The Clustering Of Galaxies Around Radio-Loud AGNs

We examine the hypothesis that mergers and close encounters between galaxies can fuel AGNs by increasing the rate at which gas accretes towards the central black hole. We compare the clustering of galaxies around radio-loud AGNs with the clustering around a population of radio-quiet galaxies with similar masses, colors and luminosities. Our catalog contains 2178 elliptical radio galaxies with flux densities greater than 2.8 mJy at 1.4 GHz from the 6dFGS survey. We find that radio AGNs with more than 200 times the median radio power have, on average, more close (r<160 kpc) companions than their radio-quiet counterparts, suggestive that mergers play a role in forming the most powerful radio galaxies. For ellipticals of fixed stellar mass, the radio power is not a function of large-scale environment nor halo mass, consistent with the radio powers of ellipticals varying by orders of magnitude over billions of years.Comment: 12 pages, 6 figure

TCP throughput guarantee in the DiffServ Assured Forwarding service: what about the results?

Since the proposition of Quality of Service architectures by the IETF, the interaction between TCP and the QoS services has been intensively studied. This paper proposes to look forward to the results obtained in terms of TCP throughput guarantee in the DiffServ Assured Forwarding (DiffServ/AF) service and to present an overview of the different proposals to solve the problem. It has been demonstrated that the standardized IETF DiffServ conditioners such as the token bucket color marker and the time sliding window color maker were not good TCP traffic descriptors. Starting with this point, several propositions have been made and most of them presents new marking schemes in order to replace or improve the traditional token bucket color marker. The main problem is that TCP congestion control is not designed to work with the AF service. Indeed, both mechanisms are antagonists. TCP has the property to share in a fair manner the bottleneck bandwidth between flows while DiffServ network provides a level of service controllable and predictable. In this paper, we build a classification of all the propositions made during these last years and compare them. As a result, we will see that these conditioning schemes can be separated in three sets of action level and that the conditioning at the network edge level is the most accepted one. We conclude that the problem is still unsolved and that TCP, conditioned or not conditioned, remains inappropriate to the DiffServ/AF service

Formalizing Size-Optimal Sorting Networks: Extracting a Certified Proof Checker

Since the proof of the four color theorem in 1976, computer-generated proofs have become a reality in mathematics and computer science. During the last decade, we have seen formal proofs using verified proof assistants being used to verify the validity of such proofs. In this paper, we describe a formalized theory of size-optimal sorting networks. From this formalization we extract a certified checker that successfully verifies computer-generated proofs of optimality on up to 8 inputs. The checker relies on an untrusted oracle to shortcut the search for witnesses on more than 1.6 million NP-complete subproblems.Comment: IMADA-preprint-c

Tidal interactions at the edge of the Local Group: New evidence for tidal features in the Antlia Dwarf Galaxy

Using deep B band imaging down to mu_{B} = 26 mag arcsec^{-2}, we present evidence for tidal tails in the Antlia Dwarf galaxy, one of the most distant members of the Local Group. This elongation is in the direction of Antlia's nearest neighbor, the Magellanic-type NGC 3109. The tail is offset by less than 10 degrees from a vector linking the centers of the two galaxies, indicative of interactions between the pair. Combined with the warped disc previously identified in NGC 3109, Antlia and NGC 3109 must be at a small separation for tidal features to be present in Antlia. We calculate that Antlia cannot be completely disrupted by NGC 3109 in a single interaction unless its orbit pericenter is less than 6 kpc, however multiple interactions could significantly alter its morphology. Therefore despite being located right at the edge of the Local Group, environmental effects are playing an important role in Antlia's evolution.Comment: 8 pages, 4 figures, accepted for publication in ApJ

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes

Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and β cell dysfunction. We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin. CE stabilize the ER-associated protein degradation (ERAD) system and promote misfolded proinsulin proteasomal degradation. This involves activation of nuclear and membrane estrogen receptor-α (ERα), promoting transcriptional repression and proteasomal degradation of the ubiquitin-conjugating enzyme and ERAD degrader, UBC6e. The selective ERα modulator bazedoxifene mimics CE protection of β cells in females but not in males. : Estrogens prevent diabetes in women, but the mechanism is poorly understood. Xu et al. report that estrogens activate the endoplasmic-reticulum-associated protein degradation pathway, which promotes misfolded proinsulin degradation, suppresses endoplasmic reticulum stress, and protects insulin secretion in mice and in human pancreatic β cells. Keywords: estrogens, beta cell, islet, endoplasmic reticulum stress, proinsulin misfolding, diabetes, bazedoxifene, sex dimorphism, ERAD, SER

