A logic programming framework for modeling temporal objects

Published versio

Beyond sustainable buildings: eco-efficiency to eco-effectiveness through cradle-to-cradle design

Sustainable building development focuses on achieving buildings that meet performance and functionality requirements with minimum adverse impact on the environment. Such eco-efficiency strategies are however not feasible for achieving long-term economic and environmental objectives as they only result in damage reduction without addressing design flaws of contemporary industry. The cradle-to-cradle (C2C) design philosophy which has been described as a paradigm changing innovative platform for achieving ecologically intelligent and environmentally restorative buildings appears to offer an alternative vision which, if embraced, could lead to eco-effectiveness and the achievement of long-term environmental objectives. Adoption of C2C principles in the built environment has however been hindered by several factors especially in a sector where change has always been a very slow process. From a review of extant literature, it is argued that the promotion of current sustainable and/or gree n building strategies - which in themselves are not coherent enough due to their pluralistic meanings and sometimes differing solutions - are a major barrier to the promotion of C2C principles in the built environment. To overcome this barrier to C2C implementation, it is recommended that research should focus on developing clearly defined and measurable C2C targets that can be incorporated into project briefs from the inception of development projects. These targets could enable control, monitoring and comparison of C2C design outcomes with eco-efficient measures as well as serve as a guide for project stakeholders to achieve eco-effective “nutrient” management from the project conceptualization phase to the end of life of the building

Psychometric Properties of the Perceived Social Support from Family and Friends Scale: Data from an Adolescent Sample in Ghana

Several studies have found that perceived social support plays a crucial role in the psychological and physical wellbeing of young people. A number of instruments measuring perceived social support have been developed and validated, including the Perceived Social Support from Family and Friends subscales. The psychometric properties of the Perceived Social Support from Family and Friends subscales have been demonstrated in a range of samples, although not in Ghana. The purpose of this study is to investigate the psychometric properties of the Perceived Social Support from Family and Friends subscales in Ghanaian adolescents using data from a school-based survey (N = 770; 14–21 years). Participants completed a self-report questionnaire containing the Perceived Social Support from Family and Friends subscales, the Adolescent Stress Questionnaire, and the 12-item General Health Questionnaire. An exploratory factor analysis in addition to simultaneous confirmatory factor analyses with structural equation modelling were performed to evaluate the factor structure and factorial validity of the subscales along with Cronbach’s α and intercorrelations. Three factors and two factors were extracted for the Friends and Family subscales respectively. While the unidimensional model of the friends subscale had a better fit with the data than the three-factor model, the two-factor model of the family subscale had a better fit than the unidimensional model, even though the unidimensional models of both subscales produced higher internal consistency coefficients. With respect to construct validity, the family subscale demonstrated some evidence of convergent and discriminant validity, but the friends subscale demonstrated some evidence of only discriminant validity, in terms of the association between social support and common mental illness and perceived stress. It appears that the Perceived Social Support subscales are useful instruments for assessing social support from family and friends and could therefore be used to further our understanding about the role of social support in stressful life events and psychological functioning of Ghanaian adolescents, although further research is required for the friends subscale

Adaptive Computation of the Swap-Insert Correction Distance

The Swap-Insert Correction distance from a string $S$ of length $n$ to another string $L$ of length $m\geq n$ on the alphabet $[1..d]$ is the minimum number of insertions, and swaps of pairs of adjacent symbols, converting $S$ into $L$. Contrarily to other correction distances, computing it is NP-Hard in the size $d$ of the alphabet. We describe an algorithm computing this distance in time within $O(d^2 nm g^{d-1})$, where there are $n_\alpha$ occurrences of $\alpha$ in $S$, $m_\alpha$ occurrences of $\alpha$ in $L$, and where $g=\max_{\alpha\in[1..d]} \min\{n_\alpha,m_\alpha-n_\alpha\}$ measures the difficulty of the instance. The difficulty $g$ is bounded by above by various terms, such as the length of the shortest string $S$, and by the maximum number of occurrences of a single character in $S$. Those results illustrate how, in many cases, the correction distance between two strings can be easier to compute than in the worst case scenario.Comment: 16 pages, no figures, long version of the extended abstract accepted to SPIRE 201

