Logística reversa : oportunidade para redução de custos através do gerenciamento da cadeia integrada de valor

O artigo discorre sobre um aspecto da Logística que só agora começa a ser olhado mais atentamente pelas empresas. Enquanto a logística tradicional trata do fluxo de saída dos produtos, a Logística Reversa tem que se preocupar com o retorno de produtos, materiais e peças ao processo de produção da empresa. Devido a legislações ambientais mais severas e maior consciência por parte dos consumidores, as empresas estão não só utilizando uma maior quantidade de materiais reciclados como também tendo que se preocupar com o descarte ecologicamente correto de seus produtos ao final de seu ciclo de vida. Além disto, muitas firmas têm feito da Logística Reversa uma arma estratégica em seu planejamento de negócios. Tudo isto vem fortalecer o desenvolvimento da Logística Reversa nas empresas. E no caso brasileiro de acordos a especialistas de logística reversa esta área vem sendo considerada como um elemento importante no planejamento estratégico das organizações para adequá-las à legislação do meio ambiente atual. O trabalho vem mostrar oportunidades em redução de custos através do gerenciamento da cadeia de valor da empresa, com o envolvimento de todos os componentes. O método utilizado é o de estudo de caso em uma empresa do setor de refrigerantes

High-risk pulmonary embolism with right heart thrombi

Accuracy is essential to surface quality control when a range sensor is applied to measure the 3D shape of an automotive body part. A sensor's viewing pose, including location and orientation, is related to measurement accuracy. It is usually difficult to find an optimal solution by manual control of sensor viewpoints. A CAD-guided robot view planner developed previously can automatically generate viewpoints. Measurement accuracy can be satisfied in a certain range. However, the unpredictable image noises, especially in regions with low intensity contrast, cannot be compensated by the CADguided robot view planner. In another aspect, measurement accuracy is evaluated all over the part surface. The local accuracy of a small patch may exceed the measurement tolerance. In this paper, feedback design is applied to the CADguided robot sensor planning system. The feedback controller can evaluate the accuracy of obtained point clouds, identify problem regions, and generate new viewpoints. This process is recursively executed until the measurement accuracy reaches to a tolerant value. This feedback-based inspection system had been implemented in previous work to fill holes of a point cloud, which are caused by shadows and light reflections. In this paper, the feedback controller is specifically designed to improve the measurement accuracy. Experimental results show the success of applying this feedback system for dimensional inspection of an automotive body part. © 2007 IEEE.Link_to_subscribed_fulltex

Low genetic diversity associated with low prevalence of Anaplasma marginale in water buffaloes in Marajó Island, Brazil

The rickettsia Anaplasma marginale is the etiologic agent of bovine anaplasmosis, an important tick-borne disease affecting cattle in tropical and subtropical regions of the world. In endemic regions, the genetic diversity of this pathogen is usually related to the high prevalence of the disease in cattle. The major surface protein 1 alpha (MSP1a) has been used as a marker to characterize the genetic diversity and for geographical identification of A. marginale strains. The present study reports the characterization of A. marginale MSP1a diversity in water buffaloes. Blood samples were collected from 200 water buffaloes on Marajó Island, Brazil where the largest buffalo herd is located in the Western hemisphere. Fifteen buffaloes (7.5%) were positive for A. marginale msp1α by PCR. Four different strains of A. marginale with MSP1a tandem repeat structures (4-63-27), (162-63-27), (78-24-24-25-31) and (τ-10-10-15) were found, being (4-63-27) the most common. MSP1a tandem repeats composition in buffalos and phylogenetic analysis using msp1α gene showed that the A. marginale strains identified in buffaloes are closely related to A. marginale strains from cattle. The results demonstrated low genetic diversity of A. marginale associated with low bacterial prevalence in buffaloes and suggested that buffaloes may be reservoirs of this pathogen for cattle living in the same area. The results also suggested that mechanical transmission and not biological transmission by ticks might be playing the major role for pathogen circulation among water buffaloes in Marajó Island, Brazil.We thank the Coordination for the Improvement of Higher Education Personnel (CAPES) foundation and the National Council for Technological and Scientific Development (CNPq) for their financial support.Peer Reviewe

On the Iwasawa-Taniguchi effect of radio-quiet AGN

The existence of an anti-correlation between the Equivalent Width (EW) of the neutral narrow core of the iron Kalpha emission line and the 2-10 keV luminosity (the so-called `X-ray Baldwin' or `Iwasawa-Taniguchi' effect) has been debated in the last years. We aim at testing this claim on the largest catalogue of radio quiet AGN high-quality X-ray spectra ever published. The final sample comprises 157 objects. We search for a relation of the iron line EW not only with the X-ray luminosity, but also with the Black Hole mass, the Eddington ratio and the cosmological distance. The data presented here were analyzed homogeneously, all spectra are from the same instrument and with high Signal-to-Noise Ratio. A linear censored fit on the EW versus 2-10 keV luminosity is highly significant and yields $\log(EW_{Fe}) = (1.73\pm0.03) + (-0.17\pm0.03) \log(L_{X,44})$, where $EW_{Fe}$ is the EW of the neutral iron Kalpha line in eV and $L_{x,44}$ is the 2-10 keV X-ray luminosity in units of $10^{44}$ erg s$^{-1}$. The anti-correlation with the Eddington ratio is also very significant, while no dependence of the iron EW on the BH mass is apparent.Comment: 4 pages, 4 figures, accepted for publication in Astronomy and Astrophysics Letter

