Sistema da Área Fiscal (SAF): manual do usuário.

Apresentação, objetivo e requisitos do software; Módulo de Sistemas: tabelas, notas fiscais, relatórios, utilitários, janelas, ajuda; Módulo Tabelas: classificação fiscal, natureza da operação, origens da mercadoria, tributações pelo ICMS, dados adicionais, destinatários/remetentes, produtos, transportadoras, Unidade da Embrapa; Cadastro de registros: inclusão, alteração, exclusão, impressão, fechamento, navegação, procura; Módulo de Notas Fiscais, Relatórios; Módulo de Utilitários: status, configurações, reparar banco de dados, backup; Módulo de Ajuda; Apêndice: atalhos do teclado.bitstream/item/116805/1/835.pd

Two-hour postload glycemia is associated to an increased risk of NAFLD in healthy subjects with family history of type 2 diabetes: a case control study

Nonalcoholic fatty liver disease (NAFLD) includes steatosis and nonalcoholic steatohepatitis (NASH), which can be complicated by cirrhosis and hepatocellular carcinoma [1]. NAFLD affects over 30 % of the general population and is associated with type 2 diabetes mellitus (T2DM), obesity and metabolic syndrome. NAFLD prevalence in T2DM patients is about 70 % using ultrasonography (US). NAFLD and T2DM share insulinresistance, which in the liver increases gluconeogenesis and glycogenolysis, resulting in hyperglycemia. The pancreatic beta islet cells adapt to hyperglycemia by increasing insulin secretion. Hyperinsulinemia upregulates several lipogenic transcription factors, promoting hepatic lipid synthesis. The association between NAFLD and T2DM seems to be the result of a “common soil”. Several studies showed that NAFLD predicts T2DM and vice versa, and that each condition may act as a progression factor for the other. There is evidence of a high risk of NASH and its progression to hepatocellular carcinoma in T2DM patients [6]. Conversely, recent studies showed that NAFLD not only predicts diabetes, but also contributes to poor glycemic control and chronic complications [8]. Despite its clear link with T2DM, the association of NAFLD with family history of diabetes has been poorly investigated. A recent cross-sectional study in nondiabetic individuals with NAFLD demonstrated that family history of diabetes increased the risk of NASH and fibrosis. The aim of this study was to evaluate the prevalence of NAFLD in healthy first degree relatives of T2DM patients (T2DM-rel) and in healthy subjects without family history of T2DM and to assess the risk factors associated with NAFLD development

The activation of KSHV lytic cycle blocks autophagy in PEL cells

This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression. In addition, we extend previous observations and show that autophagy is blocked at late steps, during viral replication. This is indicated by the lack of colocalization of autophagosomes and lysosomes and by the LC3-II level that does not increase in the presence of bafilomycin A1 in primary effusion lymphoma (PEL) cells induced to enter the lytic cycle, either by TPA/sodium butyrate (BC3 and BCBL1) or by doxycycline (TRExBCBL1-Rta). The autophagic block correlates with the downregulation of RAB7, whose silencing with specific siRNA results in an autophagic block in the same cells. Finally, by electron microscopy analysis, we observed viral particles inside autophagic vesicles in the cytoplasm of PEL cells undergoing viral replication, suggesting that they may be involved in viral transpor

Montando questionários para medir a satisfação do usuário: avaliação de interface de um sistema que utiliza técnica de recuperação de imagens por conteúdo.

O resumo intuitivo e atraente da interface com o usuário é essencial para o sucesso de qualquer sistema computacional. Dentro do escopo de sistemas CBIR (content-Based Image Retrieval), que são sistemas inerentemente interativos de recuperação de imagens baseadas em conteúdo, a interface do usuário ainda é um elemento constituído de pouca pesquisa e desenvolvimento. Um dos maiores obstáculos para a eficácia de design desses sistemas consiste da necessidade em prover aos usuários uma interface de alta qualidade na formulação de perguntas e exibição dos resultados. O objetivo principal deste trabalho visou analisar a interação do usuário em sistemas CBIR em relação à funcionalidade e usabilidade por meio da interação de usuários reais dentro do domínio da aplicação e propor questionário que reflita, fielmente os pontos avaliados. Para alcançar esse desafio, a interação humano-computador foi avaliada, adotando técnicas de questionamento a fim de mensurar a satisfação do usuário em relação ao uso do sistema

