Functional compounds of einkorn and emmer genotypes

Three einkorn and two emmer genotypes were analysed for concentration of microelements (Fe, Zn and Se) and lipid soluble antioxidants (α-tocopherol, α-tocotrienol and β-carotene). A diversity was observed in micronutrient content, but most of the genotypes have significantly higher trace element and antioxidant contents than the control wheat variety. The emmer genotypes contain lower Fe and β-carotene concentration than einkorn genotypes. The einkorn genotypes have significant higher antioxidant content than the wheat control. On average einkorn has more than three times more β-carotene than the wheat variety. Our results are useful for species/variety choice in functional food production not only for organic but also for conventional farmers, who have/want to operate under low input conditions, especially in Central Europe

p-BioSPRE-an information and communication technology framework for transnational biomaterial sharing and access

Biobanks represent key resources for clinico-genomic research and are needed to pave the way to personalised medicine. To achieve this goal, it is crucial that scientists can securely access and share high-quality biomaterial and related data. Therefore, there is a growing interest in integrating biobanks into larger biomedical information and communication technology (ICT) infrastructures. The European project p-medicine is currently building an innovative ICT infrastructure to meet this need. This platform provides tools and services for conducting research and clinical trials in personalised medicine. In this paper, we describe one of its main components, the biobank access framework p-BioSPRE (p-medicine Biospecimen Search and Project Request Engine). This generic framework enables and simplifies access to existing biobanks, but also to offer own biomaterial collections to research communities, and to manage biobank specimens and related clinical data over the ObTiMA Trial Biomaterial Manager. p-BioSPRE takes into consideration all relevant ethical and legal standards, e.g., safeguarding donors’ personal rights and enabling biobanks to keep control over the donated material and related data. The framework thus enables secure sharing of biomaterial within open and closed research communities, while flexibly integrating related clinical and omics data. Although the development of the framework is mainly driven by user scenarios from the cancer domain, in this case, acute lymphoblastic leukaemia and Wilms tumour, it can be extended to further disease entities.FP7/2007-2013/27008

A Distribution of the First Order Statistic When the Sample Size is Random

Statistical distributions also known as probability distributions are used to model a random experiment. Probability distributions consist of probability density functions (pdf) and cumulative density functions (cdf). Probability distributions are widely used in the area of engineering, actuarial science, computer science, biological science, physics, and other applicable areas of study. Statistics are used to draw conclusions about the population through probability models. Sample statistics such as the minimum, first quartile, median, third quartile, and maximum, referred to as the five-number summary, are examples of order statistics. The minimum and maximum observations are important in extreme value theory. This paper will focus on the probability distribution of the minimum observation, also known as the first order statistic, when the sample size is random

日本の上演芸術におけるモルナール受容（I） -モルナール戯曲の日本の劇団による初期上演について-

Articledepartmental bulletin pape

Political witchcraft

Der Fall von North Berwick mag zwar anfangs als unbedeutender Zwischenfall gegolten, doch gewann während der öffentlichen Verhandlungen, die in Edinburgh unter sorgfältiger Aufsicht von König James VI von Schottland abgehalten wurden, rasch mehr an Komplexität und Bedeutung für die Monarchie als je ein Hexenverfolgungsprozess zuvor. Wie der Titel dieser Arbeit zeigt („Politische Hexenjagd: Eine Neuaufnahme von Stewart Conns Drama „The Burning“ in seinem historischen Kontext“) ist es ihr Ziel, alle Unterschiede zwischen den tatsächlichen und den fiktionalen Ereignissen des Theaterstücks zu identifizieren und zu vergleichen. Um diesen wichtigen Kontrast herauszuarbeiten wird eine genaue Analyse des historischen Kontexts und theatrischen Umfelds, zusammen mit der Verschwörungstheorie gegeben, gefolgt von einer ausführlichen Diskussion der Hexenprozesse. Ein weiteres Kapitel beschäftigt sich mit den Hauptfiguren des Dramas im Vergleich mit ihren historischen Vorbildern. Abschließend werden die historischen Fakten mit den Ereignissen im Drama verglichen.Researchers who study the North Berwick witch-hunt (1590-1) are in a unique position, for these accusations marked the beginning of a long tradition that included enormous literary corpus and authentic documentation. This fortunate situation of dealing with such a fascinating material is thanked on the one hand, to the personal involvement of King James VI, whose person gained special prominence to the events and continues to distinguish the affair from other Scottish witchcraft cases even today, but on the other, also to the fact that, these trials embodied much more than simple witchcraft charges. The case of North Berwick was the most extensive – yet not the first – political witch-hunt in the history of Scotland that aimed to eliminate one particular rival (Bothwell) whom James VI and his court – seemingly – feared the most. The craze started as a relatively marginal affair – the healing potency of a maid, Gilles Duncan became suspicious – and ended with the fierce removal of the King's cousin, Francis Stewart, 5th Earl of Bothwell from the royal court. This thesis explores and compares the original historical events of the actual witch-hunt with the incidents portrayed by Stewart Conn in his play, The Burning. In doing so, the paper introduces the reader to the author and his play, examines the theory of witchcraft and absolutism, analyzes the historical background of the event and compares it with its fictional counterpart, deals with the witchcraft trials, focuses on the dramatic characters and reviews both the historical and fictional outcome

