Proposal for a Performance Dashboard for the Monitoringof Water and Sewage Service Companies (WaSCs)

The water and sewage industry provides an essential service to the community, but it is characterized by natural monopoly tendencies of service suppliers. In this framework, it is very important to assist regulators with a small set of critical indicators (performance dashboard) for the evaluation and monitoring of the service provided by Water and Sewage Companies (WaSCs). The paper originates from the analysis of situation of Piemonte (Italy), where each regional and local body adopts a proprietary Performance Measurement System (PMS). In order to improve the coordination of information flow and to support the definition of common service standards, a methodology to merge existing PMSs and define a unique shared reference system is proposed. The Kaplan and Norton's Balanced Scorecard (BSC) is adopted as the reference model of this approach. BSC is widely recognized to be an exhaustive and balanced framework in describing the performances of an organization and ensures that all the operational aspects of WaSCs are adequately monitored. The output of the proposed procedure is a general performance dashboard for the monitoring of WaSCs. The dashboard is shown and some remarks about indicators properties are developed. In particular, this analysis highlights some common pitfalls originated by a ‘rushed' aggregation of several performance indicators. Description is supported by several example

Publication and patent analysis of European researchers in the field of production technology and manufacturing systems

This paper develops a structured comparison among a sample of European researchers in the field of Production Technology and Manufacturing Systems, on the basis of scientific publications and patents. Researchers are evaluated and compared by a variegated set of indicators concerning (1) the output of individual researchers and (2) that of groups of researchers from the same country. While not claiming to be exhaustive, the results of this preliminary study provide a rough indication of the publishing and patenting activity of researchers in the field of interest, identifying (dis)similarities between different countries. Of particular interest is a proposal for aggregating analysis results by means of maps based on publication and patent indicators. A large amount of empirical data are presented and discusse

Battery choice and management for New Generation Electric Vehicles

Different types of electric vehicles (EVs) have been recently designed with the aim of solving pollution problems caused by the emission of gasoline-powered engines. Environmental problems promote the adoption of new-generation electric vehicles for urban transportation. As it is well known, one of the weakest points of electric vehicles is the battery system. Vehicle autonomy and, therefore, accurate detection of battery state of charge (SoC) together with battery expected life, i.e., battery state of health, are among the major drawbacks that prevent the introduction of electric vehicles in the consumer market. The electric scooter may provide the most feasible opportunity among EVs. They may be a replacement product for the primary-use vehicle, especially in Europe and Asia, provided that drive performance, safety, and cost issues are similar to actual engine scooters. The battery system choice is a crucial item, and thanks to an increasing emphasis on vehicle range and performance, the Li-ion battery could become a viable candidate. This paper deals with the design of a battery pack based on Li-ion technology for a prototype electric scooter with high performance and autonomy. The adopted battery system is composed of a suitable number of cells series connected, featuring a high voltage level. Therefore, cell equalization and monitoring need to be provided. Due to manufacturing asymmetries, charge and discharge cycles lead to cell unbalancing, reducing battery capacity and, depending on cell type, causing safety troubles or strongly limiting the storage capacity of the full pack. No solution is available on the market at a cheap price, because of the required voltage level and performance, therefore, a dedicated battery management system was designed, that also includes a battery SoC monitoring. The proposed solution features a high capability of energy storing in braking conditions, charge equalization, overvoltage and undervoltage protection and, obviously, SoC information in order to optimize autonomy instead of performance or vice-versa

Reversible viscosity and Navier--Stokes fluids

Exploring the possibility of describing a fluid flow via a time-reversible equation and its relevance for the fluctuations statistics in stationary turbulent (or laminar) incompressible Navier-Stokes flows.Comment: 7 pages 6 figures, v2: replaced Fig.6 and few changes. Last version: appendix cut shorter, because of a computational erro

Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ

Nucleophosmin (NPM1) is a multifunctional nucleolar protein implicated in ribogenesis, centrosome duplication, cell cycle control, regulation of DNA repair and apoptotic response to stress stimuli. The majority of these functions are played through the interactions with a variety of protein partners. NPM1 is frequently overexpressed in solid tumors of different histological origin. Furthermore NPM1 is the most frequently mutated protein in acute myeloid leukemia (AML) patients. Mutations map to the C-terminal domain and lead to the aberrant and stable localization of the protein in the cytoplasm of leukemic blasts. Among NPM1 protein partners, a pivotal role is played by the tumor suppressor Fbw7γ, an E3-ubiquitin ligase that degrades oncoproteins like c-MYC, cyclin E, Notch and c-jun. In AML with NPM1 mutations, Fbw7γ is degraded following its abnormal cytosolic delocalization by mutated NPM1. This mechanism also applies to other tumor suppressors and it has been suggested that it may play a key role in leukemogenesis. Here we analyse the interaction between NPM1 and Fbw7γ, by identifying the protein surfaces implicated in recognition and key aminoacids involved. Based on the results of computational methods, we propose a structural model for the interaction, which is substantiated by experimental findings on several site-directed mutants. We also extend the analysis to two other NPM1 partners (HIV Tat and CENP-W) and conclude that NPM1 uses the same molecular surface as a platform for recognizing different protein partners. We suggest that this region of NPM1 may be targeted for cancer treatment

ISOCAM observations in the Lockman Hole - II The 14.3 micron deep survey: data reduction, catalogue and source counts

We present a new analysis of the ISOCAM 14.3 micron deep survey in a 20x20 square arcmins area in the Lockman Hole. This survey is intermediate between the ultra-deep surveys and the shallow surveys in the ELAIS fields. The data have been analyzed with the method presented by Lari et al. (2001). We have produced a catalogue of 283 sources detected above the 5-sigma threshold, with fluxes in the interval 0.1-8 mJy. The catalogue is 90% complete at 1 mJy. The positional accuracy, estimated from the cross-correlation of infrared and optical sources, is around 1.5 arcsec. The search for the optical counterparts of the sources in the survey is performed on a medium-deep r' band optical image (5-sigma depth of r'=25), making use of the radio detections when available. The photometry has been checked through simulations and by comparing the data with those presented in a shallower and more extended ISOCAM survey in the Lockman Hole, that we have presented in a companion paper. Only 15% of the 14.3 micron sources do not have an optical counterpart down to r'=25 mag. We use the 6.7/14.3 micron colour as a star/galaxy separator, together with a visual inspection of the optical image and an analysis of the observed Spectral Energy Distribution of the ISOCAM sources. The stars in the sample turn out to be only 6% of the sample. We discuss the 14.3 micron counts of extragalactic sources, combining our catalogue with that obtained from the shallower ISOCAM survey. The data in the two surveys are consistent, and our results fully support the claims in previous works for the existence of an evolving population of infrared galaxies, confirming the evident departure from non-evolutionary model predictions.Comment: Version accepted by Astronomy and Astrophysics. Images have been heavily degraded to fill the archive size. A full resolution version can be downloaded at the following link http://dipastro.pd.astro.it/giulia/Deep/1252.ps.g