Role of endocrine status and cell type in adhesion of human endometrial cells to the peritoneum in nude mice

Objective: To investigate the role of different cellular types (epithelial and stromal endometrial cells and peritoneal cells) in the ectopic implantation of endometrium and to evaluate the importance of endocrine environment on the adhesion of endometrial cells to the peritoneum. Design: Experimental prospective study. Setting: University hospital, department of cell biology. Animal(s): One hundred one nude mice. Intervention(s): Monolayer culture of human epithelial and stromal endometrial cells obtained from patients undergoing hysterectomy or laparoscopy for benign disease. Intraperitoneal injection of cells into nude mice. Main Outcome Measure(s): Two weeks after cell injection, adhesion of endometrial cells was evaluated by histological and immunohistochemical examination. Result(s): Mixed cultures of stromal and epithelial cells, but not purified epithelial or stromal cells alone, adhered to the mouse peritoneum and led to endometriotic-like nodules. Pretreatment of cells with estrogen alone or with estrogen and progestin resulted in a higher percentage of animals developing endometriotic-like nodules, whereas treatment with progestin alone did not affect endometriotic implantation. Conclusion(s): Our data indicate that the success of endometrial cell implantation is dependent on the cooperativeness between stromal and epithelial endometrial cells, as well as on the endocrine environment of endometrial cells, but not that of recipient animals. The results emphasize the role of both endometrial cell types for ectopic implantation. (C) 2002 by American Society for Reproductive Medicine.Peer reviewe

Long-term survival of patients with apparent early-stage (FIGO I-II) epithelial ovarian cancer: a population-based study

