Identification of the Cis-Acting Elements and Trans-Acting Factors That Mediate Cell-Specific and Thyroid Hormone Stimulation of Growth Hormone Gene Expression

This chapter reviews the physical and biological properties of thyroid hormone receptors and the relationship of the receptor to the avian erythroblastosis virus (AEV) v-erbA gene. The properties of thyroid hormone nuclear receptors derived from studies using GHi and GC cells are described in the chapter. The thyroid hormone receptor is related to the avian erythroblastosis virus v-erbA gene. The AEV—a defective leukemia retrovirus—induces sarcomas and erythroblastosis in vivo and induces the transformation of fibroblasts and erythroblasts to neoplastic phenotypes in vitro. The chapter also reviews the studies in which the rat growth hormone gene was used as a model to identify cis-acting DNA sequences and transacting regulatory proteins that are essential for cell-specific expression and transcriptional stimulation of the gene by the thyroid hormone. The thyroid hormone regulates the growth hormone gene expression at the transcriptional level. A detailed functional and protein-DNA footprint analysis of the elements that are involved in mediating thyroid hormone and cell-specific basal expression of the gene is also presented in the chapter.Peer reviewe

Social Spending and Aggregate Welfare in Developing and Transition Economies

Notwithstanding the unprecedented attention devoted to reducing poverty and fostering human development via scaling up social sector spending, there is surprisingly little rigorous empirical work on the question of whether social spending is effective in achieving these goals. This paper examines the impact of government spending on the social sectors (health, education, and social protection) on two major indicators of aggregate welfare (the Inequality-adjusted Human Development Index and child mortality), using a panel dataset comprising 55 developing and transition countries from 1990 to 2009. We find that government social spending has a significantly positive causal effect on the Inequality-adjusted Human Development Index, while government expenditure on health has a significant negative impact on child mortality rate. These results are fairly robust to the method of estimation, the use of alternative instruments to control for the endogeneity of social spending, the set of control variables included in the regressions, and the use of alternative samples

Inflation and Labor Market Flexibility: The Squeaky Wheel Gets the Grease

Inflation can grease the wheels of the labor market by relaxing downward wage rigidity but it can also increase uncertainty and have a negative sand effect. This paper studies the grease effect of inflation by looking at whether the interaction between inflation and labor market regulations affects how employment responds to changes in output. The results show that in industrial countries with highly regulated labor markets, the grease effect of inflation dominates the sand effect. In the case of developing countries, we rarely find a significant effect of inflation on labor market regulations and provide evidence indicating that this could be due to the presence of a large informal sector and limited enforcement of de jure labor market regulations

Vulnerability to weather disasters: the choice of coping strategies in rural Uganda

When a natural disaster hits, the affected households try to cope with its impacts. A variety of coping strategies, from reducing current consumption to disposing of productive assets, may be employed. The latter strategies are especially worrisome because they may reduce the capacity of the household to generate income in the future, possibly leading to chronic poverty. We used the results of a household survey in rural Uganda to ask, first, what coping strategies would tend to be employed in the event of a weather disaster, second, given that multiple strategies can be chosen, in what combinations would they tend to be employed, and, third, given that asset-liquidation strategies can be particularly harmful for the future income prospects of households, what determines their uptake? Our survey is one of the largest of its kind, containing over 3000 observations garnered by local workers using smartphone technology. We found that in this rural sample, by far, the most frequently reported choice would be to sell livestock. This is rather striking because asset-based theories would predict more reliance on strategies like eating and spending less today, which avoid disposal of productive assets. It may well be that livestock is held as a form of liquid savings to, among other things, help bounce back from a weather disaster. Although, we did find that other strategies that might undermine future prospects were avoided, notably selling land or the home and disrupting the children's education. Our econometric analysis revealed a fairly rich set of determinants of different subsets of coping strategies. Perhaps most notably, households with a more educated head are much less likely to choose coping strategies involving taking their own children out of education

Validity of Simple Indicators of Emotional I11-Health for Use in Epidemiological Studies

The validity of simple symptom inventories as indicators of emotional ill-health was tested by a comparison with clinical appraisals of emotional health status. The indices tested were the Health Opinion Survey Index, an index based on ten »key« questions from the Cornell Medical Index, and the anxiety index used in the Israel Ischemic Heart Disease Project. The test was conducted in a household sample and a sample of patients attending a psychiatric clinic.All the indices were found to be of moderate validity as indicators of the presence or absence of emotional disturbance. All were weakly correlated with the degree of disturbance. The indices did not differ significantly in their validity. Educational level significantly affected the responses to the Health Opinion Survey Index.It was concluded that when superior methods are not feasible, but only then, it is justifiable to use simple indices of this sort for the measurement of emotional health in epidemiological studies. The indices should not be regarded as being of more than moderate validity, and due attention should be paid to the possible confounding influence of factors other than emotional health.</jats:p