History of mental health problems moderates the association between partner support during childbirth and women's mental health in the postpartum period

" Background: Partner support during childbirth is an important protective factor for women's perinatal mental health. However, its protective role in women experiencing vulnerabilities is largely unknown, namely in those with history of mental health problems. Aim: This study analysed (1) the association between partner support during childbirth and depressive, anxiety, and childbirth-related post-traumatic stress disorder symptoms in the postpartum period; and (2) the moderating role of previous diagnosis of mental health problems in those associations. Design: Cross-sectional study with 284 women. Methods: At 2 months postpartum, participants reported on sociodemographic, obstetric, and mental health-related data, partner support during childbirth, and depressive (Edinburgh Postnatal Depression Scale), anxiety (State Anxiety Inventory), and childbirth-related post-traumatic stress disorder (City Birth Trauma Scale) symptoms. Findings: More partner support during childbirth was associated with lower depressive, anxiety, and childbirth-related post-traumatic stress disorder symptoms. Previous diagnosis of mental health problems was associated with higher depressive, anxiety, and childbirth-related post-traumatic stress disorder symptoms and moderated the association between partner support during childbirth and depressive and anxiety symptoms. Higher partner support during childbirth was associated with lower depressive and anxiety symptoms, only in women without a previous diagnosis of mental health problems. Discussion: Findings suggest that partner support during childbirth can be a protective factor for women's postpartum mental health, particularly for women without a previous diagnosis of mental health problems. However, for those with a previous diagnosis of mental health problems, this support was not associated with symptoms. Conclusion: Women with a history of mental health problems may require additional support beyond that provided by their partners to prevent or mitigate postpartum mental health problems."This work was funded by the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education), under the grant HEI-LAB (UIDB/05380/2020; https://doi.org/10.54499/UIDB/05380/2020) and project 2022.01825.PTDC (http://doi.org/10.54499/2022.01825.PTDC). This research was funded by” la Caixa'' Foundation's Social Research Call 2023 under the project code LCF/PR/SR23/57000014. Funding was received in Portugal by the FSE and FCT – Fundação para a Ciência e a Tecnologia, I.P. (Individual CEEC 2023.06934.CEECIND [RC]; Individual grant 2024.06405.BD [DT]; Individual grant 2024.03648.BD [DF]). The funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. The authors have stated that they had no interests that might be perceived as posing a conflict or bias

Psychometric properties of the Fear of Birth Scale in women in the perinatal period: A multicountry study.

Assessing Fear of Birth Scale's (FOBS) psychometric properties in the perinatal period using multicountry data is a step toward effectively screen clinically significant fear of childbirth (FOC) in maternal healthcare settings. FOBS psychometric properties were analyzed in women in the perinatal period using data from Australia, Germany, Lithuania, Poland, and Portugal. FOBS' reliability, criterion (known group and convergent), concurrent, predictive, and clinical validity were analyzed. FOBS was completed by 3431 women in pregnancy (n = 2984) or postpartum (n = 447). Sociodemographic, obstetric, neonatal, and mental health-related data, depressive and anxiety symptoms, and tokophobia severity were self-reported. FOBS has good reliability. Known-group validity was established based on differences in sociodemographic, obstetric, neonatal, and mental health-related variables. Convergent validity was found with depressive and anxiety symptoms, and birth trauma. Concurrent validity was found with tokophobia severity. FOBS scores in pregnancy predicted elective cesarean section, and postpartum depressive and anxiety symptoms. FOBS discriminates between women with and without clinically significant FOC in pregnancy and postpartum, with optimal cut-offs across countries. This multicountry study suggested that FOBS is a psychometrically strong measure that can be an effective tool to screen clinically significant FOC in the perinatal period

Psychometric properties of the Brazilian version of the Personal Experience Screening Questionnaire

Summary Introduction: The Personal Experience Screening Questionnaire (PESQ) is an instrument devised for assessing the magnitude of drug misuse among adolescents. However, its psychometric properties have not been evaluated in adolescent samples outside the United States. Objective: To assess the internal reliability and validity of the Brazilian version of the PESQ. Method: A cross-sectional study was carried out with 84 adolescents from a clinical sample and a community-based sample. All of them answered the PESQ. Results: Among adolescents from the community, the PESQ problem severity index, which can vary from 18 to 72, was 26.48±9.28, whereas the clinical sample scored 42.89±10.02 (p<0.001). Cronbach's alpha was 0.91. Factor analysis resulted in a four-factor solution. Furthermore, both samples also had different mean scores for the other distinct content areas measured by the instrument. Conclusion: Evidence to support the reliability and validity of the Brazilian version of the Personal Experience Questionnaire was found

Editor's Choice – European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on Radiation Safety

info:eu-repo/semantics/publishedVersio

Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes

Background: Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of the METABRIC cohort suggested that MED7 may regulate lymphovascular invasion (LVI). Thus MED7 expression was assessed in large breast cancer (BC) cohorts to determine clinicopathological significance. Methods: MED7 gene expression was investigated in the METABRIC cohort (n = 1980) and externally validated using bc-GenExMiner v4.0. Immunohistochemical expression was assessed in the Nottingham primary BC series (n = 1280). Associations with clinicopathological variables and patient outcome were evaluated. Results: High MED7 mRNA and protein expression was associated with good prognostic factors: low grade, smaller tumour size, good NPI, positive hormone receptor status (p < 0.001), and negative LVI (p = 0.04) status. Higher MED7 protein expression was associated with improved BC-specific survival within the whole cohort and ER+/luminal subgroup. Pooled MED7 gene expression data in the external validation cohort confirmed association with better survival, corroborating with the protein expression. On multivariate analysis, MED7 protein was independently predictive of longer BC-specific survival in the whole cohort and Luminal A subtype (p < 0.001). Conclusions: MED7 is an important prognostic marker in BC, particularly in ER+luminal subtypes, associated with improved survival and warrants future functional analysis

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a growing number of diseases. Evidence is now emerging that, through interactions with the gut-brain axis, the bidirectional communication system between the central nervous system and the gastrointestinal tract, the gut microbiome can also influence neural development, cognition and behaviour, with recent evidence that changes in behaviour alter gut microbiota composition, while modifications of the microbiome can induce depressive-like behaviours. Although an association between enteropathy and certain psychiatric conditions has long been recognized, it now appears that gut microbes represent direct mediators of psychopathology. Here, we examine roles of gut microbiome in shaping brain development and neurological function, and the mechanisms by which it can contribute to mental illness. Further, we discuss how the insight provided by this new and exciting field of research can inform care and provide a basis for the design of novel, microbiota-targeted, therapies.GB Rogers, DJ Keating, RL Young, M-L Wong, J Licinio, and S Wesseling