Metabolic and cardiovascular response to exercise in patients with type 1 diabetes

Physical activity is an effective therapeutic tool for cardiovascular risk prevention. However, exercise aerobic capacity of patients with type 1 diabetes (T1DM) has not been thoroughly investigated. Aim of the present study is to evaluate exercise aerobic capacity in patients with T1DM compared to a normal control population

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes

Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. Methods: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3.6 ± 0.9 years). Previous fragility fractures were recorded. The FRAX score (without BMD) was calculated and biochemical parameters (plasma glucose, HbA1c, lipid profile and renal function) were assessed. Serum 25OH-vitamin D, calcium, PTH and OPN were evaluated at baseline. The association between OPN and fracture prevalence at baseline was evaluated by a logistic model. Results: OPN levels were higher in patients with previous fractures (n.25) than in patients without previous fractures at baseline (n.39) (p = 0.006). The odds of having fractures at baseline increased by 6.7 (1.9–31.4, 95% CI, p = 0.007) for each increase of 1 ng/ml in OPN levels, after adjustment for vitamin D and HbA1c levels. Fracture incidence was 4.7%. Higher OPN associated with a decrease in HDL-cholesterol (p = 0.048), after adjustment for age, basal HDL-cholesterol, basal and follow-up HbA1c and follow-up duration. 25OH-vitamin D associated with an increase in FRAX-estimated probability of hip fracture at follow-up (p = 0.029), after adjustment for age, 25OH-vitamin D and time. Conclusions: In post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile

Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study

AIMS:Glucagon-like peptide 1 receptor agonists (GLP-1 RA) induce weight loss and reduction in adipose tissue, but the effects of GLP-1 RA on the distribution of fat deposits have been poorly investigated. METHODS: In 25 patients with type 2 diabetes (16 females and 9 males, mean age 63.5 ± 8.8 years), treated with GLP-1 RA (exenatide, n. 12; liraglutide, n.13), both before and 3 months after starting treatment, an abdominal ultrasonographic scan, with Doppler of renal arteries, and echocardiography were performed. Subcutaneous fat width (peri-umbilical and sub-xiphoid), deep fat deposits (pre-aortic, peri-renal, and epicardial), and renal resistive index (RI) were evaluated. RESULTS: GLP-1 RA induced highly significant (p < 0.001) decrease in BMI and in fat thickness at all the assessed sites, without differences between exenatide and liraglutide treatment. A slight decrease in RI (p = 0.055) was also found. The percent changes of fat thickness was different between sites (p < 0.025), and the changes in subcutaneous deposits showed no significant correlation (p = 0.064) with those of deep fat deposits. CONCLUSIONS: A short course of treatment with GLP-1 RA, besides weight loss, induces a redistribution of adipose tissue deposits, possibly contributing to a better cardiovascular risk profile in patients with type 2 diabetes mellitus

Jogos de empresas: Uma estratégia de motivação no processo de ensino e aprendizagem dos cursos de Administração

A teoria das organizações vem se desenvolvendo e sendo enriquecida pela crescente diversidade de correntes epistemológicas, entre elas a Abordagem Institucional. No entanto a capacidade de absorção do conhecimento vem tendo uma grande defasagem em relação às demandas do mercado de trabalho. O presente estudo enfatiza a aplicação da metodologia de jogos de empresas como auxiliar no processo de ensino/aprendizagem, tendo em vista o marco da Abordagem Institucional, de caráter interpretativo. A pesquisa foi feita com base nos dados de duas turmas do curso de graduação em administração, onde em uma delas foi aplicado um jogo de negócios e na outra não. Utilizando-se de análise qualitativa e quantitativa, pode-se concluir que os jogos de negócio podem ser uma metodologia muito útil na simulação da realidade, na avaliação do desempenho e no auxílio do ensino das diversas correntes da teoria das organizações.jogos de empresas, abordagem institucional, teoria das organizações, estratégia de aprendizagem e gestão empresarial.

Satélites de Monitoramento: CD-ROM para o ensino de sensoriamento remoto.

O CD-ROM Satélites de Monitoramento apresenta textos, figuras, tabelas e mapas que ilustram, a partir de uma interface de fácil acesso, os principais instrumentos de sensoriamento remoto que contribuem para o conhecimento dos diferentes aspectos da agricultura e do meio ambiente do Brasil