Background: Women with presumed early-stage epithelial ovarian cancer (EOC) who have not received comprehensive surgical staging are at risk for recurrence. The aim of our study was to analyze the overall long term survival of EOC patients with a presumed early stage EOC. Methods: A population-based cancer registry was used to identify patients with an early-stage EOC cancer diagnosed between 1989 and 1997. The area under study has no surgical gynecologic oncologist and no tertiary referral center. We categorized patients into two subgroups: low-risk (Ia-Ib well and moderately differentiated) and high-risk (Ia-Ib poorly differentiated or IC-II). Survival curves were calculated from the time of surgery using Kaplan-Meier methods and statistical comparisons were performed using the log-rank test and the Cox proportional hazards regression model. Results: Fifty patients having an apparent early-stage disease (FIGO I-II) were evaluated. Forty-one patients have been operated by obstetrician-gynecologists and 9 by general surgeons. Twenty-one (42%) have been categorized as low-risk and 29 (58%) as high-risk. An optimal, modified, minimal and inadequate surgical staging was performed in 6, 10, 26 and 58, respectively. The median follow-up time was 147 months (range: 2.5-165). The 5- and 10-year overall survival was 95 and 89% for low-risk and 72 and 33% for high-risk subgroups, respectively. Conclusions: The surgical staging is frequently incomplete when performed in small hospitals with few patients by nonspecialists. Women in the high-risk group and incompletely staged have a less favorable prognosis than those reported in the literature. [Ed.]]]> Ovarian Neoplasms/mortality ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery eng oai:serval.unil.ch:BIB_3235 2022-05-07T01:14:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_3235 Le chant ou la prose. Une lecture midrachique d'Exode 14 et 15 Banon, D. info:eu-repo/semantics/article article 1996 BCPE(G), vol. 48.7-8, pp. 18-27 fre oai:serval.unil.ch:BIB_323505DF5FA9 2022-05-07T01:14:32Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_323505DF5FA9 Lésions musculaires traumatiques? : quelles investigations faire et à quel moment Theumann, N. Richarme, D. info:eu-repo/semantics/article article 2011 Schweizerische Zeitschrift für Sportmedizin und Sporttraumatologie = Revue Suisse de Médecine et Traumatologie du Sport, vol. 59, no. 1, pp. 22-26 info:eu-repo/semantics/altIdentifier/pissn/1422-0644 urn:issn:1422-0644 fre https://serval.unil.ch/resource/serval:BIB_323505DF5FA9.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_323505DF5FA90 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_323505DF5FA90 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_3235068797E7 2022-05-07T01:14:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_3235068797E7 Contro un’idea di lirica moderna: Fortini, Friedrich e il Simbolismo diaco, francesco info:eu-repo/semantics/article article 2017 «Mosaico italiano», XIII 165 ita oai:serval.unil.ch:BIB_32354 2022-05-07T01:14:32Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_32354 Polymorphisms, resistance and drug response - Beyond B-subtype HIV-1. Telenti, A info:eu-repo/semantics/article article 2004 Antivir Ther, vol. 9, pp. 1 oai:serval.unil.ch:BIB_32355C8454B3 2022-05-07T01:14:32Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_32355C8454B3 Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder. info:doi:10.1016/j.biopsych.2015.02.025 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsych.2015.02.025 info:eu-repo/semantics/altIdentifier/pmid/25861698 Rucker, J.J. Tansey, K.E. Rivera, M. Pinto, D. Cohen-Woods, S. Uher, R. Aitchison, K.J. Craddock, N. Owen, M.J. Jones, L. Jones, I. Korszun, A. Barnes, M.R. Preisig, M. Mors, O. Maier, W. Rice, J. Rietschel, M. Holsboer, F. Farmer, A.E. Craig, I.W. Scherer, S.W. McGuffin, P. Breen, G. info:eu-repo/semantics/article article 2016 Biological Psychiatry, vol. 79, no. 4, pp. 329-336 info:eu-repo/semantics/altIdentifier/eissn/1873-2402 urn:issn:0006-3223 <![CDATA[BACKGROUND: Defining the molecular genomic basis of the likelihood of developing depressive disorder is a considerable challenge. We previously associated rare, exonic deletion copy number variants (CNV) with recurrent depressive disorder (RDD). Sex chromosome abnormalities also have been observed to co-occur with RDD. METHODS: In this reanalysis of our RDD dataset (N = 3106 cases; 459 screened control samples and 2699 population control samples), we further investigated the role of larger CNVs and chromosomal abnormalities in RDD and performed association analyses with clinical data derived from this dataset. RESULTS: We found an enrichment of Turner's syndrome among cases of depression compared with the frequency observed in a large population sample (N = 34,910) of live-born infants collected in Denmark (two-sided p = .023, odds ratio = 7.76 [95% confidence interval = 1.79-33.6]), a case of diploid/triploid mosaicism, and several cases of uniparental isodisomy. In contrast to our previous analysis, large deletion CNVs were no more frequent in cases than control samples, although deletion CNVs in cases contained more genes than control samples (two-sided p = .0002). CONCLUSIONS: After statistical correction for multiple comparisons, our data do not support a substantial role for CNVs in RDD, although (as has been observed in similar samples) occasional cases may harbor large variants with etiological significance. Genetic pleiotropy and sample heterogeneity suggest that very large sample sizes are required to study conclusively the role of genetic variation in mood disorders

Clinical case of the month. The role of radiotherapy for the treatment of advanced squamous cell carcinoma of the vulva. Case report and review of the literature

peer reviewedLocally advanced squamous cell carcinoma of the vulva is treated with concomitant chemoradiotherapy if surgery is too mutilating and/or implies the use of stomy. We report in this paper, the unusual case of a young patient treated successfully with this non-surgical approach

Epidémie du Covid 19 en Belgique francophone : regard sur les patients dialysés en techniques ambulatoires

