An Evaluation of the St. Louis Regional Community Placement Program

Unavailable

Perceptions Regarding Concussions in Collegiate Football at the University of Mississippi

Concussions are a form of mild traumatic brain injury (mTBI) that can occur from any force to the head or body that causes the brain to move within the skull. Concussions are common in the sport of football due to the highly physical nature of the sport, and injured athletes can experience a wide array of symptoms. Like other players participating with powerhouse football programs, those at the University of Mississippi are at risk of concussion throughout their collegiate career. Whether players and fans perceive the risks of concussion equally has not been previously studied. Considering the passionate history of football at the University, the purpose of this project was to survey full-time students, faculty, and staff at the University of Mississippi regarding their views of the effects and associated risks of concussion on Ole Miss players. We set out to determine which position was perceived to be at greatest risk of concussion. We were also interested in how the public viewed, and was influenced by, the media’s presentation of concussions. We sought to analyze responses based on Ole Miss classification, self-reported devotion to Ole Miss football, identification as current, former, or non-athletes in football or other sports. The results of this study serve to open a dialogue regarding the safety of Ole Miss football players in years to come

Functional and genetic analyses of dipeptidyl peptidase 4 deficiency (Dpp4/Cd26) in a rat model

[no abstract

Treatment of aortic stenosis with a self-expanding transcatheter valve: the International Multi-centre ADVANCE Study

Aim Transcatheter aortic valve implantation has become an alternative to surgery in higher risk patients with symptomatic aortic stenosis. The aim of the ADVANCE study was to evaluate outcomes following implantation of a self-expanding transcatheter aortic valve system in a fully monitored, multi-centre ‘real-world' patient population in highly experienced centres. Methods and results Patients with severe aortic stenosis at a higher surgical risk in whom implantation of the CoreValve System was decided by the Heart Team were included. Endpoints were a composite of major adverse cardiovascular and cerebrovascular events (MACCE; all-cause mortality, myocardial infarction, stroke, or reintervention) and mortality at 30 days and 1 year. Endpoint-related events were independently adjudicated based on Valve Academic Research Consortium definitions. A total of 1015 patients [mean logistic EuroSCORE 19.4 ± 12.3% [median (Q1,Q3), 16.0% (10.3, 25.3%)], age 81 ± 6 years] were enrolled. Implantation of the CoreValve System led to a significant improvement in haemodynamics and an increase in the effective aortic valve orifice area. At 30 days, the MACCE rate was 8.0% (95% CI: 6.3-9.7%), all-cause mortality was 4.5% (3.2-5.8%), cardiovascular mortality was 3.4% (2.3-4.6%), and the rate of stroke was 3.0% (2.0-4.1%). The life-threatening or disabling bleeding rate was 4.0% (2.8-6.3%). The 12-month rates of MACCE, all-cause mortality, cardiovascular mortality, and stroke were 21.2% (18.4-24.1%), 17.9% (15.2-20.5%), 11.7% (9.4-14.1%), and 4.5% (2.9-6.1%), respectively. The 12-month rates of all-cause mortality were 11.1, 16.5, and 23.6% among patients with a logistic EuroSCORE ≤10%, EuroSCORE 10-20%, and EuroSCORE >20% (P< 0.05), respectively. Conclusion The ADVANCE study demonstrates the safety and effectiveness of the CoreValve System with low mortality and stroke rates in higher risk real-world patients with severe aortic stenosi

Advancement of Multifunctional support structure technologies (AMFSST)

The multifunctional support structure (MFSS) technology is promising a reduction of overall mass and packing volume for spacecraft (S/C) electronic components. This technology eliminates the electronic box chassis and the cabling between the boxes by integrating the electronics, thermal control and the structural support into one single element. The ultimate goal of the MFSS technology is to reduce size, weight, power consumption, cost and production time for future spacecraft components. The paper focus on the main challenges and solutions related to the thermal management within the MFSS technology based on the selected charge regulator (CR) application. Starting with the main set of thermal requirements for the CR the paper will include, conceptual and detailed design based on highconductivity carbon fibre CFRP, description and results of the thermal material sample test program ; parameter and results for the performed first thermal simulationComment: Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions

Die stereotaktische Injektion von Patienten-Liquor mit GAD-Enzephalitis fördert die Entstehung spontaner epileptischer Aktivität im Hippocampus der Ratte

Die limbische Enzephalitis ist eine Erkrankung, welche aufgrund moderner Diagnostik immer häufiger diagnostiziert wird. Es handelt sich um eine Autoimmunerkrankung, bei der verschiedene Antikörper gegen intrazelluläre Proteine oder mebranständige Rezeptorkanäle nachgewiesen wurden. Einer dieser Antikörper sind die GAD-Ak, Antikörper gegen die Glutamatdecarboxylase, deren pathophysiolgische Bedeutung jedoch nicht vollständig geklärt wurde. Dies soll in dieser Forschungsarbeit weiter untersucht werden

Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells

Exposure to fine particulate matter (PM2.5) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM2.5 exaggerate adipose inflammation and insulin resistance in mice with diet-induced obesity. Here, we elucidate the hypothesis that such systemic effects may be triggered by adhered particle components affecting adipose tissue directly. Studying adipocytes differentiated from primary human mesenchymal stem cells, we found that lipophilic organic chemicals (OC) from diesel exhaust particles induced inflammation-associated genes and increased secretion of the chemokine CXLC8/interleukin-8 as well as matrix metalloprotease 1. The oxidative stress response gene haem oxygenase-1 and tumour necrosis factor alpha were seemingly not affected, while aryl hydrocarbon receptor-regulated genes, cytochrome P450 1A1 (CYP1A1) and CYP1B1 and plasminogen activator inhibitor-2, were clearly up-regulated. Finally, expression of β-adrenergic receptor, known to regulate adipocyte homoeostasis, was down-regulated by exposure to these lipophilic OC. Our results indicate that low concentrations of OC from combustion particles have the potential to modify expression of genes in adipocytes that may be linked to metabolic disease. Further studies on mechanisms linking PM exposure and metabolic diseases are warranted.publishedVersio

Five-year outcome in 18 010 patients from the German Aortic Valve Registry

OBJECTIVES: To determine the 5-year outcome in patients treated by isolated transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (sAVR)—a prospective observational cohort study. METHODS: A total of 18 010 patients were included (n = 8942 TAVI and n = 9068 sAVR) in the German Aortic Valve Registry (GARY) who were treated in 2011 and 2012 at 92 sites in central Germany. Eligible patients with TAVI and sAVR were matched using propensity scores in a nearest-neighbour approach. Patients with repeat procedures or unequivocal indication for one treatment option (e.g. frailty) were excluded (n = 4785 for TAVI and n = 2 for sAVR). This led to 13 223 patients (4157 TAVI and 9066 sAVR) as an unmatched subcohort. The main outcome measure was the 5-year all-cause mortality. RESULTS: TAVI patients were significantly older (80.9 ± 6.1 vs 68.5 ± 11.1 years, P < 0.001), had a higher Society of Thoracic Surgeons (STS) score (6.3 ± 4.9 vs 2.6 ± 3.0, P < 0.001) and a higher 5-year all-cause mortality (49.8% vs 16.5%, P < 0.0001). There was no major difference in in-hospital stroke, in-hospital myocardial infarction, or temporary and chronic dialysis. In the propensity score-matched group (n = 3640), there were 763 deaths (41.9%) among 1820 TAVI patients compared with 552 (30.3%) among 1820 treated with sAVR during the 5-year follow-up (hazard ratio 1.51, 95% confidence interval 1.35–1.68; P < 0.0001). New pacemaker implantation was performed in 448 patients (24.6%) after TAVI and in 201 (11.0%) after sAVR (P < 0.0001). CONCLUSIONS: The 5-year follow-up data show that TAVI patients were significantly older and had a higher STS score than sAVR patients. After propensity score matching, TAVI with early-generation prosthesis was associated with significantly higher 5-year all-cause mortality than sAVR

Concomitant mitral regurgitation in patients with low-gradient aortic stenosis: an analysis from the German Aortic Valve Registry

Background: Patients with severe aortic stenosis (AS) frequently presented mitral regurgitation (MR), which may interfere with the standard echocardiographic measurements of mean pressure gradient (MPG), flow velocity, and aortic valve area (AVA). Aims: Herein we investigated the prevalence and severity of MR in patients with severe AS and its role on the accuracy of the standard echocardiographic parameters of AS quantification. Methods: Of all patients with severe AS undergoing transcatheter or surgical aortic valve replacement enrolled in the German Aortic Registry from 2011 to 2017, 119,641 were included in this study. The population was divided based on the values of left ventricular ejection fraction ([LVEF] > 50%, LVEF 31-50%, and LVEF <= 30%] and AVA (0.80 to <= 1.00 cm(2), 0.60 to < 0.80 cm(2), 0.40 to < 0.60 cm(2), and 0.20 to < 0.40 cm(2)). Results: Overall, 77,890 (65%) patients with mild to-moderate and 4262 (4%) with severe MR were compared with 37,489 (31%) patients without MR. Patients with mild-to-moderate and severe MR presented significantly lower mPG (Delta mPG [95%CI] - 1.694 mmHg [- 2.123 to - 1.265], p 50%: AVA 0.80 to 1.00 cm(2); LVEF 31-50%: AVA 0.60 to 0.80 cm(2)). Conclusions: In patients with severe AS, concomitant MR is common, contributes to the onset of a low-gradient AS pattern, and affects the diagnostic accuracy of flow-dependent AVA measurements. In this setting, a multimodality, AVA-centric approach should be implemented