Los genes: del laboratorio a la prensa

La información sobre temas relacionados con genética comienza su auge en los medios de comunicación en 1999. En el informe Quiral del citado año reflejaba cómo los artículos periodísticos relacionados con la genética iniciaban un importante incremento sobre todo en los suplementos de Salud. = Information issues regarding genetics begins to grow in the media in 1999. The 1999. Quiral report mentioned the fact articles on genetics were growing rapidly, particularly in health newspaper supplements

Exploratory Analysis of Functional Data via Clustering and Optimal Segmentation

We propose in this paper an exploratory analysis algorithm for functional data. The method partitions a set of functions into $K$ clusters and represents each cluster by a simple prototype (e.g., piecewise constant). The total number of segments in the prototypes, $P$, is chosen by the user and optimally distributed among the clusters via two dynamic programming algorithms. The practical relevance of the method is shown on two real world datasets

Interannual variations of the terrestrial water storage in the Lower Ob' Basin from a multisatellite approach

International audienceTemporal variations of surface water volume over inundated areas of the Lower Ob' Basin in Siberia, one of the largest contributor of freshwater to the Arctic Ocean, are estimated using combined observations from a multisatellite inundation dataset and water levels over rivers and floodplains derived from the TOPEX/POSEIDON (T/P) radar altimetry. We computed time-series of monthly maps of surface water volume over the common period of available T/P and multisatellite data (1993–2004). The results exhibit interannual variabilities similar to precipitation estimates and river discharge observations. This study also presents monthly estimates of groundwater and permafrost mass anomalies during 2003–2004 based on a synergistic analysis of multisatellite observations and hydrological models. Water stored in the soil is isolated from the total water storage measured by GRACE when removing the contributions of both the surface reservoir, derived from satellite imagery and radar altimetry, and the snow estimated by inversion of GRACE measurements. The time variations of groundwater and permafrost are then obtained when removing the water content of the root zone reservoir simulated by hydrological models

Constrained Regional Recovery of Continental Water Mass Time-variations from GRACE-based Geopotential Anomalies over South America

International audienceWe propose a ''constrained'' least-squares approach to estimate regional maps of equivalent-water heights by inverting GRACE-based potential anomalies at satellite altitude. According to the energy integral method, the anomalies of difference of geopotential between the two GRACE vehicles are derived from along-track K-Band Range-Rate (KBRR) residuals that correspond mainly to the continental water storage changes, once a priori known accelerations (i.e. static field, polar movements, atmosphere and ocean masses including tides) are removed during the orbit adjustment process. Newton's first law merely enables the Difference of Potential Anomalies from accurate KBRR data and the equivalent-water heights to be recovered. Spatial constraints versus spherical distance between elementary surface tiles are introduced to stabilize the linear system to cancel the effects of the north-south striping. Unlike the ''mascons'' approach, no basis of orthogonal functions (e.g., spherical harmonics) is used, so that the proposed regional method does not suffer from drawbacks related to any spectrum truncation. Time series of 10-day regional maps over South America for 2006-2009 also prove to be consistent with independent datasets, namely the outputs of hydrological models, ''mascons'' and global GRACE solutions

Surface freshwater storage variations in the Orinoco floodplains using multi-satellite observations

Variations in surface water extent and storage are poorly characterized from regional to global scales. In this study, a multi-satellite approach is proposed to estimate the water stored in the floodplains of the Orinoco Basin at a monthly time-scale using remotely-sensed observations of surface water from the Global Inundation Extent Multi-Satellite (GIEMS) and stages from Envisat radar altimetry. Surface water storage variations over 2003-2007 exhibit large interannual variability and a strong seasonal signal, peaking during summer, and associated with the flood pulse. The volume of surface water storage in the Orinoco Basin was highly correlated with the river discharge at Ciudad Bolivar (R = 0.95), the closest station to the mouth where discharge was estimated, although discharge lagged one month behind storage. The correlation remained high (R = 0.73) after removing seasonal effects. Mean annual variations in surface water volume represented similar to 170 km(3), contributing to similar to 45% of the Gravity Recovery and Climate Experiment (GRACE)-derived total water storage variations and representing similar to 13% of the total volume of water that flowed out of the Orinoco Basin to the Atlantic Ocean

