Shaping Nuclear Waste Policy at the Juncture of Federal and State Law

Nuclear waste has long been the Achilles’ heel of the civilian nuclear power industry. The spent nuclear fuel that reactors generate remains radioactive for hundreds of thousands of years, however, all the spent fuel that has been generated to date is stored in temporary, short-term facilities. As the federal government struggles to develop a permanent solution, many temporary storage facilities are nearing capacity. A few states in which civilian reactors are located have placed severe constraints on the construction of additional needed storage, potentially causing the shutdown of the federally-licensed reactors. In part because of this pressure from the states, Congress has sought to create a federal, centralized interim storage facility while development of a permanent repository proceeds. This controversial effort has yet to succeed. This note will suggest that a new approach to the interim storage problem is necessary—one that involves granting the federal government exclusive authority over nuclear waste storage facilities

Socio-Ecological Vulnerability and Resilience in an Arena of Rapid Environmental Change: Community Adaptation to Climate Variability in the Upper Zambezi Floodplain

近年、食料、水、繊維、エネルギーの需要拡大を満たすため、人々はいまだかつてない供給を生態システムから求めるようになった。これらの需要は生態系のバランスに圧力を与え、自然環境が許容量を取り戻す能力を減少させ、大気・水の浄化作用、廃棄物の処理、アメニティ等の生態系サービスを供与する能力を弱体化させた。社会経済開発と環境持続可能性との間に明らかな緊張関係が存在している。生態系の財とサービスの減少を引き起こした直接的な原因は、生息地の変化、外来種の侵入、過度の収奪、汚染や気候変動と変化などである。これらのプロセスは社会生態的レジリアンス喪失の脅威を与え、環境と社会経済変化の双方に対する感受性を高める。本報告では、社会経済の脆弱性とレジリアンスを検討する科学的方法、特にこれら広範囲の問題に対する学際的アプローチについて議論する。また、脆弱性に対する社会経済レジリアンスと適応の本質を分析する。レジリアンスに影響を与えている政治経済、社会文化的ネットワークとダイナミズムについて歴史的、現代的生産の文脈の中で議論することによって説明される。経済活動と「河川文明」を擁する人間の居住地域である氾濫原生態システムを研究の対象とする。事例として現在生物物理的、社会経済的変化を示しているザンビア西部ザンベジ河上流渓谷のBulozi「自然」氾濫原に焦点を当てる。この氾濫原は現在のLozi民の祖先が居住し、彼らは生態財とサービスを氾濫原から得、強力で活気に満ちた政治経済を生み出してこの地域を独占し、余剰食料を使うことができ、また軍を擁し経済的機会を享受した。今日、Bulozi は低開発の地域とされており、この状況は気候の変動によって悪化しているが、気候変動は長い年月の間に社会的に蓄積された脆弱性に対しては追加の要因となるのみである。本報告ではBulozi の脆弱性の原因とレジリアンスを高めるための適応的能力を議論する。人々が外的内的圧力に対して適応し、社会生態システム(SES)のバランスを維持する能力は、彼らが在地的「所有」の立場から問題に対処する能力に依存している。同時に、社会生態システム(SES)のバランスを保全しながら、生活水準を向上する機運、コントロール、動機の感覚を社会が再び取り戻すことは、現在の生産行為を修正し、生産活動を多様化する彼らの能力に依存している。People have made unprecedented demands on ecosystems in recent decades to meet growing demands for food, water, fibre and energy. These demands have placed pressure on ecosystem balances, depleted the ability of the natural environment to replace biocapacity consumed and weakened the capacity to deliver ecosystem services such as purification of air and water, waste disposal and aesthetically pleasing environments. There is an apparent tension between the aspirations of social and economic development and environmental sustainability.Direct drivers of change that engender a reduction in ecosystem goods and services include habitat change, invasive species, over exploitation, pollution and, climate variability and change. These processes threaten to diminish socio-ecological resilience and heighten sensitivity to both environmental and socio-economic change.This paper seeks to discuss the scientific ways in which socio-ecological vulnerability and resilience can be examined, in particular the inter disciplinarity of approach necessary to address these wide ranging issues. It will also analyse the nature of socio-ecological resilience and adaptation to vulnerability. This is contextualised in a discussion covering the historical and contemporary production of politico-economic and socio-cultural dynamics affecting resilience.The study considers floodplain ecosystems, sites of human settlement, productivity and the appearance of ‘hydraulic civilisations’. An example discussed here is the Bulozi ‘natural’ floodplain of the Upper Zambezi Valley in western Zambia, currently exhibiting biophysical and socio-economic change. This floodplain was populated by the ancestors of the present Lozi peoples who, using the ecological goods and services offered by the plain, produced a strong and vibrant politicoeconomy that became dominant in the region, using surplus food with which to specialise, raise an army and take advantage of economic opportunities. Today Bulozi is an arena of relative underdevelopment and this condition may become exacerbated by increasing climate dynamics, but these act only as additional stressors to socially created vulnerabilities that became entrenched over time. The paper identifies the production of vulnerability in Bulozi and the adaptive capacity required to increase resilience.It also discusses recent activities in the domain of community adaptation to climate change and concludes that people’s capacity to adapt to exogenous and endogenous pressures and maintain the integrity of the socio-ecological system (SES) depends much on their ability to engage with stressors from a position of autochthonous ‘ownership’. It depends also on their ability to access new capabilities and diversify productive activities so that society can regain a sense of momentum, control and motivation to enhance living standards whilst conserving the integrity of the SES