Nutritional psychiatry research: an emerging discipline and its intersection with global urbanization, environmental challenges and the evolutionary mismatch

In 21st-century public health, rapid urbanization and mental health disorders are a growing global concern. The relationship between diet, brain function and the risk of mental disorders has been the subject of intense research in recent years. In this review, we examine some of the potential socioeconomic and environmental challenges detracting from the traditional dietary patterns that might otherwise support positive mental health. In the context of urban expansion, climate change, cultural and technological changes and the global industrialization and ultraprocessing of food, findings related to nutrition and mental health are connected to some of the most pressing issues of our time. The research is also of relevance to matters of biophysiological anthropology. We explore some aspects of a potential evolutionary mismatch between our ancestral past (Paleolithic, Neolithic) and the contemporary nutritional environment. Changes related to dietary acid load, advanced glycation end products and microbiota (via dietary choices and cooking practices) may be of relevance to depression, anxiety and other mental disorders. In particular, the results of emerging studies demonstrate the importance of prenatal and early childhood dietary practices within the developmental origins of health and disease concept. There is still much work to be done before these population studies and their mirrored advances in bench research can provide translation to clinical medicine and public health policy. However, the clear message is that in the midst of a looming global epidemic, we ignore nutrition at our peril

Malignant peripheral nerve sheath tumour: A rare tumour of the breast

Malignant peripheral nerve sheath tumour is a rare tumour of the breast and this report highlights the radiological and histological features and the difficulties in making a diagnosis. A high index of suspicion when dealing with a breast lesion that has both cystic and solid components in a background of von Recklingausen’s neurofibromatosis will make the diagnosis easie

Identifying the impact of G-quadruplexes on Affymetrix 3' arrays using cloud computing.

A tetramer quadruplex structure is formed by four parallel strands of DNA/ RNA containing runs of guanine. These quadruplexes are able to form because guanine can Hoogsteen hydrogen bond to other guanines, and a tetrad of guanines can form a stable arrangement. Recently we have discovered that probes on Affymetrix GeneChips that contain runs of guanine do not measure gene expression reliably. We associate this finding with the likelihood that quadruplexes are forming on the surface of GeneChips. In order to cope with the rapidly expanding size of GeneChip array datasets in the public domain, we are exploring the use of cloud computing to replicate our experiments on 3' arrays to look at the effect of the location of G-spots (runs of guanines). Cloud computing is a recently introduced high-performance solution that takes advantage of the computational infrastructure of large organisations such as Amazon and Google. We expect that cloud computing will become widely adopted because it enables bioinformaticians to avoid capital expenditure on expensive computing resources and to only pay a cloud computing provider for what is used. Moreover, as well as financial efficiency, cloud computing is an ecologically-friendly technology, it enables efficient data-sharing and we expect it to be faster for development purposes. Here we propose the advantageous use of cloud computing to perform a large data-mining analysis of public domain 3' arrays

Spatial Effects of the Social Marketing of Insecticide-Treated Nets on Malaria Morbidity.

Randomized controlled trials have shown that insecticide-treated nets (ITNs) have an impact on both malaria morbidity and mortality. Uniformly high coverage of ITNs characterized these trials and this resulted in some protection of nearby non-users of ITNs. We have now assessed the coverage, distribution pattern and resultant spatial effects in one village in Tanzania where ITNs were distributed in a social marketing programme. The prevalence of parasitaemia, mild anaemia (Hb <11 g/dl) and moderate/severe anaemia (Hb <8 g/dl) in children under five was assessed cross-sectionally. Data on ownership of ITNs were collected and inhabitants' houses were mapped. One year after the start of the social marketing programme, 52% of the children were using a net which had been treated at least once. The ITNs were rather homogeneously distributed throughout the village at an average density of about 118 ITNs per thousand population. There was no evidence of a pattern in the distribution of parasitaemia and anaemia cases, but children living in areas of moderately high ITN coverage were about half as likely to have moderate/severe anaemia (OR 0.5, 95% CI: 0.2, 0.9) and had lower prevalence of splenomegaly, irrespective of their net use. No protective effects of coverage were found for prevalence of mild anaemia nor for parasitaemia. The use of untreated nets had neither coverage nor short distance effects. More efforts should be made to ensure high coverage in ITNs programmes to achieve maximum benefit