Monitoring groundwater storage changes in the highly seasonal humid tropics: Validation of GRACE measurements in the Bengal Basin

International audienceSatellite monitoring of changes in terrestrial water storage provides invaluable information regarding the basin-scale dynamics of hydrological systems where ground-based records are limited. In the Bengal Basin of Bangladesh, we test the ability of satellite measurements under the Gravity Recovery and Climate Experiment (GRACE) to trace both the seasonality and trend in groundwater storage associated with intensive groundwater abstraction for dry-season irrigation and wet-season (monsoonal) recharge. We show that GRACE (CSR, GRGS) datasets of recent (2003 to 2007) groundwater storage changes (ΔGWS) correlate well (r = 0.77 to 0.93, p value < 0.0001) with in situ borehole records from a network of 236 monitoring stations and account for 44% of the total variation in terrestrial water storage (ΔTWS) highest correlation (r = 0.93, p value < 0.0001) and lowest root-mean-square error (<4 cm) are realized using a spherical harmonic product of CSR. Changes in surface water storage estimated from a network of 298 river gauging stations and soil-moisture derived from Land Surface Models explain 22% and 33% of ΔTWS, respectively. Groundwater depletion estimated from borehole hydrographs (-0.52 ± 0.30 km3 yr-1) is within the range of satellite-derived estimates (-0.44 to -2.04 km3 yr-1) that result from uncertainty associated with the simulation of soil moisture (CLM, NOAH, VIC) and GRACE signal-processing techniques. Recent (2003 to 2007) estimates of groundwater depletion are substantially greater than long-term (1985 to 2007) mean (-0.21 ± 0.03 km3 yr-1) and are explained primarily by substantial increases in groundwater abstraction for the dry-season irrigation and public water supplies over the last two decades

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress

The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects, the pathogenesis of which still remains poorly understood. In particular, NBS1 gene mutations are associated with microcephaly and strongly impaired cerebellar development, both in humans and in the mouse model. These phenotypes strikingly overlap those induced by inactivation of MYCN, an essential promoter of the expansion of neuronal stem and progenitor cells, suggesting that MYCN and the MRN complex might be connected on a unique pathway essential for the safe expansion of neuronal cells. Here, we show that MYCN transcriptionally controls the expression of each component of the MRN complex. By genetic and pharmacological inhibition of the MRN complex in a MYCN overexpression model and in the more physiological context of the Hedgehog-dependent expansion of primary cerebellar granule progenitor cells, we also show that the MRN complex is required for MYCN-dependent proliferation. Indeed, its inhibition resulted in DNA damage, activation of a DNA damage response, and cell death in a MYCN- and replication-dependent manner. Our data indicate the MRN complex is essential to restrain MYCN-induced replication stress during neural cell proliferation and support the hypothesis that replication-born DNA damage is responsible for the neuronal defects associated with MRN dysfunctions.Cell Death and Differentiation advance online publication, 12 June 2015; doi:10.1038/cdd.2015.81

Функционирование маркетинговых терминов в английском языке и способы их перевода на русский язык

Целью исследования является определение способов перевода английской терминологии на русский язык

DNA strand break repair and neurodegeneration.

A number of DNA repair disorders are known to cause neurological problems. These disorders can be broadly characterised into early developmental, mid-to-late developmental or progressive. The exact developmental processes that are affected can influence disease pathology, with symptoms ranging from early embryonic lethality to late-onset ataxia. The category these diseases belong to depends on the frequency of lesions arising in the brain, the role of the defective repair pathway, and the nature of the mutation within the patient. Using observations from patients and transgenic mice, we discuss the importance of double strand break repair during neuroprogenitor proliferation and brain development and the repair of single stranded lesions in neuronal function and maintenance