Microbial Monitoring from the Frontlines to Space: Department of Defense Small Business Innovation Research Technology Aboard the International Space Station

The RAZOR (trademark) EX, a quantitative Polymerase Chain Reaction (qPCR) instrument, is a portable, ruggedized unit that was designed for the Department of Defense (DoD) with its reagent chemistries traceable to a Small Business Innovation Research (SBIR) contract beginning in 2002. The PCR instrument's primary function post 9/11 was to enable frontline soldiers and first responders to detect biological threat agents and bioterrorism activities in remote locations to include field environments. With its success for DoD, the instrument has also been employed by other governmental agencies including Department of Homeland Security (DHS). The RAZOR (Trademark) EX underwent stringent testing by the vendor, as well as through the DoD, and was certified in 2005. In addition, the RAZOR (trademark) EX passed DHS security sponsored Stakeholder Panel on Agent Detection Assays (SPADA) rigorous evaluation in 2011. The identification and quantitation of microbial pathogens is necessary both on the ground as well as during spaceflight to maintain the health of astronauts and to prevent biofouling of equipment. Currently, culture-based monitoring technology has been adequate for short-term spaceflight missions but may not be robust enough to meet the requirements for long-duration missions. During a NASA-sponsored workshop in 2011, it was determined that the more traditional culture-based method should be replaced or supplemented with more robust technologies. NASA scientists began investigating innovative molecular technologies for future space exploration and as a result, PCR was recommended. Shortly after, NASA sponsored market research in 2012 to identify and review current, commercial, cutting edge PCR technologies for potential applicability to spaceflight operations. Scientists identified and extensively evaluated three candidate technologies with the potential to function in microgravity. After a thorough voice-of-the-customer trade study and extensive functional and safety evaluations, the RAZOR (trademark) EX PCR instrument(Bio-Fire Defense, Salt Lake City, UT) was selected as the most promising current technology for spaceflight monitoring applications

Plasmas and Controlled Nuclear Fusion

Contains reports on eleven research projects split into three section.U. S. Atomic Energy Commission (Contract AT(30-1)-3980

Plasmas and Controlled Nuclear Fusion

Contains research objectives and reports on four research projects.U. S. Atomic Energy Commission (Contract AT(30-1)-3980)U. S. Atomic Energy Commission (GK-2581

Risk analysis for smart homes and domestic robots using robust shape and physics descriptors, and complex boosting techniques

In this paper, the notion of risk analysis within 3D scenes using vision based techniques is introduced. In particular the problem of risk estimation of indoor environments at the scene and object level is considered, with applications in domestic robots and smart homes. To this end, the proposed Risk Estimation Framework is described, which provides a quantified risk score for a given scene. This methodology is extended with the introduction of a novel robust kernel for 3D shape descriptors such as 3D HOG and SIFT3D, which aims to reduce the effects of outliers in the proposed risk recognition methodology. The Physics Behaviour Feature (PBF) is presented, which uses an object's angular velocity obtained using Newtonian physics simulation as a descriptor. Furthermore, an extension of boosting techniques for learning is suggested in the form of the novel Complex and Hyper-Complex Adaboost, which greatly increase the computation efficiency of the original technique. In order to evaluate the proposed robust descriptors an enriched version of the 3D Risk Scenes (3DRS) dataset with extra objects, scenes and meta-data was utilised. A comparative study was conducted demonstrating that the suggested approach outperforms current state-of-the-art descriptors

Challenge Demcare: management of challenging behaviour in dementia at home and in care homes:Development, evaluation and implementation of an online individualised intervention for care homes; and a cohort study of specialist community mental health care for families

