Analysis of abnormal operation procedures in sequences of loss of the RHRS at midloop operation

Several studies indicate the importance that the sequence of loss of residual heat removal system (RHRS) at midloop operation has in the global risk of the plant. In this sense, several simulations of loss of the RHRS with closed and open primary system with the TRACE V4.160 code have been performed considering different availability of steam generators. This paper aims to analyze not only the thermalhydraulic behavior of the plant after the loss of RHRS, but also the interaction of the simulation results with the abnormal operation procedures and with the event trees of the sequences of loss of RHRS at midloop operation. The simulation results show that the main parameters depends on primary vent and the number of steam generators available. After a detailed study of phenomenology and abnormal procedures some modifications have been proposed in these procedures

Applying consumer responsibility principle in evaluating environmental load of carbon emissions

There is a need for a proper indicator in order to assess the environmental impact of international trade, therefore using the carbon footprint as an indicator can be relevant and useful. The aim of this study is to show from a methodological perspective how the carbon footprint, combined with input- output models can be used for analysing the impacts of international trade on the sustainable use of national resources in a country. The use of the input-output approach has the essential advantage of being able to track the transformation of goods through the economy. The study examines the environmental impact of consumption related to international trade, using the consumer responsibility principle. In this study the use of the carbon footprint and input-output methodology is shown on the example of the Hungarian consumption and the impact of international trade. Moving from a production- based approach in climate policy to a consumption-perspective principle and allocation, would also help to increase the efficiency of emission reduction targets and the evaluation of the ecological impacts of international trade

A Consumption-Based Approach to Carbon Emission Accounting – Sectoral Differences and Environmental Benefits

In recent years there has been growing concern about the emission trade balances of countries. This is due to the fact that countries with an open economy are active players in international trade. Trade is not only a major factor in forging a country’s economic structure, but contributes to the movement of embodied emissions beyond country borders. This issue is especially relevant from the carbon accounting policy and domestic production perspective, as it is known that the production-based principle is employed in the Kyoto agreement. The research described herein was designed to reveal the interdependence of countries on international trade and the corresponding embodied emissions both on national and on sectoral level and to illustrate the significance of the consumption-based emission accounting. It is presented here to what extent a consumption-based accounting would change the present system based on production-based accounting and allocation. The relationship of CO2 emission embodied in exports and embodied in imports is analysed here. International trade can blur the responsibility for the ecological effects of production and consumption and it can lengthen the link between consumption and its consequences. Input-output models are used in the methodology as they provide an appropriate framework for climate change accounting. The analysis comprises an international comparative study of four European countries (Germany, the United Kingdom, the Netherlands, and Hungary) with extended trading activities and carbon emissions. Moving from a production-based approach in climate policy to a consumption-based principle and allocation approach would help to increase the efficiency of emission reductions and would force countries to rethink their trading activities in order to decrease the environmental load of production activities. The results of this study show that it is important to distinguish between the two emission accounting approaches, both on the global and the local level

Preliminary metabolic screening method for clone selection in the ambr15

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Reachable sets analysis in the cooperative control of pursuer vehicles

This thesis is concerned with the Pursuit-and-Evasion (PE) problem where the pursuer aims to minimize the time to capture the evader while the evader tries to prevent capture. In the problem, the evader has two advantages: a higher manoeuvrability and that the pursuer is uncertain about the evader's state. Cooperation among multiple pursuer vehicles can thus be used to overcome the evader’s advantages. The focus here is on the formulation and development of frameworks and algorithms for cooperation amongst pursuers, aiming at feasible implementation on real and autonomous vehicles. The thesis is split into Parts I and II. Part I considers the problem of capturing an evader of higher manoeuvrability in a deterministic PE game. The approach is the employment of Forward Reachable Set (FRS) analysis in the pursuers’ control. The analysis considers the coverage of the evader’s FRS, which is the set of reachable states at a future time, with the pursuer’s FRS and assumes that the chance of capturing the evader is dependent on the degree of the coverage. Using the union of multiple pursuers’ FRSs intuitively leads to more evader FRS coverage and this forms the mechanism of cooperation. A framework for cooperative control based on the FRS coverage, or FRS-based control, is proposed. Two control algorithms were developed within this framework. Part II additionally introduces the problem of evader state uncertainty due to noise and limited field-of-view of the pursuers’ sensors. A search-and-capture (SAC) problem is the result and a hybrid architecture, which includes multi-sensor estimation using the Particle Filter as well as FRS-based control, is proposed to accomplish the SAC task. The two control algorithms in Part I were tested in simulations against an optimal guidance algorithm. The results show that both algorithms yield a better performance in terms of time and miss distance. The results in Part II demonstrate the effectiveness of the hybrid architecture for the SAC task. The proposed frameworks and algorithms provide insights for the development of effective and more efficient control of pursuer vehicles and can be useful in the practical applications such as defence systems and civil law enforcement

