The management of bronchus intermedius complications after lung transplantation: A retrospective study

<p>Abstract</p> <p>Background</p> <p>Airway complications following lung transplantation remain a significant cause of morbidity and mortality. The management of bronchial complications in Bronchus Intermedius (BI) is challenging due to the location of right upper bronchus. The aim of this study was to analyze the results of BI Montgomery T-tube stent in a consecutive patients with lung transplantations.</p> <p>Methods</p> <p>Between January 2007 and December 2010, 132 lung transplantations were performed at Foch Hospital, Suresnes, France. All the patients who had BI Montgomery T-tube after lung transplantation were included in this retrospective study. The demographic and interventional data and also complications were recorded.</p> <p>Results</p> <p>Out of 132 lung transplant recipients, 12 patients (9 male and 3 female) were entered into this study. The indications for lung transplantation were: cystic fibrosis 8 (67%), emphysema 3 (25%), and idiopathic pulmonary fibrosis 1 (8%). Most of the patients (83%) had bilateral lung transplantation. The mean interval between lung transplantation and interventional bronchoscopy was 11.5 ± 9.8 (SD) months. There was bronchial stenosis at the level of BI in 7 patients (58.3%). The Montgomery T-tube number 10 was used in 9 patients (75%). There was statistically significant difference in Forced Expiratory Volume in one second (FEV1) before and after stent placement (p = 0.01). The most common complication after stent placement was migration (33%).</p> <p>Conclusion</p> <p>BI complications after lung transplantation are still a significant problem. Stenosis or malacia following lung transplantation could be well managed with modified Montgomery T-tube.</p

Search for electron antineutrino appearance in a long-baseline muon antineutrino beam

Electron antineutrino appearance is measured by the T2K experiment in an accelerator-produced antineutrino beam, using additional neutrino beam operation to constrain parameters of the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) mixing matrix. T2K observes 15 candidate electron antineutrino events with a background expectation of 9.3 events. Including information from the kinematic distribution of observed events, the hypothesis of no electron antineutrino appearance is disfavored with a significance of 2.40σ and no discrepancy between data and PMNS predictions is found. A complementary analysis that introduces an additional free parameter which allows non-PMNS values of electron neutrino and antineutrino appearance also finds no discrepancy between data and PMNS predictions

Measurement of the νμν_μ charged-current cross sections on water, hydrocarbon, iron, and their ratios with the T2K on-axis detectors

We report a measurement of the flux-integrated $\nu_{\mu}$ charged-current cross sections on water, hydrocarbon, and iron in the T2K on-axis neutrino beam with a mean neutrino energy of 1.5 GeV. The measured cross sections on water, hydrocarbon, and iron are $\sigma^{\rm{H_{2}O}}_{\rm{CC}}$ = (0.840$\pm 0.010$(stat.)$^{+0.10}_{-0.08}$(syst.))$\times$10$^{-38}$cm$^2$/nucleon, $\sigma^{\rm{CH}}_{\rm{CC}}$ = (0.817$\pm 0.007$(stat.)$^{+0.11}_{-0.08}$(syst.))$\times$10$^{-38}$cm$^2$/nucleon, and $\sigma^{\rm{Fe}}_{\rm{CC}}$ = (0.859$\pm 0.003$(stat.) $^{+0.12}_{-0.10}$(syst.))$\times$10$^{-38}$cm$^2$/nucleon respectively, for a restricted phase space of induced muons: $\theta_{\mu}$0.4 GeV/$c$ in the laboratory frame. The measured cross section ratios are ${\sigma^{\rm{H_{2}O}}_{\rm{CC}}}/{\sigma^{\rm{CH}}_{\rm{CC}}}$ = 1.028$\pm 0.016$(stat.)$\pm 0.053$(syst.), ${\sigma^{\rm{Fe}}_{\rm{CC}}}/{\sigma^{\rm{H_{2}O}}_{\rm{CC}}}$ = 1.023$\pm 0.012$(stat.)$\pm 0.058$(syst.), and ${\sigma^{\rm{Fe}}_{\rm{CC}}}/{\sigma^{\rm{CH}}_{\rm{CC}}}$ = 1.049$\pm 0.010$(stat.)$\pm 0.043$(syst.). These results, with an unprecedented precision for the measurements of neutrino cross sections on water in the studied energy region, show good agreement with the current neutrino interaction models used in the T2K oscillation analyses