Background: Dementia with challenging behaviour (CB) causes significant distress for caregivers and the person with dementia. It is associated with breakdown of care at home and disruption in care homes. Challenge Demcare aimed to assist care home staff and mental health practitioners who support families at home to respond effectively to CB. Objectives: To study the management of CB in care homes (ResCare) and in family care (FamCare). Following a conceptual overview, two systematic reviews and scrutiny of clinical guidelines, we (1) developed and tested a computerised intervention; (2) conducted a cluster randomised trial (CRT) of the intervention for dementia with CB in care homes; (3) conducted a process evaluation of implementation of the intervention; and (4) conducted a longitudinal observational cohort study of the management of people with dementia with CB living at home, and their carers. Review methods: Cochrane review of randomised controlled trials; systematic meta-ethnographic review of quantitative and qualitative studies. Design: ResCare – survey, CRT, process evaluation and stakeholder consultations. FamCare – survey, longitudinal cohort study, participatory development design process and stakeholder consultations. Comparative examination of baseline levels of CB in the ResCare trial and the FamCare study participants. Settings: ResCare – 63 care homes in Yorkshire. FamCare – 33 community mental health teams for older people (CMHTsOP) in seven NHS organisations across England. Participants: ResCare – 2386 residents and 861 staff screened for eligibility; 555 residents with dementia and CB; 277 ‘other’ residents; 632 care staff; and 92 staff champions. FamCare – every new referral (n = 5360) reviewed for eligibility; 157 patients with dementia and CB, with their carer; and 26 mental health practitioners. Stakeholder consultations – initial workshops with 83 practitioners and managers from participating organisations; and 70 additional stakeholders using eight group discussions and nine individual interviews. Intervention: An online application for case-specific action plans to reduce CB in dementia, consisting of e-learning and bespoke decision support care home and family care e-tools. Main outcome measures: ResCare – survey with the Challenging Behaviour Scale; measurement of CB with the Neuropsychiatric Inventory (NPI) and medications taken from prescriptions; implementation with thematic views from participants and stakeholders. FamCare – case identification from all referrals to CMHTsOP; measurement of CB with the Revised Memory and Behaviour Problems Checklist and NPI; medications taken from prescriptions; and thematic views from stakeholders. Costs of care calculated for both settings. Comparison of the ResCare trial and FamCare study participants used the NPI, Clinical Dementia Rating and prescribed medications. Results: ResCare – training with group discussion and decision support for individualised interventions did not change practice enough to have an impact on CB in dementia. Worksite e-learning opportunities were not readily taken up by care home staff. Smaller homes with a less hierarchical management appear more ready than others to engage in innovation. FamCare – home-dwelling people with dementia and CB are referred to specialist NHS services, but treatment over 6 months, averaging nine contacts per family, had no overall impact on CB. Over 60% of people with CB had mild dementia. Families bear the majority of the care costs of dementia with CB. A care gap in the delivery of post-diagnostic help for families supporting relatives with dementia and significant CB at home has emerged. Higher levels of CB were recorded in family settings; and prescribing practices were suboptimal in both care home and family settings. Limitations: Functionality of the software was unreliable, resulting in delays. This compromised the feasibility studies and undermined delivery of the intervention in care homes. A planned FamCare CRT could not proceed because of insufficient referrals. Conclusions: A Cochrane review of individualised functional analysis-based interventions suggests that these show promise, although delivery requires a trained dementia care workforce. Like many staff training interventions, our interactive e-learning course was well received by staff when delivered in groups with facilitated discussion. Our e-learning and decision support e-tool intervention in care homes, in its current form, without ongoing review of implementation of recommended action plans, is not effective at reducing CB when compared with usual care. This may also be true for staff training in general. A shift in priorities from early diagnosis to early recognition of dementia with clinically significant CB could bridge the emerging gap and inequities of care to families. Formalised service improvements in the NHS, to co-ordinate such interventions, may stimulate better opportunities for practice models and pathways. Separate services for care homes and family care may enhance the efficiency of delivery and the quality of research on implementation into routine care. Future work: There is scope for extending functional analysis-based interventions with communication and interaction training for carers. Our clinical workbooks, video material of real-life episodes of CB and process evaluation tool resources require further testing. There is an urgent need for evaluation of interventions for home-dwelling people with dementia with clinically significant CB, delivered by trained dementia practitioners. Realist evaluation designs may illuminate how the intervention might work, and for whom, within varying service contexts

Relationship between adenovirus DNA replication proteins and nucleolar proteins B23.1 and B23.2

Adenovirus infection subverts nucleolar structure and function. B23 is a nucleolar protein present in two isoforms (B23.1 and B23.2) and both isoforms have been identified as stimulatory factors for adenovirus DNA replication. Here, it is demonstrated that the two isoforms of B23, B23.1 and B23.2, interact and co-localize differently with viral DNA replication proteins pTP and DBP in adenovirus-infected cells. Thus, the mechanism by which the two proteins stimulate viral DNA replication is likely to differ. These data also demonstrate the importance of testing both isoforms of B23 for interactions with viral proteins and nucleic acids

Education in adult basic life support training programs

The Panel on Educational Issues in Adult Basic Life Support Training Programs reviewed the characteristics of adult learners, aspects of educational theory, issues concerning barriers to learning and performing CPR, and issues concerning testing and evaluation.The panel made the following recommendations: a comprehensive evaluation of the basic life support program with the goal of improving the program design and educational tools must be initiated; adult programs must be designed to motivate laypersons to become trained in CPR, as well as to target relatives and friends of high-risk individuals; and emotional and attitudinal issues, including the student's reluctance to act in an emergency, must be addressed. Programs must incorporate information on the willingness of an individual to perform CPR; CPR programs must be simplified and focus on critical success factors; flexible educational approaches in programs are encouraged; flexible programming that addresses the needs of the allied health professional is encouraged; formal testing should be eliminated for layperson programs; and formal testing for health care providers and instructors should be continued.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30976/1/0000649.pd