Sci, Dept Phys, Bangkok, ThailandCukurova Univ, Adana, TurkeyMiddle E Tech Univ, TR-06531 Ankara, TurkeyBogazici Univ, Istanbul, TurkeyIstanbul Tech Univ, TR-80626 Istanbul, TurkeyUkrainian Acad Sci, Inst Phys &Technol, Ctr Nat Sci, UA-310108 Kharkov, UkraineUniv Bristol, Bristol, Avon, EnglandRutherford Appleton Lab, Didcot OX11 0QX, Oxon, EnglandUniv London Imperial Coll Sci Technol &Med, London, EnglandBrunel Univ, Uxbridge UB8 3PH, Middx, EnglandBaylor Univ, Waco, TX 76798 USAUniv Alabama, Tuscaloosa, AL USABoston Univ, Boston, MA 02215 USABrown Univ, Providence, RI 02912 USAUniv Calif Davis, Davis, CA 95616 USAUniv Calif Los Angeles, Los Angeles, CA USAUniv Calif Riverside, Riverside, CA 92521 USAUniv Calif San Diego, La Jolla, CA 92093 USAUniv Calif Santa Barbara, Santa Barbara, CA 93106 USACALTECH, Pasadena, CA 91125 USACarnegie Mellon Univ, Pittsburgh, PA 15213 USAUniv Colorado, Boulder, CO 80309 USACornell Univ, Ithaca, NY USAFairfield Univ, Fairfield, CT 06430 USAFermilab Natl Accelerator Lab, Batavia, IL 60510 USAUniv Florida, Gainesville, FL USAFlorida Int Univ, Miami, FL 33199 USAFlorida State Univ, Tallahassee, FL 32306 USAFlorida Inst Technol, Melbourne, FL 32901 USAUniv Illinois, Chicago, IL USAUniv Iowa, Iowa City, IA USAJohns Hopkins Univ, Baltimore, MD USAUniv Kansas, Lawrence, KS 66045 USAKansas State Univ, Manhattan, KS 66506 USALawrence Livermore Natl Lab, Livermore, CA USAUniv Maryland, College Pk, MD 20742 USAMIT, Cambridge, MA 02139 USAUniv Minnesota, Minneapolis, MN USAUniv Mississippi, University, MS 38677 USAUniv Nebraska, Lincoln, NE USASUNY Buffalo, Buffalo, NY 14260 USANortheastern Univ, Boston, MA 02115 USANorthwestern Univ, Evanston, IL USAUniv Notre Dame, Notre Dame, IN 46556 USAOhio State Univ, Columbus, OH 43210 USAPrinceton Univ, Princeton, NJ 08544 USAUniv Puerto Rico, Mayaguez, PR USAPurdue Univ, W Lafayette, IN 47907 USAPurdue Univ Calumet, Hammond, LA USARice Univ, Houston, TX USAUniv Rochester, Rochester, NY 14627 USARockefeller Univ, New York, NY 10021 USARutgers State Univ, Piscataway, NJ USAUniv Tennessee, Knoxville, TN USATexas A&amp;M Univ, College Stn, TX USATexas Tech Univ, Lubbock, TX 79409 USAVanderbilt Univ, Nashville, TN 37235 USAUniv Virginia, Charlottesville, VA USAWayne State Univ, Detroit, MI USAUniv Wisconsin, Madison, WI 53706 USAVienna Univ Technol, A-1040 Vienna, AustriaUniv Haute Alsace Mulhouse, Univ Strasbourg, CNRS, IN2P3,Inst Pluridisciplinaire Hubert Curien, Strasbourg, FranceMoscow MV Lomonosov State Univ, Skobeltsyn Inst Nucl Phys, Moscow, RussiaUniv Estadual Campinas, Campinas, SP, BrazilDubna Joint Nucl Res Inst, Dubna 141980, RussiaSuez Canal Univ, Suez, EgyptCairo Univ, Cairo, EgyptFayoum Univ, Al Fayyum, EgyptBritish Univ Egypt, Cairo, EgyptSultan Qaboos Univ, Muscat, OmanUniv Haute Alsace, Mulhouse, FranceBrandenburg Tech Univ Cottbus, Cottbus, GermanyATOMKI, Inst Nucl Res, Debrecen, HungaryEotvos Lorand Univ, Budapest, HungaryVisva Bharati Univ, Santini Ketan, W Bengal, IndiaKing Abdulaziz Univ, Jeddah 21413, Saudi ArabiaUniv Ruhuna, Matara, Sri LankaIsfahan Univ Technol, Esfahan, IranSharif Univ Technol, Tehran, IranIslamic Azad Univ, Ctr Rech Phys Plasmas, Sci &Res Branch, Tehran, IranUniv Siena, I-53100 Siena, ItalyCNRS, IN2P3, Paris, FranceUniv Michoacana, Morelia, Michoacan, MexicoSt Petersburg State Polytechn Univ, St Petersburg, RussiaUniv Trento, Padua, ItalyUniv Belgrade, Fac Phys, Belgrade 11001, SerbiaUniv Rome, Fac Ingn, Rome, ItalyIst Nazl Fis Nucl, Scuola Normale &Sez, Pisa, ItalyAlbert Einstein Ctr Fundamental Phys, Bern, SwitzerlandGaziosmanpasa Univ, Tokat, TurkeyAdiyaman Univ, Adiyaman, TurkeyCag Univ, Mersin, TurkeyIzmir Inst Technol, Izmir, TurkeyOzyegin Univ, Istanbul, TurkeyMarmara Univ, Istanbul, TurkeyKafkas Univ, Kars, TurkeyUniv Southampton, Sch Phys &Astron, Southampton, Hants, EnglandUniv Belgrade, Fac Phys &Vinca, Inst Sci Nucl, Belgrade, SerbiaMimar Sinan Univ, Istanbul, TurkeyArgonne Natl Lab, Argonne, IL 60439 USAErzincan Univ, Erzincan, TurkeyYildiz Tekn Univ, Istanbul, TurkeyTexas A&amp;M Univ, Doha, QatarUniv Estadual Paulista, Sao Paulo, BrazilMinistry of Education and Research, Estonian Research Council: IUT23-4Ministry of Education and Research, Estonian Research Council: IUT236MIUR project (Italy): 20108T4XT

Centrality, rapidity and transverse momentum dependence of J/ψ suppression in Pb–Pb collisions at sNN=2.76 TeV

AbstractThe inclusive J/ψ nuclear modification factor (RAA) in Pb–Pb collisions at sNN=2.76 TeV has been measured by ALICE as a function of centrality in the e+e− decay channel at mid-rapidity (|y|<0.8) and as a function of centrality, transverse momentum and rapidity in the μ+μ− decay channel at forward-rapidity (2.5<y<4). The J/ψ yields measured in Pb–Pb are suppressed compared to those in pp collisions scaled by the number of binary collisions. The RAA integrated over a centrality range corresponding to 90% of the inelastic Pb–Pb cross section is 0.72±0.06(stat.)±0.10(syst.) at mid-rapidity and 0.58±0.01(stat.)±0.09(syst.) at forward-rapidity. At low transverse momentum, significantly larger values of RAA are measured at forward-rapidity compared to measurements at lower energy. These features suggest that a contribution to the J/ψ yield originates from charm quark (re)combination in the deconfined partonic medium