Measurement of the charged-current electron (anti-)neutrino inclusive cross-sections at the T2K off-axis near detector ND280

The electron (anti-)neutrino component of the T2K neutrino beam constitutes the largest background in the measurement of electron (anti-)neutrino appearance at the far detector. The electron neutrino scattering is measured directly with the T2K off-axis near detector, ND280. The selection of the electron (anti-)neutrino events in the plastic scintillator target from both neutrino and anti-neutrino mode beams is discussed in this paper. The flux integrated single differential charged-current inclusive electron (anti-)neutrino cross-sections, $d\sigma/dp$ and $d\sigma/d\cos(\theta)$, and the total cross-sections in a limited phase-space in momentum and scattering angle ($p > 300$ MeV/c and $\theta \leq 45^{\circ}$) are measured using a binned maximum likelihood fit and compared to the neutrino Monte Carlo generator predictions, resulting in good agreement

Search for neutral-current induced single photon production at the ND280 near detector in T2K

Neutrino neutral-current (NC) induced single photon production is a sub-leading order process for accelerator-based neutrino beam experiments including T2K. It is, however, an important process to understand because it is a background for electron (anti)neutrino appearance oscillation experiments. Here, we performed the first search of this process below 1 GeV using the fine-grained detector at the T2K ND280 off-axis near detector. By reconstructing single photon kinematics from electron–positron pairs, we achieved 95% pure gamma ray sample from $5.738\times {10}^{20}$ protons-on-targets neutrino mode data. We do not find positive evidence of NC induced single photon production in this sample. We set the model-dependent upper limit on the cross-section for this process, at $0.114\times {10}^{-38}$ cm2 (90% C.L.) per nucleon, using the J-PARC off-axis neutrino beam with an average energy of $\left\langle {E}_{\nu }\right\rangle \sim 0.6$ GeV. This is the first limit on this process below 1 GeV which is important for current and future oscillation experiments looking for electron neutrino appearance oscillation signals

Measurements of (nu)over-bar(mu) and (nu)over-bar(mu) + nu(mu) charged-current cross-sections without detected pions or protons on water and hydrocarbon at a mean anti-neutrino energy of 0.86 GeV

International audienceWe report measurements of the flux-integrated |$\overline{\nu}_\mu$| and |$\overline{\nu}_\mu+\nu_\mu$| charged-current cross-sections on water and hydrocarbon targets using the T2K anti-neutrino beam with a mean beam energy of 0.86 GeV. The signal is defined as the (anti-)neutrino charged-current interaction with one induced |$\mu^\pm$| and no detected charged pion or proton. These measurements are performed using a new WAGASCI module recently added to the T2K setup in combination with the INGRID Proton Module. The phase space of muons is restricted to the high-detection efficiency region, |$p_{\mu}>400~{\rm MeV}/c$| and |$\theta_{\mu}200~{\rm MeV}/c$|⁠, |$\theta_{\pi}600~{\rm MeV}/c$|⁠, |$\theta_{\rm p}<70^{\circ}$| is required. In this paper, both the |$\overline{\nu}_\mu$| cross-sections and |$\overline{\nu}_\mu+\nu_\mu$| cross-sections on water and hydrocarbon targets and their ratios are provided by using the D’Agostini unfolding method. The results of the integrated |$\overline{\nu}_\mu$| cross-section measurements over this phase space are |$\sigma_{\rm H_{2}O}=(1.082\pm0.068(\rm stat.)^{+0.145}_{-0.128}(\rm syst.)) \times 10^{-39}\,{\rm cm^{2} / nucleon}$|⁠, |$\sigma_{\rm CH}=(1.096\pm0.054(\rm stat.)^{+0.132}_{-0.117}(\rm syst.)) \times 10^{-39}\,{\rm cm^{2} / nucleon}$|⁠, and |$\sigma_{\rm H_{2}O}/\sigma_{\rm CH} = 0.987\pm0.078(\rm stat.)^{+0.093}_{-0.090}(\rm syst.)$|⁠. The |$\overline{\nu}_\mu+\nu_\mu$| cross-section is |$\sigma_{\rm H_{2}O} = (1.155\pm0.064(\rm stat.)^{+0.148}_{-0.129}(\rm syst.)) \times 10^{-39}\,{\rm cm^{2} / nucleon}$|⁠, |$\sigma_{\rm CH}=(1.159\pm0.049(\rm stat.)^{+0.129}_{-0.115}(\rm syst.)) \times 10^{-39}\,{\rm cm^{2} / nucleon}$|⁠, and |$\sigma_{\rm H_{2}O}/\sigma_{\rm CH}=0.996\pm0.069(\rm stat.)^{+0.083}_{-0.078}(\rm syst.)$|⁠

