Ventilatory Phenotypes among Four Strains of Adult Rats.

Our purpose in this study was to identify different ventilatory phenotypes among four different strains of rats. We examined 114 rats from three in-house, inbred strains and one outbred strain: Brown Norway (BN;n = 26), Dahl salt-sensitive (n = 24), Fawn-hooded Hypertensive (FHH: n = 27), and outbred Sprague-Dawley rats (SD; n = 37). We measured eupneic (room air) breathing and the ventilatory responses to hypoxia (12% O2-88% N2), hypercapnia (7% CO2), and two levels of submaximal exercise. Primary strain differences were between BN and the other strains. BN rats had a relatively attenuated ventilatory response to CO2 (P \u3c 0.001), an accentuated ventilatory response to exercise (P \u3c 0.05), and an accentuated ventilatory roll-off during hypoxia (P \u3c 0.05). Ventilation during hypoxia was lower than other strains, but hyperventilation during hypoxia was equal to the other strains (P \u3e 0.05), indicating that the metabolic rate during hypoxia decreased more in BN rats than in other strains. Another strain difference was in the frequency and timing components of augmented breaths, where FHH rats frequently differed from the other strains, and the BN rats had the longest expiratory time of the augmented breaths (probably secondary to the blunted CO2 sensitivity). These strain differences not only provide insight into physiological mechanisms but also indicate traits (such as CO2 sensitivity) that are genetically regulated. Finally, the data establish a foundation for physiological genomic studies aimed at elucidating the genetics of these ventilatory control mechanisms

Heat transport of clean spin-ladders coupled to phonons: Umklapp scattering and drag

We study the low-temperature heat transport in clean two-leg spin ladder compounds coupled to three-dimensional phonons. We argue that the very large heat conductivities observed in such systems can be traced back to the existence of approximate symmetries and corresponding weakly violated conservation laws of the effective (gapful) low--energy model, namely pseudo-momenta. Depending on the ratios of spin gaps and Debye energy and on the temperature, the magnetic contribution to the heat conductivity can be positive or negative, and exhibit an activated or anti-activated behavior. In most regimes, the magnetic heat conductivity is dominated by the spin-phonon drag: the excitations of the two subsystems have almost the same drift velocity, and this allows for an estimate of the ratio of the magnetic and phononic contributions to the heat conductivity.Comment: revised version, 8 pages, 3 figures, added appendi

An investigation into the time-saving benefits of using a computerised taxation program

Software programs designed to calculate the tax liability of individuals and other types of tax entity are being designed and used with increasing frequency. Research done in the United States of America appears to indicate that these programs do not achieve any saving in time and, in fact, may take longer to use than to complete a tax return by hand. As the South African revenue collection system appears to be moving closer to a self-assessment system, where the calculation of tax owing will be the responsibility of the taxpayer, the research essay sets out to determine whether there is a saving in time when calculating a tax liability using a tax software program, instead of calculating it by hand. In addition, the research aims to determine how much time, on average, is saved or lost, using such a program, and whether there is any correlation between the time taken to perform a calculation by hand and that using the software program. It does so by comparing the average estimated time it would take to complete tax calculations for individuals by hand with the average time taken to complete the same tax calculations using a tax software program. The average time taken to do the calculations by hand is based on the time allocation given for questions by the authors of a published question bank for university students. The time taken using software is determined by using a stop-watch to time each question being processed. The results, subject to assumptions made in carrying out the research, show that there is a substantial saving in time using the software program. Based on the data, however, the results indicate a weak correlation between the estimated time taken to do a calculation by hand and the estimated time using the software program. Possible reasons for the weak correlation are discussed. A recommendation is also made for the standardization and certification of existing tax calculation software

On the contrasting spin dynamics of La2−xSrxCuO4La_{2-x}Sr_xCuO_4, Nd2−xCexCuO4Nd_{2-x}Ce_xCuO_4 and YBa2Cu3O6+xYBa_2Cu_3O_{6+x} near half filling

