This body of art: The singular plural of the feminine

I explore the possibility that the feminine, like art, can be thought in terms of Jean-Luc Nancy’s concept of the singular plural. In Les Muses, Nancy claims that art provides for the rethinking of a technë not ruled by instrumentality. Specifically, in rethinking aesthetics in terms of the debates laid out by Kant, Hegel and Heidegger, he resituates the ontological in terms of the specificity of the techniques of each particular artwork; each artwork establishes relations particular to its world or worlds. What is at stake in the singular plural is the multiplicity of relations that are lost in the unifying gestures that arise out of radical oppositions. I rethink the singular plural through a phenomenological encounter with Barb Hunt’s artwork, Antipersonnel, a collection of hand-knitted replicas of antipersonnel landmines

Cultivating Perception: Phenomenological Encounters with Artworks

Phenomenally strong artworks have the potential to anchor us in reality and to cultivate our perception. For the most part, we barely notice the world around us, as we are too often elsewhere, texting, coordinating schedules, planning ahead, navigating what needs to be done. This is the level of our age that shapes the ways we encounter things and others. In such a world it is no wonder we no longer trust our senses. But as feminists have long argued, thinking grounded in embodied experience can be more open to difference; such embodied thinking helps us to resist the colonization of a singular, only seemingly neutral, perspective that closes down living potentialities

Wherein to Catch the Conscience of the Queen: Dystopian Politics in Elizabethan Drama

Though established English history portrays Elizabeth I (1533-1603) as uniting England under the new Protestant religion, recent historical evidence reveals that extensive counter-currents still existed. This thesis examines how the politico-religious beliefs of Elizabethan and Jacobean playwrights manifest themselves in their drama, particularly through imagery and allusions. It draws especially from Frances Yates to assert that imagery of white magic, Christian Cabala, and alchemy in these dramatists’ works refers to the pure imperial reform movement of Elizabeth’s reign, and also from Clare Asquith to illuminate a reading of Shakespeare as a playwright who encoded in his plays a Catholic message and a history of the underground movement in England that presents an alternative history to the established one

The Effect of Conjugation on the Competition Between Internal Conversion and Electron Detachment: A Comparison Between Green Fluorescent and Red Kaede Protein Chromophores

Kaede, an analogue of green fluorescent protein (GFP), is a green-to-red photoconvertible fluorescent protein used as an in vivo ‘optical highlighter’ in bioimaging. The fluorescence quantum yield of the red Kaede protein is lower than that of GFP, suggesting that increasing the conjugation modifies the electronic relaxation pathway. Using a combination of anion photoelectron spectroscopy and electronic structure calculations, we find that the isolated red Kaede protein chromophore in the gas phase is deprotonated at the imidazole ring, unlike the GFP chromophore that is deprotonated at the phenol ring. We find evidence of an efficient electronic relaxation pathway from higher lying electronically excited states to the S1 state of the red Kaede chromophore that is not accessible in the GFP chromophore. Rapid autodetachment from high lying vibrational states of S1 is found to compete efficiently with internal conversion to the ground electronic state

Retrieval of Genuine Ultraviolet Liquid-Microjet Photoelectron Spectra

Ultraviolet liquid-microjet photoelectron spectroscopy is a powerful technique for the determination of electron binding energies of molecules in aqueous solution and for exploring their photochemical dynamics. However, our poor understanding of inelastic scattering of low energy electrons (<10 eV) in water has hindered the determination of accurate vertical ionization energies; although several algorithms have been implemented to retrieve genuine binding energies from experimental spectra, a consensus on the parameters employed is yet to be reached. Here, we investigate the effect of these parameters on the retrieval of true photoelectron spectra of water, phenol, and phenolate. We show that the scattering cross sections, obtained by extrapolating the cross sections in amorphous ice to zero electron kinetic energy, describe the distortion observed in our spectra accurately and that the description of the transmission of electrons at the liquid-vacuum interface is crucial to infer a value for the electron affinity of water at the surface, and we emphasize the importance of considering concentration depth profiles when retrieving true photoelectron spectra of surface-active solutes. Our work highlights the potential for accurate ultraviolet photoelectron spectroscopy of aqueous solutions of organic molecules

