Lyman-alpha transfer in primordial hydrogen recombination

Cosmological constraints from the cosmic microwave background (CMB) anisotropies rely on accurate theoretical calculations of the cosmic recombination history. Recent work has emphasized the importance of radiative transfer calculations due to the high optical depth in the HI Lyman lines. Transfer in the Lyman-alpha line is dominated by true emission and absorption, Hubble expansion, and resonant scattering. Resonant scattering causes photons to diffuse in frequency due to random kicks from the thermal velocities of hydrogen atoms, and also to drift toward lower frequencies due to energy loss via atomic recoil. Past analyses of Lyman-alpha transfer during the recombination era have either considered a subset of these processes, ignored time dependence, or incorrectly assumed identical emission and absorption profiles. We present here a fully time-dependent radiative transfer calculation of the Lyman-alpha line including all of these processes, and compare it to previous results that ignored the resonant scattering. We find a faster recombination due to recoil enhancement of the Lyman-alpha escape rate, leading to a reduction in the free electron density of 0.45% at z=900. This results in an increase in the small-scale CMB power spectrum that is negligible for the current data but will be a 0.9 sigma correction for Planck. We discuss the reasons why we find a smaller correction than some other recent computations.Comment: 16 pages, 7 figures, matches PRD accepted version. Fixed bug in numerical transport code, resulting in slightly reduced effect on recombination histor

Stitching of near-nulled subaperture measurements

A metrology system for measuring aspheric test objects by subaperture stitching. A wavefront-measuring gauge having a limited capture range of wavefront shapes collects partially overlapping subaperture measurements over the test object. A variable optical aberrator reshapes the measurement wavefront with between a limited number of the measurements to maintain the measurement wavefront within the capture range of the wavefront-measuring gauge. Various error compensators are incorporated into a stitching operation to manage residual errors associated with the use of the variable optical aberrator

Hubble Space Telescope survey of the Perseus Cluster -IV: Compact stellar systems in the Perseus Cluster core and Ultra Compact Dwarf formation in star forming filaments

We present the results of the first search for Ultra Compact Dwarfs (UCDs) in the Perseus Cluster core, including the region of the cluster around the unusual Brightest Cluster Galaxy (BCG) NGC 1275. Utilising Hubble Space Telescope Advanced Camera for Surveys imaging, we identify a sample of 84 UCD candidates with half-light radii 10 pc < r_e < 57 pc out to a distance of 250 kpc from the cluster centre, covering a total survey area of ~70 armin^2. All UCDs in Perseus lie in the same size-luminosity locus seen for confirmed UCDs in other regions of the local Universe. The majority of UCDs are brighter than M_R = -10.5, and lie on an extrapolation of the red sequence followed by the Perseus Cluster dwarf elliptical population to fainter magnitudes. However, three UCD candidates in the vicinity of NGC 1275 are very blue, with colours (B-R)_0 < 0.6 implying a cessation of star formation within the past 100 Myr. Furthermore, large blue star clusters embedded in the star forming filaments are highly indicative that both proto-globular clusters (GCs) and proto-UCDs are actively forming at the present day in Perseus. We therefore suggest star forming filaments as a formation site for some UCDs, with searches necessary in other low redshift analogues of NGC 1275 necessary to test this hypothesis. We also suggest that tidal disruption of dwarf galaxies is another formation channel for UCD formation in the core of Perseus as tidal disruption is ongoing in this region as evidenced by shells around NGC 1275. Finally, UCDs may simply be massive GCs based on strong similarities in the colour trends of the two populations.Comment: 18 pages, 20 figures, 3 tables. Accepted for publication in MNRA

The SLUGGS Survey: Calcium Triplet-based Spectroscopic Metallicities for Over 900 Globular Clusters

Although the colour distribution of globular clusters in massive galaxies is well known to be bimodal, the spectroscopic metallicity distribution has been measured in only a few galaxies. After redefining the calcium triplet index-metallicity relation, we use our relation to derive the metallicity of 903 globular clusters in 11 early-type galaxies. This is the largest sample of spectroscopic globular cluster metallicities yet assembled. We compare these metallicities with those derived from Lick indices finding good agreement. In 6 of the 8 galaxies with sufficient numbers of high quality spectra we find bimodality in the spectroscopic metallicity distribution. Our results imply that most massive early-type galaxies have bimodal metallicity, as well as colour, distributions. This bimodality suggests that most massive galaxies early-type galaxies experienced two periods of star formation.Comment: 23 pages, 13 figures. Accepted for publication in MNRAS. For more information about the SLUGGS Survey please see http://sluggs.swin.edu.a

