3D Particle Track Reconstrution in a Single Layer Cadmium-Telluride Hybrid Active Pixel Detector

In the past 20 years the search for neutrinoless double beta decay has driven many developements in all kind of detector technology. A new branch in this field are highly-pixelated semiconductor detectors - such as the CdTe-Timepix detectors. It compromises a cadmium-telluride sensor of 14 mm x 14 mm x 1 mm size with an ASIC which has 256 x 256 pixel of 55 \textmu m pixel pitch and can be used to obtain either spectroscopic or timing information in every pixel. In regular operation it can provide a 2D projection of particle trajectories; however, three dimensional trajectories are desirable for neutrinoless double beta decay and other applications. In this paper we present a method to obtain such trajectories. The method was developed and tested with simulations that assume some minor modifications to the Timepix ASIC. Also, we were able to test the method experimentally and in the best case achieved a position resolution of about 90 \textmu m with electrons of 4.4 GeV.Comment: 10 pages, 15 figure

Down-regulation of serotonergic genes expression in the raphe nuclei of midbrain under chronic social defeat stress in male mice

Background: 
There is ample experimental evidence supporting the hypothesis that the brain serotonergic system is involved in the control of chronic social defeat stress (CSDS), depression and anxiety. The study aimed to analyze mRNA levels of the serotonergic genes in the raphe nuclei of the midbrain that may be associated with chronic social defeats consistently shown by male mice in special experimental settings. 

Methodology/Principal Findings: 
The serotonergic genes were the Tph2, Sert, Maoa and Htr1a. The Bdnf, Creb, Cphn, Gapdh, Hprt, B2M, 18S and Actb genes were also studied. The experimental groups were composed of male mice with experience of defeats in 21 daily encounters and male mice with the same track record of defeats followed by a no-defeat period without agonistic interactions (relative rest for 14 days). It has been shown that mRNA levels of the Tph2, Maoa, Sert, Htr1a, Bdnf and Creb genes in the raphe nuclei of defeated mice are decreased as compared with the controls. Under CSDS the Cphn, Gapdh, Hprt, B2M, 18S, Actb genes are also down-regulated. The expression of the serotonergic genes as well as the Cphn and Creb genes is not restored to the control level after the 2 weeks of relative rest. mRNA levels of other genes are not recovered to the control levels, although some up-regulation was observed in rested losers. Significant positive correlations were found between the total time of avoidance behavior demonstrated by the 21-day defeaters in agonistic interactions and Sert, Maoa, Bdnf, Gapdh and 18S mRNA levels. 

Conclusions: 
CSDS experience inducing the development of mixed anxious/depression-like state in male mice down-regulates the serotonergic genes expression associated with the synthesis, inactivation and reception of serotonin. The Bdnf and Creb genes as well as the cell and metabolic Cphn, Gapdh, Hprt, B2M, Actb and 18S genes in the midbrain raphe nuclei are also down-regulated under CSDS. Period of relative rest is not enough for most genes to recover expression to the control levels

Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice

The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions. Groups of animals that had the same winning and losing track record followed by a no-fight period for 14 days were also studied. Snca mRNA levels were increased in the raphe nuclei in the losers and in the VTA of the winners. After fighting deprivation Snca mRNA levels were decreased to the control level in both groups. Snca mRNA levels were similar to the control level in the VTA of the losers and in the raphe nuclei of the winners. However Snca gene expression was increased in these areas after no-fight period in the winners and losers in comparison with respective mRNA levels in the undeprived animals. Significant positive correlations were found between the mRNA levels of Snca and Bdnf genes in the raphe nuclei. It was concluded, that social experience affects Snca gene expression depending on brain areas and functional activity of monoaminergic systems in chronically victorious or defeated mice