Temporal change in India’s imbalance of carbon emissions embodied in international trade

In India, rapid industrialization and reorganization of the global supply chain are driving economic growth, accompanied by increasing exports and carbon emissions. India is poised to succeed China as the next world manufactory, which will lead to huge emissions in the country. To formulate appropriate emission mitigation measures, it is necessary to further understand the temporal change in India’s emissions at the sectoral level from both the production and consumption perspectives. However, existing studies that have estimated emissions in India have paid less attention to the link among original emitters, final producers and final consumers and to its temporal change. Based on an emission inventory compiled in this study, we trace emission flows from original emitters to final producers and then to final consumers through the international supply chain by using an environmentally extended multi-regional input-output model. This study finds that both production-based and consumption-based emissions in India increased constantly from 2000 to 2014, and production-based emissions had higher growth rates due to the increased coal share. The major receivers of India’s exported emissions were developed countries (e.g., the European Union and the United States), while the main sources of India’s imported emissions were developing countries (e.g., China and Russia). From 2011 to 2014, India’s net exported emissions increased by 29.2% because of the decrease of imported emissions. Moreover, intermediate products (63% and 73.7%) were the major contributors to exported and imported emissions, most of which were embodied in manufacturing products (48.8% and 65.7%, respectively). Therefore, international cooperation to optimize the energy and trade structure and to improve energy efficiency can be effective in mitigating carbon emissions in India

An Analysis of Proposed Alternatives for Unifying Euthanasia Laws and Protocols

This study proposes to the United States Congress a national public policy on legalizing euthanasia for all citizens. A change in public policy would permit a person to have the right to choose termination of life-sustaining means when alternatives only cause unnecessary suffering, prolong the dying process, and/or keep a person in unconsciousness or a meaningless existence. This proposal consists of three major goals: 1) to establish legal statutes at the national level; 2) to justify individual liberty, society concerns, and state interests; and, 3) to improve efficient utilization of health care resources relating to life-sustaining treatment. To pursue these goals, two strategies have been designed 1) unifying the legal statutes; and 2) refining mechanisms in health care delivery services in regard to life-sustaining treatment. The proposal for unification of the legal statutes includes introducing a uniform guideline for defining death, extending the boundary of the Patient Self-Determination Act, unifying living will statutes, and developing national living will guidelines. In refining mechanisms in health care delivery services regarding life-sustaining treatment, the proposals would: 1) emphasize pain management and palliative care as alternatives to euthanasia; 2) re-evaluate financially burdensome life-sustaining treatment; 3) prioritize health care costs and screen for accessing health care services; and, 4) encourage voluntary choice of medical treatments. This study proposes a uniform guideline for the states to make euthanasia permissible, in accordance with legal safeguards. It is hoped this proposal will arouse national attention and facilitate the United States Congress in taking appropriate action to deal with this pressing matter

Nature's objects : geology, aesthetics, and the understanding of materiality in eighteenth-century Britain and France