Ultracompact dwarfs in the Perseus Cluster:UCD formation via tidal stripping

We present the results of a Keck/DEIMOS survey of Ultra Compact Dwarfs (UCDs) in the Perseus Cluster core. We confirm cluster membership for 14 UCDs, with radial velocities ~5300 km s$^{-1}$. Two of these confirmed Perseus UCDs have extremely blue colours ($B-R < 0.6$ mag), reside in star forming filaments surrounding NGC 1275, and have likely formed as massive star clusters in the last ~100 Myr. We also measure a central velocity dispersion of a third, UCD13 ($\sigma_0 = 38 \pm 8$ km s$^{-1}$), the most extended UCD in our sample. We determine it to have radius $R_{e} = 85 \pm 1.1$ pc, a dynamical mass of ($2.3 \pm 0.8)\times10^{8}$ M$_{\odot}$, and a metallicity [Z/H]$= -0.52^{+0.33}_{-0.29}$ dex. UCD13 and the cluster's central galaxy, NGC 1275, have a projected separation of 30 kpc and a radial velocity difference of ~20 km s$^{-1}$. Based on its size, red colour, internal velocity dispersion, dynamical mass, metallicity and proximity to NGC 1275, we argue that UCD13 is likely the remnant nucleus of a tidally stripped dE, with this progenitor dE having $M_{B} \approx -16$ mag and mass $\sim10^{9}$ M$_{\odot}$.Comment: 9 pages, 5 figures, accepted for publication in MNRA

Fostering collaborative research for rare genetic disease: The example of Niemann-Pick type C disease

Rare disease represents one of the most significant issues facing the medical community and health care providers worldwide, yet the majority of these disorders never emerge from their obscurity, drawing little attention from the medical community or the pharmaceutical industry. The challenge therefore is how best to mobilize rare disease stakeholders to enhance basic, translational and clinical research to advance understanding of pathogenesis and accelerate therapy development. Here we describe a rare, fatal brain disorder known as Niemann-Pick type C (NPC) and an innovative research collaborative known as Support of Accelerated Research for NPC (SOAR-NPC) which illustrates one pathway through which knowledge of a rare disease and its possible treatments are being successfully advanced. Use of the “SOAR” mechanism, we believe, offers a blueprint for similar advancement for many other rare disorders

Variable effects of exposure to formulated microbicides on antibiotic susceptibility in firmicutes and proteobacteria

Microbicides are broad-spectrum antimicrobial agents that generally interact with multiple pharmacological targets. While they are widely deployed in disinfectant, antiseptic, and preservative formulations, data relating to their potential to select for microbicide or antibiotic resistance have been generated mainly by testing the compounds in much simpler aqueous solutions. In the current investigation, antibiotic susceptibility was determined for bacteria that had previously exhibited decreased microbicide susceptibility following repeated exposure to microbicides either in formulation with sequestrants and surfactants or in simple aqueous solution. Statistically significant increases in antibiotic susceptibility occurred for 12% of bacteria after exposure to microbicides in formulation and 20% of bacteria after exposure to microbicides in aqueous solutions, while 22% became significantly less susceptible to the antibiotics, regardless of formulation. Of the combinations of a bacterium and an antibiotic for which British Society for Antimicrobial Chemotherapy breakpoints are available, none became resistant. Linear modeling taking into account phylogeny, microbicide, antibiotic, and formulation identified small but significant effects of formulation that varied depending on the bacterium and microbicide. Adaptation to formulated benzalkonium chloride in particular was more likely to increase antibiotic susceptibility than adaptation to the simple aqueous solution. In conclusion, bacterial adaptation through repeated microbicide exposure was associated with both increases and decreases in antibiotic susceptibility. Formulation of the microbicide to which the bacteria had previously adapted had an identifiable effect on antibiotic susceptibility, but it effect was typically small relative to the differences observed among microbicides. Susceptibility changes resulting in resistance were not observed. IMPORTANCE The safety of certain microbicide applications has been questioned due to the possibility that microbicide exposure could select for microbicide and antibiotic resistance. Evidence that this may happen is based mainly on in vitro experiments where bacteria have been exposed to microbicides in aqueous solution. Microbicides are, however, normally deployed in products formulated with surfactants, sequestrants, and other compounds. While this may influence the frequency and extent of susceptibility changes, few studies reported in the literature have assessed this. In the current investigation, therefore, we have investigated changes in antibiotic susceptibility in bacteria which exhibited decreased microbicide susceptibility following repeated exposure to microbicides in simple aqueous solutions and in formulation. We report that the microbicide formulation had an identifiable effect on antibiotic susceptibility, but it was typically small relative to the differences observed among microbicides. We did not observe susceptibility changes resulting in resistance

A New covert channel over RTP

In this thesis, we designed and implemented a new covert channel over the RTP protocol. The covert channel modifies the timestamp value in the RTP header to send its secret messages. The high frequency of RTP packets allows for a high bitrate covert channel, theoretically up to 350 bps. The broad use of RTP for multimedia applications, including VoIP, provides plentiful opportunities to use this channel. By using the RTP header, many of the challenges present for covert channels using the RTP payload are avoided. Using the reference implementation of this covert channel, bitrates of up to 325 bps were observed. Speed decreases on less reliable networks, though message delivery was flawless with up to 1% RTP packet loss. The channel is very difficult to detect due to expected variations in the timestamp field and the flexible nature of RTP