Теоретичні основи попередження суїциду серед засуджених жінок

Філіпенко, Н. Є. Теоретичні основи попередження суїциду серед засуджених жінок / Н. Є. Філіпенко // Вісник Кримінологічної асоціації України. - 2013. - № 4. - С. 180-183.Виконано аналіз концептуальних засад, поглядів та ідей щодо розуміння сутності попередження суїциду серед засуджених жінок, визначення його основоположних засад та функціональних напрямків, а також встановлено специфіку попередження суїциду серед засуджених жінок відносно протидії та запобігання злочинності у цілому.The analysis of the conceptual foundations, views and ideas for understanding the counteraction crime official, determination of its fundamental bases and functional areas is made; also it was established specificity of prevention crime official to the general framework of opposition and prevention crime.Выполнен анализ концептуальных основ, взглядов и идей относительно понимания сущности предупреждения суицида среди осужденных женщин, определение его основных устоев и функциональных направлений, а также установлено специфику предупреждения суицида среди осужденных женщин относительно противодействия и предотвращения преступности в целом

Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice

Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been allowed to fight for 14 days. This experiment demonstrated increased Th, Dat1 and Snca but not Bdnf mRNA levels in the former group as compared to the controls. In the latter group, the expression of the Th and Dat1 genes was still enhanced, while the level of Snca mRNA did not differ from that in the controls. These findings suggest that positive fighting experience enhances the expression of the genes concerned with dopaminergic systems and this enhanced expression is preserved for a long time afterwards. Significant positive correlations were found between the level of aggression and Th and Snca mRNA levels in the winners

Three dimensional photograph of single electron tracks through a scintillator

The reconstruction of particle trajectories makes it possible to distinguish between different types of charged particles. In high-energy physics, where trajectories are rather long, large size trackers must be used to achieve sufficient position resolution. However, in low-background experiments tracks are rather short and three dimensional trajectories could only be resolved in time-projection chambers so far. For detectors of large volume and therefore large drift distances, which are inevitable for low-background experiments, this technique is limited by diffusion of charge carriers. In this work we present a "proof-of-principle" experiment for a new method for the three dimensional tracking of charged particles by scintillation light: We used a setup consisting of a scintillator, mirrors, lenses and a novel imaging device (the hybrid photo detector) in order to image two projections of electron tracks through the scintillator. We took data at the T-24 beam-line at DESY with relativistic electrons with a kinetic energy of 5 GeV and from this data successfully reconstructed their three dimensional propagetion path in the scintillator. With our setup we achieved a position resolution of about 28 mum in the best case.Comment: 9 pages, 13 figures, 1 tabl

Scalability study of solid xenon

We report a demonstration of the scalability of optically transparent xenon in the solid phase for use as a particle detector above a kilogram scale. We employed a cryostat cooled by liquid nitrogen combined with a xenon purification and chiller system. A modified {\it Bridgeman's technique} reproduces a large scale optically transparent solid xenon.Comment: arXiv admin note: substantial text overlap with arXiv:1410.649

A novel concept for the manufacture of individual sapphire-metallic hip joint endoprostheses.

At the present time, artificial joints made with metallic, ceramic, metal-polymeric or ceramicpolymeric friction pairs substituting for the natural biomechanic articulations "head of the hip joint-acetabulum" are widely used for endoprosthetic operations on hip joints. Experience gained in the course of more than 2000 operations has shown that along with the advantageous properties of modern endoprosthetic constructions made of metal, ceramics and polymers, they have certain drawbacks. Among them are insufficient biological inertness and susceptibility to excessive wear of the friction pair components. In addition, as a result of wear of the hinge friction pair, toxic and oncologically dangerous products of degradation accumulate in the different organs and tissues. This in turn results in severe complications and demands correspondingly complicated corrective intervention, often leading to worse disability than that which the original operation was designed to cure. The aim of the study reported here was the development and clinical validation of a highly effective and long-lived hip joint endoprosthesis with a sapphire head whose wear capacity is superior to all others. The endoprosthesis consists of a metallic pedicle, a dismountable articulation (metallic necklayer of supramolecular polyethylene-sapphire head) and an acetabular cup. The endoprostheses with the sapphire head proved themselves positively in clinical trials and are considered to be highly promising for future applications