Search for CP Violation in Neutrino and Antineutrino Oscillations by the T2K Experiment with 2.2 x 10(21) Protons on Target

International audienceThe T2K experiment measures muon neutrino disappearance and electron neutrino appearance in accelerator-produced neutrino and antineutrino beams. With an exposure of 14.7(7.6)×1020 protons on target in the neutrino (antineutrino) mode, 89 νe candidates and seven anti-νe candidates are observed, while 67.5 and 9.0 are expected for δCP=0 and normal mass ordering. The obtained 2σ confidence interval for the CP-violating phase, δCP, does not include the CP-conserving cases (δCP=0, π). The best-fit values of other parameters are sin2θ23=0.526-0.036+0.032 and Δm322=2.463-0.070+0.071×10-3  eV2/c4

Characterization of nuclear effects in muon-neutrino scattering on hydrocarbon with a measurement of final-state kinematics and correlations in charged-current pionless interactions at T2K

This paper reports measurements of final-state proton multiplicity, muon and proton kinematics, and their correlations in charged-current pionless neutrino interactions, measured by the T2K ND280 near detector in its plastic scintillator (C8H8) target. The data were taken between years 2010 and 2013, corresponding to approximately 6 × 1020 protons on target. Thanks to their exploration of the proton kinematics and of imbalances between the proton and muon kinematics, the results offer a novel probe of the nuclear-medium effects most pertinent to the (sub-)GeV neutrino-nucleus interactions that are used in accelerator-based long-baseline neutrino oscillation measurements. These results are compared to many neutrino-nucleus interaction models which all fail to describe at least part of the observed phase space. In case of events without a proton above a detection threshold in the final state, a fully consistent implementation of the local Fermi gas model with multinucleon interactions gives the best description of the data. In the case of at least one proton in the final state, the spectral function model agrees well with the data, most notably when measuring the kinematic imbalance between the muon and the proton in the plane transverse to the incoming neutrino. Within the models considered, only the existence of multinucleon interactions are able to describe the extracted cross section within regions of high transverse kinematic imbalance. The effect of final-state interactions is also discussed

Search for light sterile neutrinos with the T2K far detector Super-Kamiokande at a baseline of 295 km

We perform a search for light sterile neutrinos using the data from the T2K far detector at a baseline of 295 km, with an exposure of 14.7ð7.6Þ × 1020 protons on target in neutrino (antineutrino) mode. A selection of neutral-current interaction samples is also used to enhance the sensitivity to sterile mixing. No evidence of sterile neutrino mixing in the 3 þ 1 model was found from a simultaneous fit to the charged-current muon, electron and neutral-current neutrino samples. We set the most stringent limit on the sterile oscillation amplitude sin2 θ24 for the sterile neutrino mass splitting Δm241 < 3 × 10−3 eV2=c4