Symmetries of the Dirac operators associated with covariantly constant Killing-Yano tensors

The continuous and discrete symmetries of the Dirac-type operators produced by particular Killing-Yano tensors are studied in manifolds of arbitrary dimensions. The Killing-Yano tensors considered are covariantly constant and realize certain square roots of the metric tensor. Such a Killing-Yano tensor produces simultaneously a Dirac-type operator and the generator of a one-parameter Lie group connecting this operator with the standard Dirac one. The Dirac operators are related among themselves through continuous or discrete transformations. It is shown that the groups of the continuous symmetry can be only U(1) and SU(2), specific to (hyper-)Kahler spaces, but arising even in cases when the requirements for these special geometries are not fulfilled. The discrete symmetries are also studied obtaining the discrete groups Z_4 and Q. The briefly presented examples are the Euclidean Taub-NUT space and the Minkowski spacetime.Comment: 27 pages, latex, no figures, final version to be published in Class. Quantum Gravit

Turning points: the personal and professional circumstances that lead academics to become middle managers

In the current higher education climate, there is a growing perception that the pressures associated with being an academic middle manager outweigh the perceived rewards of the position. This article investigates the personal and professional circumstances that lead academics to become middle managers by drawing on data from life history interviews undertaken with 17 male and female department heads from a range of disciplines, in a post-1992 UK university. The data suggests that experiencing conflict between personal and professional identities, manifested through different socialization experiences over time, can lead to a ‘turning point’ and a decision that affects a person’s career trajectory. Although the results of this study cannot be generalized, the findings may help other individuals and institutions move towards a firmer understanding of the academic who becomes head of department—in relation to theory, practice and research

Thermal noise limitations to force measurements with torsion pendulums: Applications to the measurement of the Casimir force and its thermal correction

A general analysis of thermal noise in torsion pendulums is presented. The specific case where the torsion angle is kept fixed by electronic feedback is analyzed. This analysis is applied to a recent experiment that employed a torsion pendulum to measure the Casimir force. The ultimate limit to the distance at which the Casimir force can be measured to high accuracy is discussed, and in particular the prospects for measuring the thermal correction are elaborated upon.Comment: one figure, five pages, to be submitted to Phys Rev

Persistence of the immune response induced by BCG vaccination.

BACKGROUND: Although BCG vaccination is recommended in most countries of the world, little is known of the persistence of BCG-induced immune responses. As novel TB vaccines may be given to boost the immunity induced by neonatal BCG vaccination, evidence concerning the persistence of the BCG vaccine-induced response would help inform decisions about when such boosting would be most effective. METHODS: A randomised control study of UK adolescents was carried out to investigate persistence of BCG immune responses. Adolescents were tested for interferon-gamma (IFN-gamma) response to Mycobacterium tuberculosis purified protein derivative (M.tb PPD) in a whole blood assay before, 3 months, 12 months (n = 148) and 3 years (n = 19) after receiving teenage BCG vaccination or 14 years after receiving infant BCG vaccination (n = 16). RESULTS: A gradual reduction in magnitude of response was evident from 3 months to 1 year and from 1 year to 3 years following teenage vaccination, but responses 3 years after vaccination were still on average 6 times higher than before vaccination among vaccinees. Some individuals (11/86; 13%) failed to make a detectable antigen-specific response three months after vaccination, or lost the response after 1 (11/86; 13%) or 3 (3/19; 16%) years. IFN-gamma response to Ag85 was measured in a subgroup of adolescents and appeared to be better maintained with no decline from 3 to 12 months. A smaller group of adolescents were tested 14 years after receiving infant BCG vaccination and 13/16 (81%) made a detectable IFN-gamma response to M.tb PPD 14 years after infant vaccination as compared to 6/16 (38%) matched unvaccinated controls (p = 0.012); teenagers vaccinated in infancy were 19 times more likely to make an IFN-gamma response of > 500 pg/ml than unvaccinated teenagers. CONCLUSION: BCG vaccination in infancy and adolescence induces immunological memory to mycobacterial antigens that is still present and measurable for at least 14 years in the majority of vaccinees, although the magnitude of the peripheral blood response wanes from 3 months to 12 months and from 12 months to 3 years post vaccination. The data presented here suggest that because of such waning in the response there may be scope for boosting anti-tuberculous immunity in BCG vaccinated children anytime from 3 months post-vaccination. This supports the prime boost strategies being employed for some new TB vaccines currently under development