88 research outputs found
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.
Get PDFPKR is activated in MDS patients and its subcellular localization depends on disease severity
No full textActivation of nuclear inositide signalling pathways during erythropoietin therapy in low-risk MDS patients
No full textPI-PLCβ-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes
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PLCB1 (phospholipase C, beta 1 (phosphoinositide-specific))
Get PDFReview on PLCB1 (phospholipase C, beta 1 (phosphoinositide-specific)), with data on DNA, on the protein encoded, and where the gene is implicated
Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes
No full textThe physiology and pathology of inositide signaling in the nucleus
No full textNuclear inositide signaling is nowadays a well-established issue and a growing field of investigation, even though the very first evidence came out at the end of the 1980's. The understanding of its biological role is supported by the recent acquisitions dealing with pathology and namely hematological malignancies. Here, we review this issue highlighting the main achievements in the last year
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