sectional study

Backgrounds: The aim of this study is identify the main morphological patterns of the pancreas in AIDS patients in use of Higly Active Antiretorviral Therapy (HAART). Methods: We conducted a cross sectional study in the year of 2010. The inclusion criteria were patients older than 18 years who died of AIDS with the use of HAART (2006–2009) and underwent to autopsy. They were compared with a group of 109 patients who died of AIDS in 1995 before the HAART therapy. All the autopsies were made in the Death Verification Service of São Paulo. Results: The HAART group presented pancreas abnormalities lighter than no HAART users. In the HAART group, histology shows: reduction of zymogen granules in the acinar cells (ZG) higher percentage of cases, “dysplasia-like” presents lower and pancreatic acinar atrophy, presents higher percentage of cases compared to no HAART group. The exocrine pancreas in treated patients was distinguished by the high level of atrophy, sharp reduction of zymogen granules and high level of apoptosis, reflecting degeneration and lower level of protein-caloric malnutrition. Conclusions: The islets of Langerhans in HAART group were increased in number and volume and with high level of nuclear dysplasia. The antiviral therapy and a longer survival resulted in a higher atrophy and reduction of enzymes, increasing the apoptosis and generated important changes in the pancreatic islets, probably resulting in clinical laboratory repercussion. We found no evidence of pancreatic histopathological lesions secondary to antiretroviral therapy

Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis

© 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by sustained synovitis. Recently, several studies have proposed neutrophils and Th17 cells as key players in the onset and perpetuation of this disease. The main goal of this work was to determine whether cytokines driving neutrophil and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease duration and before treatment (VERA). Methods: Cytokines related to neutrophil and Th17 activation were quantified in the serum of VERA and established RA patients and compared with other very early arthritis (VEA) and healthy controls. Synovial fluid (SF) from RA and osteoarthritis (OA) patients was also analyzed. Results: VERA patients had increased serum levels of cytokines promoting Th17 polarization (IL-1b and IL-6), as well as IL-8 and Th17-derived cytokines (IL-17A and IL-22) known to induce neutrophil-mediated inflammation. In established RA this pattern is more evident within the SF. Early treatment with methotrexate or corticosteroids led to clinical improvement but without an impact on the cytokine pattern. Conclusions: VERA patients already display increased levels of cytokines related with Th17 polarization and neutrophil recruitment and activation, a dysregulation also found in SF of established RA. 0 Thus, our data suggest that a cytokine-milieu favoring Th17 and neutrophil activity is an early event in RA pathogenesis.This work was supported by a grant from Sociedade Portuguesa de Reumatologia/Schering-Plough 2005. RAM and RC were funded by Fundação para a Ciência e a Tecnologia (FCT) SFRH/BD/30247/2006 and SFRH/BD/40513/2007, respectively. MMS-C was funded by Marie Curie Intra-European Fellowship PERG-2008-239422 and a EULAR Young Investigator Award

ANALISES DE VARIAVEIS PARA ESTRUTURAÇÀO DE UM MODELO ECONOMICO E AMBIENTAL: QUANTIFICAÇÃO DA SUSTENTABILIDADE NO SETOR AGROINDUSTRIAL BRASILEIRO.

Este artigo tem por finalidade analisar os conceitos de manutenção e preservação do meio ambiente que promovem desenvolvimento sustentável, tendo em vista a proposta de um modelo econômico e ambiental. Assim, intervenções no padrão da gestão pública que implique no aumento do grau de eficácia na utilização dos recursos financeiros propiciarão uma transformação no paradigma de desenvolvimento que não mais poderá ser excludente e danoso para o meio ambiente. A compreensão do significado de desenvolvimento social e econômico envolve os mecanismos de distribuição das riquezas geradas e neste contexto, a viabilização do conceito de sustentabilidade implicará em mudanças no comportamento social (coletivo) e individual. A discussão quanto ao comportamento e uso racional e planejado dos recursos naturais será fundamental para a perpetuação desses recursos para as gerações futuras.----------------------------------------------Analyzing the concepts of maintenance and preservation of the environment that promote sustainable development is the purpose of this article in order to draft of a model economic and environmental. Therefore, interventions to change the standard of public administration involving in increasing the degree of efficiency in the use of financial resources provide a change in paradigm of development that can no longer be exclusionary and harmful to the environment. The understanding of the meaning of social and economic development involves the mechanisms of distribution of the wealth generated in this context, the viability of the concept of sustainability will lead to changes in social behaviour (collective) and individual. The discussion about the behavior and planned and rational use of natural resources is central to the perpetuation of these resources for future generations.Sustentabilidade, modelo econômico, gerações futuras, Sustainability, economic model, future generations, Environmental Economics and Policy,

Memorándum A: Ámbito internacional: Jurisprudencia de los tribunales penales internacionales

Nos concentramos en estudiar la regla a través del ámbito internacional. Esto es la exposición y el análisis de la jurisprudencia de la Corte Penal Internacional (en adelante CPI), del Tribunal Penal Internacional para la ex Yugoslavia (en adelante TPIY), de la Corte Especial para Sierra Leona (en adelante CESL), de las Salas Especiales de las Cortes de Camboya (en adelante SECC), del Tribunal Especial para el Líbano (en adelante TEL) y de los Páneles de Timor Oriental. La exposición de dicha regla tratará los temas de autoría mediata a través de aparatos organizados de poder, de coautoría mediata y de estos modos de responsabilidad aplicados a los delitos sexuales tanto cuando son calificados de manera autónoma como cuando son subsumidos en los tipos de tortura o persecució