UV Photoelectron Spectroscopy of Aqueous Solutions

Knowledge of the electronic structure of an aqueous solution is a prerequisite to understanding its chemical and biological reactivity and its response to light. One of the most direct ways of determining electronic structure is to use photoelectron spectroscopy to measure electron binding energies. Initially, photoelectron spectroscopy was restricted to the gas or solid phases due to the requirement for high vacuum to minimize inelastic scattering of the emitted electrons. The introduction of liquid-jets and their combination with intense X-ray sources at synchrotrons in the late 1990s expanded the scope of photoelectron spectroscopy to include liquids. Liquid-jet photoelectron spectroscopy is now an active research field involving a growing number of research groups. A limitation of X-ray photoelectron spectroscopy of aqueous solutions is the requirement to use solutes with reasonably high concentrations in order to obtain photoelectron spectra with adequate signal-to-noise after subtracting the spectrum of water. This has excluded most studies of organic molecules, which tend to be only weakly soluble. A solution to this problem is to use resonance-enhanced photoelectron spectroscopy with ultraviolet (UV) light pulses (hν ≲ 6 eV). However, the development of UV liquid-jet photoelectron spectroscopy has been hampered by a lack of quantitative understanding of inelastic scattering of low kinetic energy electrons (≲5 eV) and the impact on spectral lineshapes and positions.In this Account, we describe the key steps involved in the measurement of UV photoelectron spectra of aqueous solutions: photoionization/detachment, electron transport of low kinetic energy electrons through the conduction band, transmission through the water-vacuum interface, and transport through the spectrometer. We also explain the steps we take to record accurate UV photoelectron spectra of liquids with excellent signal-to-noise. We then describe how we have combined Monte Carlo simulations of electron scattering and spectral inversion with molecular dynamics simulations of depth profiles of organic solutes in aqueous solution to develop an efficient and widely applicable method for retrieving true UV photoelectron spectra of aqueous solutions. The huge potential of our experimental and spectral retrieval methods is illustrated using three examples. The first is a measurement of the vertical detachment energy of the green fluorescent protein chromophore, a sparingly soluble organic anion whose electronic structure underpins its fluorescence and photooxidation properties. The second is a measurement of the vertical ionization energy of liquid water, which has been the subject of discussion since the first X-ray photoelectron spectroscopy measurement in 1997. The third is a UV photoelectron spectroscopy study of the vertical ionization energy of aqueous phenol which demonstrates the possibility of retrieving true photoelectron spectra from measurements with contributions from components with different concentration profiles

Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF.

BACKGROUND: In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the effect on patient and programme outcomes. METHODS: We randomly allocated 20 laboratories (clusters) in medium-burden districts of South Africa to either an Xpert (immediate Xpert) or microscopy (Xpert deferred) group (1:1), stratified by province. At two primary care clinics per laboratory, a systematic sample of adults giving sputum for tuberculosis investigation was assessed for eligibility. The primary outcome was mortality at 6 months from enrolment. Masking of participants' group allocation was not possible because of the pragmatic trial design. The trial is registered with the ISRCTN registry (ISRCTN68905568) and the South African Clinical Trial Register (DOH-27-1011-3849). FINDINGS: Between June and November, 2012, 4972 people were screened, and 4656 (93·6%) enrolled (median age 36 years; 2891 [62%] female; 2212 [62%] reported being HIV-positive). There was no difference between the Xpert and microscopy groups with respect to mortality at 6 months (91/2324 [3·9%] vs 116/2332 [5·0%], respectively; adjusted risk ratio [aRR] 1·10, 95% CI 0·75-1·62]). INTERPRETATION: Xpert did not reduce mortality at 6 months compared with sputum microscopy. Improving outcomes in drug-sensitive tuberculosis programmes might require not only better diagnostic tests but also better linkage to care. FUNDING: Bill & Melinda Gates Foundation