Memantine for prevention of migraine: a retrospective study of 60 cases.

The objective was to retrospectively characterise the efficacy of memantine as preventive therapy in a series of patients with frequent migraine. Patients in a university headache clinic completed a survey regarding their experience with memantine, and medical records were reviewed. All patients who received memantine as preventive therapy for migraine over a 15-month period were mailed surveys and consent forms for record review. Patients were treated with memantine beginning at a dose of 5 mg/day, increasing if needed by 5 mg/week up to 10 mg twice a day. The majority of patients (36 out of 54) treated with memantine for at least 2 months reported a significant reduction in estimated headache frequency, and improved function. Side effects were uncommon and generally mild. This limited retrospective case review suggests that memantine may be an effective preventive therapy for patients with frequent migraine. A prospective trial is warranted

Depinning of a superfluid vortex line by Kelvin waves

We measure the interaction of a single superfluid vortex with surface irregularities. While vortex pinning in superconductors usually becomes weaker at higher temperatures, we find the opposite behavior. The pinning steadily increases throughout our measurement range, from 0.15Tc to over 0.5Tc. We also find that moving the other end of the vortex decreases the pinning, so we propose Kelvin waves along the vortex as a depinning mechanism.Comment: 5 figures; substantial revision including 2 new figure

USA – Why US electric deregulation could stall

Letter from America by Edward L. Flippen (a partner with McGuire Woods LLP in Richmond, Virginia and an adjunct professor of law at the College of William and Mary, Washington and Lee University, and the University of Richmond) discussing the deregulation of the electric utility in states such as California and Virginia and impact on prices. Published in the Letter from … section of Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

The Energy Policy Act of 2005: a missed opportunity

Commentary by Edward L Flippen (Partner, McGuire Woods LLP, Richmond, Virgina; Lecturer in Law at the University of Virginia School of Law; Honorary Senior Research Fellow at the University College London Faculty of Laws) on the United States energy policy legislation of 2005. Published in Amicus Curiae – Journal of the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies. The Journal is produced by SALS at the IALS (Institute of Advanced Legal Studies, School of Advanced Study, University of London)

The Role of public utility regulation: oversight or onsite?

Brief commentary by Edward L. Flippen (Partner, McGuireWoods LLP; Lecturer in law, University of Virginia Law School; Distinguished Senior Fellow, George Mason University School of Law) on regulation in the United States of public utilities such as electric and gas utilities. Published in Amicus Curiae – Journal of the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies. The Journal is produced by SALS at the IALS (Institute of Advanced Legal Studies, School of Advanced Study, University of London)

Engineering robust polar chiral clathrate crystals

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Royal Society of Chemistry 2013.The R-(+)-enantiomeric form of Dianin's compound and the S-(+)-enantiomeric form of its direct thiachroman analogue both obtained chromatographically employing a cellulose tris(3,5-dimethylphenylcarbamate) column, are shown to undergo supramolecular assembly to form a polar clathrate lattice which is stable even in the absence of a consolidating guest component

Paying the price for more power

Article by Edward L. Flippen (Attorney and adjunct professor of law at the Marshall-Wythe School of Law, at the College of William and Mary) looking at the need for US energy policy to turn to time-sensitive pricing in order to help balance electricity demand and supply. Published in Amicus Curiae - Journal of the Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

America – What the US needs is a new electric meter

Letter from America from Edward L. Flippen (Attorney at Law, McGuire Woods LLP, Richmond, Virginia and a visiting professor of law at George Mason University School of Law – discussing President George W. Bush’s plans to develop a national energy policy and its likely effect on consumers and the electrical utilities in the United States. Published in the Letter from … section of Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

US electric deregulation: still critically important

Comment on the merits and prospects of electric utilities deregulation in the United States, with reference to similar action in Australia and the United Kingdom. Article by Mr Edward L. Flippen (a partner with McGuire Woods LLP and a visiting professor of law at George Mason University School of Law). Published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London