In the French-speaking part of Belgium, between march and end of may 2020, 284 patients have suffered a Covid-19 infection, 7,9% of the prevalent dialysis population. Some of them have been&nbsp; diagnosed through rt-PCT as they were symptomatic, others, asymptomatic,&nbsp; being diagnosed by swab viral culture. Fifty two patients died (18% of the positive patients). The vast majority of them were patients on hemodialysis, only ten cases have been observed in patients on home dialysis techniques. Primary renal disease were diabetes or renal hypertensive disease in more than 50% of the patients and the most important comorbidities were cardiac ischemic or congestive disease, autonomy problems, cancer and smoking habits.En Belgique francophone, pendant la période mars à fin&nbsp; mai 2020, 284 patients en dialyse ont contracté le Covid-19, soit 7,9% de la population prévalente, qu’ils aient été diagnostiques par rt-PCT parce que symptomatiques ou dépistés par culture virale systématique alors qu’asymptomatiques. Cinquante-deux décès ont été observés soit 18% de la population atteinte. La toute grand majorité de ces patients (274) étaient traités par hémodialyse en centre, seuls 10 patients étaient en traitement à domicile. Leurs maladies rénales primitives étaient à plus de 50% des diabète et pathologies vasculaires hypertensives et leurs comorbidités essentielles, les pathologies cardiovasculaires ischémiques et congestives, les problèmes d’autonomie, les néoplasies et le tabagisme

Covid-19 epidemic in the dialysis units of the french speaking part of Belgium : special insight into patients on home dialysis

In the French-speaking part of Belgium, between march and end of may 2020, 284 patients have suffered a Covid-19 infection, 7,9% of the prevalent dialysis population. Some of them have been  diagnosed through rt-PCT as they were symptomatic, others, asymptomatic,  being diagnosed by swab viral culture. Fifty two patients died (18% of the positive patients). The vast majority of them were patients on hemodialysis, only ten cases have been observed in patients on home dialysis techniques. Primary renal disease were diabetes or renal hypertensive disease in more than 50% of the patients and the most important comorbidities were cardiac ischemic or congestive disease, autonomy problems, cancer and smoking habits.</jats:p

De uitholling van het beroepsgeheim.

Het beroepsgeheim haalt met de regelmaat van de klok het nieuws: advocaten praten (strategisch) hun mond voorbij in de pers, psychiaters en medici staan onder druk om hun beroepsgeheim te schenden, de privacy van werknemers wordt in de weegschaal gelegd met het belang van beroepsgeheim.In het rapport over de toekomst van de advocatuur werd ruim aandacht besteed aan het belang van het beroepsgeheim en voor Minister Geens is het één van de prioriteiten bij de hervorming van de advocatuur.Een dergelijke wijdvertakte problematiek vraagt een publicatie die een multidisciplinaire visie biedt, met stemmen uit academische, juridische en medische hoek.De Potpourri V–wet en de Wet van 17 mei 2017 'om de strijd tegen het terrorisme te bevorderen' hebben een aantal belangrijke uitzonderingen toegevoegd aan het beroepsgeheim.De figuur van het ‘casusoverleg' wordt in het leven geroepen, en sommige personen en instanties krijgen een meldingsplicht. Bovendien is de evolutie van de rechtspraak van het Hof van Cassatie over de toelaatbaarheid van onrechtmatig of onregelmatig verkregen bewijsmiddelen in volle evolutie. Tijd dus voor een stand van zaken.In deze Cahier wordt bekeken hoe de figuur ‘beroepsgeheim' er vandaag uitziet, en hoe de practicus ermee moet omgaan. De auteurs focussen elk vanuit hun specialiteit op de actuele vraagstukken en bieden visies vanuit de magistratuur, de medische wereld en de advocatuur.Het beroepsgeheim wordt bekeken vanuit verschillende standpunten – welke zijn de beperkingen en bedreigingen en welke is de impact op elke besproken beroepsgroep?Het beroepsgeheim haalt met de regelmaat van de klok het nieuws: advocaten praten (strategisch) hun mond voorbij in de pers, psychiaters en medici staan onder druk om hun beroepsgeheim te schenden, de privacy van werknemers wordt in de weegschaal gelegd met het belang van beroepsgeheim.In het rapport over de toekomst van de advocatuur werd ruim aandacht besteed aan het belang van het beroepsgeheim en voor Minister Geens is het één van de prioriteiten bij de hervorming van de advocatuur.Een dergelijke wijdvertakte problematiek vraagt een publicatie die een multidisciplinaire visie biedt, met stemmen uit academische, juridische en medische hoek.De Potpourri V–wet en de Wet van 17 mei 2017 'om de strijd tegen het terrorisme te bevorderen' hebben een aantal belangrijke uitzonderingen toegevoegd aan het beroepsgeheim.De figuur van het ‘casusoverleg' wordt in het leven geroepen, en sommige personen en instanties krijgen een meldingsplicht. Bovendien is de evolutie van de rechtspraak van het Hof van Cassatie over de toelaatbaarheid van onrechtmatig of onregelmatig verkregen bewijsmiddelen in volle evolutie. Tijd dus voor een stand van zaken.In deze Cahier wordt bekeken hoe de figuur ‘beroepsgeheim' er vandaag uitziet, en hoe de practicus ermee moet omgaan. De auteurs focussen elk vanuit hun specialiteit op de actuele vraagstukken en bieden visies vanuit de magistratuur, de medische wereld en de advocatuur.Het beroepsgeheim wordt bekeken vanuit verschillende standpunten – welke zijn de beperkingen en bedreigingen en welke is de impact op elke besproken beroepsgroep