We present simple calculations which show that incommensurability upon doping and the width of the magnetically ordered phase in Mott-Hubbard insulators depend strongly on the location of the hole/electron pockets in the Brillouin zone. For $LaSrCuO$ systems, we found the pockets at $(\pm \pi/2,\pm \pi/2)$, in which case the corrections to the antiferromagnetic spin stiffness grow with doping and destroy the commensurate antiferromagnetic ordering already at a very small doping. On the other hand, in $NdCeCuO$, the hole pockets are located at $(\pi,0)$ and the symmetry related points, in which case the corrections to the stiffness scale linearly with the density of carriers and do not destroy commensurate spin ordering. For $YBCuO$, systems the situation is less certain, but our results favor hole pockets at $(\pi/2,\pi/2)$. We also discuss briefly the tendency towards phase separation.Comment: 18 pages, LaTe

Microscopic Theory for the Markovian Decay of Magnetization Fluctuations in Nanomagnets

We present a microscopic theory for the phonon-driven decay of the magnetization fluctuations in a wide class of nanomagnets where the dominant energy is set by isotropic exchange and/or uniaxial anisotropy. Based on the Zwanzig-Mori projection formalism, the theory reveals that the magnetization fluctuations are governed by a single decay rate $\omega_c$, which we further identify with the zero-frequency portion of the associated self-energy. This dynamical decoupling from the remaining slow degrees of freedom is attributed to a conservation law and the discreteness of the energy spectrum, and explains the omnipresent mono-exponential decay of the magnetization over several decades in time, as observed experimentally. A physically transparent analytical expression for $\omega_c$ is derived which highlights the three specific mechanisms of the slowing down effect which are known so far in nanomagnets.Comment: 7 page

Diffusion of heat, energy, momentum, and mass in one-dimensional systems

We study diffusion processes of local fluctuations of heat, energy, momentum, and mass in three paradigmatic one-dimensional systems. For each system, diffusion processes of four physical quantities are simulated and the cross correlations between them are investigated. We find that, in all three systems, diffusion processes of energy and mass can be perfectly expressed as a linear combination of those of heat and momentum, suggesting that diffusion processes of heat and momentum may represent the heat mode and the sound mode in the hydrodynamic theory. In addition, the dynamic structure factor, which describes the diffusion behavior of local mass density fluctuations, is in general insufficient for probing diffusion processes of other quantities because in some cases there is no correlation between them. We also find that the diffusion behavior of heat can be qualitatively different from that of energy, and, as a result, previous studies trying to relate heat conduction to energy diffusion should be revisited.Comment: 7 pages, 4 figure

State-Dependent and -Independent Effects of Dialyzing Excitatory Neuromodulator Receptor Antagonists into the Ventral Respiratory Column

Unilateral dialysis of the broad-spectrum muscarinic receptor antagonist atropine (50 mM) into the ventral respiratory column [(VRC) including the pre-Bötzinger complex region] of awake goats increased pulmonary ventilation (V̇i) and breathing frequency (f), conceivably due to local compensatory increases in serotonin (5-HT) and substance P (SP) measured in effluent mock cerebral spinal fluid (mCSF). In contrast, unilateral dialysis of a triple cocktail of antagonists to muscarinic (atropine; 5 mM), neurokinin-1, and 5-HT receptors does not alter V̇i or f, but increases local SP. Herein, we tested hypotheses that 1) local compensatory 5-HT and SP responses to 50 mM atropine dialyzed into the VRC of goats will not differ between anesthetized and awake states; and 2) bilateral dialysis of the triple cocktail of antagonists into the VRC of awake goats will not alter V̇i or f, but will increase local excitatory neuromodulators. Through microtubules implanted into the VRC of goats, probes were inserted to dialyze mCSF alone (time control), 50 mM atropine, or the triple cocktail of antagonists. We found 1) equivalent increases in local 5-HT and SP with 50 mM atropine dialysis during wakefulness compared with isoflurane anesthesia, but V̇i and f only increased while awake; and 2) dialyses of the triple cocktail of antagonists increased V̇i, f, 5-HT, and SP

