Multi-Retranslation Corpora: Visibility, Variation, Value, and Virtue

Variation among human translations is usually invisible, little understood, and under-valued. Previous statistical research finds that translations vary most where the source items are most semantically significant or express most ‘attitude’ (affect, evaluation, ideology). Understanding how and why translations vary is important for translator training and translation quality assessment, for cultural research, and for machine translation development. Our experimental project began with the intuition that quantitative variation in a corpus of historical retranslations might be used to project quasi-qualitative annotations onto the translated text. We present a web-based system which enables users to create parallel, segment-aligned multi-version corpora, and provides visual interfaces for exploring multiple translations, with their variation projected onto a base text. The system can support any corpus of variant versions. We report experiments using our tools (and stylometric analysis) to investigate a corpus of 40 German versions of a work by Shakespeare. Initial findings lead to more questions than answers

Evaluation of An Oral Health Education Session for Early Head Start Home Visitors

Objectives Home visiting programs promote the education and health of Early Head Start (EHS) children and pregnant women. However, EHS\u27s oral health component is unevenly implemented. We conducted an educational intervention to improve oral health knowledge and motivational interviewing techniques among Wisconsin EHS home visitors. Methods A questionnaire assessing oral health-related knowledge and confidence was administered to home visitors before and after an educational session. Changes between pre/post-responses were analyzed with McNemar\u27s test and Wilcoxon Signed Rank test. Results After the intervention there were increases in both knowledge and confidence related to oral health communication. Knowledge increases were observed in such topics as fluoridation, dental caries, and caregivers’ role in assisting and supervising children\u27s tooth brushing. Conclusions A brief educational intervention was associated with increased home visitor knowledge and confidence in communicating oral health messages to EHS caregivers and pregnant women

Multi-Retranslation Corpora: Visibility, Variation, Value, and Virtue

Variation among human translations is usually invisible, little understood, and under-valued. Previous statistical research finds that translations vary most where the source items are most semantically significant or express most ‘attitude’ (affect, evaluation, ideology). Understanding how and why translations vary is important for translator training and translation quality assessment, for cultural research, and for machine translation development. Our experimental project began with the intuition that quantitative variation in a corpus of historical retranslations might be used to project quasi-qualitative annotations onto the translated text. We present a web-based system which enables users to create parallel, segment-aligned multi-version corpora, and provides visual interfaces for exploring multiple translations, with their variation projected onto a base text. The system can support any corpus of variant versions. We report experiments using our tools (and stylometric analysis) to investigate a corpus of 40 German versions of a work by Shakespeare. Initial findings lead to more questions than answers

Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype

Tumorigenesis results from the convergence of cell autonomous mutations and corresponding stromal changes that promote tumor cell growth. Mutations and stromal changes both accumulate with age and together account for the dramatic increase in cancer incidence with age. One change that occurs with age is the accumulation of stromal senescent cells. Senescent stromal cells secrete pro-tumorigenic factors collectively termed the senescence-associated secretory phenotype (SASP). The SASP impacts every stage of tumorigenesis and is a promising therapeutic target. As such, it is important to understand how the SASP is regulated. Many but not all SASP factors are regulated transcriptionally by NF-kB and its upstream activator p38MAPK. However, many pro-tumorigenic SASP factors, including osteopontin (OPN), are not dependent on NF-κB or other canonical SASP regulators such as ATM, leaving the regulation of these factors an open question. Here, I report that the transcription factor c-Myb regulates OPN, IL-6, IL-8 and other SASP factors. The regulation of OPN is direct as c-Myb binds to the OPN promoter in senescent cells, and this binding is required for promoter activation. Further, OPN is also regulated by the known SASP regulator C/EBPβ. In response to senescence, the full-length activating C/EBPβ isoform LAP2 increases binding to the OPN, IL-6, and IL-8 promoters. Using a microarray and RNAi approach, we identified 57 additional putative c-Myb-dependent SASP factors and 125 additional putative C/EBPβ SASP factors. There is a high degree of overlap between c-Myb- and C/EBPβ-dependent factors. The importance of both c-Myb and C/EBPβ is underscored by our finding that the depletion of either factor reduces the ability of senescent fibroblasts to promote the growth of preneoplastic epithelial cells. Furthermore, I describe a post-transcriptional SASP mRNA stability regulator pathway. This pathway is dependent on p38MAPK, but is distinct from p38MAPK’s role in NF-κB transcription of SASP factors. In fully senescent fibroblasts, p38MAPK regulates the removal of mRNA-destabilizing protein AUF1 from the 3’-UTRs of numerous SASP factor mRNAs, resulting in increased mRNA stability. Given p38MAPK’s role in both transcriptional and post-transcriptional regulation of the SASP, we tested the ability of p38MAPK inhibitors to inhibit tumor growth. Treatment of mice with an orallyadministered p38MAPK inhibitor significantly decreased tumor growth in senescent fibroblast-supported xenograft models. Importantly, p38MAPK inhibition acts upon the microenvironment by removing stromal support of tumor growth. Interestingly, p38MAPK inhibition also inhibits the tumor promoting activities of cancer-associated fibroblasts (CAFs). CAFs have a secretory profile similar to senescent fibroblasts. This work indicates that p38MAPK inhibition is a viable therapeutic for targeting both senescent fibroblast and CAF stromal support of tumor cell growth

The filmic fugue of Ken Russell’s Pop Goes the Easel

First broadcast as an episode of BBC Television’s Monitor in 1962, Ken Russell’s documentary film Pop Goes the Easel profiles four young artists: Pauline Boty, Peter Phillips, Derek Boshier and Peter Blake. With an exuberant and richly varied approach to filming, Pop Goes the Easel is a rich and revealing document of early Pop Art in London. This article situates the film within the context of television’s engagement with the visual arts in the medium’s first 25 years. It is argued that part of its significance within the tradition of the visual arts on television is its resistance to the determinations of an explanatory voice. Also, that its achievement combines and develops approaches of photojournalism, documentary and art cinema from the mid- and late 1950s. It is further proposed that Pop Goes the Easel is especially note-worthy for its finely-balanced tensions between discourses traditionally understood as oppositional: the stasis of artworks versus the linear narrative of film; the indexical qualities of documentary versus the inventions of fiction; the mass-produced elements and images of popular culture versus the individual authorship and authority of high art; the abstracted rationality of critical discourse versus explosions of embodied sensuality; and the determinations and closure of a singular meaning versus polysemous openness

Binary-induced collapse of a compact, collisionless cluster

We improve and extend Shapiro's model of a relativistic, compact object which is stable in isolation but is driven dynamically unstable by the tidal field of a binary companion. Our compact object consists of a dense swarm of test particles moving in randomly-oriented, initially circular, relativistic orbits about a nonrotating black hole. The binary companion is a distant, slowly inspiraling point mass. The tidal field of the companion is treated as a small perturbation on the background Schwarzschild geometry near the hole; the resulting metric is determined by solving the perturbation equations of Regge and Wheeler and Zerilli in the quasi-static limit. The perturbed spacetime supports Bekenstein's conjecture that the horizon area of a near-equilibrium black hole is an adiabatic invariant. We follow the evolution of the system and confirm that gravitational collapse can be induced in a compact collisionless cluster by the tidal field of a binary companion.Comment: 9 Latex pages, 14 postscript figure