Minimally invasive compared to open surgery in patients with low-risk cervical cancer following simple hysterectomy:An exploratory analysis from the Gynegologic Cancer Intergroup/Canadian Cancer Trials Group CX.5/SHAPE trial

Objective: The Laparoscopic Approach to Cervical Cancer trial demonstrated that minimally invasive radical hysterectomy was associated with worse disease-free survival and overall survival among women with early-stage cervical cancer. It is unknown whether this applies to patients with low-risk disease following simple hysterectomy. Methods: Among patients who underwent simple hysterectomy in the Simple Hysterectomy And PElvic node assessment trial, univariate and multivariate Cox models were used to assess the association of minimally invasive versus open surgery with clinical outcomes, including pelvic and extra-pelvic recurrence-free survival, overall recurrence-free survival, and overall survival. Other variables included age, race, performance status, body mass index, stage, histologic type and grade, diagnostic procedure, lymphovascular space invasion before surgery and on final pathology, lymph node status, residual disease, and lesions &gt;2 cm on final pathology. Results: A total of 338 patients underwent simple hysterectomy. Of those, 281 (83%) were performed by minimally invasive surgery and 57 (17%) by open surgery. With a median follow-up of 4.5 years, a total of 12 (4.3%) recurrences were observed in 281 patients having simple hysterectomy by minimally invasive surgery versus 3 in 57 (5.3%) having open surgery (p = .73 from Fisher exact test). Although not randomized, the 2 groups were comparable except for histology and residual disease in the hysterectomy specimen. Patients with minimally invasive surgery had more adenocarcinoma and less adenosquamous compared to open surgery (35.9% versus 22.9% and 3.6% versus 14%, respectively; p = .005). Significantly fewer patients treated by minimally invasive surgery had residual disease in the hysterectomy specimen compared to open surgery (43.1 versus 57.9%; p = .04). No statistically significant difference between minimally invasive and open surgery in pelvic and extra-pelvic recurrence-free survival, overall recurrence-free survival, or overall survival was found. Conclusion: Our data indicate no statistical evidence that minimally invasive surgery is associated with poorer clinical outcomes for patients meeting the SHAPE criteria who underwent simple hysterectomy. Because the surgical approach was not a randomization factor, a large prospective trial is needed to confirm our results before a routine simple hysterectomy by minimally invasive surgery can be recommended.</p

ESMO–ESGO–ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up

AbstractThe first joint European Society for Medical Oncology (ESMO), European SocieTy for Radiotherapy & Oncology (ESTRO) and European Society of Gynaecological Oncology (ESGO) consensus conference on endometrial cancer was held on 11–13 December 2014 in Milan, Italy, and comprised a multidisciplinary panel of 40 leading experts in the management of endometrial cancer. Before the conference, the expert panel prepared three clinically-relevant questions about endometrial cancer relating to the following four areas: Prevention and screening, surgery, adjuvant treatment and advanced and recurrent disease. All relevant scientific literature, as identified by the experts, was reviewed in advance. During the consensus conference, the panel developed recommendations for each specific question and a consensus was reached. Results of this consensus conference, together with a summary of evidence supporting each recommendation, are detailed in this article. All participants have approved this final article