Quark description of the Nambu-Goldstone bosons in the color-flavor locked phase

We investigate the color-singlet order parameters and the quark description of the Nambu-Goldstone (NG) bosons in the color-flavor locked (CFL) phase. We put emphasis on the NG boson (phason) called ``H'' associated with the $\mathrm{U_B(1)}$ symmetry breaking. We qualitatively argue the nature of H as the second sound in the hydrodynamic regime. We articulate, based on a diquark picture, how the structural change of the condensates and the associated NG bosons occurs continuously from hadronic to CFL quark matter if the quark-hadron continuity is realized. We sharpen the qualitative difference between the flavor octet pions and the singlet phason. We propose a conjecture that superfluid H matter undergoes a crossover to a superconductor with tightly-bound diquarks, and then a crossover to superconducting matter with diquarks dissociated.Comment: 14 pages, 1 table, 1 figure and confusing statements are correcte

Dynamic correlations in stochastic rotation dynamics

The dynamic structure factor, vorticity and entropy density dynamic correlation functions are measured for Stochastic Rotation Dynamics (SRD), a particle based algorithm for fluctuating fluids. This allows us to obtain unbiased values for the longitudinal transport coefficients such as thermal diffusivity and bulk viscosity. The results are in good agreement with earlier numerical and theoretical results, and it is shown for the first time that the bulk viscosity is indeed zero for this algorithm. In addition, corrections to the self-diffusion coefficient and shear viscosity arising from the breakdown of the molecular chaos approximation at small mean free paths are analyzed. In addition to deriving the form of the leading correlation corrections to these transport coefficients, the probabilities that two and three particles remain collision partners for consecutive time steps are derived analytically in the limit of small mean free path. The results of this paper verify that we have an excellent understanding of the SRD algorithm at the kinetic level and that analytic expressions for the transport coefficients derived elsewhere do indeed provide a very accurate description of the SRD fluid.Comment: 33 pages including 16 figure

The Effects of Lesions in the Dorsolateral Pons on the Coordination of Swallowing and Breathing in Awake Goats

The purpose of this retrospective study was to gain insight into the contribution of the dorsolateral pons to the coordination of swallowing and breathing in awake goats. In 4 goats, cannulas were chronically implanted bilaterally through the lateral (LPBN) and medial (MPBN) parabrachial nuclei just dorsal to the Kölliker–Fuse nucleus (KFN). After \u3e2 weeks recovery from this surgery, the goats were studied for 5½ h on a control day, and on separate days after receiving 1 and 10 μl injections of ibotenic acid (IA) separated by 1 week. The frequency of swallows did not change during the control and 1 μl IA studies, but after injection of 10 μl IA, there was a transient 65% increase in frequency of swallows (P \u3c 0.05). Under control conditions swallows occurred throughout the respiratory cycle, where late-E swallows accounted for 67.6% of swallows. The distribution of swallow occurrence throughout the respiratory cycle was unaffected by IA injections. Consistent with the concept that swallowing is dominant over breathing, we found that swallows increased inspiratory (TI) and expiratory (TE) time and decreased tidal volume (VT) of the breath of the swallow (n) and/or the subsequent (n + 1) breath. Injections of 10 μl IA attenuated the normal increases in TI and TE and further attenuated VT of the n breath. Additionally, E and I swallows reset respiratory rhythm, but injection of 1 or 10 μl IA progressively attenuated this resetting, suggesting a decreased dominance over respiratory motor output with increasing IA injections. Post mortem histological analysis revealed about 50% fewer (P \u3c 0.05) neurons remained in the KFN, LPBN, and MPBN in lesioned compared to control goats. We conclude that dorsolateral pontine nuclei have a modulatory role in a hypothesized holarchical neural network regulating swallowing and breathing particularly contributing to the normal dominance of swallowing over breathing in both rhythm and motor pattern generation