Addressing Follower Motivation Within the Kelley Typology of Followership Using Significance Quest Theory

This thesis sought to build upon the Kelley typology of followership by examining the motivational factors that affect follower behavior in follower-leader interactions that the original theory did not explore. The motivational mechanism I argued accounted for differences in follower behavior was Significance Quest theory. This thesis examined whether the interaction between the activation of an individual’s significance quest and the closeness to a network perceived as valuable to them would influence follower behavior. Additional factors, such as narratives valued by the network and regulatory focus orientation, are also explored. Partial support was found for two hypotheses. Implications and future directions of these findings are discussed

Practice-Based Management Data of Consecutive Subjects Assessed for the Median Arcuate Ligament Syndrome at a Single Tertiary Institution

BACKGROUND The pathophysiology of median arcuate ligament syndrome (MALS) is poorly understood. The diagnostic process remains inadequately standardized, with an absence of precise criteria to guide therapeutic management. METHODS We studied consecutive subjects referred to the Department of Angiology at the University Hospital of Zurich over the past 17 years due to suspected MALS. We focused on (1) the imaging criteria that led to diagnosis, notably the results of color duplex ultrasound and the consistency with different imaging tests; (2) the clinical consequences focusing on symptom resolution. RESULTS We included 33 subjects; in 8 subjects (24.2%), the diagnosis of MALS was retained. The median expiration peak systolic velocity (PSV) on ultrasound was 3.05 (Q1; 2.1-Q3; 3.3). To confirm the sonographic results, either a CT or MRI was performed on all patients, with consistent findings confirming a significant stenosis. Seven patients underwent surgery, all involving arcuate ligament release. Four procedures were laparoscopic, one was via laparotomy, and two were robot-assisted. Additionally, two patients required angioplasty with stenting as a secondary intervention. Only two (28.6%) of the seven operated patients experienced a relief of symptoms. None experienced a relief of symptoms following secondary angioplasty, despite stent patency. The prevalence of psychiatric disorders was comparable between patients with retained and rejected diagnoses, 38% and 36%, respectively. CONCLUSIONS Our study confirmed sonography and CT/MRI consistency. However, most patients with MALS did not benefit from invasive treatment. The majority (83%) of patients without MALS were diagnosed with alternative conditions, mainly functional disorders

Sécurité des données de capteurs ambiants dans les habitats à l’aide d’autoencodeurs

Dans ce mémoire, nous visons à implémenter un prototype d’algorithme de cryptographie basé sur les réseaux de neurones. Dans le cadre des travaux sur la reconnaissance d’activités au sein d’habitats intelligents opérés par le LIARA (Laboratoire d’Intelligence Ambiante pour la Reconnaissance d’Activités), une attention est portée de plus en plus sur la protection de la vie privée des individus. En effet pendant longtemps, on a eu affaire à des données de capteurs simples comme les tapis de pressions, les détecteurs électromagnétiques, les détecteurs de mouvement. Comme ces données ne permettent pas d’avoir accès à des informations génériques basiques sur ce qui se déroulait au sein des murs des résidences suivies, l’aspect sécurité occupait une petite place dans les travaux. Dans le cadre d’un projet de déploiement à grande échelle de maisons intelligentes financé par MEDTEQ (le Consortium pancanadien de recherche industrielle et d’innovation en technologies médicales du Québec) et Age-Well (un réseau canadien visant à élaborer des technologies et des services pour le vieillissement en santé) notre équipe explore l’utilisation des réseaux de neurones pour sécuriser les données transmises entre les maisons intelligentes et les serveurs de traitement de données. Afin de bien comprendre nos besoins, il est important de poursuivre cette question cruciale en parallèle avec une étude du potentiel des réseaux de neurones pour remplacer la cryptographie traditionnelle dans l’encodage de données plus complexes. En effet, ces derniers temps, nous avons étudié des capteurs plus informatifs tels que les caméras thermiques, les caméras de profondeurs, les capteurs RFID et les radars à ultra large bande. Ces capteurs ont plus d’informations sur les activités qui se déroulent dans une résidence, mais ils impliquent une plus grande charge de traitement. En conséquence, il semble donc intéressant d’étudier la possibilité d’utiliser une architecture de réseau de neurones artificiels pour encoder localement les données et les décoder à distance afin d’augmenter la sécurité, de réduire les calculs supplémentaires et de diminuer la taille des données à transmettre. En somme, cette étude portera sur l’étude comparative de ces encodages au sein d’habitats intelligents et consistera à mettre en place un système d’encodage de données fonctionnel basé sur des autoencodeurs