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Architecture, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 353-390).Explorations of aesthetic design and scientific experimentation have traditionally relied upon the natural world as a source of inspiration. Notably absent from previous studies of the eighteenth century is the dynamic connections between contrasting disciplines of this time period. Terrestrial objects such as diamonds, silver, gold, and stone, situated between architecture, the decorative arts, and geology, superseded classical models of Aristotelian emulation, which privileged original visual forms. They evoked newfound tensions between modalities of intuition and empirical observation, providing alternate paradigms of nature based upon firsthand experience. This dissertation takes up an extensive assembly of historical actors who analyzed these objects - architects, artisans, chemists, collectors, engravers, geologists, jewelers, and silversmiths. Late Enlightenment designers Robert Adam, William Chambers, and Batty Langley as well as intellectuals Denis Diderot and Louis Dutens explored some of the same materials that piqued the curiosity of silversmiths Pierre-Simon Augustin Dupre, Francois-Thomas Germain, and Jacques Roettiers. Artisan Pierre de Fontanieu and chemists Antoine Laurent de Lavoisier and Jean-Louis Baptiste Rome de l'Isle also problematized the aesthetic usages of these objects, arriving at differing conclusions. Pervasive debates throughout Europe attempted to determine the quotient of hardness in minerals, plasticity of metal, or durability of stone. These provocative cross-currents between the domains of the arts, sciences, and politics generated remarkable insight into these objects taken from the earth; in turn, these intersections shaped a unique conception of materiality, which anticipated untapped potential for architectural styles, artistic production, and geological determination. Mining and related images of the subterranean - mineralogical atlases, etchings of rock formations, maps of sedimentary deposits, imagined grottos, and utopian architecture - are framed as part of a geological imaginary, a contributor to modernism's early inheritance. The first chapter contemplates how the cutting of diamonds as raw stones cultivated attitudes towards jewelry settings, formulas for false gemstones, and chemical demonstrations. Artisans judged a diamond's functional and authentic attributes in order to craft acceptable imitations. In focusing upon silver and gold, the second chapter traces the material transformations of valuable metals from decorative ornament into commemorative coins and medals during the French Revolution. Fiscal currency circulated as economic signifiers that embodied human values superimposed onto natural resources. The third chapter examines several types of stone from limestone, granite, to marble demonstrating how their visual and structural properties became articulated through Gothic revival practices in Georgian England. Antiquarian and genealogical discourses not only influenced conceptions of stone as a building material, but they also focused upon geological explanations as a mutual foundation of comprehension. The conclusion merges the mythological stories behind these objects with their historical narratives, elucidating why cultural misinterpretations are as important as factual evidence. Derived from corporeal perception and abstract theorization, materiality revealed unknown dimensions of these prosaic objects, whose telluric origins became recast as both ancient and modem.Ph.D

Cell clone selection-impact of operation modes and medium exchange strategies on clone ranking

Bioprocessing has been transitioning from batch to continuous processes. As a result, a considerable amount of resource was dedicated to optimising strategies for continuous production. However, the focus has been on developing a suitable and scalable perfusion strategy with little attention given to the selection of optimal cell clones. Cell line development and lead clone selection are critical to bioprocess development. The screening and selection process is typically performed in stages. Microwell plates (MWP) are used to narrow down the number of clone candidates, which will undergo further selective screening in progressively larger small-scale bioreactors (12 mL–3 L) to identify the top clone for GMP production. Perfusion mode is typically applied at bench-scale for optimisation purposes, while process development and cell clone screening studies at mL-scale still commonly use fed-batch methods. The change of operation mode from bolus feeding to perfusion with a regular exchange of medium, leads to questions regarding the reliability and fit of initial clone selection. Is the early-stage clone ranking impacted by the discrepancy in the operation mode, and does this potentially result in the exclusion of cell clones suitable for perfusion processes? To address this question, we evaluated various CHO cell clones expressing two antibody products using MWP methodologies in fed-batch and semi-perfusion mode. We assessed growth, metabolic, and productivity performance, and ranked cell clones using two different strategies. The first strategy evaluated clones based on a single parameter: the cell-specific productivity (qP). The second considered a collection of multiple parameters using the metric of the Manufacturability index (MICL). Both ranking strategies showed an impact of operation mode and perfusion rate on the clone ranking. Notably, depending on the chosen operation mode, different sets of candidate clones might have been selected for further, more extensive screening. Additionally, we evaluated the reproducibility of our results demonstrating consistency in cell clone growth performance and ranking